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7576101 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents  
The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions...
7435408 Porous particles comprising excipients for deep lung delivery  
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
7071177 P-(sulfonyl) aryl and heteroarylamines as anti-inflammatory agents  
This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use,...
6753298 Agents for combating Neospora spec  
Compositions for controlling diseases caused by protozoans of the genus Neospora, which are characterized in that they comprise one or more active compounds which inhibit the microtubulin system of...
6342510 Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist  
Combinations of a cyclooxygenase-2 inhibitor and a leukotriene B 4 receptor antagonist are described for treatment of inflammation and inflammation-related disorders.
6291442 Pharmacological modulators of voltage-gated potassium ion channels  
Disclosed herein is the discovery that an allosteric receptor site exists on the intracellular surface of Shaker class voltage-gated potassium ion channels that is distinct from the pore and is...
6211185 Concentrate comprising a sulfonamide in solution, a 2,4-diaminopyrimidine in stable suspension within said solution, and a suspending agent  
A palatable antimicrobial drug concentrate comprising: (a) a sulfonamide and/or sulfonamide salt in aqueous solution; (b) a 2,4-diaminopyrimidine in stable suspension within said solution; and (c)...
6194399 Aryldiamine derivatives useful as antibacterial agents  
Disclosed are pharmaceutical compositions and formulations comprising the compound: ##STR1## wherein: (a) R 1 , R 2 , R 3 , and R 4 are independently selected from the group consisting of...
6004948 Derivatives of benzosulphonamides as inhibitors of the enzyme cyclooxygenase II  
Compounds of the formula (I) in which A is oxygen, sulphur or NH; B is a group of the formula (IIa) or (IIb); and the other variables have the meaning given in claim 1, may be used as inhibitors of...
5955458 Penicillin glycolate  
New solvates of penicillin, in particular amoxycillin glycolate has been provided for together with a simple one-step process to prepare the same.
5824661 Sulfur-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism  
Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S (b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a...
5814623 Parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamides  
Disclosed herein are parenteral solutions containing 7-halo-1,2,3, 4-tetrahydro-3-aryl-6-quinazoline sulfonamide in Tris or Bis-Tris or Tris buffer useful in the treatment of hypertension, heart...
5723452 Therapeutic benzonitriles  
The present invention relates to novel compounds of formula (I): ##STR1## or a physiologically functional derivative thereof, pharmaceutical formulations containing them, processes for their...
5633240 Parenteral solutions containing metolazone  
Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in Tris or Bis-Tris or Tris buffer useful in the treatment of hypertension, heart...
5273970 Treatment of protozoal diseases  
The antibacterial substance baquiloprim (2,4-diamino-5-[8-dimethylamino-7-methyl-5-quinolylmethyl]py rimidine) is shown to be active against protozoal infections, e.g. toxoplasmosis. Preferably the...
5189031 Urea derivatives, compositions and use  
The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are...
5110808 Amide derivatives, compositions and use  
The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are...
5084449 Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase  
Disclosed are substituted bis(4-aminophenyl-sulfonees of general formula ##STR1## wherein R 1 is hydrogen, alkyl or cycloalkyl; group, R 2 is hydrogen or C 1 -C 3 alkyl, R 3 is nitrile,...
5075108 Melphalan derivatives  
A compound of formula I ##STR1## wherein R 1 is of formula II ##STR2## wherein R 4 and R 5 , which may be the same or different, are bromo, chloro, iodo or alkylsulphonyl; R 2 is of formula...
5053228 Polymeric temperature sensitive drug carrier  
The drug carrier of this invention provides a temperature-sensitive polymer chemically bonded to a drug. The drug carrier is capable of releasing a drug continuously in the body. The drug carrier...
5026690 Antiviral agent  
The present invention relates to the use of sulphonamide derivatives for the treatment of diseases caused by viruses, especially caused by enclosed viruses such as, e.g., herpes simplex, as well as...
5008255 Method for enhancing solubility of trimethoprim with sodium sulfacetamide, and synergistic pharmaceutical compositions derived therefrom  
A method of preparing aqueous pharmaceutical compositions containing a synergistic combination of trimethoprim and sodium sulfacetamide is described. The method results in a significant improvement...
4981873 Substituted sulphonamides, pharmaceuticals thereof and methods of using them  
The present invention concerns compounds of the formula: ##STR1## where R 1 is an alkyl or alkenyl radical containing up to 6 carbon atoms, a cycloalkyl radical containing 3 to 7 carbon atoms, an...
4855289 Combination of two active substances  
The invention concerns the use of a compound with diuretic properties and of a magnesium supplementation in the form of magnesium monoaspartate hydrochloride, magnesium oxide, magnesium hydroxide...
4849563 Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity  
Compounds of the formula: ##STR1## wherein R 1 s an alkyl of 1-6 carbon atoms, benzyl, phenyl, or phenyl substituted by halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, amino,...
4829058 Substituted bis-(4-aminophenyl)-sulfones  
Disclosed are substituted bis(4-aminophenyl)-sulfones of general formula ##STR1## wherein R 1 is hydrogen, alkyl or cycloalkyl; group, R 2 is hydrogen or C 1 -C 3 alkyl, R 3 is nitrile,...
