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5763404 |
Methods for using LHRH antagonists with low histamine release
Antide is the decapeptide, N-Ac-D-2-Nal,D-pClPhe, D-3-Pal, Ser,NicLys, D-NicLys, Leu, ILys, Pro, D-Ala,NH 2 which is an antagonist of luteinizing hormone releasing hormone (LHRH). This...
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5763402 |
Promotion or inhibition of spermatogenesis
A method of promoting or inhibiting spermatogenesis, said method comprising administering to a male an effective amount of PACAP, a PACAP agonist, a PACAP antagonist, PC4, a PC4 agonist, or a PC4...
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5759991 |
Neurotrophic peptide derivatives
The invention provides human- or rat-derived neurotrophic peptides and derivatives thereof, precursor peptides thereof, genes encoding the same, transformants containing recombinant expression...
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5760000 |
Inhibition of liver cancer by the use of GnRH and GnRH analogs
The invention provides a method for treating liver cancer in a mammal comprising administering to the mammal an inhibitory effective amount of at least one GnRH-related compound. Pharmaceutical...
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5753226 |
Methods of enhancing epithelial cell proliferation
Methods of enhancing epithelial cell proliferation are disclosed. The methods comprise the step of contacting epithelial cells with a compound that binds to reovirus type 3 receptor. Methods of...
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5753617 |
Peptide inhibitors of cellular adhesion
Novel cyclic peptides of the selectin 54-63 sequence exhibit unexpected and desired properties. Specific points of cyclization or conformational restriction in conjunction with specific...
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5753628 |
Peptide inhibitors of TNF containing predominantly D-amino acids
Peptides which consist of six to eight, predominately D-amino acids and which bind to tumor necrosis factor-alpha, prevent tumor necrosis factor-alpha from binding to its receptors and inhibit...
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5753621 |
Pulmonary surfactant protein fragments
This invention discloses that certain fragments of a pulmonary surfactant protein exhibit unexpected surface activity. These protein fragments are useful in preparing formulations for the treatment...
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5753625 |
Treatment for inhibiting the progression of autoimmune disease
The progression of autoimmune disease is inhibited by the administration of peptides having the sequence of MHC Class I antigen α1-domains. These fragments include the amino acids between...
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5750506 |
Bradykinin antagonists with extended hydrophobic side chains
Bradykinin antagonists, particularly Cys 6 analogs, which have an extended hydrophobic side chain.
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5747447 |
Stable polypeptide composition
A (injectable biologically active) polypeptide is stabilized by dissolving said polypeptide forming a liquid solution in citrate buffer of about pH 5.0-5.5.
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5747457 |
Linear adhesion inhibitors
Linear peptides of the formula I X-A-Cys(R 1 )-B-Z I, in which A, B, R 1 , X and Z are as defined, are highly active inhibitors of the binding of the...
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5744354 |
Calcineurin inhibitory compounds and anchoring protein to induce IL-2 gene expression
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are...
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5744450 |
GnRH analogs
Peptides which include unnatural amino acids and which either promote or inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads....
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5739109 |
Method of treating neuroinflammatory degenerative diseases
The present invention relates to a method of treating neuroinflammatory degenerative diseases which are cytokine mediated. The method involves administration of an effective amount of Peptide T or...
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5736507 |
Peptides derived from autoantigen for use in immunotherapy of autoimmue diseases
The present invention relates to novel peptides derived from the autoantigen HC gp-39, said peptides comprising at least one of the amino acid sequences FGRSFTLAS (SEQ ID No. 1), FTLASSETG (SEQ ID...
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5736517 |
Treatment of cancer with peptides
A method of treating cancer in a human patient, the method involving administering to the patient a cancer cell inhibiting amount of an analog of a naturally occurring biologically active peptide...
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5733880 |
Anthracene derivatives for use as anticancer agents
A compound having the structural formula, ##STR1## where R 1 and R 2 are independently hydrogen or hydroxyl. R 2 and R 3 are independently oxo or hydrogen, one of R 5 and R 6 is A--B and the...
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5731289 |
Double-chain hemoregulatory peptides
The present invention relates to peptide compounds comprising two single-chain hemoregulatory, for example haemopoiesis-inhibiting, peptides linked by a bridging group terminally attached to the...
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5728677 |
Methods of inhibiting T-cell dependent proliferation of peripheral blood lymphocytes using the CD2-binding domain of lymphocyte function associated antigen 3
Polypeptides and proteins comprising the CD2-binding domain of LFA-3 are disclosed. DNA sequences that code on expression for those polypeptides and proteins, methods of producing and using those...
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5719123 |
Ciclosporin form for pulmonary administration
Pulmonary administration of Ciclosporin in orthorhombic crystal form (designated "CY-A/X-III"), e.g. for the treatment of obstructive or inflammatory airways disease, e.g. asthma, as well as...
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5716935 |
Use of antiotensin II analogs in tissue repair
Analogs of angiotensin II are useful in accelerating wound healing. These analogs form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an...
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5714469 |
Method of treating sepsis
The invention relates to the method of preventing and treating sepsis using (S)-5-oxo-L-prolyl-L-α-glutamyl-L-α-aspartyl-N 8 -(5-amino-1-carboxypentyl)-8-oxo-N 7 - N-...
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5712251 |
Treatment method
A method of treating prostate cancer in warm-blooded animals comprising administering to warm-blooded animals an effective amount of a peptide of Formula I and an anti-androgen.
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5710123 |
Peptide inhibitors of selectin binding
The present invention provides novel peptides having as their core region portions of the 109-118 amino acid sequence of P-selectin, E-selectin or L-selectin. The invention also provides...
