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5650393 |
Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems
Amphiphilic derivatives of amino acids or peptides are provided, comprising a polyhydroxylated hydrophilic part derived from a sugar, from a polyol, from an aminopolyol or from an oligosaccharide,...
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5648336 |
Bradykinin antagonist peptides containing indane-substituted amino acids
The present invention pertains to modified bradykinin antagonist peptides of the formula X-A 0 -B 1 -C 2 -D 3 -E 4 -F 5 -G 6 -H 7 -J 8 -K 9 , where at least one of F 5 , H 7 and J 8 is...
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5648330 |
Method and composition for treating vascular graft occlusion
The invention provides RGD containing peptides which are cyclized and contain hydrophobic moieties adjacent the carboxy terminus of the RGD sequence. Such peptides have an high affinity for the...
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5648333 |
Peptides having bradykinin antagonist action
Peptides of the formula I A-B-C-E-F-K-P-G-M-F'-I (I), wherein the terms A, B, C, E, F, K, P, G, M, F', and I are defined in the specification, have bradykinin...
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5646119 |
D-amino acid histatin-based peptides as anti-fungal and anti-bacterial agents
D-amino acid histatins and histatin-based peptides histatins and methods for treatment of fungal or bacterial infection are described. These D-amino acid histatins and histatin-based peptides are...
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5643872 |
Cyclic anti-aggregatory peptides
This invention relates to compounds of the formula: ##STR1## wherein: A' is absent, Asn, Gln, Ala or Abu; A is absent or a D- or L-amino acid chosen from Arg, HArg, (Me 2 )Arg, (Et 2 )Arg, Abu,...
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5643877 |
Compounds comprising gonadotropin releasing hormone (GnRH) and methods for controlling reproduction in fish
Novel peptide hormones which influence the release of gonadotropins by the pituitary gland in fish are disclosed. Methods in which such peptides may be administered to fish to control their...
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5641751 |
Tumor necrosis factor inhibitors
Peptides which consist of 4-25 amino acids and which bind to tumor necrosis factor-alpha, prevent tumor necrosis factor-alpha from binding to its receptors and inhibit tumor necrosis factor-alpha...
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5639726 |
Peptide mediated enhancement of thrombolysis methods and compositions
The invention relates generally to peptides which decrease the half-life of active plasminogen activator inhibitor-1. This invention further relates to methods and compositions for using peptides...
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5637568 |
Composition for the sustained and controlled release of medicamentous substances and a process for preparing the same
A composition designed for the sustained and controlled release of medicamentous peptide substances having the formula (I): Ac-D-Nal-D-pClPhe-R 3 -Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH 2 wherein R...
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5633229 |
Method of using prophenins-antibiotic peptides
Peptide-based compounds containing multiple proline residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection, especially Gram-negative bacterial...
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5633230 |
Treatment of cytomegalovirus infection
Described herein are anti-cytomegalovirus peptides. In a preferred embodiment, the peptide is acetyl-[D-Arg] 9 -NH 2 . The use of these peptides, either per se or in combination with other...
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5631221 |
Pollenosis-inducing polypeptide, process for preparing the same, and uses thereof
A polypeptide having a molecular weight of 40,000±5,000 daltons and an isoelectric point of 9.5±0.5 is prepared from a cedar pollen. The polypeptide which induces pollenosis can be suitably used...
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5629294 |
Compositions and methods for preventing adhesion formation
Compositions and methods for prevention of adhesion formation, whereby an effective amount of one or more adhesion preventing RGD-containing peptides is administered for a period of time sufficient...
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5624894 |
Brain-enhanced delivery of neuroactive peptides by sequential metabolism
The invention provides novel peptide derivatives which are designed to deliver pharmacologically active peptides into the central nervous system by sequential metabolism. The peptide is placed in a...
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5622702 |
Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a...
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5620955 |
Bombesin receptor antagonists and uses thereof
Bombesin is an amphibian peptide that has a structure closely related to that of several mammalian peptides, including Gastrin Releasing Peptide (GRP) and Neuromedins B and C. Bombesin, GRP and...
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5620956 |
Methods of using CD8 binding domain peptides
The present invention provides compositions comprising a peptide having between about 7 and about 20 amino acid residues, the peptide being capable of binding a CD8 molecule on a cytolytic T...
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5620959 |
Bombesin antagonists
The present invention provides polypeptides of the formula XX 1 TrpX 2 X 3 X 4 X 5 X 6 X 7 NH 2 , methods of treatment using the polypeptides, pharmaceutical compositions comprising such...
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5616562 |
Methods and compositions using substance P to promote wound healing
Healing of wounds in mammalian tissue may be enhanced by the application of certain neuropeptides, optionally in combination with known growth promoting hormones. Exemplary neuropeptides include...
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5612382 |
Composition for percutaneous absorption of pharmaceutically active ingredients
A pharmaceutical composition for transdermally delivering pharmaceutically active ingredients through skin or mucosal tissues. The composition comprises pharmaceutically active ingredients in...
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5610075 |
Competitive electrochemiluminescence assays for endotoxins using a ruthenium label
This invention is directed to a process for performing a competitive, electrochemiluminescence assay for endotoxins. In particular, the invention involves the use of ruthenium (II)tris-bipyridine...
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5609870 |
Methods for the preparation of immunogens against gastrin
Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in...
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5610139 |
Antimicrobial compositions and pharmaceutical preparations thereof
Antimicrobial compositions which are effective against methicillin-resistant Staphylococcus aureus organisms (MRSAs) contain peptides isolated from horseshoe crabs combined with one or more...
