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5656277 |
Nor- and homo- bile acids derivatives as absorption enhancers for medicaments
The use of nor- and homo-bile acids derivatives as absorption enhancers for medicaments is described. Said derivatives show the advantage of improving the absorption of medicaments through mucosae...
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5643884 |
Lupane triterpenoid derivatives
This invention relates generally to the field of medicinal chemistry, and more specifically to derivatives of a subclass of triterpenoid acids that have multi-medicament properties, that is...
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5643889 |
Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof
A cholesterol-cordycepin conjugate having the formula ##STR1## wherein: n is an integer from 1 to 8; R 1 is selected from the group of consisting of T, T' and Y; T is ##STR2## T' is ##STR3## where...
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5643898 |
Combination of derivatives of pyrimidine and of hydrocortisone for inducing and stimulating the growth of hair and reducing its loss
1. Combination intended to induce and to stimulate the growth of hair and to reduce its loss, characterized in that it comprises: a) a component (A) containing, in an anhydrous, physiologically...
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5641765 |
17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
Invented are 17α and 17β-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these...
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5637310 |
Method of treating prostatic adenocarcinoma
Invented is a Method of Treating Prostatic Adenocarcinoma by employing asteroid 5-α-reductase inhibiting compound or a combination of steroid 5-α-reductase inhibiting compounds.
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5618806 |
17α and 17β-substituted estra-1,3,5(10)-triene-3-carbboxlic acid
Invented are 17α and 17β-substituted acyl-3-carboxy aromatic A ring analogues of steroidal synthetic compounds. Representative of such compounds include the following ##STR1## wherein Z is α or...
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5609873 |
Use of an ecdysteroid for the preparation of cosmetic or dermatological compositions intended, in particular, for strengthening the water barrier function of the skin or for the preparation of a skin cell culture medium, as well as to the compositions
The invention relates to a cosmetic or dermatological composition, as well as a cell culture medium. This composition and this medium contain an ecdysteroid, an ecdysteroid derivative or a plant or...
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5610149 |
Steroidal polyamines
New steroidal polyamines have the structure of formula I or formula II: ##STR1## wherein R 1 and R 2 are independently N(R') 3 + or H in the α- or β- position except both R 1 and R 2 are...
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5607691 |
Compositions and methods for enhanced drug delivery
The present invention relates to methods of delivering pharmaceutical agents across membranes, including the skin layer or mucosal membranes of a patient. A pharmaceutical agent is covalently...
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5603935 |
Composition for the treatment of snoring and methods of use thereof
A composition and method for the treatment of snoring comprising an effective amount of discorea villosa and zingiber officinale in a physiologically acceptable carrier, to be administered in the...
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5604216 |
Compositions containing esters of unsaturated fatty acids
Pharmaceutical and nutritional compositions are disclosed containing, in association with a suitable diluent or carrier, at least 10% by weight of a cholesterol fatty acid ester where the fatty...
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5591733 |
Methods, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified...
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5587368 |
Administration of a 27-hydroxycholesterol or related compound or sterol-27-hydroxylase stimulant to prevent restenosis following vascular endothelial injury
A method for preventing or reducing restenosis wherein a 27-hydroxycholesterol or a 25,26 and/or 27-aminocholesterol, or a sterol 27-hydroxylase stimulant, is administered in a restenosis...
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5582828 |
Active fractions of Cordyceps sinensis and method of isolation thereof
A method for identifying and isolating the active fractions in Cordyceps sinensis. It covers a findings of the structure of an active compound that is present in the active fraction, an isolation...
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5574022 |
Method of attenuating physical damage to the spinal cord
A method is disclosed for attenuation of nervous system damage after injury which comprises administering therapeutic amounts of PREG, PREG-S, or esters of PREG or PREG-S together with an enhancer...
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5567694 |
17-Aryl and 17-heterocyclyl-5β,14β-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
17-aryl and heterocyclyl-5β,14β-androstane compounds having the formula (I) ##STR1## wherein R is an aryl ring or a saturated or unsaturated heterocyclic ring are active on the cardiovascular...
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5565443 |
Subcutaneous implants based on normegestrol derivatives
Subcutaneous implant for preventing conception for at least one year in women comprising an amount effect to prevent conception without suppressing intermontly bleeding of a steroid compound of...
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5561124 |
17-α-acyl steroids which inhibit 5-α-reductase
The invention relates to substituted 17α-acyl steroidal 5α-reductase inhibiting compounds. The invention also relates to pharmaceutical compositions containing these compounds and their use for...
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5556644 |
Nutritional supplement for the elderly
A multinutrient nutritional supplement is provided that is designed to be most effective in increasing the immunity and decreasing the instances and severity of infection particularly among older...
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5554386 |
Delivery of therapeutic agents to receptors using polysaccharides
This invention relates to a method of directing a therapeutic agent to selected cells, wherein a complex is formed between a polysaccharide capable of interacting with a cell receptor and a...
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5550107 |
Combination therapy for the treatment of estrogen-sensitive disease
A method of treatment of breast and endometrial cancer in susceptible warm-blooded animals may include inhibition of ovarian hormonal secretion by surgical (ovariectomy) or chemical (use of an LHRH...
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5550120 |
Regulating neuropeptide hormone secretion
Methods are described for regulating neuropeptide secretion to alleviate premature labor, hypertension, fluid imbalance, and risk of heart disease: using neuroactive steroids targeted for a...
