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7612053 |
7-Substituted fused ring tetracycline compounds
7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds...
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7612045 |
Compounds, compositions and methods for controlling biofilms and bacterial infections
The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention...
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7595309 |
7-substituted tetracycline compounds
The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
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7553828 |
9-aminomethyl substituted minocycline compounds
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states,...
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7553827 |
Transdiscal administration of cycline compounds
The present invention relates to injecting a cycline compound into a diseased intervertebral disc.
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7541347 |
Minocycline oral dosage forms for the treatment of acne
Minocycline oral dosage forms containing a controlled release carrier are useful for the treatment of acne.
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7521437 |
7-phenyl-substituted tetracycline compounds
7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are...
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7456158 |
4-dedimethylaminotetracycline derivatives
The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and...
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7435408 |
Porous particles comprising excipients for deep lung delivery
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
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7404964 |
Injectable compositions for the controlled delivery of pharmacologically active compound
The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the...
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7354928 |
Small molecule inhibitors targeted at Bcl-2
The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-X L . In particular, the present invention provides non-peptide cell permeable small...
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RE40183 |
7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula
wherein R, X, R 5 and R 6 are defined in the specification. The...
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7345024 |
Pharmaceutical preparation, method for its production as well as its use
The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have...
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RE40086 |
Method for treating bacterial infection with novel 7-substituted-9-substituted amino 6-demethyl-6-deoxytetracyclines
The disclosure is drawn to a method of using novel 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds to treat infections caused by a wide spectrum of bacterial organisms,...
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7326696 |
Amino-methyl substituted tetracycline compounds
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
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7241746 |
Method and composition for treating periodontal disease
The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is...
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7241741 |
Methods and compositions for the treatment of asthma and related disorders
The present invention provides methods for the treatment of respiratory tract mucositis in individuals in need of such treatment, the method comprising the systemic administration to the individual...
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7232572 |
Methods of treating rosacea
A method of treating rosacea in a human in need thereof comprising administering to said human a tetracycline compound in an amount that is effective to treat rosacea, but has substantially no...
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7214669 |
Tetracycline derivatives and methods of use thereof
A treatment for inhibiting microbial or tumor growth is disclosed, which comprises adding to a subject in need of treatment an effective amount of one or more tetracycline derivatives.
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7211267 |
Methods of treating acne
A method of treating acne in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat acne but has substantially...
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7208482 |
9-aminoacyl tetracycline compounds and methods of use thereof
A compound of formula (I):
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7202235 |
Tetracycline compounds for treatment of cryptosporidium parvum related disorders
Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related...
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7189703 |
Treatment and diagnosis of alzheimer's disease
The invention relates to a method of treating Alzheimer's disease in a mammal comprising administering to the mammal an anti-microbial agent having anti- Chlamydia pneumoniae activity. The...
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7179615 |
Method of prophylaxis and treatment
The present invention relates generally to a method for the prophylaxis and treatment of parasitic infections in animals and birds. More particularly, the present invention contemplates a method...
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7115557 |
Use of certain drugs for treating nerve root injury
The present invention relates to a method and a pharmaceutical composition for treatment of nerve disorders comprising administration of a therapeutically effective dosage of at least two...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7094397 |
Methods and reagents for the treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in...
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7060732 |
Antibiotic/benzoyl peroxide dispenser
Two separate compositions, one containing an effective anti-acne treating amount of a first active ingredient and one containing a second active ingredient that is incompatible with the first...
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7056902 |
4-dedimethylamino tetracycline compounds
The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline...
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7056533 |
Medicament incorporation matrix
A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating...
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7053073 |
Treatment for reactive arthritis or bursitis
A treatment for conditions in human beings associated with either or both reactive arthritis or bursitis comprising a combination of valacyclovir hydrochloride, minocycline hydrochloride, and...
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7045507 |
Substituted tetracycline compounds as synergistic antifungal agents
Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.
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7014858 |
Use methods of treating acne and telangiectasia
A method of treating telangiectasia in a human in need thereof comprising administering to said human a tetracycline compound in an amount that is effective to treat telangiectasia, but has...
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7011826 |
Control of acidosis
The present invention relates to a vaccine for the prevention of lactic acidosis in a vertebrate, said vaccine comprising at least one isolated microorganism, or fragment or fragments thereof,...
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7008631 |
Methods of simultaneously treating ocular rosacea and acne rosacea
A method for simultaneously treating ocular rosacea and acne rosacea in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is...
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6949519 |
Macrolide solvates
Azithromycin in the form of a monohydrate comprising from 4.0% to 6.5% of water, a process for its preparation and its use in pharmaceutical compositions.
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6946453 |
4-dedimethylaminotracycline derivatives
The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and...
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6946137 |
Methods for the controlled delivery of pharmacologically active compounds
The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the...
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6914057 |
Inhibitor of cataract formation
Methods of reducing the risk of cataract development in a mammal are provided and include administering to the mammal an effective amount of a tetracycline derivative. A preferred tetracycline...
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6890526 |
Methods and reagents for the treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in...
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6884784 |
Diagnosis and management of infection caused by chlamydia
The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae . The invention is based, in part, upon the...
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6849615 |
13-substituted methacycline compounds
13-substituted methacycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 13-substituted methacycline compounds are described.
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6841547 |
Method for decreasing low density lipoprotein
The present invention relates to a method for decreasing elevated serum/plasma LDL-cholesterol levels or LDL-cholesterol levels and CRP levels in a mammal in need thereof. The methods comprises...
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6841546 |
Substituted tetracycline compounds as antifungal agents
Methods and compositions for treating fungal associated disorders in subjects are discussed.
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6833389 |
Use of thiamphenicol and derivatives thereof for the preparation of pharmaceutical compositions useful in the treatment of Chlamydia pneumoniae infections
Use of thiamphenicol and derivatives thereof for the preparation of pharmaceutical compositions useful for the treatment Chlamydia pneumoniae infections is described.
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6825176 |
E2 displacement assay for identifying inhibitors of HPV
The present invention generally relates to an assay for identifying inhibitors of Human Papillomavirus (HPV), comprising: a) contacting a HPV E2 transactivation domain with a probe to form a...
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6818635 |
7-substituted tetracycline compounds
The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
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6818634 |
7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful...
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6818625 |
Method for increasing survival rate of cells in animal cell culture under hypoxia condition
The present invention relates to a method for increasing survival rate of cells in animal cell culture under hypoxia condition by adding antibiotics to the culture media. The method of present...
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6761899 |
Particulate animal feed supplements and processes for the preparation thereof
A medicated animal feed additive in a solid particulate or granular form having improved resistance to powdering and good fracture toughness is provided. The animal feed additive according to the...
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