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7202216 |
Drug therapy for celiac sprue
Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an...
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7199099 |
Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria
A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The...
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7199103 |
Synthetic compounds and compositions with enhanced cell binding
Compositions of the invention include composites comprising a biomaterial having compounds thereon with enhanced cell binding with respect to collagen. These composites are useful for soft and hard...
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7196063 |
Peptides and pharmaceutical compositions comprising same
The present invention relates to an NST500 compound of general formula (I): comprising the following components: X 1 —X 2 —{(X 3 ) a /X 4 /X 5 }—X 6 , wherein: X 1 stands for a saturated or...
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7192930 |
Method and peptide for regulating cellular activity
Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used...
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7192928 |
T cell antigen receptor peptides
The present invention provides peptides which affect T-cells, presumably by action on the T-cell antigen receptor. The present invention further relates to the therapy of various inflammatory and...
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7189694 |
Inhibitors of autophosphorylation protein kinases
The subject invention concerns peptide molecules that specifically inhibit the enzymatic function of tyrosine kinases, including the JAK and EGF receptor (EGFR) family of kinases, to...
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7182945 |
Anti-inflammatory peptides derived from C-reactive protein
A peptide corresponding to positions 62–71 of the sequence of human C-reactive protein (CRP) of the formula: Glu 62 -Ile-Leu-Ile-Phe-Trp-Ser-Lys-Asp-Ile 71 and modifications thereof obtained by...
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7183258 |
Two synthetic peptides for treatment and prevention of cancers
Two synthetic peptides, Atroporin (AT) and Kaotree (KT), each consisting of ten amino acids and their use for the treatment and/or prevention of various types of cancers is disclosed. The amino...
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7179784 |
Surfactant peptide nanostructures, and uses thereof
This work describes a new class of short polypeptides that can self-assemble to form regular nanotubes with an average diameters of about 50 nm. These peptides (7 to 8 amino acids) have a structure...
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7169752 |
Compounds and compositions for prevention of overdose of oxycodone
The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of...
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7160862 |
Integrin binding motif containing peptides and methods of treating skeletal diseases
Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan...
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7157091 |
MAGE-A1 peptides presented by HLA class II molecules
The invention provides isolated HLA DRB1*15-binding peptides consisting of the amino acid sequence set forth as SEQ ID NO:7 with 0–10 amino acids added to either or both ends of the amino acid...
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7157425 |
Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a...
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7157423 |
Fumaric acid amides
Fumaric acid amides of the general formula (I)
wherein R 1 represents OR 3 or a D- or L-amino acid radical —NH—CHR 4 —COOH bonded via an amide bond, wherein R 3 is hydrogen, a...
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7153834 |
Pharmaceutical compositions
Disclosed is a pharmaceutical composition suitable for oral administration in the form of a homogeneous solution which on exposure to water or gastrointestinal fluids forms an emulsion having a...
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7153833 |
Therapeutic uses of SMR1 peptides
A method for treating or reducing the severity of a disease or disorder mediated by a membrane metallopeptidase by administering to a mammal a SMR1-peptide or a pharmaceutically active amount of a...
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7147838 |
Gastrin receptor-avid peptide conjugates
A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin...
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7148195 |
LHRH antagonists having improved solubility properties
The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. Medicaments in which the peptides according to the invention are contained can be...
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7144864 |
Carboxypeptidase R inhibiting peptide
A novel carboxypeptidase R (CPR) inhibiting peptide is prepared using rational structure-based strategies, incorporating two principle facts: (a) CPR has a strong affinity for basic amino acids...
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7144854 |
Long lasting anti-angiogenic peptides
Modified anti-angiogenic peptides are disclosed. The modified peptides are capable of forming a peptidase stabilized anti-angiogenic peptide. The modified anti-angiogenic peptides, particularly...
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7144569 |
Diagnosis of coeliac disease using a gliadin epitope
A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope...
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7138369 |
Compounds and methods for modulating apoptosis
Cyclic peptides and compositions comprising such cyclic peptides are provided. The cyclic peptides comprise a classical cadherin cell adhesion recognition sequence HAV. Methods for using such...
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7138370 |
Specific binding agents of human angiopoietin-2
Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and...
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7138103 |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable...
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7135453 |
Reagents and methods for smooth muscle therapies
The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth...
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7135457 |
Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g.,...
