Patents in Class 514/151

Matches 1 - 50 out of 89

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Match	Document	Document Title
1	7585856	Resolvins: Biotemplates for novel therapeutic interventions The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as...
2	7576072	Heterocyclic inhibitors of MEK and methods of use thereof Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X, Y and Z are as defined in the specification....
3	7514442	Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
4	7494984	Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors The invention encompasses a series of bicyclic heterocyclic compounds of Formula I which are inhibitors of HIV integrase and prevent viral integration into human DNA. This action makes the...
5	7470695	N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
6	7452872	Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives A method of increasing the bioavailability of balsalazide by administration of an oral dosage form with food is provided, as well as an article of manufacture comprising an oral dosage form of...
7	7399760	Pyrimidinedione derivatives Pyrimidinedione derivatives of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and...
8	7223797	Meldonium salts, method of their preparation and pharmaceutical composition on their basis New salts of Meldonium, the method of their preparation, and pharmaceutical formulation on their basis have been described. The general formula of these salts is X − (CH3)3N+NHCH2CH2COOH where X...
9	7214669	Tetracycline derivatives and methods of use thereof A treatment for inhibiting microbial or tumor growth is disclosed, which comprises adding to a subject in need of treatment an effective amount of one or more tetracycline derivatives.
10	7169407	Carbonyl stress-decreasing agent The present invention provides agents that decrease carbonyl stress comprising biguanides, such as metoformin. Through oral administration and such, the carbonyl stress-decreasing agents of the...
11	7166594	Streptogramin derivatives, their preparation and compositions containing them Group A streptogramin derivatives of general formula (I) in which: R 1 represents a halogen atom or an azido or thiocyanato radical, R 2 represents a hydrogen atom or a methyl or ethyl...
12	7087648	Methods for modulating macrophage proliferation using polyamine analogs Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or...
13	7070941	Methods and compositions for tagging via azido substrates The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog...
14	7045495	Combination of bryostatin and paclitaxel for treating cancer This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for...
15	6932985	Azide method and composition for controlling deleterious organisms Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising azide and...
16	6790841	2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents Compounds which are active against viruses have the following Formulas: wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of...
17	6608048	Tricyclic protein kinase inhibitors This invention provides compounds of Formula (I), where A″, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the...
18	6593314	Neuraminidase inhibitors The present invention provides compounds of formula Ia and Ib or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from...
19	6444638	Combinations of PKC inhibitors and therapeutic agents for treating cancers This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for...
20	6436915	Pyrazole compounds Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle...
21	6407081	Method for inhibiting cytokine production by cells The invention concerns a method for inhibiting cytokine production by cells, in particular animal or human cells, and their secretion, which consists in applying on said cells at least an azo...
22	6395719	Methods for increasing levels of acetylcholine The present invention is directed to increasing levels of acetylcholine by the administration of 2-aryl-3-aroylbenzo[b]thiophenes.
23	6369066	Substituted 1,3-oxathiolanes with antiviral properties This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of the formula (I): wherein; R 1 is hydrogen, and R 2 is cytosine or 5-fluorocytosine; and...
24	6297258	Substituted 3-cyanoquinolines This invention provides compounds of formula I having the structure ##STR1## wherein G 1 , G 2 , R 1 , R 4 , Z, n, and X are defined in the specification or a pharmaceutically acceptable salt...
25	6297250	Pyrimidopyrimidine compounds A range of dipyridamole analogues useful for inhibiting transport of nucleosides or purines across cell membranes, thereby to potentiate the activity of various cytotoxic antitumor drugs, is...
26	6287601	Topical nitric oxide donor compositions Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID...
27	6284764	Substituted bicyclic derivatives useful as anticancer agents The invention relates to compounds of the formula 1 ##STR1## and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R 1 , R 3 and R 4 are as defined herein. The invention...
28	6271212	Prodrug azide compositions and compounds Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and...
