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7084117 |
Pharmaceutical compositions which inhibit vascular proliferation and method of use thereof
The present invention relates to a method of treating vascular proliferation in a patient in need thereof. The method includes the step of administering a therapeutically effective amount of a...
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7067490 |
Hepta-, Octa-and nonapeptides having antiangiogenic activity
Compounds of formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions...
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7067489 |
Hematopoietic stimulation
Methods and products for stimulating hematopoiesis, preventing low levels of hematopoietic cells and producing increased numbers of hematopoietic and mature blood cells are provided. The methods...
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7063842 |
Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
Modulating agents for inhibiting an interaction between α-catenin and β-catenin are provided. The modulating agents comprise one or more of: (a) a β-catenin HAV motif; (b) a peptide analogue or...
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7060670 |
Stereoselective antifibrillogenic peptides and peptidomimetics thereof
The present invention relates to antifibrillogenic agents for inhibiting amyloidosis and/or for cytoprotection for the treatment amyloidosis disorders. These agents include peptides, isomers...
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7053054 |
Purified LH
A process for the purification of recombinant human Luteinizing Hormone (LH) from a sample of crude recombinant LH in the supernatant of CHO cells comprises the combined use of the ion-exchange...
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7052703 |
T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof
This invention provides nucleic acids containing sequences from a TCRγ transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame...
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7037897 |
TRI-, TETRA-, and penta-peptides having antiangiogenic activity
Compounds of formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions...
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7034002 |
Angiotensin converting enzyme inhibitor
The present invention provides an angiotensin converting enzyme inhibitor having strong activity of inhibiting angiotensin converting enzyme, good hue and easily to take in which is a composition...
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7034003 |
Somatostatin and somatostatin agonists for decreasing body weight
The present invention relates to a method of decreasing body weight in a patient. The method includes the step of administering a therapeutically effective amount of a somatostatin or a...
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7033794 |
Basolateral sorting signal and inhibitors thereof
Mono-leucine dependent basolateral sorting signal consisting of the amino acid sequence X 1 h 2 X 3 h 4 L p 5 p 6 , wherein: X 1 represents a polar amino acid residue or alanine, h 2 represents...
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7026289 |
Method and compositions for treating hyperlipidemia and other conditions
The present invention relates to a method of treating hyperlipidemia and to reducing triacylglycerols, glycerol and cholesterol in a patient. The method includes the step of administering a...
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7026296 |
Methods of treating dry eye disorders
Inhibitors of cytokine synthesis in nonimmune, resident ocular surface cells are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
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7022675 |
Wound healing compositions
Methods and compositions based on chemical analogs of angiotensin II and analogs of angiotensin II fragments useful for accelerating wound healing in mammals.
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7005418 |
Method for the therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction
The present inventions provides a method for therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction by short term induction...
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7005420 |
Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least...
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6992063 |
Compositions and method for regulating apoptosis
Peptides and peptidomimetics capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The peptides and mimetics are based on the...
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6989371 |
Bombesin analogs for treatment of cancer
The present invention encompasses novel peptides that are antagonists to bombesin and bombesin like peptides and are useful in the treatment of cancer. The invention particularly relates to the...
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6982249 |
Bradykinin analogs as selective inhibitors of cell activation
The present invention provides bradykinin peptide analogs, compositions, and methods of inhibiting thrombin-induced platelet and other cell activation. The bradykinin analogs comprise single or...
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6967192 |
Seventeen amino acid peptide (Peptide P) for treating ischemia and reperfusion injury
Peptide P, having the amino acid sequence Tyr-D-Ala-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-His-Se
r-Ile-NH2-SEQ ID NO:1, is useful to treat ischemia.
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6964948 |
Therapeutic peptide-based constructs derived from Domain II of bactericidal/permeability-increasing protein
The present invention relates generally to small peptide-based constructs, including derivatized constructs, and their therapeutic uses. The constructs and derivatized constructs can have at least...
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6962904 |
Elastin peptide analogs and uses thereof
The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated...
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6953779 |
Melanocortin receptor antagonists and modulations of melanocortin receptor activity
The clinical outcome of disseminated melanoma is grim. Small molecular weight antagonists (preferably about seven amino acid residues) specific for MCR on melanoma cells are provided for the...
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6951652 |
Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases
A vaccine is disclosed which is useful for protecting a host from Gram negative infections and the effects of endotoxin, therefore preventing sepsis and septic shock. The vaccine is prepared by...
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6951843 |
Peptide derivatives and their pharmaceutically acceptable salts, thereof, processes for preparation of both and use thereof
The present invention provides a peptide derivative of formula (I)
wherein X is —CHOH— or —CO—; R 1 and R 2 are hydrogen or substituted oxycarbonyl; R 3 is substituted oxycarbonyl;...
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6949513 |
Polypeptides of covalently linked synthetic bioactive peptide analog(s) for treatment of cancer
A polypeptide of the formula (I),
P a -L-P b -L-P c -L-P d .
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6939847 |
Use of colostrinin, constituent peptides thereof, and analogs thereof, as oxidative stress regulators
The present invention provides methods that utilize compositions containing colostrinin, an constituent peptide thereof, an active analog thereof, and combinations thereof, as an oxidative stress...
