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7384917 Chimeric natriuretic peptides  
Peptides of Dendroaspis, including chimeric peptides thereof, are provided, as well as methods of using the peptides as natriuretics, diuretics, and/or vasodilators.
7361637 Hypotensors  
There are provided a method for selection of a substance which is capable of controlling activation of prorenin where an adjusting ability of the activation of prorenin by protein-protein...
7071169 Pyrane derivatives as both ACE-and NEP-inhibitors  
Compounds of the formula (I), wherein R1, R1–R7 and alk have meaning as defined, pharmaceutical compositions thereof, and use thereof for the treatment and/or prevention of cardiovascular d...
6998137 Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix  
The present invention relates to compositions and methods for the modulated release of one or more proteins or peptides. The composition is comprised of a biocompatible polymeric matrix, a protein...
6551578 Modulated release particles for aerosol delivery  
A modulated release aerosol formulation is disclosed. The formulation comprises a polysaccharide polymer having a selected medicament associated therewith, a fluid carrier for carrying and...
6495338 Drug screening and diagnosis based on paracrine tubular renin-angiotensin system  
The present invention relates to a method for screening drugs for use in treating hypertension using the tubular renin-angiotensinogen system identified by the present invention. The invention...
6468507 Non-aqueous aerosol formulation comprising rosiglitazone maleate, a non-aqueous carrier, and an amino acid stabilizer  
A non-aqueous medicinal aerosol formulation comprising rosiglitazone maleate, a fluid carrier, and an amino acid stabilizer. The aerosol formulation may also include drug combination formulations...
6464959 Non-aqueous aerosol suspension comprising troglitazone, a fluid propellant, and an amino acid stabilizer  
A non-aqueous medicament aerosol formulation comprising troglitazone, or a derivative thereof, a fluid carrier, and an amino acid stabilizer. The aerosol formulation may also include drug...
6201072 Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties  
A water soluble, biodegradable ABA- or BAB-type tri-block polymer is disclosed that is made up of a major amount of a hydrophobic A polymer block made of a biodegradable polyester and a minor...
6191156 Compositions and methods for treating bladder dysfunction  
A method for treating patients having bladder dysfunction is described. The method involves the step of treating a patient with a renin-angiotensin system inhibitor. Preferably the inhibitor is an...
6034175 Salts of peptides with carboxy-terminated polyesters  
This invention relates to novel salts composed of a cation derived from a peptide containing at least one basic group and an anion derived from a carboxy-terminated polyester, processes for the...
5981470 Uterine fibroid treatment  
The use of a) an angiotensin-converting enzyme (ACE) inhibitor such as Captopril or Enalapril, b) an angiotensin II-receptor antagonist such as Saralasin or Losartan, or c) a renin inhibitor, such...
5932462 Multiarmed, monofunctional, polymer for coupling to molecules and surfaces  
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure ##STR1## wherein Z is a moiety that can be activated for attachment to biologically active...
5776885 Sustained and controlled release of water insoluble polypeptides  
A pharmaceutical composition for the sustained release of a peptide wherein the composition includes a polylactide polymer, a polymer of lactic acid and glycolic acid, or a mixture of such polymers...
5688770 Antiglaucoma compositions and methods  
The present invention relates to ophthalmo-logical pharmaceutical compositions comprising a renin inhibitor and to methods for using said composition in the treatment of glaucoma.
5672584 Cyclic prodrugs of peptides and peptide nucleic acids having improved metabolic stability and cell membrane permeability  
Provided are cyclic prodrugs of biologically active peptides and peptide nucleic acids exhibiting improved cell membrane permeability and enzymatic stability, containing...
5643879 Amino-substituted heterocycles as renin inhibitors  
The invention concerns novel renin-inhibitory compounds which contain an amino-substituted heterocycle at the P2 position. These are useful for treating renin-associated hypertension, congestive...
5523289 Pharmaceutical composition  
A pharmaceutical tablet composition comprising a compound of the formula (II): ##STR1## wherein R1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-1-oxo-4-piperazinyl, 2-oxo-4-piperazinyl,...
5468732 Phosphorus containing renin inhibitors  
Phosphorus containing polypeptides as renin inhibitors, useful as antihypertensive agents.
5459131 Renin inhibitors  
Renin inhibiting compounds of the formula: ##STR1## wherein A is a moiety selected from those of the formula: ##STR2## where Z is O, S, SO, or SO2, P is 1 or 2 and X is --O-- or --S--; and analogs...
5445832 Process for the preparation of microspheres made of a biodegradable polymeric material  
The process is aimed at providing a composition designed for the sustained and controlled release of medicamentous peptide substances, obtained in the form of microspheres of a biodegradable...
5401722 Peptide analogues  
New peptide analogues of the formula I R1 --Z--NR2 --CHR3 --CR4 --(CH2)o --(CR5)t --(CH2)v --CE--Cw H2w --R6 Iin which R1 to R6 Z, E, o, t and w have the meanings described herein, and the salts...
5389616 Amino acid derivatives  
The compounds of the formula ##STR1## wherein A, R1, R2, R3, R4, R5 and R6 are as set forth above, are described.The compounds of formula I have an inhibitory activity on the natural enzyme renin...
5378690 New renin-inhibitory oligopeptides, their preparation and their use  
Oligopeptides of formula (I): ##STR1## where R1 -R5 are various organic groups, and A represents a group of formula --NH-- or --(CH2)n --, in which n represents an integer of from 1 to 3, have...
