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5945420 |
Immunopotentiating and infection protective agent and production thereof
An immunopotentiating and infection protective agent comprising riboflavin and/or a riboflavin derivative, which is safe for the human, animals or the like, an immunopotentiating and infection...
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5929055 |
Therapeutic method for management of diabetes mellitus
A method for treating diabetes in a mammal by moderately controlling blood glucose concentration in the mammal together with administering to the mammal an amount of a tetracycline compound...
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5919775 |
Method for inhibiting expression of inducible nitric oxide synthase with tetracycline
The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the...
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5912411 |
Mice transgenic for a tetracycline-inducible transcriptional activator
Transgenic mice carrying a transgene comprising a nucleic acid molecule encoding protein useful for regulating the expression of genes in eukaryotic cells in a highly controlled manner are...
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5908838 |
Method for the treatment of acne
A method for the treatment of acne is provided which results in the reduction of vestibular side effects following administration of oral tetracycline antibiotics.
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5906977 |
Conjugate for treating inflammatory diseases
The present invention relates pharmaceutical compositions comprising a conjugate of an active substance, a linker and a carrier for the treatment and/or diagnosis of inflammatory diseases. The...
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5883074 |
Potentiators of antibacterial agents
Methods for screening for compounds which potentiate the activity of antibacterial agents against bacteria resistant to the antibacterial agent alone, pharmaceutical compositions including such...
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5859310 |
Mice transgenic for a tetracycline-controlled transcriptional activator
Transgenic mice carrying two transgenes, the first coding for a transactivator fusion protein comprising a tet repressor and a polypeptide which directly or indirectly activates transcription of a...
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5856315 |
Methods for inhibiting proliferation of tumor cells and tumor growth
The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of 7- substituted amino!-9- (substituted...
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5843925 |
Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of a 7- substituted amino!-9- (substituted...
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5843482 |
Products and processes for the treatment of the alimentary canal
Complexes of bismuth, e.g. bismuth salts, and polyacrylate, e.g. carbomer, are discloses which may be incorporated into pharmaceutical compositions for oral, oral delayed-release, and rectal...
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5834449 |
Treatment of aortic and vascular aneurysms with tetracycline compounds
A method for inhibiting the formation and progression of abnormal vascular dilatation and/or aneurysms. The method includes administering a tetracycline compound to a mammal in an amount which is...
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5834450 |
9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
This invention relates to compounds of the formula ##STR1## wherein R 1 , R 2 and R 3 are defined as in the specification and the pharmaceutically acceptable salts of such compounds. Compounds of...
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5827840 |
Promotion of wound healing by chemically-modified tetracyclines
A method for improving the healing response of epithelialized tissue (e.g., skin, mucosae) to acute traumatic injury is disclosed. The method includes employing a tetracycline compound, having...
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5824666 |
Low PH, hydrolytically stable, cosmetic compositions containing acidic actives
The present invention relates to leave on, oil-in-water, skin care compositions, comprising: (A) from about 0.05% to about 20% of an acidic active ingredient, preferably having a solubility...
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5789395 |
Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit...
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5773430 |
Serine proteinase inhibitory activity by hydrophobic tetracycline
A method for inhibiting the activity of serine proteinase in biological systems includes administering to the system a serine proteinase inhibitory amount of a hydrophobic...
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5770588 |
Non-antibacterial tetracycline compositions of the prevention and treatment of root caries
Methods of inhibiting root caries formation on mammalian tooth surfaces are disclosed. The methods include topically contacting the tooth root surfaces with an effective amount of a...
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5753636 |
Injection solution for intramuscular and subcutaneous administration to animals
An injection solution for subcutaneous or intramuscular administration to an animal, and a method of producing same, are provided. The injection solution is substantially free of chloride ions and...
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5698533 |
Ophthalmic pharmaceutical composition
A method of administering a drug to an eye including the steps of: (a) admixing a pharmaceutically acceptable hydrocarbonaceous semi-solid or oil which contains the drug with water at a temperature...
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5691385 |
Growth promotion
β-Phenethanolamines are effective in promoting growth and improving feed efficiency and leanness in animals.
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5674539 |
Method of treating skin and composition
A topical medication for the treatment of skin pathology including acne is comprised of tetracycline, minocycline, clindamycin, erythromycin, or doxicycline and selenium sulfide or sulfur in a...
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5674858 |
Medicaments for treating gastrointestinal disorders
The use is described of both (i) ranitidine bismuth citrate and (ii) one or more Helicobacter pylori-inhibiting antibiotics in treating or preventing gastrointestinal disorders. Pharmaceutical...
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5668122 |
Method to treat cancer with tetracyclines
The present invention provides a method to treat susceptible cancers in humans comprising administering a cancer-treating amount of a member of the tetracycline family or a pharmaceutically...
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5646135 |
Method for controlling coccidiosis
The present invention relates to an improved method for controlling coccidiosis in poultry which comprises administering to poultry on shuttle medication an additional medication prior to switching...
