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8183207 |
Treatment of osteolytic disorders and cancer using CSF1R extracellular domain fusion molecules
Methods of using colony stimulating factor receptor (CSF1R) extracellular domain (ECD) fusion molecules for treating osteolytic bone loss, cancer metastasis, cancer metastasis-induced osteolytic...
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8183201 |
Methods of treating αvβ3 integrin-associated diseases by administering polypeptides selective for αvβ3 integrin
The invention provides disintegrin variants, and more specifically to disintegrin variants which are selective αvβ3 integrin antagonists for treatment and prevention of αvβ3 integrin-associated dis...
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8168181 |
Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling; variants and derivatives of the polynucleotides and corresponding...
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8163694 |
Method of treating diseases or abnormal conditions of periodontal or dental tissues with GDF5
The present invention concerns improved osteoinductive materials comprising matrix materials and morphogenetic proteins, wherein depending on the subject matter the proteins may be dimeric or...
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8147862 |
Highly mineralized osteogenic sponge compositions and uses thereof
Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed...
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8148326 |
Flowable carrier matrix and methods for delivering to a patient
A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These...
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8148333 |
Stable composition comprising a PTHrP analogue
The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) analogue and methods of using a PTHrP analogue and the PTHrP compositions...
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8148329 |
Osteogenic implants with combined implant materials and methods for same
Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The...
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8133864 |
PAR-2 agonist
The present invention relates to a pharmaceutical composition for preventing/treating conditions associated with PAR-2. The present invention also relates to a method for preventing/treating the...
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8114394 |
Use of IL-1 antagonists to treat gout
Methods of treating, inhibiting, or ameliorating gout, including chronic acute (refractory) gout, pseudogout, or drug-induced gout, in a human subject in need thereof, comprising administering to a...
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8110547 |
Compositions for buccal delivery of parathyroid hormone
Compositions and pharmaceutical formulations for buccally delivering parathyroid hormone comprising a) a delivery agent, b) a PTH component and, optionally, c) an antiresorptive agent are provided.
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8101564 |
Methods for regulating osteoclast differentiation and bone resorption using LRRc17
Provided is a purified, negative regulator of osteoclast differentiation and bone resorption, specifically LRRc17. Further provided are methods and compositions for treating degenerative bone...
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8101676 |
Osteogenic paste compositions and uses thereof
Described are osteogenic paste compositions with enhanced osteoinductive properties for use in bone repair. Compositions comprising a quickly resorbable paste carrier, a more slowly resorbed...
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8101198 |
Osteogenic enhancer composition
An osteogenic enhancer composition for bone and cartilage repair and methods of using the same are described.
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8092823 |
Osteogenic implants with combined implant materials and methods for same
Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The...
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8080060 |
Processes and systems for loading medical implants with simulative growth agents
Methods and systems for providing an improved apparatus and packaging system to more expeditiously hydrate or reconstitute medical grafts and to effectively and uniformly seed the medical grafts...
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8080521 |
Flowable carrier matrix and methods for delivering to a patient
A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These...
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8076281 |
Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment
A method and pharmaceutical composition for inhibiting the effect of glucocorticoids, particularly dexamethasone, which suppress growth hormone secretion, by administering ghrelin or a ghrelin...
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8076293 |
Use of BiP or a variant, homologue, derivative or fragment thereof in the manufacture of a medicament for the prevention or treatment of bone loss or bone resorption
The present invention relates to the use of BiP or a variant, homologue, derivative or fragment thereof in the manufacture of a medicament for the prevention or treatment of bone loss or bone...
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8053412 |
NELL-1 peptides
Recombinant NELL peptides and methods of preparing the same are disclosed.
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8048857 |
Flowable carrier compositions and methods of use
A composition is provided for faster bone repair and early orthopedic implant fixation. The composition comprises an osteoinductive or osteopromotive biological factor embedded in a carrier slurry....
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8039433 |
Osteogenic compositions containing a coloring agent
An osteogenic composition is provided for implantation at or near a target tissue site beneath the skin, the osteogenic composition comprising a growth factor and a coloring agent, wherein the...
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8029769 |
Protein formulation
A low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, is intended to be used as a therapeutic, as a...
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8008074 |
Compositions and methods for improving bone mass through modulation of receptors of PTH and fragments thereof
The present invention relates to the discovery of novel receptors for the signaling of PTH and/or fragments of PTH, and the role of cPTH in bone development. The novel PTH receptors identified are...
