Matches 1 - 50 out of 241 1 2 3 4 5 >
Match Document Document Title
7504228 Integrin linked kinase modulation of monocyte activation  
Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the...
7452874 Thrombopoietin mimetics  
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
7452873 Inhibitors of GSK-3 and uses thereof  
The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions...
7435408 Porous particles comprising excipients for deep lung delivery  
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
7414040 Thrombopoietin mimetics  
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
RE39866 Nonpeptide insulin receptor agonists  
Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds...
7214669 Tetracycline derivatives and methods of use thereof  
A treatment for inhibiting microbial or tumor growth is disclosed, which comprises adding to a subject in need of treatment an effective amount of one or more tetracycline derivatives.
7157449 Medicament for the treatment of diseases caused by parasitic protozoa  
The present invention relates to the use of an inhibitor of CTP synthetase, such as a glutamine analogue, and a substance capable of suppressing toxic effects thereof in vivo, in the manufacture of...
7151095 Immunoregulatory compounds and derivatives and methods of treating diseases therewith  
Compounds are disclosed having the structure of Formula I: where R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is: where R 5 is selected from the group...
7105503 Pyrazole compounds  
Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell...
7045512 Fungicidal phenoxyphenylhydrazine derivatives  
A fungicidally active compound of the formula: a) wherein Q is —NY—NH—, —N═N—, or X is oxygen, sulfur, sulfoxide, or sulfone; n is 0 or 1; Y is hydrogen, C 1 –C 4 ...
7026343 Pharmacologic inhibition of Myc function  
The c-Myc oncoprotein, a helix-loop-helix-leucine zipper (HLH-ZIP) transcription factor, is frequently deregulated in human cancers. All known functions of c-Myc, including those pertaining to...
6932985 Azide method and composition for controlling deleterious organisms  
Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising azide and...
6881727 Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same  
Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
6809087 Sodium salt of an azo derivative of 5-aminosalicylic acid  
The present invention relates to the sodium salt of (Z)-2-hydroxy-5-([4-[3-[4-[(2-methyl-1H-imidazo[4,5-c]pyridi n-1-yl)methyl ]-1-piperidinyl]-3-oxo-1-phenyl-1-propenyl]phenyl]azo]benzoi c acid,...
6713075 Topical composition comprising an aldehyde or ketone-based cosmetic bonding agent  
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a bonding agent selected from the group consisting of aldehydes and ketones having the...
6696472 Substituted N-phenoxy-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity  
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
6696430 Use of vital dye for facilitating surgical procedures for vitreo-retinal surgery  
A method for performing retinal membrane removal is disclosed using vital dyes which are applied to the membrane. Compositions including vital dyes which are useful in the retinal membrane removal...
6686344 Organic-arsonic compounds  
Novel organic arsonic compounds are described as tumor inhibiting, and cancer treating compounds. Methods and compositions for inhibiting tumor cells and treating cancer are also provided.
6645512 Topical composition comprising a functionally acylating cosmetic bonding agent  
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of an acylating bonding agent having the structure: wherein X represents a cosmetic benefit...
6638921 Pyridoxal-5-phosphate derivatives as HIV integrase inhibitors  
A compound of formula I and pharmaceutically acceptable derivatives thereof Cx, R 1 and R 2 being as defined in the disclosure may be used to inhibit the activity of HIV integrase.
6610660 O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-&lsqb (2-carboxylato) pyrrolidin-1-yl&rsqb diazen-1-ium-1,2-diolates  
Diazeniumdiolates, wherein the N 1 position is substituted by an inorganic or organic moiety and the O 2 -oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also...
6552008 Thrombopoietin mimetics  
Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an...
6521607 (R)-chiral halogenated substituted N-phenoxy N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity  
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma...
6491934 Topical composition comprising a diazonium salt-based cosmetic bonding agent  
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a diazonium salt bonding agent having the structure wherein X represents a cosmetic...
6488947 Topical composition comprising a functional aromatic derivative cosmetic bonding agent  
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a functional aromatic derivative bonding agent having a structure selected from the group...
