|
Match
|
Document |
Document Title |
|
|
5976784 |
Calcitriol derivatives and their uses
A method of treating metabolic bone diseases such as osteoporosis, as well as other disease states treatable with vitamin D compounds, comprises administering an effective amount of one or more...
|
|
|
5977092 |
Drug for curing/ameliorating concomitant syndrome of tumor
A drug for curing/ameliorating the concomitant syndrome of tumor which comprises a compound represented by the following general formula (I) as the active ingredient: ##STR1## wherein R 1 ...
|
|
|
5972917 |
1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
The invention provides 1α-hydroxyvitamin D compounds in which the C-25 or equivalent position of the C-17 side chain has a double bond and method for their use in the treatment and prophylaxis of...
|
|
|
5968917 |
Composition containing diosgenin
Method of treating osteoporosis according to the present invention comprises the administration to a subject in need thereof a therapeutically effective amount of diosgenin, a therapeutically...
|
|
|
5948443 |
Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease
The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American...
|
|
|
5942255 |
Methods of enhancing lean tissue mass and bone mineral content and compositions therefor
The invention is directed to a method of enhancing lean tissue mass in a subject by administering calcium to the subject, thereby enhancing the lean tissue mass in the subject. The invention is...
|
|
|
5942502 |
Method of treating diseases resulting from calcium metabolism disorders
A method of treating human diseases resulting from calcium metabolism disorders which comprises administering to a subject having the disease an effective daily dose of...
|
|
|
5939408 |
Vitamin D.sub.3 analogs
Compounds of the formula ##STR1## wherein R is hydrogen, fluorine, or hydroxyl, each R 2 is lower alkyl or C(R 3 ) 3 and R 3 is halogen, X is CH 2 or when R is hydroxy, X is hydrogen or...
|
|
|
5939407 |
Method of protecting against neuron loss
The present invention pertains to a method of protecting against neuron loss in a subject by administering a compound that protects against neuron loss by acting through a vitamin D receptor. Some...
|
|
|
5935559 |
Silicone composition containing a water-sensitive active agent
An emulsion comprising an oily phase dispersed in an aqueous phase with the aid of a silicone emulsifying agent, the oily phase comprising at least 50% by weight of silicone oil and the aqueous...
|
|
|
5932565 |
Vitamin D analogues
The invention relates to compounds of formula (I): ##STR1## wherein Q and R are as defined in the specification. The compounds are useful in the treatment of a number of disorders including...
|
|
|
5929056 |
Vitamin D compounds and method of preparing these compounds
The present invention relates to vitamin D compounds of the general formula ##STR1## wherein: R 1 is a hydrogen atom or a hydroxy group; R 2 is a (C 1 -C 3 )alkyl group, a hydroxy(C 1 -C 3...
|
|
|
5929057 |
Pharmaceutical composition for the treatment of leukemia containing 9-cis-retinoic acid-α-tocopherol ester
9-Cis-retinoic acid-α-tocopherol esters, pharmaceutical compositions containing the same and use of the same as a medicine for the treatment of leukemia, in particular, the remission of leukemia...
|
|
|
5919776 |
Substituted aminoquinolines as modulators of chemokine receptor activity
The present invention is directed to aminoquinolines of Formula I: ##STR1## (wherein R 1 , R 2 , R 3 , and R 4 are defined herein) which are useful as modulators of chemokine receptor activity. In...
|
|
|
5905074 |
Vitamin D derivative
A compound of the formula ##STR1## useful for treating vitamin D dependent disorders.
|
|
|
5902806 |
Crystalline vitamin D derivative
A crystalline (5Z,7E,23S)-26,26,26,27,27,27-hexafluoro-9,10-secocholesta-5
,7,10(19)-trie n-1α,3β,23,25-tetraol monohydrate has an excellent preservation stability, and is therefore useful as a...
|
|
|
5900416 |
Aqueous caffeine dosage forms
Aqueous caffeine solutions containing a co-solubilizing agent selected from niacinamide, nicotinic acid and mixtures thereof present at a level up to the maximum concentration soluble in water and...
