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6372731 |
Vitamin D derivatives with C-25 substituents, process for their preparation, intermediate products and their use in preparing medicaments
A vitamin D derivative and its uses with substituents at C-25 of general formula I
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6369046 |
Methods for treating dementia
This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used...
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6369099 |
Method of locking 1 α-OH of vitamin D compounds in axial orientation
A method of modifying or altering the structure of a 1α-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a...
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6361758 |
Cosolvent formulations
Stable pharmaceutical formulations of a therapeutic agent, a low molecular weight alcohol and a glycol derivative are disclosed. Preferred formulations include...
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6359012 |
Method for making 24(S)-hydroxyvitamin D2
The invention provides a method for making 24(S)-hydroxyvitamin D 2 which is a stereospecific synthesis.
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6344437 |
Medicine drink food and feed having an action of strengthening bone
The present invention is to provide a novel medicine, drink, food or feed having an action of strengthening bone. More specifically, the present invention is to provide a medicine, drink, food or...
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6329357 |
Therapeutically effective 1α, 25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
A method for treatment of diseases caused by deficiency or overproduction of the vitamin D 3 metabolites by administering analogs of 1α,25-dihydroxyvitamin D 3 . These analogs are selective...
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6329354 |
Methods for the treatment of osteoporosis
Methods of treatment for osteoporosis in a human or other animal subject, comprising: administering a bone-active phosphonate to said subject, at a level of at least about 0.1 LED per day of said...
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6322821 |
Veterinary pharmaceutical composition
A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene...
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6306844 |
Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
This invention provides pharmaceutical uses for 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D 3 . This compound is characterized by high bone calcium mobilization activity demonstrating...
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6303588 |
Therapeutic methods utilizing naturally derived bio-active complexes and delivery systems therefor
Methods are disclosed for correcting biological information transfer in a patient in need of such therapy which comprise administration to a patient of a composition comprising a therapeutically...
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6294524 |
Use of ergosterol and its apparent compounds for stimulating the proliferation of skin cells
The invention concerns the use of compounds of formula (I) in which R represents a linear or branched, substituted or not substituted, saturated or unsaturated C 1 -C 12 hydrocarbon chain, for...
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6291444 |
Treatment of t-cell immunodeficiencies with vitamin D compounds
A method for treating a T-cell immunodeficiency in a mammal by administering an amount of a vitamin D compound, such as vitamin D 3 , its active form 1α,25-dihydroxyvitamin D 3 or other compounds...
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6291533 |
Dietary supplements for each specific blood type
Dietary supplement compositions designed to be responsive to specific blood types, and thus most beneficial for people with specific antigenic blood types.
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6277837 |
2-alkyl-19-nor-vitamin D compounds
This invention provides a novel class of vitamin D related compounds, namely, the 2-alkyl-19-nor-vitamin D derivatives, as well as a general method for their chemical synthesis. The compounds have...
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6274169 |
Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol
The invention relates to stable compositions comprising 1α, 25-dihydroxycholecalciferol, a unit dose system comprising the same in a sealed vessel, and a process for preparing them.
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6265392 |
Low oxygen content compositions of 1α, 25-dihydroxycholeclciferol
The invention relates to stable aqueous formulations comprising 1α,25-dihydroxycholecalciferol, a unit dose system comprising the same in a sealed vessel, and a process for preparing them.
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6264986 |
Stable emulsions and dry powders of mixtures of fat-soluble vitamins, their preparation and use
The present invention relates to stable emulsions and dry powders of mixtures of fat-soluble vitamins, and to processes for their preparation and to their use.
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6262041 |
Use of vitamin D analogs to treat conditions related to increased oxidative stress
A pharmaceutical composition for reducing the rate at which skin ages or for treating cancer, acne or rosacea. The composition comprises a pharmaceutically acceptable excipient in combination with...
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6251883 |
Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
1α,24(S)-Dihydroxy vitamin D 2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The...
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6248732 |
Ophthalmological composition comprising activated vitamin D
An ophthalmic composition comprises active vitamin D as an effective component and is used for preventing deterioration of the optical transparency, occurrence of high intraocular pressure diseases...
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6245360 |
Nutritional supplement
A single entity product is provided for administration to persons being treated for nutritional deficiencies associated with addiction to alcohol, wherein the product is an extended-release...
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6242434 |
24-hydroxyvitamin D, analogs and uses thereof
The invention provides 24-hydroxyvitamin D compounds and methods for their use in the treatment and prophylaxis of hyperparathyroidism and hyperproliferative diseases, and in the modulation of the...
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6228849 |
Method for treating symptoms associated with premenstrual syndrome by administering a combination of calcium and vitamin D
The present invention is directed to a method for treating symptoms associated with premenstrual syndrome. The method comprises administering to an individual in need of treatment an amount of a...
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6211169 |
Stable calcitriol solution for packaging into vials
The invention provides a therapeutic calcitriol solution which is suitable for packaging into pharmaceutical vials without producing discoloration of the antioxidant component of the solution.
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6211168 |
Methods for preparation and use of 1α,24 (S)-dihydroxy vitamin D2
1α,24(S)-Dihydroxy vitamin D 2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The...
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6207656 |
Vitamin D analogues and their neuronal effects
The present invention is directed, inter alia, to methods of utilizing low calcemic vitamin D analogues. Particularly, the present invention is directed to using low calcemic vitamin D analogues to...
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6187764 |
A and D vitamins and their metabolites: A new treatment for seasonal allergic rhinitis and atopy
The present invention discloses a method of treating seasonal allergic rhinitis by administering retinol and ergocalciferol to individuals suffering from a hypersensitive immunological response to...