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5545634 |
Activation of androgen receptors with low dose non-masculinizing androgenic compounds
A method of treatment or prevention of breast and endometrial cancer, osteoporosis and endometriosis in susceptible warm-blooded animals comprising administering a low dose. Of a progestin or other...
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5538721 |
Stabilization of aminosteroids for topical ophthalmic and other applications
The invention provides methods for stabilizing amino-substituted steroid therapeutic agents in topical ophthalmic and other pharmaceutical formulations using effective stabilizing amounts of...
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5534505 |
Ursodeoxycholic acid-containing medicament in a liquid adminstration form
The active agent ursodeoxycholic acid has proved therapeutically active in infants, inter alia for the treatment of cholestatic hepatic diseases. A problem when administering this active agent, a...
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5527788 |
Method and composition for treating obesity comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent
The invention describes a method and composition for treating obesity or related disorders in animals using an anorectic agent and dehydroepiandrosterone (DHEA). The composition effectively...
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5525349 |
Compositions and methods for treating the cornea inconjunction with laser irradiation
Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing...
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5514667 |
Method for topical treatment of herpes infections
A method for the topical treatment of herpes virus infections of the skin and mucous membranes is disclosed- This method uses a topical preparation comprising an anti-vital drug in combination with...
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5512556 |
Use of a pregnane derivative
The invention relates to a use of pregnane derivatives of the following general formula: ##STR1## in which R=H 2 , (H,OH), (H,OAcyl), or O, and especially the pregnane...
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5480913 |
Anti-androgen compounds
Disclosed are novel classes of anti-androgens including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.
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5439899 |
Cosalane and related compounds having activity against aids and aids-related infections
Novel compounds having anti-HIV activity are disclosed along with formulations and methods for treating human immunodeficiency viral infections employing these compounds.
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5439685 |
Pharmaceutical composition for the prevention of sexually transmitted diseases
A pharmaceutical composition for the prevention of sexually transmitted diseases, intended to be contacted with a mucosa. The composition contains, on the one hand, at least one constituent active...
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5422393 |
Natriuretic hormone
A purified naturally occurring natriuretic compound, identified as Natriuretic Hormone, and a method for isolation of the compound. The natriuretic compound has a molecular weight of about 360, a...
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5403590 |
Method of pulsatile drug infusion
A method of pulsatile infusion of a drug or other therapeutic agent is described. The pulsatile infusion method minimizes tachyphylaxis, while enabling the target cell, tissue, or organ to benefit...
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5397563 |
Perfluoro-t-butyl-containing steroids for use in fluorine-19 NMR and/or MRI
Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The...
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5393513 |
Stable, highly concentrated fluoro carbon emulsions
A non-toxic, brominated perfluorocarbon emulsion for internal and intravenous use in animals (including humans) is disclosed, for use as an oxygen transport medium and as a contrast enhancement...
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5389623 |
Redox carriers for brain-specific drug delivery
Compounds of the formula ##STR1## and the nontoxic pharmaceutically acceptable salt thereof, wherein D is the residue of a centrally acting drug containing at least one reactive functional group...
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5382434 |
Low steroid dose dry pharmaceutical preparation
Disclosed are dry pharmaceutical preparations containing potent steroidal medicinal agents in combination with an excipient capable of binding the agent to an extent greater than 80% and a having a...
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5376641 |
Method for making a steroid water soluble
A complex of branched beta cyclodextrin and steroid is formed by mixing a steroid and a branched beta cyclodextrin together in water for a period of about 4 to 24 hours under ambient conditions....
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5362720 |
Methods of treating or preventing breast or endometrial cancer with low dose non-masculinizing androgenic compounds
A method of treatment or prevention of breast and endometrial cancer, osteoporosis and endometriosis in susceptible warm-blooded animals comprising administering a low dose of a progestin or other...
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5356881 |
Plant-derived wildlife repellents
Products from the plant species Nerium oleander and, Urginea maritima, are prepared and tested as wildlife repellents comparing them with digitalis products. Chemical compounds derived from these...
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5344826 |
Tricycle steroid analogs
Novel tricyclic steriod analogs are disclosed which are 1H-benz[e]indene dodecahydro compounds that are useful for enhancing GABA-induced chloride currents at the GABA receptor/chloride ionophore...
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5344827 |
Steroid sulphatas inhibitors
Novel steroid 3-thiophosphonates are disclosed which are useful as steroid sulphatase inhibitors.
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5336506 |
Targeting of therapeutic agents using polysaccharides
The invention relates to a method for the targeting of a therapeutic agent to a specific population of cells, wherein a complex is formed between the therapeutic agent and a polysaccharide capable...
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5324719 |
Therapeutical method for the treatment of hypertension
A therapeutical method for treating hypertension is disclosed which comprises administering to a patient in need thereof an effective amount of an imino derivative of 3β,...
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5321018 |
Use of 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis
A novel use for 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis inasmuch as these compounds when administered to humans are converted to a metabolite, such as a 1α,25-dihydroxylated...
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5321019 |
Bile acid sulfurated derivatives
Compounds of formula I: ##STR1## in which the various R groups have the meanings defined in the disclosure are useful as medicaments for the treatment of hepatobiliary diseases.
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RE34578 |
Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
A topical drug application for the alleviation of kerato-conjunctivitis sicca (dry eye syndrome) is comprised of a solution of sex steroids or their derivatives suspended or dissolved in a vehicle,...
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5292730 |
Modulation of immune system with Δ5-androstenes
Alzheimer's disease and immune deficiency disorders may be effectively treated by administering a Δ5-Androstene-3β-ol-17-one having a C 7 substituent selected from the group consisting of oxo,...
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