|
|
|
5891865 |
Treatment of arthritic disease induced by infectious agents
A method of treating arthritis symptoms induced by an infectious agent of an arthritis patient comprising administering to an arthritis patient an amount of vitamin D compound effective to reduce...
|
|
|
5891866 |
Methods of treatment
A method of inducing inhibition or loss of cell proliferation in solid tumors utilizing a Vitamin D 3 analog, as well as a method of inducing loss of cell proliferation in solid tumors utilizing...
|
|
|
5888994 |
Fluorinated Vitamin D.sub.3 analogs
A compound of formula I ##STR1## wherein R is hydrogen, fluorine or hydroxy, and X is CH 2 or when R is hydroxy, X is hydrogen or CH 2 which are useful in the treatment of...
|
|
|
5880113 |
19-nor-vitamin D compounds
This invention provides a novel class of vitamin D-related compounds, namely the 1c-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit...
|
|
|
5880114 |
Treatment of immune deficiency with vitamin D compounds
A method for treating immune deficiency in a mammal by administering an amount of a vitamin D compound, such as Vitamin D 3 , its active form 1α,25-dihydroxyvitamin D 3 or other compounds...
|
|
|
5872113 |
Fluorinated vitamin D3 analogs
Fluorinated Vitamin D 3 analogs, intermediates for their preparation, compositions comprising the analogs and methods of treatment of osteoporosis and related conditions with these and related...
|
|
|
5869472 |
Synthesis of 1α-hydroxy vitamin D
A method for 1α-hydroxylation of vitamin D compounds using the appropriate vitamin D as the starting material. The method requires no separatory procedures prior to the actual hydroxylation step.
|
|
|
5861386 |
Method for treating and preventing secondary hyperparathyroidism
A method for preventing loss of bone mass or bone mineral content in a human being suffering from secondary hyperparathyroidism by administering a sufficient amount of 1α--OH vitamin D 2 ,...
|
|
|
5843927 |
18,19-dinor-vitamin D compounds
18,19-dinor-vitamin D 3 analogs in which the angular methyl group attached to carbon 13 of the CD-ring and the exocyclic methylene group attached to carbon 10 of the A-ring have been removed and...
|
|
|
5840718 |
22-epimeric-1,25-dihydroxy-16,22,23-triene-cholecalciferol
The invention relates to a compound of the formula ##STR1## wherein R is hydroxy and R 1 is H 2 or CH 2 or R is hydrogen or fluoro and R 1 is CH 2 and (b) an inert carrier. Compounds of...
|
|
|
5837224 |
Method of inhibiting photoaging of skin
Photoaging of undamaged skin due to UVB irradiation exposure is inhibited by administering an agent that inhibits (1) the activity of UVB irradiation inducible MMPs in the skin, (2) one or both of...
|
|
|
5830885 |
Antiproliferative vitamin D.sub.3 hybrids
Vitamin D 3 analogues of formula ##STR1## wherein R represents a 1-hydroxyalkyl group or 1-fluoroalkyl group in a trans- configuration with a 3-hydroxyl group on the A ring and R 2 represents the...
|
|
|
5827500 |
Process for identifying RAR-receptor-antagonist compounds
The present invention relates to a process for identifying RAR-antagonist molecules, characterized in that it comprises the following steps: (i) a sufficient amount of an RAR-agonist molecule is...
|
|
|
5824650 |
Topical composition containing a substance P antagoinst
The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating...
|
|
|
5824313 |
Vaccine compositions and method for induction of mucosal immune response via systemic vaccination
The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include, but are not limited to, 1,25-dihydroxy Vitamin...
|
|
|
5817621 |
External remedy possessing trophoprotective effect
A dermatological composition for external use comprising a lipid ointment base, vitamin A, a salicylic acid or a derivative thereof, D-camphor, a biogenic GABAergic substance, a biogenic...