6458776 5-ASA derivatives having anti-inflammatory and antibiotic activity and methods of treating diseases therewith  
Compounds are disclosed represented by the following formula: where R 1 is a substituted or unsubstituted phenyl group, and where Z is selected such that a compound, Z-R 1 -NH 2 , formed by...
6440981 Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones  
A method for inhibiting the growth of neoplastic cells by exposure to 2,9-disubstituted purin-6-ones.
6436915 Pyrazole compounds  
Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle...
6417178 Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits  
Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other...
6407081 Method for inhibiting cytokine production by cells  
The invention concerns a method for inhibiting cytokine production by cells, in particular animal or human cells, and their secretion, which consists in applying on said cells at least an azo...
6372449 Opthalmic methods and uses  
Ophthalmic membranes and uses are described. Intraocular membranes and structures within the eye are identified by instilling into the eye a trypan blue solution which marks in a visually...
6306841 Treatment of female sexual dysfunction  
Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina,...
6287601 Topical nitric oxide donor compositions  
Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID...
6271218 Method for inhibiting deoxyribonucleotide triphosphate biosynthesis  
Process for inhibiting deoxyribonucleotide triphosphate biosynthesis by cells, comprising application onto these cells of at least one of the azo derivatives of the formula (I), in which R 1 , R 2...
6251882 Alkyl ketones as potent anti-cancer agents  
Novel alkyl ketone compounds having potent cytotoxic activity are described as anti-tumor agents and are particularly effective against leukemia and breast tumor cells.
6225296 Inhibitory effects of synthetic and natural colorant on carcinogenesis VIII  
A method of inhibiting Epstein-Barr virus early antigen induction in Epstein-Barr virus genome-carrying cells which have been cultivated in vitro in a medium containing at least one chemical...
6200963 Aryl sulfonic acids as FSH antagonists  
wherein: R 1 is a moiety selected from: ##STR2## R 2 is CH 2 CH 2 CONH 2 or CH 2 CH 2 OH; R 3 and R 4 are independent substituents selected from the group including H, --N(CH 3 )...
6197341 Formulations of balsalazide and its derivatives  
The invention provides a unit formulation which comprises a 2-hydroxy-5-phenylazobenzoic acid derivative which is particularly sodium balsalazide dihydrate which formulation has a density of at...
6165998 Antifungal agents  
The present invention provides azo and stilbene compounds having the structure: wherein XY is NN, CHCH, (CO)--NH or NH--(CO); wherein Z is CR 6 or N; wherein R 1 , R 2 and R 5 are...
6156741 Therapeutic substituted guanidines  
The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one...
6045827 Treatment of equine laminitis  
Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID...
5905073 Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents  
The present invention provides a method of colon cancer chemoprevention or chemotherapy comprising administering to an individual suffering from colon cancer or at risk to develop colon cancer a...
5861435 Method for preventing settlement of aquatic fouling organisms  
A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to...
5747477 Azo derivatives of 5-aminosalicylic acid  
Compounds of formula I and their salts and solvates are useful for the treatment or prevention of inflammatory bowel disease. Pharmaceutical compositions including these compounds and processes for...
5681832 Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity  
Aroylaniline compounds which exhibit anti-retroviral activity, pharmaceutical compositions containing such aroylaniline compounds, and methods for treating a retroviral-infected host comprising...
5674865 Nonpeptidyl integrin inhibitors having specificity for the GPII.sub.b III.sub.a  
A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII b III a receptor and is...
5627175 Azoxycyanobenzene compounds  
The invention is directed to azoxycyanobenzene derivatives of the formula: ##STR1## wherein n is 0-3; each R represents halogen, nitro, cyano, alkyl, haloalkyl, alkoxy, or haloalkoxy; and each R 1 ...
5585373 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid derivative as antitumor agent  
A derivative of 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0 ]hept-3'-yl)propionic acid represented by the formula ##STR1## wherein R 1 is a hydrogen atom, a lower alkyl group optionally having one or...
5585367 Method of treating humans and animals infected with viruses of the retrovirus group  
Compositions useful in methods of treating humans and animals infected with viruses of the retrovirus group contain azoic compounds of the general formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 ...
Matches 1 - 50 out of 241 1 2 3 4 5 >