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6677327 |
Phytosterol and phytostanol compositions
The present invention relates to an edible phytosterol or phytostanol composition useful in the food industry and to methods of preparing such an edible composition. The edible composition...
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6670345 |
Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid
The invention relates to the use of betulinic acid derivatives for the inhibition and or prevention of cancer growth. The invention also relates to novel betulinic acid derivatives useful for...
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6660725 |
Method and composition for modulating amyloidosis
Methods for modulating amyloid deposition in a subject are described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to a subject, such that...
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6656970 |
Method and compositions for solubilization of pentacyclic triterpenes
The present invention provides compositions and methods for the solubilization of poorly soluble drugs such as triterpenes like betulinic acid and/its derivatives in pharmaceutically acceptable...
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6649602 |
Use of an H1 antagonist and a safe steroid to treat eye conditions
Composition and method of treating VKC, GPC, and AKC with H1 antagonists and ocularly safe steroids are disclosed.
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6645953 |
Meiosis regulating compounds
Sterol derivative compounds, structurally related to natural compounds which can be extracted from bull testes and from human follicular fluid, useful for regulating meiosis in oocytes and in male...
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6642219 |
Progestogen-antiprogestogen regimens
An estrogen-free contraceptive is provided which does not have the bleeding-related drawbacks of conventional progestogen-only pills. Thus the invention is a contraceptive kit comprising a combined...
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6642217 |
Triterpenes having human antifungal and antiyeast activity
Methods of treating a fungal or yeast infection and of killing or inhibiting fungi or yeast are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other...
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6623763 |
Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism
A pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system, for the release of the active substance 17-β-estradiol, contained therein in dissolved form being...
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6620793 |
Therapeutic use of ganglioside GM1 in the treatment of spinal cord injury
The invention relates to a method for amelioration of neurological outcome in humans with spinal cord damage by administration of ganglioside GM 1 . Another object of the present invention is to...
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6617319 |
Methods of use for 2-deoxy ecdysterone
The invention provides a process for the isolation of 2-deoxy ecdysterone from Zoanthus sp process comprising the steps (a) preparing crude methanol extract of Zoanthus sp., (b) subjecting the...
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6610675 |
Inactive metabolite approach to soft drug design
The invention provides novel soft steroidal anti-inflammatory agents, pharmaceutical compositions containing said agents, and methods of administering same to mammals in the treatment of...
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6605605 |
Estrogenic substances combined with cruciferous indole compounds
Provided herein are medicinal compositions of matter that comprise an estrogenic medication component and a cruciferous indole component (indole 3-carbinol, diindolylmethane, or any derivative...
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6602902 |
Dha-pharmaceutical agent conjugates to improve tissue selectivity
The invention provides conjugates of cis-docosahexaenoic acid and pharmaceutical agents useful in treating noncentral nervous system conditions. Methods for selectively targeting pharmaceutical...
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6599927 |
Use of an H&plus , K&plus -ATPase inhibitor in the treatment of Widal's Syndrome
The invention provides a method for the treatment of polyposis which comprises treating a subject suffering from polyposis with an H + , K + -ATPase inhibitor and, optionally, a glucocorticoid. The...
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6599513 |
Products for topical applications comprising oil bodies
The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for...
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6593316 |
Use of &Dgr 5-androstene-3βol-7,17-dione in the treatment of lupus erythematosus
Lupus erythematosus can be treated by administering therapeutic amounts of Δ5-androstene-3β-ol-7,17-dione and metabolizable precursors thereof, such as Δ5-androstene-3β-acetoxy-7,17-dione,...
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6593310 |
Treatment of osteoporosis
A method for treating osteoporosis which comprises administering to a mammal in need of such treatment an effective amount, typically in the range of 0.1 to 100 micrograms per kg of body weight, of...
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6589945 |
Use of sterolsulfates as active substances for producing means to inhibit serin proteases
A process for treating human skin by inhibiting serine protease formation involving contacting the skin with a composition containing a sterol sulfate.
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6583129 |
Administration of non-oral androgenic steroids to women
The present invention provides compositions, methods, and kits for improving health in a woman having elevated SHBG levels, or who is receiving oral estrogen supplementation, by non-orally...
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6579864 |
3-methylene steroid derivatives
The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R 1 is H or together with R 3 forms a β-epoxide or R 1 is absent if there is a 5-10 or 4-5 double...
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6579853 |
Brain cell or nerve cell-protective agents comprising ginsenoside Rb1
The present invention provides preparations for efficaciously administering ginsenoside Rb 1 or its salt useful as cytoprotective agents. More particularly, the present invention provides...
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6569839 |
Fast-acting pharmaceutical compositions and methods of use
A pharmaceutical composition comprising at least one local anesthetic, at least one anti-inflammatory agent and at least one antibiotic are disclosed. The local anesthetic has a peak effect no...
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6562805 |
Cosalane compounds and methods for their use
The present invention relates to methods, compounds and compositions for inhibiting effective binding of a chemokine to its cellular receptor. In one form of the invention, a method includes...
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6558943 |
Method for propagating fungi using solid state fermentation
A solid state fermentation (SSF) method is provided which is effective for both small- and large-scale fungal cultivation. Also provided is SSF media for fungal cultivation. The media preferably...
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6555530 |
Use of estrogens and delta-gonadien-21-Ol-3,20-diones for treating insulin dependent and non-insulin dependent diabetes
Analysis of full-blood glucose, serum insulin, serum triglycerides and total serum cholesterol were performed. Glucose levels in blood samples from the oral glucose tolerance test were used for...