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7132400 |
Alpha-fetoprotein peptides and uses thereof
The subject invention addresses the need for methods of treatment and prevention of breast cancer, and other cancers, by providing a peptide of eight to twenty amino acids in length which comprises...
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7129226 |
Mimetic insect allatostatin analogs for insect control
Novel pseudopeptide analogs of the insect allatostatin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a...
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7128912 |
Fibronectin binding protein compositions and methods of use
Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB...
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7125849 |
Peptide-based angiogenesis inhibitors and methods of use thereof
Angiogenesis inhibitors and methods of use thereof are disclosed. The inhibitors are substantially pure oligopeptides consisting essentially of 7–20 amino acid residues and comprising a...
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7125850 |
Methods of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA...
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7122522 |
Alpha-fetoprotein peptides and uses thereof
Therapeutic compounds which are cell proliferation modulators, preferably inhibitors. These modulators contain amino acid structures that are arranged as a hydrophilic analog of an...
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7118872 |
Binding polypeptides for B lymphocyte stimulator protein (BLyS)
Binding polypeptides comprising specific amino acid sequences are disclosed that bind B Lymphocyte Stimulator (BLyS) protein or BLyS-like polypeptides. The binding polypeptides can be used in...
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7119064 |
Use of colostrinin, constituent peptides thereof, and analogs thereof as modulators of intracellular signaling molecules
The present invention provides methods that utilize compositions containing colostrinin, a constituent peptide thereof, an active analog thereof, and combinations thereof, as modulators of...
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7115566 |
Compounds and method for the prevention and treatment of diabetic retinopathy
The invention provides peptide derivatives designed to deliver peptides having growth factor inhibitory activity, especially somatostatin analogs, to the retina by sequential metabolism. The...
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7115272 |
Compositions and methods for WT1 specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise a WT1 polypeptide comprising an immunogenic portion of WT1,...
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7112333 |
T cell epitopes of ryegrass pollen allergen
The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne . Therapeutic peptides within the scope of the invention comprise at least one T...
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7112565 |
Stabilized pharmaceutical composition in lyophilized form
A stabilized pharmaceutical composition in lyophilized form comprising: a cyclic polypeptide compound represented by the general formula (I):
wherein R 1 is a hydrogen atom or an acyl group...
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7109170 |
Region of factor IXa protease domain that interacts with factor VIIIa and methods therefor
Novel polypeptides or derivatives comprising the factor VIIIa binding site on factor IXa are disclosed. The novel polypeptides or derivatives have anti-coagulation activity. Nucleic acids encoding...
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7109171 |
Methods for treating FSH related conditions with GnRH antagonists
Methods for treating FSH related conditions, such as prostatic intraepithelial neoplasia, pedophilia, infertility, or vaginal bleeding, with GnRH antagonists are disclosed. The methods of the...
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7105487 |
Method for inducing onset of the reproductive cycle of female breeding animals
A method for inducing the onset of the reproductive cycle of female breeding animals is provided. To this end, the animals are injected with an agent that contains synthetically produced FSH...
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7097997 |
Method for diagnosing a transmissible spongiform subacute encephalyopathy caused by an unconventional transmissible agent strain in a biological sample
The invention relates to a method for diagnosing a transmissible spongiform subacute encephalopathy (TSSE) caused by an unconventional transmissible agent (UTA) or prion. The method involves...
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7094413 |
Combined therapy for treatment of HIV infection
The present invention relates to pharmaceutical preparations and methods for treating individuals infected with the human immunodeficiency virus (HIV). The pharmaceutical preparations comprise an...
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7081495 |
Cationic compounds and their use as macro molecular carriers
Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C 6-24 -alkyl group containing α-amino acyl groups,...
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7071166 |
Skin wound healing promoters
The present invention provides healing promoters for skin wounds such as rupture, abrasion, surgical incision, skin ulcer and burn. Coexistence of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH 2 ...
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7071165 |
LHRH antagonist peptides
Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide...
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7067490 |
Hepta-, Octa-and nonapeptides having antiangiogenic activity
Compounds of formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions...
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7067489 |
Hematopoietic stimulation
Methods and products for stimulating hematopoiesis, preventing low levels of hematopoietic cells and producing increased numbers of hematopoietic and mature blood cells are provided. The methods...
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7063842 |
Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
Modulating agents for inhibiting an interaction between α-catenin and β-catenin are provided. The modulating agents comprise one or more of: (a) a β-catenin HAV motif; (b) a peptide analogue or...
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