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4800198 Method of inducing the differentiation of malignant cells with secosterol  
The invention provides a method for inducing the differentiation of malignant cells utilizing certain seco-sterol compounds, such as the differentiation of leukemia cells to normal macrophages and...
4749710 Immunosuppressive agents  
The invention relates to pharmaceutical compositions comprising at least one Vitamin D derivative and a method of using the pharmaceutical compositions in suppressing immune responses.
4743442 Skin care composition  
Skin care composition containing mineral salts releasing sodium, potassium, megnesium, calcium and zinc salts in defined concentration, and, optionally, compounds releasing copper, manganese,...
4740432 Vegetable origin fatty substance composition and cosmetic compositions containing the same  
Vegetable fatty substance composition for use in cosmetics containing: fatty acid triglycerides 85-94%, fatty acid esters containing 40 carbon atoms 7-14%, vitamins 0.01-1.0%, antioxidant 0.5-1.5%...
4732759 Bath preparations and method for producing the same  
A bath preparations comprise a cyclodextrin clathrate compound of vitamin, saccharifying enzyme and other materials of baths. The vitamin may be selected from the group consisting of vitamin A,...
4729895 Composition for solid pharmaceutical preparations of active vitamins D.sub. 3  
This invention is concerned with a composition for solid pharmaceutical preparations of active vitamins D 3 , having the remarkably improved stability of active vitamins D 3 , and an extremely...
4725427 Effervescent vitamin-mineral granule preparation  
Flavored, effervescent, water soluble compositions containing water-soluble and oil-soluble vitamins and amino acid chelated minerals in bioavailable form are contained in a composition consisting...
4719205 Side-chain unsaturated 1-hydroxyvitamin D compounds  
Novel 1-hydroxylated vitamin D compounds containing a 22, 23-cis double bond in the side chain are provided. The compounds are characterized by an unexpectedly high binding affinity for the protein...
4719204 Fowl bone mineralization with 28-NOR 1α-hydroxyvitamin D.sub.2 analogs  
The invention provides, as novel vitamin D derivatives, analogs of vitamin D 2 compounds which lack the 24-methyl substituent and are identified as 1α-hydroxy-28-norvitamin D 2 and...
4717721 Sidechain homo-vitamin D compounds with preferential anti-cancer activity  
This invention relates to a method for enhancing cell differentiation in malignant cells by exposing the cells to a 1α-hydroxylated vitamin D derivative characterized by a 17-side chain greater in...
4711881 1α,25-dihydroxy-26,27-dimethylcholecalciferol and its use in the treatment of calcium pathobolism  
1α,25-Dihydroxy-26,27-dimethylcholecalciferol represented by formula: ##STR1## This compound is prepared by irradiating 26,27-dimethylcholesta-5,7-diene-1α,3β,25-triol with ultraviolet light,...
4689180 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound  
The invention provides a novel vitamin D derivative, 1α,25-dihydroxy-22Z-dehydrovitamin D 2 . The compound is characterized by unexpectedly high ability to raise serum calcium levels. The compound...
4670247 Process for preparing fat-soluble vitamin active beadlets  
A process is described for the preparation of fat-soluble vitamin active beadlet compositions which exhibit superior stability when exposed to the feed pelleting process. The process includes...
4661294 Biologically active 1-thio derivatives of vitamin D  
Novel synthetic derivatives of vitamin D compounds are disclosed as well as processes for their synthesis. The novel compounds are 1-alpha-thio and acylated, 1-beta-thio derivatives of vitamin D...
4652405 Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol  
1α,25-Dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol, analogs of 1α,25-dihydroxy-cholecalciferol which is physiologically the most active metabolite of vitamin...
4628050 Antinephritic pharmaceutical composition containing 24, 25-dihydroxycholecalciferol as an active ingredient  
Disclosed herein is a pharmaceutical composition in dosage unit form, which comprises a dosage effective for treating nephritic disease of a compound of 24,25-dihydroxycholecalciferol as an active...
4619920 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D.sub.3  
The invention provides a new derivative of vitamin D 3 , 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxy-cholecalci ferol and a process for preparing the same. The compound is characterized by...