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5610141 |
Double chain peptide compounds having hemoregulatory activity
Dipeptide compounds are disclosed, the two peptide chains being joined together at a Cα-atom of a non-terminal amino acid by a divalent bridging group --A--. The Cα-atoms joined to group --A--...
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5610140 |
Bradykinin receptor antagonists with neurokinin receptor blocking activity
The present invention provides a heterodimeric compound possessing bradykinin and neurokinin receptor antagonist activities useful in the treatment of asthma and other inflammatory diseases...
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5610142 |
Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids
Novel compounds with as few as three natural amino acids that incorporate a substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoyl bridge in place of selected fragments of peptidic bradykinin...
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5607920 |
Concanavalin a binding proteins and a 76kD chondrocyte membrane protein (CMP) from chondrocytes and methods for obtaining same
The invention is directed to purified and isolated concanavalin A-binding proteins from chondrocytes that are not present in dedifferentiated cells from chondrocytes. The invention is also directed...
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5604203 |
Analogs of peptide YY and uses thereof
The invention provides analogs of PYY. The invention also provides compositions and methods useful for controlling biological activities such as cell proliferation, nutrient transport, lipolysis,...
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5603933 |
CD4 peptides for binding to viral envelope proteins
Disclosed are compositions and methods for use in viral binding and inactivation and in protecting cells from viral infection, particularly, for use in protecting target human CD4 + cells from...
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5602094 |
Treatment of tumors
Malignant gliomas are treated by modifying the eicosanoid biosynthetic pathway with reduction of the inhibitory effect of prostanoids on the cytotoxic activity of NK and LAK cells. Synthetic...
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5602099 |
δ opioid receptor antagonists
The invention concerns compounds of the formula 1 ##STR1## and pharmaceutical compositions containing the compounds as active ingredients. The peptides of the invention are δ opioid receptor...
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5597803 |
Bradykinin peptides with modifications at the N terminus
Peptides of the formula I Z-P-A-B-C-E-F-K-(D)Q-G-M-F'-I (I) and the physiologically tolerated salts thereof, are described. They have an excellent...
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5593965 |
Anti-tumor effects of GnRH-III
The present invention provides a novel pharmaceutical composition for the treatment of breast cancer. Also provided are various methods of treating breast cancer.
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5591717 |
Branched apogenic peptide for inducing apoptosis
The present invention provides a new branched apogenic peptide for inducing apoptosis in non-quiescent cells. The branched apogenic peptide comprises an amino acid core of at least three and...
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5591719 |
Method for treating acute and chronic inflammatory disorders using polypeptides with fibronectin activity
A method for treating acute or chronic inflammatory or autoimmune disorders using polypeptides with fibronectin or related activity is provided. The method involves (administering an amount of) one...
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5589457 |
Process for the synchronization of ovulation
A method for synchronizing ovulation in cattle by sequential injection of hormones is disclosed. A hormone selected from the group consisting of gonadotropin releasing hormone (GnRH), luteinizing...
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5589459 |
Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock
The present invention provides methods of using peptides of the formula R 1 --(A--B--C) n --R, wherein R 1 and R are independently H or an amino acid residue or a fatty acid residue; A is an...
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5585356 |
Matrix metalloproteinase peptides: role in diagnosis and therapy
A family of metalloproteinases exist which cleave extracellular matrix molecules. These metalloproteinases are secreted in a latent inactive form and require activation in order to specifically...
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5585355 |
Method for increasing blood-ocular barrier permeability with permeabilizer peptides
The permeability of the blood-ocular barrier to therapeutic or diagnostic agents in the bloodstream of a host is increased by administering a permeabilizer peptide, preferably bradykinin or a...
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5583110 |
Detection of neoplasms by hormonal tumor stimulation test
A method for screening for cancer, a cancer test, a screening system a patient monitoring system and medicinal dosage form for measuring stimulating a specific, detectable response from a...
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5578306 |
Method for preventing embryo implantation
Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for β 3 ...
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5578566 |
KGF receptor-derived antagonists of KGF binding
The invention provides KGFR peptides which inhibit binding between keratinocyte growth factor (KGF) and its receptor. The sequence of the peptides is derived from regions in the receptor which...
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5574012 |
Analogs of hirudin having anti-platelet activity
This invention relates to peptide derivatives which are useful anticoagulant agents.
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5574011 |
Compositions and methods for the treatment of male-pattern baldness
The present invention provides methods and compositions of LHRH analogs for the treatment of male-pattern baldness. Male-pattern baldness is treated by the administration of compositions containing...
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5567682 |
Method of treating Alzheimer's disease
The present invention relates to a method of treating the symptoms of Alzheimer's disease by the intranasal administration of a therapeutically effective amount of specific short chain peptides, in...
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5560915 |
Composition for treating IgE mediated allergies comprising substance P and allergen
The invention provides the therapeutic compositions and a treatment method for alleviating IgE mediated allergis by administration of substance P together with a specific allergen are thereby...
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5556836 |
Use of D-glucopyranuronic acids and their derivatives for incorporation in pharmacologically active peptides and their salts
Use of 7-amino-L-glycero-L-gulo-2,6-anhydro-7-desoxy-heptonic acid and 2-benzoxycarbonylamino-0 1 -methyl-2-desoxy-β-glucopyranuronic acid, their derivatives and the enantiomorphous compounds for...
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5550107 |
Combination therapy for the treatment of estrogen-sensitive disease
A method of treatment of breast and endometrial cancer in susceptible warm-blooded animals may include inhibition of ovarian hormonal secretion by surgical (ovariectomy) or chemical (use of an LHRH...
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5545408 |
Biocompatible implant for the timing of ovulation in mares
The disclosed invention relates to a method for controlling the timing of the ovulation of mares using an LHRH agonist, and to a biocompatible implant for use in such a method.
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