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7122531 |
Regulation of intracellular glucocorticoid concentrations
This invention relates to the interconversion of inactive 11-keto steroids with their active 11B-hydroxy equivalents, to methods by which the conversion of the inactive to the active form may be...
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7122532 |
Regulation of intracellular glucocorticoid concentrations
This invention relates to the interconversion of inactive 11-keto steroids with their active 11B-hydroxy equivalents, to methods by which the conversion of the inactive to the active form may be...
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7122533 |
Cosalane compounds and methods for their use
The present invention relates to methods, compounds and compositions for inhibiting effective binding of a chemokine to its cellular receptor. In one form of the invention, a method includes...
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7115287 |
Topical medicament and method of use
A topical medicament, and associate method of use, for the treatment of dermatologic conditions in both humans and animals is provided. The medicament includes a mixture of Vitamin A, Vitamin D,...
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7101576 |
Nanoparticulate megestrol formulations
The present invention is directed to nanoparticulate compositions comprising megestrol. The megestrol particles of the composition have an effective average particle size of less than about 2000 nm.
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7101693 |
Plasticized hydrophilic glasses for improved stabilization of biological agents
The stabilization of biomaterials such as proteins in a nominally dry, hydrophilic glassy matrix is vastly improved by the addition of an appropriate amount of a small-molecule pasticizer such as a...
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7090865 |
Composition and method for treating autoimmune hemolytic anemia
Disclosed are a composition and method to treat or prevent antibody-induced anemia and particularly, autoimmune hemolytic anemia. The composition comprises a bisphosphonate and a pharmaceutically...
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7087588 |
Nitric oxide donors capable of reducing toxicity from drugs
Use of organic compounds containing the —ONO 2 function, or inorganic compound containing the —NO group or compositions comprising said compounds to reduce the toxicity caused by drugs to the...
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7084153 |
Medicaments comprising steroids and a novel anticholinergic
A pharmaceutical composition comprising:
(a) a salt of formula 1
wherein: X − is an anion with a single negative charge; and (b) a steroid 2,
processes for preparing...
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7078059 |
Treatment of bone diseases
The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis...
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7074778 |
Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of...
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7067504 |
Di-steroidal prodrugs of ethinyl estradiol
The present invention is a di-steroidal prodrug of ethinyl estradiol according to formula I:
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7067505 |
Di-steroidal prodrugs of estradiol
The present invention is a di-steroidal prodrug of estradiol having the following formula:
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RE39104 |
Process for the production of dry pharmaceutical forms and the thus obtained pharmaceutical compositions
A process for the production of a solid dispersion of at least one therapeutic agent in a hydrophilic carrier having enhanced solubility in an aqueous media comprising dissolving at least one...
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7045513 |
DHEA composition and method
Disclosed are improved pharmaceutical formulations comprising dehydroepiandrosterone (DHEA), enriched in selected polymorphic forms, for therapeutic applications. In one embodiment, the formulation...
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7037907 |
Estradiol conjugates and uses thereof
A conjugated prodrug of an estradiol compound conjugated to a biological activity modifying agent.
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7018991 |
17β-amino and hydroxylamino-11 β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
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7015202 |
Use of glycyrrhizin and its derivatives as MCP-1 production inhibitors
The object of the present invention is to provide the use of glycyrrhizin and its derivatives for inhibition of MCP-1 production. The present invention discloses an MCP-1 production inhibition...
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7012060 |
TNF receptor and steroid hormone in a combined therapy
The present invention relates to the use of a TNF Receptor together with a steroid hormone to produce a pharmaceutical composition for the treatment of lethal bacterial and viral infections as well...
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6998394 |
Process for isolating physalins from plants and pharmaceutical compositions containing physalins
The present invention relates to a process for obtaining Physalis angulata extracts, particularly to isolate ergostane-type steroidal derivatives, such as physalins, which are useful in the...
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6982284 |
Compositions and methods for modification of skin lipid content
The topical use of ursolic acid compounds to alter the lipid content of mammalian skin is disclosed. The compounds can be encapsulated in liposomes and administered in this form to the skin in, for...
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6977083 |
Bioadhesive tablet containing testosterone/testosterone ester mixtures and method for producing a predetermined testosterone time-release profile with same
The method of making a bioadhesive tablet for controlling testosterone blood level, especially in elderly men suffering from partial androgen deficiency, includes spray-drying an alcoholic solution...
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6960474 |
Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator
Selective androgen receptor modulators (SARMs) having antagonist activity in hormone-dependent tumors while exhibiting no activity or agonist activity against other nontumor tissues containing the...
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6956030 |
Use of mometasone furoate for treating upper airway diseases
The administration of aerosolize particles of mometasone furoate in the form of dry powders, solutions, or aqueous suspension for treating corticosteroid-responsive diseases of the surfaces of...
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6949531 |
14 β, 16, 17-methylene steroids as novel androgens
Disclosed are androgenic steroids of the (14β,17α)-17-(hydroxymethyl) type. The invention relates to an improvement thereof, which is based on the presence of a β-oriented, annellated...
