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5369015 |
Method for producing an angiotensin converting enzyme inhibitor-containing composition
Disclosed is a method for producing an angiotensin converting enzyme inhibitor composition from natural materials, which composition is of use as an antihypertensive drug or diet. The method...
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5364841 |
Treatment of obesity and essential hypertension and related disorders
The administration of antagonists and blockers of amylin or CGRP or both for the treatment of obesity and essential hypertension and associated lipid disorders and atherosclerosis.
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5358934 |
Materials and methods for control of pests
The subject invention concerns novel peptides which have the property of interfering with the biosynthesis of the enzyme trypsin. This property enables the use of these peptides to, for example,...
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5348943 |
Cosmetic and skin treatment compositions
Methods and compositions for (a) improving and/or maintaining the health of skin, and (b) increasing subcutaneous fat in warm-blooded animals are disclosed. The methods utilize an effective amount...
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5340817 |
Method of treating tumors with anti-tumor effective camptothecin compounds
A camptothecin analog having the structure shown below: ##STR1## where Z is H or C 1 -8 alkyl and R is NO 2 , NH 2 , N 3 , hydrogen, halogen, COOH, OH, O-C 1 -3 alkyl, SH, S-C 1 -3 alkyl, CN, CH 2 ...
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5338664 |
Assay for detection of bacterial iron transport inhibitors
The present invention relates to a method for identifying a TonB inhibitor in a test sample comprising: (a) growing a TonB + microorganism in the presence of the test sample and a lethal agent,...
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5338726 |
Endothelin converting enzyme inhibitors
Compounds are disclosed which inhibit endothelin converting enzyme. These compounds are useful for treating hypertension, congestive heart failure, myocardial infarction, reperfusion injury,...
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5338668 |
Opioid peptides derived from wheat proteins
Disclosed are opioid peptides recovered from hydrolysates of wheat proteins with an acid protease and further a neutral or alkaline protease. Of those peptides, the structure of four opioid...
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5326751 |
Enkephalin analogs
A new class of opioid receptor analogs is described based on an alanine substitution in the three position in the enkephalin analog DPDPE. The alanine-substituted analogs show increased selectivity...
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5317014 |
Peptides and pseudopeptides derived from tachykinin
A compound of formula (I): ##STR1## in which: R 1 and R 2 , which are identical or different, represent hydrogen, or alkyl, cycloalkyl or benzyl, B represents a residue of an aromatic amino...
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5312811 |
Peptide derivatives and antidemetia agents
A novel peptide derivative having the formula: ##STR1## wherein A between Pro and Q 2 is Arg or Lys: Q 1 is pGlu or H; Q 2 is --Gly--OH or OH; Y 1 is H or --CO--T and Y 2 is OH or T; wherein T...
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5312812 |
Pharmaceutical compositions comprising novel oligopeptides exhibiting selective inhibiting effect upon the proliferation of hemopoietic cells
The present invention relates to novel peptides of formulae Xaa Glu Asp Cys Lys (SEQ I.D. No: 1), and Glu Asp Cys Lys ...
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5298491 |
Derivatives of endogenous mediators, their salts, method of preparation, applications and compositions in which they are present
Derivatives of biologically active molecules containing a primary amine group and a hydroxylated nucleus, and their addition salts with mineral or organic acids, having general formula I: ...
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5298493 |
Compound for use in dietetics, reanimation and therapeutics containing protein fractions based on three types of minipeptides
Methods of treating patients with new compositions intended for use in dietetics, reanimation and therapeutics are provided. The new compositions contain a protein fraction based on three types of...
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5298490 |
Tetra and penta-peptides useful in regulating the immune system
Tetrapeptides and pentapeptides are disclosed which are capable of regulating the function of cells of the mammalian immune system. Also provided are pharmaceutical compositions containing the...
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5284876 |
Method of treating tardive dyskinesia using dopaminergic agents of prodrugs of therapeutic agents
This invention pertains to a method for treating a subject for Tardive Dyskinesia by administering a dopaminergic agent to the subject such that the dopaminergic agent enters the brain or by...
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5284834 |
Adenosine functionalized congeners as cardiovascular treating agents for animals and methods for using same
This invention comprises a series of N 6 -substituted adenosine analogues bearing functionalized chains for the covalent attachment to probes or solid supports. In these compounds coronary...
