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5863901 |
Use of bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders and acute liver disorders
This invention relates to a method of treating a chronic fibrogenetic liver disorder and/or an acute liver disorder and/or complications associated therewith, comprising administering to a patient...
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5863763 |
Insect neuropeptides
The present invention relates to novel peptides isolated from the blowfly Calliphora vomitoria. The invention also relates to nucleic acid molecules encoding these peptides, vectors and host cells...
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5855884 |
Treatment of stress-induced migraine headache with a corticotropin releasing hormone blocker
Non-traumatic immobilization (restrain) stress causes rapid degranulation of rat dura mast cells, as shown both by light and electron microscopy. These morphologic findings were accompanied by...
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5854212 |
Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
A compound of the formula ##STR1## is disclosed which is useful for the treatment of fungal infections and for the treatment of infections caused by Pneumocystis carinii.
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5849701 |
Peptide inhibitors of fibronectin and related collagen-binding proteins
Peptides derived from the second type 1 repeat of human endothelial cell thrombospondin which bind to the gelatin-binding domain of fibronectin have been isolated and synthetically produced. The...
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5846548 |
Combined administration of mitogenic immumo stimulator and a thymomimetic
A method of tumor therapy involves controlling the immune system by co-administration of a mitogenic immuno-stimulating substance and a thymomimetic substance.
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5846934 |
Pure somatostatin antagonist and methods of use thereof
A method for decreasing the effect of somatostatin. A peptide of formula I which is a pure somatostatin antagonist, methods for increasing the release of growth hormone, insulin and glucagon in...
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5846743 |
Polyphoshoinositide binding peptides for intracellular drug delivery
Methods and compositions for facilitating the transport of a membrane-impermeable extracellular agent having an intracellular activity across the membrane of a cell are provided. The methods...
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5840682 |
Peptide antagonists of neurotensin
The invention is directed to a compound of formula ##STR1## in which R represents a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH 2 --COOH radical, R 1 represents a hydrogen atom, an...
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5840688 |
Eating suppressant peptides
Peptides corresponding to specific portions of the apolipoprotein A-IV (apo A-IV) are provided. Most of the peptides correspond to the amino terminal region of apo A-IV. In addition, those peptides...
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5840306 |
DNA encoding human papillomavirus type 18
The present invention is directed to DNA molecules encoding purified human papillomavirus type 18 and derivatives thereof.
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5840690 |
Regulation of cell proliferation and differentation using peptides
Disclosed are methods of inhibiting proliferation and enhancing differentiation of a mammalian cell, inducing proliferation of a mammalian cell, enhancing wound healing, and stimulating hair growth...
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5840691 |
Method for treating ischemia using polypeptides with fibronectin activity
Methods for treating ischemia using polypeptides with fibronectin related activity are provided. The methods involve administering an effective amount of one or more polypeptides which include an...
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5837686 |
Peptides and antibodies for treatment of rheumatoid arthritis
A synthetic peptide of not more than 20 amino acid residues or analogue thereof comprising a thiol-active cysteine residue and at least two positively charged amino acid residues situated on (but...
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5834435 |
Inhibition of TNF-α pleiotropic and cytotoxic effects
The pleiotropic effects of TNF alfa in a wide variety of mammalian cell types is decreased and treated by administering glucosaminylmuramyl peptides with D-amino acid residue in a second or third...
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5834433 |
Compounds and pharmaceutical uses of peptides of bombesin and GRP
A method for controlling the growth of tumor tissues, especially small cell lung. Treatment comprises administering to a patient in need thereof, an effective amount of a bombesin/GRP type...
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5834430 |
Potentiation of antibiotics
The present invention is concerned with methods of potentiating an antibiotic. The invention also includes compositions of an antibiotic and a peptide having units of the formula: (a) (A) n ...
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5834429 |
Small peptides which inhibit binding to T-4 receptors and act as immunogens
Short peptide of the formula: R a -Ser-Thr-Thr-Thr-Asn-Tyr-R b (I) where R a represents an amino terminal residue Ala- or D-Ala and R b represents a carboxy terminal residue...
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5834432 |
Use of angiotensin II Type 2 receptor agonists in tissue repair
Angiotensin II Type 2 receptor agonists (AT2 receptor subtype agonists) are useful in accelerating wound healing. These compounds form the basis of compositions useful for accelerating wound...
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5830863 |
Neurokinin A antagonists
Antagonists of neurokinin A which are derivatives of naturally occurring neurokinin A in which the amide bond connecting the two amino acids on the carboxy terminal end is modified are described....
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5821225 |
Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which...
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5821226 |
BAL C-tail drug delivery molecules
Drug delivery conjugates of including a BAL C-tail peptide including all or a portion of the carboxy terminal region of human bile salt-activated lipase (BAL) conjugated to a biologically active...
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5814342 |
Prolonged release microcapsules
This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil...
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5811394 |
Technetium-99m labeled polypeptides for imaging
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides...
