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6733764 |
Immunostimulator anti-cancer compounds and methods for their use in the treatment of cancer
The present invention comprises a method for the treatment of cancerous tumors in mammals comprising the administration of an effective amount of an immunostimulator which enhances and potentiates...
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6716822 |
Therapeutic agent for ischemia which inhibits apoptosis under ischemic condition
The present invention relates to a therapeutic agent for ischemia which inhibits apoptosis under ischemic condition. The therapeutic agent of the present invention comprises antibacterial agents of...
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6713463 |
Methods and compositions for treating and preventing mucositis
A method of reducing or inhibiting mucositis in a patient, which includes administering an inflammatory cytokine inhibitor or a mast cell inhibitor, or a combination thereof, is disclosed.
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6706290 |
Methods for eradication of nanobacteria
Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The...
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6706713 |
Conjugate for treating inflammatory infectious and/or skin diseases
This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation...
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6683068 |
7, 9-substituted tetracycline compounds
The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial...
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RE38386 |
Retardation of metalloproteinase incidental to HIV and/or AIDS
The instant invention provides a product of manufacture for retarding the biochemical formation of metalloproteinase, including gelatinase, elastase, collaginase, and the like, within the tissues...
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6649589 |
Use of certain drugs for treating nerve root injury
The present invention relates to pharmaceutical compositions for the treatment of spinal disorders caused by the liberation of TNF-α comprising an effective amount of a TNF-α inhibitor, as well...
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6645508 |
Stable L-ascorbic acid composition
A stable composition including a water-sensitive pharmacologically active agent, such as an enzyme, an antibiotic or a vitamin, a hydrophilic non-polar primary solvent, an optional hydrophilic...
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6613756 |
Use of tetracycline derivatives in treating multiple sclerosis
A method of treating multiple sclerosis is disclosed. In one embodiment, the method comprises the step of treating a multiple sclerosis patient with a tetracycline derivative, wherein the multiple...
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6610274 |
Anti-inflammatory composition comprising tetracycline
Therapeutic composition having anti-infective activity. The therapeutic composition is a formulation comprising an antibiotic, preferably a tetracycline, most preferably doxycycline, which has not...
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6608112 |
Use of metalloproteinase inhibitors in the treatment and prevention of pulmonary emphysema
The invention provides a use of a metalloproteinase inhibitor for the preparation of a pharmaceutical composition for treating human pulmonary emphysema which comprises admixing the...
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6602516 |
Antibiotic/medicated gutta percha point
The ability to incorporate iodoform, tetracycline and a combination of iodoform/tetracycline into root canal gutta percha points is described. The iodoform, tetracycline and iodoform/tetracycline...
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6576625 |
Targeted vesicular constructs for cytoprotection and treatment of H. pylori infections
A composition for targeted vesicular for treatment of H - Pylori infections and for protection of the cell. The composition contains lectins, phospholipids, sterols, and one or more drugs. The...
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6572903 |
Wildlife nutritional supplement
The present invention is a wildlife nutritional supplement for free ranging ruminants including about 7.5-8.5% calcium, about 3.5% phosphorus, about 32-37% salt, at least one “B” series vitamin...
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6566350 |
Minocycline-containing compositions
An object of the present invention is to provide a stable pharmaceutical composition for topical administration comprising minocycline as an active ingredient. According to the present invention,...
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6531487 |
Indolo&lsqb 2,1-b&rsqb quinazole-6, 12-dione antimalarial compounds and methods of treating malaria therewith
Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo[2,1-b]quinazoline-6,12-dione compounds of Formula I. wherein A, B, C,...
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6518252 |
Method of treating aquatic animals with an antimicrobial agent and chelating agent
The present invention relates to novel method of reducing microbial infections, especially bacterial infections, of animals, especially of aquatic animals such as fish maintained in tanks or...
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6503892 |
Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve
This invention provides a method of inhibiting, preventing, and/or treating conjunctival filtering bleb leaks that may occur following glaucoma filtering surgery by administering Matrix...
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6482810 |
Antibiotic composition for inhibition of angiogenesis
Pharmaceutical compositions for delivering an effective dose of an angiogenesis inhibitor consisting of a tetracycline or tetracycline such as minocycline. The effective dosage for inhibition of...
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6479473 |
Long-acting antimicrobials
A method for producing an improved veterinary product is disclosed. The method comprises bringing a selected long-acting anticmicrobial formulation into intimate admixture with a predetermined...
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6468964 |
Control of acidic gut syndrome
According to the present invention there is provided a method for the treatment or prophylaxis of acidic gut syndrome resulting from the accumulation of acid and production of endotoxin in the...
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6432934 |
Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease
Ophthalmic compositions and methods of using the same to simultaneously treat eye surface inflammation and dry eye are disclosed. The ophthalmic preparation contains a tetracycline compound in...
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6429204 |
Method of inhibiting cancer growth
The invention is a method of inhibiting a sarcoma, such as Kaposi's sarcoma, in a mammal. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3.)
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6403640 |
Method for treating chronic prostatitis or chronic pelvic pain syndrome
The use of a COX-2 selective inhibitor for the treatment of chronic prostatitis or chronic pelvic pain syndrome is disclosed.