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5641762 |
Bone targeted inhibitors of carbonic anhydrase
The present invention relates to novel compounds useful for the treatment and prophylaxis of degenerative bone disorders and to the preparation thereof. These compounds are particularly...
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5639742 |
9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
The invention provides compounds of the formula: ##STR1## wherein R, R 1 , R 2 and W are defined in the specification. These compounds are useful as antibiotic agents.
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5604208 |
Antibiotic preparation and use of the same in plants
An antibiotic formulation comprising gentamicin, and optionally tetracycline or oxytetracycline, for use in plants.
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5567692 |
9-[(substituted glycyl) amido)]-6-demethyl-6-deoxytetracyclines
The invention provides a method for prevention, treatment or control of bacterial infections in warm blooded animals by administering a pharmacologically effect amount of a compound of the formula:...
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5532227 |
Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive glycosylation of different types of collagen and other proteins during diabetes
A method for treating mammals suffering from excessive extracellular protein glycosylation which is associated with diabetes, scleroderma and progeria by administering to the mammal a tetracycline...
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5523288 |
Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic
The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein...
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5466684 |
7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides compounds of the formula: ##STR1## wherein R, R 3 , R 4 and W are defined in the specification. These compounds are useful as antibiotic agents.
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5459135 |
Composition comprising indomethacin [non-steroidal anti-inflammatory agent] and effectively non-antibacterial tetracycline to reduce bone loss
A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity...
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5447725 |
Methods for aiding periodontal tissue regeneration
Methods for aiding periodontal tissue regeneration with compositions containing bioresorbable polymers, leachable solvents, and bioavailable drug actives. The compositions useful for these methods...
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5432170 |
Process for the production of semisolid preparations containing micronized active ingredients
A process for the production of semisolid preparations containing micronized active ingredients is described which is characterized in that a mixture of one or two nonionic surfactants with an HLB...
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5366966 |
Compound UCE6
A compound represented by formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is provided, which has an excellent antitumor activity.
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RE34656 |
Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency
Tetracyclines, antibacterial and non-antibacterial tetracyclines, have been found to be useful in the treatment of osteoporosis in humans by administering to the human suffering from osteoporosis...
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5321017 |
Composition comprising fluriprofen and effectively non-antibacterial tetracycline to reduce bone loss
A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity...
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5312813 |
Biofilm reduction method
A method of killing microorganisms which form a biofilm on a tissue or implant surfaces in a patient, and which are refractory to a biocide at a dose which is effective to kill the microorganism in...
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5308839 |
Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
A method for treating mammals suffering from rheumatoid arthritis, other tissue-destructive conditions, and chronic inflammatory or other conditions associated with excess metalloproteinase...
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5258372 |
Tetracycline activity enhancement using doxycycline or sancycline
Methods and products for overcoming bacterial resistance to tetracycline-type antibiotics by inhibiting the plasmid-mediated active efflux system for tetracycline in the resistant bacterial cell by...
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5258371 |
Method to reduce connective tissue destruction
Provided is a method of treating humans or animals suffering from a condition or disease characterized by excessive collagen destruction, which comprises administering to said human or animal an...
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5250442 |
Method of treating rheumatoid arthritis using tetracycline
A method of treating rheumatoid arthritis which includes first, taking a blood test to determine a rate of erythrocyte sedimentation and a rheumatoid factor, and then fasting for a 12-hour period...
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5242910 |
Sustained release compositions for treating periodontal disease
This invention relates to compositions/devices and methods for treating diseases of the oral cavity in humans and lower animals using polylactide/glycolide compositions/devices also containing...
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5229380 |
Method for treating helicobacter pylori gastritis
The invention relates to a method of arresting and treating duodenal and gastric ulcers, and chronic gastritis comprising administering an effective amount of [4S(4α,4aα,5aα,12aα)]-4,7-bis...
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5223248 |
Non-antibacterial tetracycline compositions possessing antiplaque properties
A method of inhibiting plaque formation on mammalian tooth surfaces is disclosed. The method includes contacting the tooth surfaces with an effective amount of a non-antibacterial tetracycline. In...
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5192752 |
Swallowable pharmaceutical compositions containing Colloidal Bismuth Subcitrate
Oral pharmaceutical compositions in unit dosage form suitable for swallowing (especially capsules) comprising a safe and effective amount of solid Colloidal Bismuth Subcitrate (CBS), and optionally...
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5183758 |
Production of 7-chloro-3-methoxy-2'-N-methyltetracycline with Actinomadura brunnea
An antibiotic complex is produced by the microorganism, Actinomadura brunnea NRRL 15216, ATCC 39216. A novel antibiotic 7-chloro-8-methoxy-2'-N-methyltetracycline, isolated from the antibiotic...
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5169637 |
Stable plurilamellar vesicles
A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for...
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5122519 |
Stable, cosmetically acceptable topical gel formulation and method of treatment for acne
Stable, cosmetically acceptable gel formulations of the tetracycline antibiotics for the topical treatment of acne in humans. Minocycline hydrochloride is the preferred antibiotic and the...
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