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7994129 |
Methods of using black bear parathyroid hormone
Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming...
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7977313 |
Methods and compositions for promoting localization of pharmaceutically active agents to bone
Compositions are provided comprising a family of peptides having binding specificity for bone, and their use to produce coating compositions. The coating compositions are used to deliver a...
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7977312 |
Compositions and methods for increasing bone mineralization
A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
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7964561 |
Protein formulations for use at elevated temperatures
Liquid formulations of bone morphogenetic proteins are provided for prolonged use at elevated temperatures. More specifically, the invention relates to liquid formulations comprising rhGDF-5,...
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7964208 |
System and methods of maintaining space for augmentation of the alveolar ridge
An implantable screw for maintaining space during bone grafting procedures is provided, where the screw has a highly-polished contoured head having a region adapted to support soft tissue, a...
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7951380 |
Methods of stimulating bone growth using ZVEGF4 polypeptides
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that...
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7943126 |
Compositions and methods for treating hypophosphatasia
The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by...
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7943579 |
Osteogenic implant matrices and endosseous tooth implants with improved osteointegration properties
Implant articles with improved osseointegrating properties, osteogenic implant materials, and process of inducing differentiation of mesenchymal stem cells, proliferation of osteoblast and...
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7943573 |
Methods for treatment of distraction osteogenesis using PDGF
The present invention relates to compositions and methods for use in osteodistraction procedures. In one embodiment, a method of stimulating osteogenesis during and/or following bone distraction...
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7923432 |
Implant depots to deliver growth factors to treat avascular necrosis
The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat bone avascular necrosis, in that such depot implant is constructed to...
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7914819 |
Polysaccharide-based biomaterials
Disclosed are a series of kneadable, pliable polymers for use in forming compositions that can be used as bone wax or as a cellular scaffold. Polymers can include a polysaccharide backbone and can...
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7910552 |
Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
The present invention relates to reindeer bone formation inducing protein called bone morphogenetic protein (BMP), such as BMP-6, containing a heparin binding site and nucleotide molecules encoding...
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7906481 |
Specific TNF-A inhibitors for treating spinal disorders mediated by nucleous pulposus
The present invention relates to a method for treating nerve disorders in a mammal or a vertebrate by administering a TNF-alpha inhibitor. The invention also relates to the use of a TNF-alpha...
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7897571 |
Recombinant lubricin molecules and uses thereof
Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial...
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7897164 |
Compositions and methods for nucleus pulposus regeneration
Compositions for nucleus pulposus regeneration is provided. Such composition may comprise a scaffolding material and a pore creating agent dispersed within the scaffolding material. The pore...
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7897163 |
Bone graft and scaffolding materials immobilized with osteogenesis enhancing peptides on the surface
The present invention relates to a bone graft material and a scaffold for tissue engineering applications, which have an osteogenesis-promoting peptide immobilized on the surface. More...
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7897564 |
Flowable carrier matrix and methods for delivering to a patient
A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These...
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7884066 |
NELL-1 enhanced bone mineralization
Provided herein are methods for enhancing bone mineralization for bone repair or regeneration and compositions and grafts therefor. Methods for screening agents that enhance or modulate NELL-1 gene...
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7875590 |
Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
Methods of using an injectable or implantable rod-shaped formulation for delivery of osteogenic proteins to treat osteoporotic and/or osteopenic bone are disclosed. The formulation comprises...
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7842667 |
Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same
A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached...
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7838491 |
Self-assembly and mineralization of peptide-amphiphile nanofibers
Peptide-amphiphilic compositions capable of self-assembly into useful nanostructures.
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7829535 |
Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway
Methods for promoting osteogenesis to accelerate or enhance bone fracture healing, treat bone defects, and enhance bone formation are disclosed. The methods modulate an arachidonic acid metabolic...
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7780994 |
Composite biomaterials comprising calcium phospate materials, collagen and glycosaminoglycans
A process for the production of a composite material comprising collagen, brushite and one or more glycosaminoglycans, said process comprising the steps of providing an acidic aqueous solution...
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7771755 |
Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active...
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7749960 |
Osteoprotegerin in milk
The present invention pertains to osteoprotegerin obtainable from milk sources, in particular human and bovine milk. The present invention also relates to the use thereof for preparing an...
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7745154 |
Preventives/remedies for myeloma tumor and method of diagnosing the same
The present invention provides a preventive or therapeutic drug for a myeloma tumor and osteoclastic bone loss associating therewith, the drug containing as an active ingredient an...
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