4617297 Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol  
The present invention relates to the method of treating disease states characterized by higher than normal levels of endogenously produced 1α,25 dihydroxy-cholecalciferol or conditions where there...
4617294 Animal feed supplement  
Free flowing, substantially dust-free, dense granular amorphous precipitated silica having a principal particle size of between about 0.14 millimeters and about 0.84 millimeters are described. This...
4613594 Fluorinated vitamin D.sub.3 compounds  
Novel hexafluoro-cholecalciferol compounds and processes for preparing such compounds are disclosed. Intermediates utilized in the preparation of such compounds and pharmaceutical preparations...
4612308 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers  
The syntheses of 25,26-dehydro-1α,23S-dihydroxycholecalciferol, 25,26-dehydro-1α,23R-dihydroxycholecalciferol, and the epimeric mixture thereof which are useful as differentiation inducing agents...
4608392 Method for producing a non greasy protective and emollient film on the skin  
A composition for topical application to the skin contains, as a fatty product to provide a nongreasy protective and emollient film thereon, a polyether oligomer having the formula ##STR1## wherein...
4599330 Method of treating milk fever  
The present invention relates to a method of preventing milk fever which comprises administering to a preparturient female ruminant an effective amount of...
4594340 25,26-dehydro-1α,24R-dihydroxycholecalciferol and 25,26-dehydro-1α,24S-dihydroxycholecalciferol and the epimeric mixture  
The syntheses of 25,26-dehydro-1α,24R-dihydroxycholecalciferol and 25,26-dehydro-1α,24S-dihydroxycholecalciferol and the epimeric mixture which are useful as differentiation inducing agent and...
4590184 Antiosteoporotic pharmaceutical composition containing 24,25-dihydroxycholecalciferol as an active ingredient  
Disclosed herein is a pharmaceutical composition in dosage unit form, which comprises a dosage effective for treating osteoporosis of a compound of 24,25-dihydroxycholecalciferol and a...
4572915 Clear micellized solutions of fat soluble essential nutrients  
Micellized aqueous formulations for fat soluble vitamins, essential nutrients, herb oils and pharmaceutical agents are obtained by a process wherein the fat soluble vitamin, essential nutrient or...
4547364 Hair treatment product  
A composition for use in removing chlorine from hair and a method for using the subject composition to remove chlorine from hair are provided. The subject composition preferably comprises ammonium...
4511564 Methods of controlling the concentration of calcium in the serum of warm-blooded animals and pharmaceutical compositions to be used therefor  
The present invention relates to a method of controlling the concentration of calcium in the serum of warm-blooded animals characterized by the administration of a pharmaceutically effective amount...
4505906 Hydroxyvitamin D.sub.2 isomers  
The invention provides, as novel vitamin D derivatives, isomers of 25-hydroxyvitamin D 2 and 1α,25-dihydroxyvitamin D 2 characterized by a double bond at the 23,24-position. The compounds are...
4501738 Pharmaceutical composition containing 24,25-dihydroxycholecalciferol as an active ingredient to treat pain, pyrexia or inflammatory diseases  
Disclosed is a pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of pains and pyrexia, hypertension, hypotension, hyperlipemia, inflammatory...
4495181 1,25-Dihydroxy-24-oxo-vitamin D.sub.3 and 1,23,25-trihydroxy-24-oxo-vitamin D.sub.3  
Novel biologically active metabolites of vitamin D 3 , 1,23,25-trihydroxy-24-oxo-vitamin D 3 (1,23,25(OH) 3 -24-oxo-D 3 ); and 1,25,-Dihydroxy-24-oxo-vitamin D 3 (1,25(OH) 2 -24-oxo-D 3 ). Also...
4486435 Spray-dried vitamin powders using hydrophobic silica  
Encapsulated vitamin powders coated with a hydrophobic silica have improved free-flowing properties making these powders more suitable for direct tableting preparation.
4481198 Vitamin D metabolism inhibitor  
This invention provides a novel vitamin D derivative, namely a 24-oxime derivative of vitamin D 3 , and a process for its preparation. The compound of this invention is an effective inhibitor of...
4461766 Method for inducing molting in laying hens  
The invention provides a method for inducing molting in egg-laying hens as a means for extending their productive egg-laying life by administering to the hens an effective amount of a side...