29	6251912	Substituted quinazoline derivatives This invention provides compounds of formula 1 having the structure ##STR1## wherein: X, R 1 , R 2 , R 3 , R 4 , Z, X, and n are as defined hereinbefore in the specification, which are useful as...
30	6191124	Methanol derivatives for treatment of retroviral infections especially HIV infections The present invention relates to compounds of formula (I) which are imidazo[2,1-b]benzothiazole-3-methanol and imidazo[2,1-b]thiazole-5-methanol derivatives useful for inhibiting a retrovirus in a...
31	6140317	Pyrrolopyrimidines and processes for their preparation There are described compounds of formula I ##STR1## wherein R 1 and R 2 are as defined in the description, Q is heterocyclyl boned via a ring nitrogen atom and having the formula IA ##STR2##...
32	6113920	Pharmaceutical compositions A pharmaceutical composition and a method of inhibiting human immunodeficiency virus (HIV) is disclosed which comprises administering to an HIV infected patient a homogenous combination of...
33	6107291	Azepine or larger medium ring derivatives and methods of use Selected novel azepine and larger medium ring compounds are effective for prophylaxis and treatment of inflammation, tissue degradation and related diseases. The invention encompasses novel...
34	6103730	Amine substituted compounds Compounds and pharmaceutical compositions, including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, have the formula: CORE MOIETY--(R) j In these...
35	6045827	Treatment of equine laminitis Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID...
36	6001824	Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same The present invention provides a compound having the structure: ##STR1## wherein R 1 is a saturated or unsaturated linear or branched chain alkyl group, or a cholestanyl group; wherein R 2 is a...
37	5958932	Substitutes O.sup.6 -benzylguanines, compositions, and methods of using same The present invention provides AGT inactivating compounds such as substituted O 6 -benzylguanines of the formula ##STR1## wherein, for example, R 1 is amino, hydroxy, or alkylamino, R 2 is...
38	5866571	9-substituted 2-(2-n-alkoxyphenyl)-purin-6-ones 9-Substituted 2-(2-n-alkoxyphenyl)purin-6-ones are prepared by cyclizing correspondingly substituted imidazoles and derivatizing the purines thus obtained. The 9-substituted 2 ...
39	5861405	S-substituted 1,3,7-trialkyl-xanthine derivatives The present invention provides 8-substituted 1,3,7-trialkylxanthines useful as A 2 -selective adenosine receptor antagonists and compositions comprising such compounds. Examples of the...
40	5861396	Purin-6-one derivatives Purin-6-one derivatives are prepared by acylating appropriately substituted imidazole carboxamides and then cyclizing to give the purines. The purin-6-one derivatives are suitable as active...
41	5856322	Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and...
42	5849769	N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection A method for treating HIV which comprises a compound of the formula ##STR1## wherein A is ##STR2## and Z i is O, Se, NR a or C(R a ) 2 , and Z ii is --O or (O) 2 ; wherein R 1 , R 2 ,...
43	5807861	Amine substituted xanthinyl compounds A method for treating a disease caused by an undesirable cell response mediated by a proliferative intracellular signaling pathway is provided wherein an effective amount of a compound is...
44	5770595	Oxime substituted therapeutic compounds Oxime-substituted compounds are preferably cyclic or heterocyclic compounds. The oxime-substituted compounds and pharmaceutical compositions thereof have the formula: CORE MOIETY--(R) j including...
45	5728687	Antitumour compositions containing taxane derivatives Pharmaceutical compositions having therapeutic synergy comprising taxol or Taxotere or analogues thereof combined with at least one therapeutically useful substance for treating neoplastic diseases.
46	5710160	Diphenyl pyridyl ethane derivatives as PDE IV inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the...
47	5616578	Method of treating human immunodeficiency virus infection using a cyclic protease inhibitor in combination with a reverse transcriptase inhibitor This invention relates to a method of treating human immunodeficiency virus (HIV) infection in a mammal comprising administering to the mammal a therapeutically effective amount of a combination...
48	5491146	Hydroxylated erythro-hydroxynonyladenines and related analogs This invention discloses various analogs of erythro-hydroxynonyladenine (EHNA) which have been modified by the addition of hydroxy groups or other moieties at the #8 or #9 carbon atoms of the...
49	5420122	3-pyrrolidinylthio-1-azabicyclo-[3.2.0]hept-2-ene-2-carboxylic acid compounds Novel 3-pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxyli c acid compounds and processes for their preparation are disclosed. These novel compounds have antimicrobial activity, and are...
50	5387747	Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present The present invention relates to the derivatives of the formula ##STR1## and their tautomeric forms, as well as their addition salts, and to their use in therapeutics, especially for the treatment...

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