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6544972 |
Methods of limiting apoptosis of cells
Methods for limiting apoptosis in a cell population by contacting such cells with a hydrophilic bile acid, such as ursodeoxycholic acid (UDCA), salts thereof, and analogs thereof (e.g., glyco- and...
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6531139 |
Self-emulsifying formulation for lipophilic compounds
The present invention provides a novel pharmaceutical composition based on the use of a particular oil phase which comprises a lipophilic, pharmaceutically active agent, a mixture of diglyceride...
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6514957 |
Method of alleviating the violence and stimulating the appetite of stag in the puberty age of the fall and method of promoting the growth of stag's horn
A method of alleviating the violence and stimulating the appetite of stags in the puberty age of the fall and a method of allowing to cut and collect more than twice stag's horn is provided by...
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6506390 |
Progestogen-anti-progestogen regimens
A contraceptive and/or HRT (hormone replacement therapy) kit comprising sequential daily dosage units each containing as the sole contraceptively effective ingredient a progestogen, or as the...
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6500815 |
Substituted 11.beta steroid derivatives, method for preparing same and intermediates of said method, use as medicine and compositions containing them
The invention concerns compounds of formula (I) wherein: X, Y, R 1 , R 2 , Z, G are as defined in the description, the methods for preparing them and the intermediates in said method, their use as...
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6495534 |
Stabilized aqueous suspensions for parenteral use
A pharmaceutical aqueous suspension formulation for parenteral administration having substantially stabilized pH, comprising a biologically active compound and a pH controlling effective...
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6491936 |
Creams containing vitamin D3 derivatives
The present invention aims to provide an O/W type creams showing improved skin absorption and heat stability of maxacalcitol as an active ingredient. The present invention provides O/W type creams...
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6488937 |
Allergy treatment method using a rapid immunotherapy protocol
A method of treating a patient sensitive to an allergen includes a desensitizing rapid immunotherapy protocol of administering to the patient a series of gradually increasing doses of a composition...
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6486170 |
Phospholipase A2 inhibitors as mediators of gene expression
A signaling pathway is identified that involves the activation of phospholipase A2 and protein kinase C in human cells, which in turn confers x-ray induction of the tumor necrosis factor α (TNF)...
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6476012 |
Estradiol-16α-carboxylic acid esters as locally active estrogens
The present invention relates to analogs of estradiol, which, in their most preferred embodiment, act as locally active estrogens without significant systemic action. A series of 16α-carboxylic...
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6468981 |
Compositions and methods for targeting pharmaceutically active materials to cells containing androgen receptors
A water soluble delivery system for nucleic acids to cells having androgen receptors, preferably prostate cells, is provided comprising a steroid moiety capable of binding to said receptors, said...
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6468975 |
Liver specific bile acid derivatives of the glucocorticoid antagonist RU486
Novel glucocorticoid receptor ligands and methods of treating diseases such as diabetes, wherein the ligands have general formula (I) wherein the variables are as defined by the present...
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6465446 |
Treatment of dermatitis by the topical application of &Dgr 5-androstene-3β-ol-7,17 dione and metabolizable precursors thereof
Dermatitis can be treated by the administration of Δ5-androstene-3β-ol-7,17 dione and metabolizable precursors thereof, such as Δ5-androstene-3β-acetoxy-7,17 dione, to the skin.
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6465421 |
Modulating body/cranial hair growth
The growth of body and/or head/cranial hair on mammalian organisms, for example humans, is modulated by administering thereto, whether topically and/or systemically, therapeutically effective...
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6458834 |
Pentacyclic triterpenes
The present invention relates to fuingicidally effective compositions containing at least one pentacyclic triterpene compound.
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6458347 |
Drug complex
Disclosed is a drug complex of a drug having a hydroxyl group, which is capable of controlling the rate of the release of the drug therefrom in blood, the drug complex being represented by the...
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6455516 |
Method and compounds for use in the treatment of steroid induced states of the central nervous system
The use of epiallopregnanolone (3β-hydroxy-5α-pregnan-20-one) for the treatment of steroid induced mood disorders and CNS disorders is disclosed. Further, the use of epiallopregnanolone for the...
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6451777 |
Method for regulating hair growth
A method for regulating the growth and loss of hair via the use of compositions containing a compound selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes,...
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6444659 |
Use of mixtures of active substances, containing phytostenols and/or phytostenol esters and potentiators, for the production of hypocholesterolemic agents
A hypocholesterolemic composition containing: (a) an active ingredient selected from the group consisting of a phytostenol, a phytostenol ester, and mixtures thereof; and (b) a potentiating agent...
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6440954 |
Inhibition of vascular smooth muscle cell proliferation
Methods of treating a mammal having a condition characterized by vascular smooth muscle cell proliferation, where the mammal is treated with progesterone or an agonist thereof. Also disclosed are...
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6436367 |
Aerosol formulations for buccal and pulmonary application
A mixed micellar aerosol pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, at least three micelle forming compounds, a phenol and a...
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6432439 |
O/W emulsion composition
An O/W emulsion composition comprising fluorometholone or clobetasone butyrate, a phospholipid, an oil, a nonionic water-soluble cellulose derivative, and water. The O/W composition has advantages...
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6423698 |
Combination therapy for the prophylaxis and/or treatment of benign prostatic hyperplasia
A combination therapy for the prophylaxis and/or treatment of benign prostatic hyperplasia in susceptible warm-blooded animals which comprises administering a combination of two or more compounds...
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6395722 |
Fatty acid derivatives of bile acids and bile acid derivatives
The present invention relates to bile acid or bile salt fatty acid conjugates (hereinafter called “BAFAC), to their use in dissolving cholesterol gallstones in bile, preventing their occurrence...
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