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6949523 |
Aglycon dammarane sapogenins, their use as anti-cancer agents, and a process for producing same
This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of...
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6949532 |
Use of mometasone furoate for treating airway passage and lung diseases
The administration of aerosolize particles of mometasone furoate in the form of dry powders, solutions, or aqueous suspension for treating corticosteroid-responsive diseases of the surfaces of...
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6936599 |
Estriol therapy for multiple sclerosis and other autoimmune diseases
The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, more particularly, Th1-mediated (cell-mediated) autoimmune diseases including:...
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6924274 |
Use of Δ5-androstene-3β-ol-7,17-dione in the treatment of lupus erythematosus
Lupus erythematosus can be treated by administering therapeutic amounts of Δ5-androstene-3β-ol-7,17-dione and metabolizable precursors thereof, such as Δ5-androstene-3b-acetoxy-7,17-dione, which...
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6921532 |
Biological Bioadhesive composition and methods of preparation and use
The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates...
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6905705 |
Multipack for removing filled bags in a predetermined sequence
This invention provides for, inter alia, a multipack comprising at least two different bags, wherein the bags are arranged in a predetermined sequence and are joined together in a single block. The...
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6872713 |
Antiprotozoal saponins
Saponins of formula (I), a stereoisomeric form thereof or a pharmaceutically acceptable addition salt thereof, wherein R 1 to R 12 have the meaning given in the description, can be isolated from...
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6831073 |
Hormonal composition consisting of an oestrogen compound and of a progestational compound
A method of treating estrogenic deficiencies in women while further avoiding the appearance of osteoporosis, withdrawal bleeding and cardiovascular diseases in post-menopausal women without any...
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6827930 |
System for attracting fish
A sport fishing system having: a rod and reel, including fishing line; at least one fishing lure or natural bait; and a controlled released fish attractant for applying to the fishing lure or...
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6790463 |
Uses of targeted oxidative therapeutic formulation in arteriosclerosis
The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction...
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6787529 |
Topical composition
The present invention relates to a pharmaceutical gel composition for application on skin, said composition comprising at least one vitamin D or vitamin D analogue and at least one corticosteroid...
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6787155 |
Anti-inflammatory pharmaceutical formulations
An oral pharmaceutical dosage form including a mixture of a delay release formulation of a non-steroidal anti-inflammatory drug (NSAID) and a mixture containing a prostaqlandin and one or more...
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6767903 |
New7α, 17α-bis-alkylated testosterone derivatives and their use in long-term therapy of androgen-dependent diseases
The invention relates to new 7α, 17α, 17β-substituted testosterone derivatives of general formula (I) and their use as pure antiandrogens for the long-term therapy of androgen-dependent...
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6759399 |
Use of antimineralocorticoid compounds against narcotic withdrawal syndrome
The method of treating narcotic withdrawal symptoms in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound having anti-mineralocorticoid...
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6756364 |
Method of reducing gastrointestinal side effects associated with orlistat treatment
A pharmaceutical combination or composition containing a lipase inhibitor, preferably orlistat, and a bile acid sequestrant is useful for treating obesity.
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6747018 |
Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5-estratriene nucleus, and...
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6720307 |
Glycosylated analogs of fusidic acid
Novel analogs of fusidic acid are described with one or more carbohydrate units attached. Certain glycosylated analogs of fusidic acid have enhanced solubility properties in diluents or excipient...
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6716437 |
Topical composition and method for enhancing lipid barrier synthesis
The present invention relates to topical compositions useful in enhancing lipid synthesis in skin comprising an effective amount of cafestol or kahweol, or derivative thereof, in combination with a...
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6713465 |
Pregnanes
This invention provides a pharmaceutically acceptable salt of 5α-pregn-16-en-3β-ol-20-one 3-sulfate ester, which is useful as a progestational agent.
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6702997 |
Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma
The present invention relates to an albuterol inhalation solution, system, kit and method for relieving bronchospasm in children suffering from asthma. In one alternative embodiment, the solution...
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6696432 |
Combination of dehydroepiandrosterone and aromatase inhibitors and use of this combination to produce a medicament for treating relative and absolute androgen deficiency in men
The present invention concerns the combination of dehydroepiandrosterone (DHEA) and at least one aromatase inhibitor and the use of such a combination to produce a medicament for treating relative...
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6689767 |
Triterpenes having antibacterial activity
Methods of treating a bacterial infection and of killing or inhibiting bacteria are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The...
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6686388 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
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6677328 |
Method for the prevention of colonic adenomas
Method for the prevention of colonic adenomas in mammals at risk of developing them by administering to such mammals an effective colonic adenoma preventive amount of ursodiol or a pharmaceutically...
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6676934 |
Pharmaceutical composition with tumor necrosis factor A and 2-methoxyestrone-3-0-sulphamate for inhibition of estrone sulphatase
A composition is described. The composition comprises i) a compound comprising a sulphamate group (“a sulphamate compound”); and ii) a biological response modifier.
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