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5273747 |
Commiphora mukul extracts and therapeutical applications thereof
The present invention relates to new therapeutic uses of lipophilic extracts of Commiphora mukul, prepared from exudate of said plant, as well as the preparation of pure compounds or highly...
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5270041 |
Sterols, their fatty acid esters and glucosides; processes for their preparation; spontaneously dispersible agents containing these compounds, and their use for treatment of tumors
There are described antitumour sterols, their fatty acid esters and glucosides, processes for their preparation, spontaneously dispersible agents containing these sterols, their fatty acid esters...
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5260341 |
Product and process for treating bovine mastitis and bovine metritis
A product for treating bovine mastitis and bovine metritis includes mixture of diacetyl and acetoin. The diacetyl and acetoin is produced by fermentation of milk and is then distilled and...
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5256408 |
Aminosteroids for ophthalmic use
Methods and compositions for preventing or treating ophthalmic diseases or disorders wherein an ophthalmically effective amount of the C 20 through C 26 aminosteroids of formula XI and their...
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5232915 |
9α-hydroxy-19,11β-bridged steroids, their production and pharmaceutical preparations containing these steroids
9α-Hydroxy-19,11β-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R 1 , R 2 , G, Z, R 4 --Y and R 4 ' --Y' follows from the description. The...
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5229370 |
Water soluble branched beta cyclodextrin steroid complex
A complex of branched beta cyclodextrin and steroid is formed by mixing a steroid and a branched beta cyclodextrin together in water for a period of about 4 to 24 hours under ambient conditions....
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5227375 |
Aromatase inhibitors
Novel aromatase inhibitors are disclosed for use in therapeutic preparations for treatment of estrogen-dependent diseases. The compounds are specified 7α-substituted androstanedione and...
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5223264 |
Pediatric effervescent dosage form
The present invention relates to oral effervescent dosage forms for the administrations of an intended ingredient to children, and processes for their administration.
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5221669 |
Antiviral compositions containing α-cyclodextrin sulfates alone and in combination with other known antiviral agents and glucocorticoids and methods of treating viral infections
The present invention is directed to antiviral compositions containing α-cyclodextrin sulfates alone and in combination with other known antiviral agents and glucocorticoids and methods of...
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5202126 |
Composition containing pregnenolone or a pregnenolone ester incorporated in liposomes, and a method for regenerating, or revitalizing the skin therewith
The present invention relates to a composition based on hydrated lipidic lamellar phases or on liposomes. In this composition, pregnenolone or a pregnenolone ester, such as, in particular,...
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5196411 |
17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors
17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors of the formula: ##STR1## wherein R is C 3 -C 8 cycloalkyl, which can be substituted with C 1 -C 4 alkoxy or C 6 ...
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5192528 |
Corticosteroid inhalation treatment method
A method for delivering a therapeutic dosage of corticosteroid drug to the lungs, for treating a lung condition or disease. An aqueous suspension of sized liposomes containing the drug in...
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5190936 |
Process for improving the therapeutic efficacy of fat-soluble corticosteroids and composition for carrying out this process
The process consists in dissolving a corticosteroid in the lipid phase of nonionic amphiphilic lipid vesicles consisting of one or more lipid lamellae. Composition for carrying out the above...
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5173483 |
Ovulation stimulating method
A method of stimulating ovulation in warm-blooded animals comprising administering to warm-blooded animals an ovulation stimulating effective amount of at least one anti-progestomimetic compound.
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5166199 |
11β-aryl-16α,17α-cyclohexano-estra-4,9-dienes
11♁-Aryl-16α,17α-cyclohexano-estra-4,9-dienes of formula ##STR1## wherein R 1 is H or a methyl group; R 2 is --OCH 3 , --SCH 3 , --N(CH 3 ) 2 , --NHCH 3 , --CN, --CHO, --COCH 3 or...
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5155045 |
Use of male essence to alter female endocrine response
A novel method for treating a human female is disclosed comprising the step of exposing the nasal region of said female to at least a portion of the axillary secretions of a human male. This...