5378689 Peptides having renin inhibitory activity, their preparation and use  
Compounds of formula (I): ##STR1## [in which: R1 is heterocyclic group having 5 or 6 ring atoms, or --NR7 R8, where R7 is alkyl and R8 is optionally substituted phenyl, optionally substituted...
5378691 Amino acid derivatives  
New amino acid derivatives of the formula I R1 --Cp H2p --(NH)y --CO--NH--CHR2 --CO--Z--Cm H2m --CO--NH--CHR3 --CR4 --(CHR5)n --CO--E--Q--Y Iin which R1 to R5, p, y, Z, m, n, E, Q and Y have the...
5376638 Methods for treating renin-related disorders with amylin antagonists  
Methods for treating conditions associated with elevated, inappropriate or undesired renin activity are disclosed which comprise administration of an effective amount of any amylin antagonist alone...
5360791 Renin-inhibiting aminodiol derivatives  
The invention relates to compounds of the formula I ##STR1## in which A denotes a radical of the formula II ##STR2## in which E denotes a CH2 group or an NR9 radical, G denotes a radical from the...
5350741 Enteric formulations of physiologically active peptides and proteins  
An enteric formulation for a proteinous drug which protects it from enzymatic degradation and promotes its uptake by the intestinal tract when administered orally, comprises either a solid mass of...
5346887 Glaucoma treatment  
A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1##...
5332742 Renin inhibitors  
A renin inhibiting compound of the formula: ##STR1## wherein R1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-l-oxo-4-piperazinyl, 2-oxo-4-piperazinyl, 4-morpholinyl, 4-thiomorpholinyl or...
5328916 Heterocyclic compounds useful for inhibition of renin  
New heterocyclic compounds of the formula X--W--CR1 R2 --CO--Y--NR3 --CHR4 --CR5 --CH2 --(CR6 R7)r --Z--Het Iin which R1 to R7, W, X, Y, Z, r and Het have the meanings defined herein, and the salts...
5283250 Quinolinyl/quinolinylalkyl-N-terminal amino hydroxy  
Non-peptidyl compounds characterized generally as quinolinyl/quinolinylalkyl-N-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. ...
5278148 Amino acid derivatives useful for treating high blood pressure  
Compounds of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 is ethyl, propyl, isopropyl, imidazol-2-yl, imidazol-4-yl, pyrazol-3-yl, thiazol-4-yl, thien-2-yl, ethoxycarbonyl,...
5260278 Diol-containing renin inhibitors  
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and diseases caused by retroviruses...
5258362 Renin inhibiting compounds  
A renin inhibiting compound of the formula: ##STR1## wherein R0 is a mimic of the Phe-His dipeptide sequence of angiotensinogen which preceeds the renin cleavage site; R4 is loweralkyl,...
5246959 Poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol amino acid derivatives as anti-hypertensive agents  
Non-peptidyl compounds characterized generally as poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension....
5229369 Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents  
Non-peptidyl compounds characterized generally as aminoalkylaminocarbonyl aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension. Compounds of...
5221667 Renin inhibiting peptides having an α-heteroatom amino acid at the P3 position  
The invention concerns novel renin-inhibitory compounds which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, glaucoma, and diseases caused by...
5219851 Tetrahydroisoquinoline-type renin inhibiting peptides  
The invention concerns novel renin-inhibitory compounds which contain a tetrahydroisoquinoline or similar heterocycle at the P3 position. These are useful for treating hypertension, congestive...
5217958 1,2-hydroxy phosphonates and derivatives thereof  
Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
5215966 Peptide and renin inhibitors  
Novel amino acid derivatives of the formula I X--Z--NH--CHR1 --CO--NR2 --CHR3 --CR4 --(CHR5)n --CO--E--W'--Ywherein X, Z, R1, R2, R3, R4, R5, E, W', Y and n have the meanings defined herein and...
5215967 Aminoacid derivatives inhibiting renin  
New amino acid derivatives of the formula R1 --Z--NR2 --CHR3 --CR4 --(CHR5)a --CO--E--Q--Ywherein R1 to R5, a, Z, E, Q and Y have the meanings defined herein, and salts thereof inhibit the activity...
5198426 Renin inhibitors containing C-terminal dihydroxy amides  
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, glaucoma and diseases caused by...
5180744 Aralkyl-N-terminal amino hydroxy  
Non-peptidyl compounds characterized generally as aralkyl-N-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular ...
5180725 Quinoxalinyl/quinoxaliy; alkyl-N-terminal amino hydroxy  
Non-peptidyl compounds characterized generally as quinoxalinyl/qunioxalinylalkyl-N-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. ...
5179102 Naphthyridinyl/naphthyridinylalkyl-n-terminal anino hydroxy β-amino acid derivatives  
Non-peptidyl compounds characterized generally as naphthyridinyl/naphthyridinylalkyl-N-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. ...
5178877 Encapsulated renin inhibitor composition  
A pharmaceutical composition comprising a solution of a tenin inhibitor of the formula: ##STR1## wherein R1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-1-oxo-4-piperazinyl,...
5175181 Imidazolyl/imidazolylalkyl-N-terminal amino hydroxy  
Non-peptidyl compounds characterized generally as imidazolyl/imidazolylalkyl-N-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. ...
5175170 β-amino acid derivatives  
Non-peptidyl compounds characterized generally as cycloalkyl/cycloalkylkyl-N-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds ...
Matches 1 - 50 out of 114 1 2 3 >