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5811074 |
Method of diagnosing pituitary dependent growth hormone deficiency
A diagnostic protocol and kit for evaluating pituitary growth hormone (GH) secretory capability as a means to identify the etiology of GH deficiency in children and adults is disclosed. The...
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5807819 |
Peptides useful for altering bone resorption
The present invention provides Arg--Gly--Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also...
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5807830 |
Method for treatment of purulent inflammatory diseases
This invention provides methods of treating purulent inflammatory diseases by administering L-Glu-L-Trp or a salt thereof.
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5801149 |
Inhibition of signal transduction molecules
A peptide capable of inhibiting the interaction of an SH2 domain containing protein with a second protein.
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5798336 |
Antimicrobial peptides
Peptides which exhibit antimicrobial activity comparable to certain known antibiotics are provided. These peptides are related in sequence to amino acid sequences within Cathepsin G. A broad...
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5798335 |
Method for the treatment or prevention of eczema/dermatitis
The present invention provides a method for the treatment or prevention of eczema/dermatitis. This method involves the administration of Peptide T or its derivatives or analogues. Preferred...
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5795866 |
ETS1 gene: a human tumor suppressor gene
The present invention relates, in general, to methods for reducing cell tumorigenicity. More particularly, the present invention provides a method for reducing cell tumorigenicity comprising...
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5795857 |
Mimetic insect pyrokinin analogs for insect control
Novel pseudopeptide analogs of the insect pyrokinin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a...
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5795858 |
Treatment or prevention of Crohn's disease and/or ulcerative colitis
The present invention provides a method for the treatment or prevention of Crohn's disease and/or ulcerative colitis. The method involves the administration of Peptide T or its derivatives or...
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5792750 |
Materials and method for control of pests
The subject invention concerns novel peptides which have the property of interfering with the biosynthesis of the enzyme trypsin. This property enables the use of these peptides to, for example,...
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5789383 |
Bradykinin antagonists for the prophylaxis or treatment of virus diseases
Bradykinin antagonists and their physiologically tolerated salts are suitable for the treatment or prophylaxis of virus diseases.
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5789411 |
Improvements to rapid opioid detoxification
Rapid opioid detoxification procedures are provided which include sedating a patient with an anesthetic agent having a short full recovery period. The patient is administered an opioid antagonist...
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5786332 |
Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels
The present invention relates to novel peptides that are potent cytokine restraining agents. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically...
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5786335 |
Sulfhydryl containing peptides for treating vascular disease
Sulfhydryl containing peptides having the formula X--A 1 --A 2 --A 3 --A 4 --A 5 --Y inhibit the formation of Lp(a) and thus are useful for treating vascular diseases such as coronary heart...
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5776892 |
Anti-inflammatory peptides
The present invention relates to peptides, peptide analogs and peptide derivatives related to platelet factor 4 which exhibit anti-inflammatory activity, to pharmaceutical compositions comprising...
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5776885 |
Sustained and controlled release of water insoluble polypeptides
A pharmaceutical composition for the sustained release of a peptide wherein the composition includes a polylactide polymer, a polymer of lactic acid and glycolic acid, or a mixture of such polymers...
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5776894 |
Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
Somatostatin peptides bearing at least one chelating group for a detectable element, said chelating group being linked to an amino group of said peptide, and said amino group having no significant...
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5776901 |
Polypeptide analogues having growth hormone releasing activity
Novel peptides of the formula A 1 -A 2 -C 1 -C 2 -C 3 -A 5 are disclosed which promote the release of growth hormone when administered to animals. These peptides can be used therapeutically.
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5776900 |
Hemoregulatory peptides
The invention provides compounds of the general formula: ##STR1## The compounds have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and...
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5773412 |
Use of peptides for altering α.sub.V β.sub.3 -mediated binding
The present invention provides Arg--Gly--Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also...
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5770565 |
Peptides for reducing or inhibiting bone resorption
The present invention provides Arg-Gly-Asp peptides that can reduce or inhibit the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention...
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5766593 |
Anti-inflammatory CD14 peptides
The invention relates to anti-inflammatory peptides that are based on peptide regions 7-10, 11-14, and 57-64 of CD14.
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5767084 |
Method of treatment for cystic fibrosis and peptides for same
Peptides derived from mutant CFTR protein which inhibit intracellular degradation and/or retention of mutant CFTR proteins are disclosed. A method of inhibiting intracellular degradation and/or...
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5767235 |
Anticoagulant hirudin variants and methods for their production
The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients....
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5763407 |
High-purity desmopressin produced in large single batches
A process for the manufacture of high purity desmopressin produced in single batches of substantial size and a method of treating diabetes insipidus with the high purity desmopressin produced...
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5763402 |
Promotion or inhibition of spermatogenesis
A method of promoting or inhibiting spermatogenesis, said method comprising administering to a male an effective amount of PACAP, a PACAP agonist, a PACAP antagonist, PC4, a PC4 agonist, or a PC4...
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