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5132299 |
11β-phenyl-4,9,15-estratrienes, their manufacture and pharmaceutical preparations containing same
New 11β phenyl-4,9,15-estratrienes of formula I ##STR1## are described, where X implies an oxygen atom or a hydroxyimino grouping N.about.OH, R 1 stands for a hydrogen atom or a methyl group, ...
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5094857 |
Treatment of acne or androgenetic alopecia by topical administration of ethisterone
There is disclosed the use of ethisterone its nor analogs as well as their corresponding 17-esters formed with pharmaceutically acceptable carboxylic acids, for the reduction of lipids, in...
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5091380 |
N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors of the formula: ##STR1## wherein R is a hydrocarbon radical selected...
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5089488 |
β-(4-isopropenylphenyl)estra-4,9-dienes, their production, and pharmaceutical preparations containing same
11 β-(4-isopropenylphenyl)-estra-4,9-dienes of general Formula I ##STR1## wherein X is an oxygen atom or a hydroxyimino grouping ##STR2## R 1 is a hydrogen atom or a methyl group, R 2 is a...
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5087620 |
Controlled dermal penetration enhancement using imidazoles
Topical compositions are described which contain a vehicle which is free of lower alkanols, a pharmacologically active agent whose dermal penetration can be enhanced and a unique penetration...
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5080885 |
Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
A non-toxic, brominated perfluorocarbon emulsion for internal and intravenous use in animals (including humans) is disclosed, for use as an oxygen transport medium and as a contrast enhancement...
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5077284 |
Use of dehydroepiandrosterone to improve immune response
The steroid hormone dehydroepiandrosterone (DHEA), when administered by feeding or by subcutaneous injection, significantly improves the host response to viral infection. Experimental animal data...
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5073548 |
11 β-substituted progesterone analogs
A 11β-aryl-19-norprogesterone steroid of the formula: ##STR1## wherein (i) R 1 is H, C 1 -4 alkyl, C 2 -4 alkenyl, C 2 -4 alkynyl, OH, OC(O)CH 3 , or OC(O)R 5 , wherein R 5 is C 2 -8 alkyl, C 2...
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5061700 |
Glyceryl acetate ointment vehicles
Compositions of matter serving as topical ointment vehicles and comprising a glyceryl acetate, preferably triacetin, and an oleaginous material that can be combined with a medicament, preferably a...
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5043331 |
Treatment of postmenopausal disorders
A method is provided for the treatment of postmenopausal disorders which comprises administering to a woman in single, oral, daily dose form during an uninterrupted consecutive sequence of 90 days....
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5002936 |
Lipophilic complexes of pharmacologically active inorganic mineral acid esters of organic compounds
The present invention provides a composition with the structure (L) m (E) n wherein (L) m and (E) n are bound as a complex, wherein L is a lipophilic compound; wherein E is a nonlipophilic,...
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5001115 |
Prodrugs of biologically active hydroxyaromatic compounds
Prodrugs of bio-active hydroxyaromatic drugs having the structural formula: A pharmaceutically acceptable prodrug of a biologically active, therapeutically effective hydroxyaromatic drug, said...
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4981686 |
Personal lubricant
A personal lubricant which is not contraceptive, does not impede sperm motility and may contain healing ingredients.
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4973474 |
2,4-diaminopyrimidine 3-oxide derivatives and their use for the treatment and prevention of hair loss
New 2,4-diaminopyrimidine 3-oxide derivatives and their use for the treatment and the prevention of hair loss. The compounds correspond to the formula: ##STR1## in which: R 1 and R 2 denote...
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4970205 |
Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid...
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4970204 |
3-substituted nitro-steroid derivatives as 5-α-reductase inhibitors
Invented are 3-nitro- substituted steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-α-reductase...