|
|
|
5817648 |
Vitamin D.sub.3 analogues having an unsaturated side chain
Vitamin D 3 analogues of the formula (I): ##STR1## wherein R 1 is hydrogen or hydroxy, R 2 is hydrogen, (C 1 -C 3 ) alkyl, phenyl, or trifluoromethyl, R 3 is branched or unbranched (C 1 -C 4...
|
|
|
5811414 |
Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin
The use of compounds of formula I as topical agents to combat the disorders of the skin, produced by photodamage, which disorders include wrinkling, elastosis and premature aging is described....
|
|
|
5807586 |
Method of dietary supplementation
The present invention relates to a method of supplementing the dietary needs of women whereby an effective amount of a life stage appropriate dietary supplement is administered to a woman at each...
|
|
|
5804573 |
Stabilized pharmaceutical composition containing derivative of vitamins D.sub.2 and D.sub.3
Pharmaceutically active derivatives of vitamin D 2 and vitamin D 3 in a solid state composition are stabilized by the presence of effective amounts of pharmaceutically acceptable antioxidant and...
|
|
|
5801164 |
Methods of treating osteoporosis prophylactically or therapeutically
Methods of treating osteoporosis prophylactically or therapeutically are disclosed. The method of treating osteoporosis includes administering to a patient suffering therefrom an effective amount...
|
|
|
5798345 |
Method of inhibiting the hyperproliferation of malignant cells
1α-hydroxy vitamin D 4 and analogues, preferably 1,24 dihydroxy vitamin D 4 , which are useful as active compounds of pharmaceutical compositions for the inhibition of hyperproliferative activity...
|
|
|
5789399 |
Treatment of pruritus with vitamin D and analogs thereof
A method for treating pruritus comprising topical administration of formulation of vitamin D or an analog of vitamin D is disclosed. The formulation comprises a therapeutically effective,...
|
|
|
5789397 |
Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
1α,24(S)-Dihydroxy vitamin D 2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The...
|
|
|
5786347 |
Vitamin D amine and amide derivatives
The invention relates to vitamin D amine and amide derivatives of general formula ##STR1## where R represents a hydrogen atom, an aliphatic, cycloaliphatic or araliphatic group, or an acyl group...
|
|
|
5776921 |
Compositions for regulation of immune responses
Androsta-5,7-diene-3β, 17β-diol, its esters and ethers and related compounds wherein ring opening of the steroid ring system between carbons 9 and 10 has occurred are active as regulators of...
|
|
|
5767111 |
18-nor-vitamin D compounds
18-nor-vitamin D 3 analogs in which the angular methyl group attached to carbon 13 of the CD-ring has been removed and replaced by a hydrogen atom. The 18-nor vitamin D compounds are characterized...
|
|
|
5763428 |
Methods of treating skin disorders with novel 1a-hydroxy vitamin D.sub.4 compounds and derivatives thereof
The disclosure is of methods of treating various skin disorders, including skin cancer, with compounds of novel 1α-hydroxy vitamin D 4 and novel analogues, thereof, including 1,25 dihydroxy...
|
|
|
5759586 |
Pharmaceutical or dietetic composition
There is disclosed a pharmaceutical or dietetic composition, comprising sodium, potassium, magnesium and calcium ions, wherein at least sodium and potassium are present as carbonates and/or...
|
|
|
5756488 |
Composition for improving calcium metabolism
A composition for improving calcium metabolism comprising, as an active ingredient, (20S,22R)-22-methyl-1α,25-dihydroxyvitamin D 3 ; and a method of treating a calcium metabolism disorder in a...
|
|
|
5753237 |
Method for augmenting immunological responses
Methods for augmenting immune responses in immunodeficient individuals are disclosed. The methods utilize steroid hormones, particularly DHEA, its prohormones (particularly DHEA-S), and...
|
|
|
5753638 |
Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the...
|
|
|
5750517 |
Method of treating sebaceous gland diseases with vitamin D.sub.3 fluorinated analogs
Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the...
|