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5710126 |
T cell epitopes of ryegrass pollen allergen
The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne. Therapeutic peptides within the scope of the invention comprise at least one T...
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5707964 |
Method for treating cancer
Certain toxic compounds (T) such as, for example, compounds based upon diphtheria toxin, ricin toxin, pseudomonas exotoxin, α-amanitin, pokeweed antiviral protein (PAP), ribosome inhibiting...
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5700779 |
Bradykinin antagonist peptides incorporating N-substituted glycines
The present invention provides bradykinin type peptides containing N-substituted glycines, particularly bradykinin antagonist peptides useful for the treatment of conditions mediated by bradykinin...
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5698522 |
6-position modified decapeptide LHRH antagonists
The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A 1 -D 2 -E 3 -G 4 -J 5 -L 6 -M 7 -Q 8 -R 9 -T 10...
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5696087 |
Method and compositions for reducing cholesterol absorption
Compositions including all or a portion and chemically or recombinantly synthesized analogues of the carboxy terminal region of bile salt-activated lipase (BAL) are described, which, when orally...
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5691307 |
O.sup.6 -substituted guanine compositions and methods for depleting O.sup.6
Novel O 6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O 6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful...
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5688770 |
Antiglaucoma compositions and methods
The present invention relates to ophthalmo-logical pharmaceutical compositions comprising a renin inhibitor and to methods for using said composition in the treatment of glaucoma.
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5688760 |
Polypeptides having bone resorption inhibitory activity comprising PTHrP-derived sequences
Polypeptides comprising an N-terminal amino acid sequence corresponding to amino acids 107-111 of parathyroid hormone related protein (PTHrP) having bone resorption inhibitory activity are...
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5686417 |
Peptide T and related peptides in the treatment of HTLV-1 myelopathy and multiple sclerosis
A composition useful in treating Multiple Sclerosis and HTLV-1 myelopathy in humans comprises: i) a peptide having as its active portion, an amino acid sequence of the formula: ...
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5686416 |
Increasing blood-brain barrier permeability with permeabilizer peptides
Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or...
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5683982 |
Synthetic lung surfactant having antioxidant properties
Synthetic pulmonary surfactants having antioxidant properties consisting of a complex of a polypeptide, with an antioxidant moiety, having an alpha-helical structure and a lipid consisting of one...
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5679641 |
Peptides of human P53 protein for use in human T cell response inducing compositions, and human P53 protein-specific cytotoxic t-lymphocytes
A peptide comprising an amino acid sequence derived from human p53 protein, wherein said amino acid sequence has the ability to bind to a human MHC Class I molecule. Its use in prophylactic or...
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5679640 |
Immunosuppressant peptides
Peptide compositions are provided which bind MHC molecules of interest and inhibit T cell activation. The peptide compositions of the present invention comprise various isosteres of naturally...
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5679639 |
Serine protease derived-polypeptides and anti-peptide antibodies, systems and therapeutic methods for inhibiting coagulation
The present invention describes polypeptides and anti-peptide antibodies capable of inhibiting serine protease enzymatic activity. In particular, polypeptides and anti-peptide antibodies derived...
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5677276 |
Immobilization of peptides to hyaluronate
The present invention provides novel conjugates of a synthetic polypeptide containing RGD or (dR)GD and a biodegradable polymer, hyaluronate. The conjugates are prepared by any one of three...
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5674848 |
Bioreactor compositions with enhanced cell binding
Compositions of the invention include packing materials having compounds thereon with enhanced cell binding with respect to collagen. These packing materials are useful for in vitro uses such as...
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5674849 |
Anti-viral compositions
An anti-viral composition includes a synergistic combination of an anti-viral nucleoside analogue, which may inhibit a virus-specific enzyme, such as viral thymidine kinase and reverse...
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5670482 |
Neuropeptide Y antagonists
The present invention relates to peptides which show improved Neuropeptide Y antagonism to pharmaceutical compositions containing such peptides and their use.
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5668109 |
Peptides for inhibiting pepsin release
Peptides derived from the C terminal sequence of sorbin, but containing at least one D-amino acid residue, inhibit pepsin release and are therefore likely to be useful in the treatment of ulcers or...
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5663145 |
Products for administering an initial high dose of Cetrorelix and producing a combination package for use when treating diseases
For application during the treatment of benign and malign tumour diseases, the product according to the invention containing the initial dose of Cetrorelix acetate and one or more maintenance doses...
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5661001 |
High molecular weight desulphatohirudin
The invention pertains to the field of thrombin inhibitors and describes the production of modified desulphatohirudins, particularly desulphatohirudins, with the aid of genetic engineering. The...
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5658885 |
Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
This invention relates to Novel α-aminoacid and α-aminoboronic acid and corresponding peptide analogs of the following formula: ##STR1##
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5656601 |
Acylated splenopentins, methods for their synthesis and their use
The invention relates to new compounds of acylated splenopentins of Formula I R 1 -arg-lys-(R 2 )-glu-val-tyr(R 3 )R 4 I wherein R 1 , R 2 , R 3 , R 4 are as defined in the specification,...
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5652211 |
Peptides for neutralizing the toxicity of Lipid A
The present invention is concerned with a peptide composition which includes a peptide having units of the formula: (a) (A) n wherein A is Lysine or Arginine and n is an integer with a minimum...
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5650392 |
Method and composition for the treatment of septic shock
The present invention contemplates a composition and method for treating septic shock in a mammal or as a prophylactic treatment prior to a surgical procedure, comprising administering a...
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