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5272151 |
Aminoacyl and oligopeptidyl derivatives of allopurinol exhibiting immunostimulatory activity, and pharmaceutical formulations containing these substances
The present invention concerns aminoacyl and oligopeptidyl derivatives of allopurinol (1,5-dihydro-4H-pyrazolo-[3,4-d]-pyrimidin-4-one) of general formula (I), and related salts with ##STR1##...
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5270302 |
Derivatives of tetrapeptides as CCK agonists
Selective and potent Type-A CCK receptor agonists of formula (I): X--Y--Z--Q (I) or a pharmaceutically acceptable salt thereof, wherein, X is...
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5268358 |
PDGF receptor blocking peptides
Methods and compositions are provided for treating several acute disease states associated with smooth muscle cell proliferation as well as the chronic process of atherogenesis utilizing...
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5260272 |
Polyanionic polyamino acid inhibitors of mineral deposition and their synthesis
Polypeptides of the formula poly (X) m (Y) n , wherein X is selected from the group consisting of aspartate, glutamate, glutamine, asparagine, mixtures and block polymers thereof, Y is...
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5260276 |
Linear and monocyclic endothelin antagonists
Novel linear and monocyclic antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling...
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5252558 |
Pentapeptide having specific inhibiting effect on epidermal cell proliferation, the salts thereof, pharmaceutical compositions comprising the same and a process for the preparation of the pentapeptide and the pharmaceutical compositions
The present invention relates to novel pentapeptide of formula Xaa Glu Asp Ser Gly (SEQ ID NO: 1) wherein Xaa is pyro-alpha-aminoadipic acid, having...
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5250516 |
Bioelastomeric materials suitable for the protection of burn areas or the protection of wound repair sites from the occurrence of adhesions
An elastomeric material, capable of reversibly contracting and relaxing by an inverse temperature transition, in a form suitable for use as a protective layer between a mammalian repair site and a...
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5248667 |
Method of treating psoriasis using synthetic peptide compositions
Peptides previously disclosed as useful for preventing HIV from binding to cell binding sites have now been shown to have thymoleptic qualities and to be useful for tretment of psoriasis in...
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5246920 |
Treatment of hyperprolactinemia
A method for the treatment of hypersecretion of prolactin in a patient which comprises co-administration of an effective amount of a growth hormone releasing compound and GHRP-6 or an analog thereof.
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5242904 |
Peptide boronic acid inhibitors of trypsin-like proteases
Peptides comprising C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, are reversible inhibitors of trypsin-like...
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5238921 |
Oligopeptide, angiotensin converting enzyme inhibitors, hypotensive agent, and method for treatment of hypertension
L-Tyr-L-Val, L-Leu-L-Tyr, L-Leu-L-Pro, L-Phe-L-Tyr, L-Tyr-L-Arg and its acid addition salts, L-Leu-L-Ser-L-Pro, L-Leu-L-Gln-L-Pro, L-Phe-L-Leu-L-Pro, L-Leu-L-Leu-L-Pro, L-Leu-L-Asn-L-Pro,...
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5227154 |
Phosphopeptides for the treatment of dental calculus
A method of inhibiting dental calculus by applying to the teeth an oral composition containing a dental calculus inhibiting amount of one or more of the phosphopeptides SEQ.ID NO:1 to SEQ.ID NO:9,...
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5225205 |
Pharmaceutical composition in the form of microparticles
A method for preparing a pharmaceutical composition in the form of microparticles, the composition thus obtained and its use for preparing injectable suspensions.
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5223485 |
Anaphylatoxin-receptor ligands
Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q-T are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease...
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5223487 |
Peptides as antiallergic agents
The following oligopeptides containing -Asp-Gly- or -Asp-Ser- are synthesized: H-Asp-Gly-Lys-OH H-Ser-Asp-Gly-Lys-OH H-Asp-Ser-Asp-Gly-Lys-OH H-Ala-Asp-Ser-Asp-Gly-Lys-OH The...
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5221665 |
N-substituted amides
N-substituted amides which inhibit hydrolysis of elastin, are described, which compounds are tri-and di- fluoromethyl ketone amide and non-naturally occurring n-substituted amino acids derivatives.