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4966890 |
Method and composition for arresting angiogenesis and capillary, cell or membrane leakage
A composition and method for arresting angiogenesis, and cell, capillary or membrane leakage comprising a pharmaceutically effective amount of angiostatic steroid and pentosan polysulfate, or a...
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4963346 |
Method and composition for treatment or prevention of dental plaque calculus and gingivitis
A method and composition is presented for the treatment or prevention of dental plaque, calculus and gingivitis. The method comprises either systemically or topically treating the oral cavity for a...
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4960592 |
Lanolin and lanolin oil skin treatment composition
A composition for the treatment of dry skin comprises a mixture of lanolin and lanolin oil. Preferably, the composition contains about 75% by weight of lanolin and about 25% by weight of lanolin oil.
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4952411 |
Method of inhibiting the transmission of AIDS virus
An inexpensive, easily available and convenient method of inhibiting the transmission of the AIDS virus in humans as a result of sexual intercourse is provided. The method relies upon a dual mode...
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4945064 |
Estrane and androstane derivatives, process for producing them and preparations containing these compounds
Estrane and androstane derivatives of formula I ##STR1## wherein X is bromine, iodine, triphenyltin or trialkyltin of 1 to 6 carbon atoms per alkyl radical, Y represents two hydrogen atoms or...
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4942158 |
Transdermal steroid penetrant compositions and methods utilizing isopropanol and isobutanol
A unique combination of isopropyl and isobutyl alcohols synergistically increases the permeability of the skin to steroid drugs.
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4939135 |
Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation
Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing...
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4938897 |
Chlorambucil derivatives and cell-discriminating agent containing the same
Disclosed herein are (1) a fluorescent substance represented by the formula (I), (2) a process for producing the fluorescent substance, and (3) a cell-discriminating agent containing the...
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4917828 |
Process for preparing ketocholanates
A process for preparing ketocholanate(s) comprises oxidizing cholanic acid compound(s), such as alkyl 3α-alkoxycarbonyloxy-7α,12α- dihydroxycholanates or alkyl...
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4912097 |
Novel 11 β-alkynylphenyl-10-nor-steroids
Novel 11β-alkynylphenyl-19-nor-steroids of the formula ##STR1## wherein R 1 is alkynyl of 2 to 8 carbon atoms optionally substituted with at least one member of the group consisting of --OH...
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4908162 |
Method of making triple bonded unsaturated fatty acids
A method is provided for preparing unsaturated fatty acids having triple bonds by reducing the double bonds of unsaturated fatty acids. The unsaturated, double-bonded fatty acid is reacted with a...
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4895727 |
Pharmaceutical vehicles for exhancing penetration and retention in the skin
This invention is a method of inducing a reservoir effect in skin and mucous membranes so as to enhance penetration and retention and reduce transdermal flux of topically applied therapeutic and...
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4883792 |
Steroid cream formulation
A steroid cream formulation which has enhanced physical and chemical stability is formed of (11β,17α)-17-(ethylthio)-9α-fluoro-11β-hydroxy-17-(m ethylthio)androsta-1,4-dien-3-one (tipredane),...
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4870066 |
Method and composition for safely delaying parturition and synchronizing farrowing in swine
A method and composition are provided for extending the gestation period of a sow so as to increase the live birth and survival rates of a swine litter without adversely affecting the sow. The...
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4866049 |
Ophthalmic compositionn and method of using same
The present invention relates to ophthalmic compositions and their preparation and use. More specifically, the invention relates to ophthalmic compositions useful in the treatment of surface...
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4859709 |
Pharmaceutical composition
A pharmaceutical composition comprising a freely flowable powder, the powder comprising a porous, high absorption silica or silicate having absorbed therein at least 10% by volume of a liquid,...
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4837026 |
Transdermal and systemic preparation and method
A composition useful for topically administering physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for systemic use or...
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4831023 |
Water washable vehicles for topical use
Anhydrous vehicles for topical use, e.g. for use with topically active pharmaceutical agents, including antibiotics, anti-fungal agents, anti-inflammatory agents, antihistamines, antipruritics and...
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