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6936587 |
Anti-invasive and anti-angiogenic compositions
A peptide compound having the sequence Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu [SEQ ID NO:2] or a substitution variant, addition variant or other chemical derivative thereof inhibits cell invasion,...
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6913761 |
Bioimplant formulation
A pharmaceutical and/or veterinary formulation comprising about 2-30% (w/w) (on an active basis) of at least one active agent, about 0.5-20.0% (w/w) of a pore-foaming agent and the balance stearin....
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6914048 |
Method for delivery of molecules to intracellular targets
Disclosed are β-peptides and β-peptide conjugates that are capable of diffusing or otherwise being transported across the cell membranes of living cells. The β-peptides contain at least six...
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6906037 |
Therapeutic peptide-based constructs
The present invention relates generally to small peptide-based constructs and their therapeutic uses. The sequences of these peptide-based constructs are based on a reverse subsequence derived from...
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6903074 |
Neuromedin b and somatostatin receptor agonists
A novel class of analogs which exhibit both high affinity and selectivity for Neuromedin B and Somatostann receptors are claimed. One example is Nal-Tyr-cyclo(D-Cys-D-Trp-Lys-D-Cys)-Abu-Nal-NH 2 .
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6900176 |
Pest control agents/depsipeptides
The present invention relates to the use of 24-membered cyclodepsipeptides of the formula (1)
in which R 1 and R 2 are as defined in the description,
for controlling animal pests in...
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6893645 |
Process to make a sustained release formulation
This invention pertains to a process for making a sustained release complex. Compound (I), which comprises Compound (A), having formula (A), and a copolymer comprising poly...
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6890902 |
Cytotoxic modified lactoferrin peptides
The present invention provides a modified lactoferrin peptide which is cytotoxic, 7 to 25 amino acids in length, with three or more cationic residues and which has one or more extra bulky and...
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6878689 |
Preventives or remedies for heart failure
Preparations for preventing or treating acute heart failure, chronic heart failure at a phase of acute exacerbation or heart failure at a phase of transition to chronic heart failure, which contain...
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6875743 |
Cell adhesion inhibitors
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical...
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6875744 |
Short bioactive peptides
Short bioactive peptides containing phenylalanine, leucine, alanine, and lysine residues are disclosed. The peptides can be used in antibacterial, antifungal, anticancer, and other biological...
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6866848 |
Antigenic polypetide sequence of factor VIII, fragments and/or epitopes there of
An antigenic polypeptide of factor VIII comprises a polypeptide included between the Glutamic Acid 1649 and Asparagine 2019, preferably between Arginine 1652 and Arginine 1917 of the polypeptide of...
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6864239 |
Methods and compounds for prevention and treatment of elevated intraocular pressure and related conditions
A GPCR-like protein is described, as well as inhibitory/antagonistic compounds and compositions comprising such inhibitors/antagonists of the protein. Such compounds may be used for treating...
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6858210 |
Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
The present invention provides domain 1 β 2 GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 β 2 GPI polypeptides and...
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6858396 |
Positively charged non-natural amino acids, methods of making and using thereof in peptides
This invention relates to positively charged non-natural amino acids, methods of making thereof, and utilization thereof in peptides.
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6855692 |
Histogranin peptides and their analgesic use
The invention relates to linear and cyclic peptide and pseudopeptide compounds useful as analgesics, pharmaceutical compositions comprising such compounds, the use of the compounds and the...
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6855695 |
Water-soluble SHPs as novel alkylating agents
The present invention relates to compounds according to the structure (I):
Where R is —CH 3 or —CH 2 CH 2 Cl; R′ is C 1 -C 7 alkyl or —CH 2 CH 2 Cl; R 2 or R 4 is OPO 3 H 2 , NO 2...
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6852688 |
Compositions for treating diabetic retinopathy and methods of using same
The subject invention provides novel methods and materials for treating diabetic retinopathy. One embodiment of the subject invention involves the co-administration of a somatostatin, or analogue...
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6852695 |
Orally active fraction of momordica charantia, active peptides thereof, and their use in the treatment of diabetes
A water soluble extract of M.charantia named MC6, methods for its preparation and methods for its use in the treatment of hyperglycemic disorders are provided. The active MC6 is characterized by...
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6852321 |
Lectin-derived progenitor cell preservation factor and methods of use
The invention relates to an isolated nucleic acid molecule that encodes a protein that is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The nucleic acid comprises...
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6852685 |
Use of colostrinin, constituent peptides thereof, and analogs thereof to promote neuronal cell differentiation
The present invention discloses a use of colostrinin, a constituent peptide thereof, and/or an analog thereof as a neural cell regulator in animals including humans.
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6852697 |
Peptides for treatment of inflammation and shock
Submandibular peptides have been isolated and characterized and provide pharmaceutical compositions for the treatment or prevention of anaphylactic reactions, endotoxic reactions and SIRS-induced...
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6844318 |
Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use
This invention is directed to antineoplastic agents conjugated to enzyme-cleavable peptides comprising the amino acid recognition sequence of a membrane-bound and/or cell-secreted peptidase, and to...
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