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6187763 |
Activated vitamin D3 emulsion-type lotions
The present invention provides a pharmaceutical composition for local administration in the form of an emulsion that contains active vitamin D 3 and is suitable for application to areas with (the)...
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6180617 |
Method for reducing absorption of undesired lipids in the gastrointestinal tract
A composition is disclosed for use in reducing the availability of undesired lipids, such as cholesterol, in the fluid media of the gastrointestinal tract prior to absorption of the lipids across...
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RE37020 |
Method for providing nutrition to elderly patients
The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a...
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6162801 |
External ophthalmic preparation containing vitamin D
An ophthalmic composition, containing ergocalciferol or cholecalciferol, i.e., an inactive vitamin D, as the active ingredient, for treating and conditioning damaged tissue of the region of the...
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6153605 |
Arylsecocholadiene derivatives
Compounds of formula (I) ##STR1## as defined by the specification. The compounds are useful in the treatment or prevention of vitamin D dependent disorders, particularly psoriasis, basal cell...
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6150346 |
Method and composition for treating or preventing osteoporosis
Method of treating or preventing osteoporosis by administering orally a 1α-hydroxyprevitamin D. This previtamin D form increases vitamin D blood level without significant risk of hypercalcemia...
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6147064 |
Oral 1α-hydroxyprevitamin D in composition and method for treating psoriasis
Method of treating psoriasis by administering orally a 1α-hydroxyprevitamin D. This previtamin D form treats psoriasis without significant risk of hypercalcemia associated with other oral dosing...
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6133250 |
Oral 1α-hydroxyprevitamin D in methods for increasing blood level of activated vitamin D
Method of increasing activated vitamin D blood level by administering orally a 1α-hydroxyprevitamin D. This previtamin D form increases vitamin D blood level without significant risk of...
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6124276 |
Vitamin D derivative with substituent at the 2β-position
1α-hydroxy-vitamin D derivatives represented by formula ##STR1## wherein R 1 represents a hydrogen atom or a hydroxyl group; and R 2 represents a straight-chain or branched C 2 -C 7 alkyl, C 2...
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RE36854 |
Vitamin D compounds and method of preparing these compounds
The invention relates to a new vitamin D compound of the general formula ##STR1## wherein: R 1 is a hydrogen atom or a hydroxy group; R 2 is a (C 1 -C 3 )alkyl group, a hydroxy(C 1 -C 3...
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6087350 |
Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
The present invention provides a method of killing a cell by first administering to the cell a vitamin D derivative and subsequently administering to the cell a cytotoxic agent. Where the cell is...
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6071897 |
Use of vitamin D compounds to prevent transplant rejection
A method of moderating transplant rejection in a transplant recipient comprising administering a dose of vitamin D compound effective to prevent transplant rejection is disclosed. Preferably, the...
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6042855 |
Use of vitamin D, its metabolites and analogs to improve tenderness of meat and meat products
A method of improving the tenderness of meat and meat products is described. The method includes administering excessive doses of vitamin D to meat producing animals prior to slaughter. The vitamin...
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6040300 |
Method of preventing colon cancer with vitamin D.sub.3 analogues
A method for preventing the initiation of colon cancer is disclosed. Vitamin D 3 analogues prevented the development of adenomas and adenocarcinomas when administered to rats prior to, and...
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6030963 |
16-ene-26,27-bishomo cholecalciferols
The invention relates to a compound of the formula ##STR1## wherein A is ##STR2## Et is ethyl, and R is hydroxy and R 1 is hydrogen or CH 2 or R is hydrogen or fluoro and R 1 is CH 2 ....
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6030962 |
Vitamin D.sub.3 analogs with bis C-20 side chains
This invention provides Vitamin D 3 analogs of the Formula I ##STR1## wherein: X is H 2 or CH 2 ; Y is hydrogen, hydroxy or fluorine; Z is hydroxy; R 1 and R 2 are a (C 1 -C 4 )...
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6025346 |
1α-hydroxy vitamin D.sub.4 and novel intermediates and analogues
Disclosed is 1α,24-dihydroxy vitamin D 4 having the following structure: ##STR1## and pharmaceutical compositions containing said compound. The compound and composition are useful in the...
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6022555 |
Animal feed containing carboxylic acids
An animal feed containing a carboxylic acid either as the sole active ingredient or in combination with 1α-hydroxylated vitamin D compounds and/or phytase. The carboxylic acid or the combination...
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6017908 |
3-EPI vitamin D.sub.2 compounds and uses thereof
Novel 3-epi vitamin D2 compounds having the orientation of the substituent attached to the carbon at position 3 of the A-ring of vitamin D2 inverted from a beta (β) to an alpha (α) configuration...
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6008209 |
Method of using vitamin D.sub.3 analogs with bis C-20 side chains
This invention provides a method of treating or preventing neoplastic diseases. The method comprises adminstering to a host in need of such treatment or prevention an effective amount of a Vitamin...
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5998393 |
Methods for assessing 1,25(OH).sub.2 D.sub.3 activity in skin and for enhancing the therapeutic use of 1,25(OH).sub.2 D.sub.3
Described are in vivo methods for testing the activity of vitamin D 3 (1,25-dihydroxyvitamin D 3 ) and analogs thereof in human skin and for testing the effect of a test compound on said activity....
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5998394 |
Compositions for treating skin conditions by enhancing the activity of 1,25(OH).sub.2 D.sub.3 using an RXR ligand and/or a 24-hydroxylase inhibitor
Described are in vivo methods for testing the activity of vitamin D 3 (1,25-dihydroxyvitamin D 3 ) and analogs thereof in human skin and for testing the effect of a test compound on said activity....
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