4442093 Method for administering 24,25-dihydroxycholecalciferol to persons suffering from hypercalcemia  
Pharmaceutical composition in dosage unit form, comprising a therapeutically effective amount of 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier. The compound of...
4428946 Method of preventing milk fever in dairy cattle  
A method for prophylactically treating dairy cattle for parturient paresis by administering to cattle vitamin D derivatives which are characterized by the presence of a hydroxyl group at at least...
4391802 Method of treating leukemia or leukemoid diseases  
A method of leukemia or leukemoid disease treatment by administration of a vitamin D derivative with a hydroxyl group at 1α-position is disclosed. It is believed that the vitamin D derivative with...
4364941 Method for regulating bone metabolism of warm-blooded animals, and pharmaceutical compositions thereof  
A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1α, 24-dihydroxycholecalciferol (1α, 24-DHCC) and...
4341774 Method for suppressing abnormal rise in immunological function and agent useful therefor  
A method for suppressing abnormal rise in immunological function which often causes various types of autoimmune diseases, and an agent useful therefor are disclosed. The method is carried out by...
4340604 Method for inhibiting the lowering of immunological function and agent therefor  
A method for inhibiting the lowering of immunological function of patients who are suffering from serious renal disorder such as chronic renal failure or uremia which comprises administering...
4335120 Administration of biologically active vitamin D.sub.3 and vitamin D.sub.2 materials  
A process for administering biologically active vitamin D 3 and vitamin D 2 materials into the blood system of a subject by providing the biologically active vitamin D 3 or D 2 material to the...
4313942 Activated vitamin D rodenticides  
The invention provides a method for chemically activating vitamin D compounds to obtain active rodenticidal preparations. The activated vitamin D preparation offers an effective and relatively...
4310522 Chicken feed composition  
The administration of 25-hydroxycholecalciferol, 24,25-dihydroxycholecalciferol, 25,26-dihydroxycholecalciferol, 1,25-dihydroxycholecalciferol, 25-hydroxydihydrotachysterol 3 ,...
4308264 Stabilized, dilute aqueous preparation of 1α,25-dihydroxycholecalciferol for neonatal administration  
1α,25-Dihydroxycholecalciferol, also known as 1α,25-dihydroxyvitamin D 3 , calcitriol or 1α,25(OH) 2 D 3 , occurs naturally in man as the active form of cholecalciferol or vitamin D 3 . The...
4248867 Stabilized oily preparation of 1α-hydroxy-vitamin D and method for manufacturing the same  
A stabilized oily preparation of a 1α-hydroxy-vitamin D for oral administration comprising a 1α-hydroxy-vitamin D and, as oily diluent, a triglyceride of saturated middle chain fatty acid which...
4237125 1α-Hydroxy-24-dehydrovitamin .sub.3 pharmaceutical compositions and uses thereof  
Novel 1α-hydroxy-24-dehydrovitamin D 3 and its hydroxyl-protected derivatives; novel 1α-hydroxy-24-dehydroprevitamin D 3 and its hydroxyl-protected derivatives; and novel...
4225596 Method for treating calcium imbalance and improving calcium absorption in mammals  
A method for treating or preventing metabolic bone disease characterized by loss of bone mass and of improving the calcium balance and calcium absorption of mammals, particularly of women in the...
4211782 Pharmaceutical combination  
Combinations comprising an anti-aggregatory substance together with one or more of an anti-oxidant and a thromboxane A 2 synthetase inhibitor are disclosed. Combinations are useful for the...
4199577 Novel 1α-hydroxy-24-oxovitamin D.sub.3, its preparing process and the novel precursors thereof  
Novel 1α,3β-dihydroxy-24-oxocholesta-5,7-diene and the hydroxyl group-protected derivatives thereof. Said novel 1α-hydroxy-24-oxovitamin D 3 and said novel intermediates are also useful as the...
4164569 Stabilized soft gelatin capsule composition of 1 α-hydroxy-vitamin D  
A soft gelatin capsule preparation of a 1α-hydroxy-vitamin D which contains sorbic acid or its salt and a process for preparing the preparation are disclosed. Sorbic acid or its salt which is...