4818753 Synthesis and method of use for 2, 4 diaminoquinazoline  
Compounds of the formula ##STR1## wherein R 1 is H, methyl, ethyl, or chloro and R 2 is hydrocarbyl of 1-12 C are useful as antifungal agents. Compounds of this series wherein R 2 is 7-12 C are...
4769447 Gamma-Glutamyl-4-azoanilides  
The present invention provides gamma-glutamyl-4-azoanilides, processes for their preparation and their use as substrates for gamma-glutamyl transferase determination, of the formula ##STR1##...
4761430 Arylbenzenesulfonamide containing pharmaceutical compositions  
The invention relates to new medicaments having lipid regulating properties nd processes for their preparation. The medicaments according to the invention contain as active principle at least one...
4735959 Carboxylic acid amides and pharmaceutical compositions containing them  
There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary...
4652556 Fungicidal N-cyanoalkyl-N-haloalkylthio sulfonamides  
Compounds of the formula: ##STR1## wherein R is aryl of 6 to 12 carbon atoms or aralkyl of 7 to 14 carbon atoms either optionally substituted with 1 to 3 substituents independently selected from...
4621100 Treatment of osteoporosis with prostaglandins  
The present invention provides a novel method for treating osteoporoses, joint and dental diseases and increasing the rate of bone healing by orally administering certain prostaglandins. Further...
4560553 Use of eucalyptol for enhancing skin permeation of bio-affecting agents  
Eucalyptol is used to enhance skin permeation of bio-affecting agents.
4522818 Diuretic/antihypertensive compositions  
A combination tablet containing metolazone and triamterene is useful in diuretic therapy and the treatment of hypertension. The composition is advantageous in the prevention of hypokalemia, a...
4518594 Use of trifluoromethanesulfonanilides  
An insecticidal composition which comprises as an active ingredient a compound of the formula: ##STR1## wherein X is a hydrogen atom or an acyl group, Y is a hydrogen atom, a lower alkyl group or a...
4478822 Drug delivery system utilizing thermosetting gels  
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
4474753 Topical drug delivery system utilizing thermosetting gels  
This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a...
4415574 Soluble N.sub.2 substituted derivatives of 2,4-diamino 5-benzyl pyrimidine, process for their preparation and medicaments containing them  
The present invention relates to novel soluble N 2 substituted derivatives of 2,4-diamino 5-benzyl pyrimidines. These derivatives correspond to the general formula III below: ##STR1## The novel...
4406895 Base-substituted anthranilic acids, a process for their preparation and their use  
The invention relates to base-substituted anthranilic acids of the formula I ##STR1## in which R denotes furyl, thienyl or phenyl, and to physiologically acceptable salts thereof, and also to a...
4341773 2,4-Diamino-5-sulfamoylbenzene sulfonic acids and process for their manufacture  
The present invention relates to compounds of the formula I ##STR1## wherein R is furyl, thienyl or phenyl, to physiologically acceptable salts thereof, to a process for their manufacture, to a...
4315931 N-Pyrimidinyl-imidoacid esters and drugs containing the said compounds  
Unsubstituted or substituted 5-phenyl- and 5-benzyl-4-amino-pyrimidine-2-imidoacid esters, their preparation, drugs containing these compounds, and their use in infectious diseases.
4301158 N-(2-Propynyl)-2,6-dinitro-benzenamine derivatives  
Fungicides are of the formula: ##STR1## wherein R and R' are each independently alkyl of 1 to 4 carbon atoms, R° is trihalomethyl in which the halo atoms are of atomic weight of from 18 to 36,...
4285947 Aldehyde adducts of triamterene  
The invention provides novel aldehyde adducts of triamterene having improved solubility and bioavailability as compared to triamterene. Pharmaceutical compositions containing the novel adducts and...
4283444 Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds  
A method of protecting keratinous material, especially wool, from attack by insects that feed on keratin, which comprises treating said material with compounds of the formula ##STR1## wherein X is...
4248855 Pharmaceutical base salts  
A salt of a polymer, containing acid groups, soluble or dispersible in water or organic solvents, is combined with a salt-forming pharmaceutically effective compound for application, orally,...
4211776 N-Substituted 2-methoxybenzenesulphonamides, process for preparing them and medicaments containing them  
The invention relates to new N-substituted benzenesulphonamides of general formula ##STR1## in which n is 2 or 3, R 1 and R 2 are hydrogen atoms, methyl, ethyl groups, or jointly form with the...
4209513 Tablet formulation  
A tablet suitable for use in the treatment of microbial infections, which tablet comprises from 80 to 98% (w/w) of a combination of a 2,4-diaminopyrimidine with a sulphonamide and not more than 20%...
4188373 Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes  
Pharmaceutical vehicles for delivery of pharmacologically active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The...
4180578 2,4-Diamino-5-(4'-methylthio)benzylpyrimidenes, compounds, compositions and method of use  
A compound selected from a 2,4-diamino-5-thiobenzylpyrimidine of the formula: ##STR1## in which R is selected from hydrogen, alkyl, lower alkoxy, and halogen and R' is alkyl; and pharmacologically...
4156722 Dinitroanilines for control of soil-borne phytopathogens  
A class of 2,6-dinitroanilines having a broad range of substituent groups on the anilino nitrogen and in the 3- and 4-positions of the phenyl ring are used for the protection of plants against...
Matches 1 - 50 out of 91 1 2 >