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6319910 |
Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha
Chemically modified tetracyclines are a new class of non-steroidal anti-inflammatory drugs which inhibit cyclooxygenase-2 and tumor necrosis factor alpha. These chemically modified tetracyclines...
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6310053 |
Long-acting oxytetracycline composition
An injectable composition is described having a higher residual effect with reduced detrimental effects such as pain at injection site, swelling, tissue irritancy or necrosis. The composition...
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6306838 |
Targeted vesicular constructs for cyto protection and treatment of h. pylori
A Novel Composition for targeted vesicular for treatment of H-Pylori infections and for protection of the cell is disclosed. The Composition Comprises Lectins, Phospholipids sterols an one or more...
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6303644 |
Proton pump inhibitor in therapeutic combination with antibacterial substances
The invention relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal track using antibacterially...
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6277829 |
Process for preparing of aqueous formulation for opthalmic use
The present invention describes a process for the preparation of aqueous formulations containing azithromycin for ophthalmic use, as well any formulations obtained by this process and their topical...
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6277061 |
Method of inhibiting membrane-type matrix metalloproteinase
The invention is a method of inhibiting the activity of membrane-type matrix metalloproteinase (MT-MMP) in biological systems. Accordingly, the invention permits the treatment of medical conditions...
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6248718 |
Lesion-directed dry dosage forms of antibacterial agents for the treatment of acute mucosal infections of the oral cavity
The invention provides a medicament for topically treating acute bacterial infections in the oral mucosa, and methods of use. The medicament comprises a dry dosage (such as a troche or powder) of...
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6248730 |
Enhancing the toxicity of warfarin in rodents
The presence of a small amount of an antibiotic, such as tetracycline or a salt or derivative thereof, in warfarin-containing rodent baits enhances the toxicity of warfarin against rodents which...
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6218368 |
Antibiotic treatment of age-related macular degeneration
A method is provided for the treatment of age-related macular degeneration by administering various antibiotics, such as tetracycline and its derivatives, rifamycin and its derivatives, macrolides,...
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6187768 |
Kit for flushing medical devices and method of preparation
A kit and for flushing a medical device a method of preparing the kit is disclosed. The kit includes a container containing a mixed solution a unit dose of a pharmacologically effective amount of...
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6180662 |
Agents acting against hyperreactive and hypoactive, deficient skin conditions and manifest dermatitides
The invention relates to the use of a) a compound or several compounds from the group consisting of flavonoids, or b) an active compound combination comprising a compound or several compounds...
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6172069 |
Method for preventing or reducing photosensitivity and or photoxicity reaction to medications
The present invention provides a method for preventing or reducing a photosensitivity and/or phototoxicity reaction which may be caused by a once-per-day dose of a medication which causes a...
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6165999 |
Tetracycline derivatives
The present invention relates to novel tetracycline derivatives, to intermediates used in their preparation, to pharmaceutical compositions containing them and to their medicinal use.
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6156346 |
Urease-responsive delivery systems for diagnostic and therapeutic applications
A delivery system that releases a diagnostic marker or therapeutic agent in a manner sensitive to the concentration of urease in a physiological compartment, particularly the gastrointestinal...
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6140306 |
Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic
The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein...
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6114316 |
Combination of bisphosphonate and tetracycline
Tissue-destructive conditions related to excess protemase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a...
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6093414 |
Silver-based antimicrobial compositions
The present invention relates generally to silver-based antimicrobial compositions and processes for making such compositions. More particularly, the present invention describes stable, purified...
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6051553 |
Method for potentiating BPI protein product bactericidal activity by administration of LBP protein products
The present invention provides methods of potentiating the gram-negative bactericidal activity of BPI protein products by means of administering LBP protein products.
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6051604 |
Methods and compositions for the prevention and treatment of gastrointestinal disorders
The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a gastrointestinal disorder caused or mediated by one or more intestinal helminths...
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6043231 |
Inhibition of excessive phospholipase A.sub.2 activity and/or production by non-antimicrobial tetracyclines
A method for treating mammals suffering from conditions associated with excess phospholipase A 2 activity and/or production comprising administering to the mammal an effective amount of a...
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6015804 |
Method of using tetracycline compounds to enhance interleukin-10 production
The invention is a method of enhancing endogenous interleukin-10 production in mammalian cells and tissues, which includes administering an effective amount of a tetracycline derivative. The method...
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6013647 |
Benzoxazinedione derivatives, method of producing them and uses thereof
This invention relates to new benzoxazinedione derivatives corresponding to the formula I: ##STR1## wherein R 1 =H or carboxyalkyl, R 2 =H, alkyl or phenyl, and R 3 represents different acid...
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5981499 |
Lesion-directed antibiotics in dry dosage forms for the treatment of shallow ulcers of the oral mucosa
The invention provides a medicament for topically treating aphthous ulcers in the oral mucosa, and methods of use. The medicament comprises a troche or powder comprising a dry dosage of one or more...
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5977091 |
Method of preventing acute lung injury
The invention discloses a novel method for preventing acute lung injury in a mammal following trauma. The method includes treating the mammal with an effective amount of a tetracycline prior to...
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5962466 |
Reduction of hair growth using inhibitors of matrix metalloproteinases
Mammalian hair growth is reduced by inhibiting the activity of a matrix metalloproteinase in the skin.
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