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5215964 |
Peptides useful in regulating the immune and nervous systems
Pentapeptides are disclosed which are capable of regulating the function of cells of the mammalian immune and/or nervous system. Also provided are pharmaceutical compositions containing the...
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5214032 |
GHL-CU pharmaceutical compositions and compounds
Methods and compositions for (a) stimulating the growth of hair in warm-blooded animals, (b) increasing subcutaneous fat in warm-blooded animals, and (c) increasing the density of hair follicles in...
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5212154 |
Preparation for treating complications in diabetes
Preparation for preventing or combating complications in diabetes, characterized in that it comprises: (a) insulin or a salt or complex thereof, and (b) a peptide of the general formula I: ...
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5212157 |
Enzyme inhibitors
Disclosed herein are peptide derivatives which inhibit the activity of human immunodeficiency virus (HIV) protease. The peptide derivatives can be represented by general formula R 1 --R 2 --Y--R...
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5200394 |
Derivatives of type A and B synergimycins
The invention synergimicin derivatives having the general formula: Z--X--R, in which Z is a type A or type B synergimycin radical linked by its reactive carbonyl position, through a branch X, where...
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5190921 |
Amino acids and peptides having a modified tyrosine residue, their preparation and their application as medicaments
These compounds are represented by formula (I), in which each of R 1 R 2 =H, C 1 -C 8 alkyl, C 3 -C 7 cycloalkyl, or aromatic; (when R 1 =H, R 2 can be an amine function-protecting radical,...
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5190922 |
Terminally modified tri-, tetra- and pentapeptide anaphylatoxin receptor ligands
Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states....
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5189018 |
Method for reduction of central nervous system (CNS) edema resulting from head and spinal cord trauma
A method for reducing the rise in intracranial pressure accompanying head trauma includes the steps of significantly reducing the mean trauma induced increase in blood brain barrier permeability by...
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5187167 |
Pharmaceutical compositions comprising quinazolin-4-one derivatives
A quinazoline of the formula:- ##STR1## wherein R 1 is alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, aryl, aryloxy, arylalkyl, halogeno, hydroxy, mercapto, pyridylthio, pyrimidinylthio,...
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5185147 |
Short polypeptide sequences useful in the production and detection of antibodies against human immunodeficiency virus
Polypeptides in the size range 6-11 amino acids from discrete regions of the human immunodeficiency virus p17 protein are immunogenic and form the basis for diagnosis and therapy of HIV-related...
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5182264 |
Angiotensin II receptor blockers as antiglaucoma agents
A method and composition for reducing and/or controlling elevated intraocular pressure, especially the elevated intraocular pressure associated with glaucoma, are disclosed in which an angiotensin...
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RE34165 |
Potent thymopentin analogs
Immunoregulating peptides are disclosed which are more potent than thymopentin or splenin and are useful for their effects on the immune system, especially the treatment of thymic deficiencies.
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5180722 |
10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
A camptothecin analog having the structure shown below: ##STR1## where Z is H or C 1 -8 alkyl and R is NO 2 , NH 2 , N 3 , hydrogen, halogen, COOH, OH, O--C 1 -3 alkyl, SH, S--C 1 -3 alkyl, CN, CH...
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5180712 |
Petide antidementia and nootropic agents
A peptide having one of the following formulae (I), (II), (III) and (IV): ##STR1## or its functional derivatives, and a pharmaceutically acceptable salt thereof are disclosed. These peptides have a...
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5169833 |
Substituted cyclic pentapeptides
The present invention provides substituted cyclic pentapeptide compounds of general Formula I: ##STR1## and the pharmaceutically-acceptable slats, esters and amides thereof, which are useful for...
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5166136 |
Spirolactam containing peptides
These are described spirolactam derivatives of formulae (Ia) and (Ib) ##STR1## wherein R represents a hydrogen atom or a conventional nitrogen protecting group; R 1 represents a hydrogen atom...
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5164367 |
Method of using copper(II) containing compounds to accelerate wound healing
Methods for the use of compositions of copper(II) containing compounds to accelerate healing of wounds in warm-blooded animals. The methods include systemic loading of copper(II) to accelerate the...
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