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5840692 |
Peptide fragments and analogs of thrombospondin
Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
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5840682 |
Peptide antagonists of neurotensin
The invention is directed to a compound of formula ##STR1## in which R represents a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH 2 --COOH radical, R 1 represents a hydrogen atom, an...
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5840688 |
Eating suppressant peptides
Peptides corresponding to specific portions of the apolipoprotein A-IV (apo A-IV) are provided. Most of the peptides correspond to the amino terminal region of apo A-IV. In addition, those peptides...
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5840690 |
Regulation of cell proliferation and differentation using peptides
Disclosed are methods of inhibiting proliferation and enhancing differentiation of a mammalian cell, inducing proliferation of a mammalian cell, enhancing wound healing, and stimulating hair growth...
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5840305 |
Treatment of HIV-Infection by interfering with host cell cyclophilin receptor activity
The present invention relates to therapeutic modalities and pharmaceutical compositions for the treatment of HIV-infection using cyclophilin A and its corresponding human cellular binding partner...
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5840691 |
Method for treating ischemia using polypeptides with fibronectin activity
Methods for treating ischemia using polypeptides with fibronectin related activity are provided. The methods involve administering an effective amount of one or more polypeptides which include an...
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5837684 |
Peptides
Peptide reagents and compositions thereof which reduce blood clotting initiated by the ternary complex of tissue factor (TF), FVIIa and FXa. The peptides have the amino acid sequences...
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5834430 |
Potentiation of antibiotics
The present invention is concerned with methods of potentiating an antibiotic. The invention also includes compositions of an antibiotic and a peptide having units of the formula: (a) (A) n ...
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5834432 |
Use of angiotensin II Type 2 receptor agonists in tissue repair
Angiotensin II Type 2 receptor agonists (AT2 receptor subtype agonists) are useful in accelerating wound healing. These compounds form the basis of compositions useful for accelerating wound...
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5834431 |
Des-Arg.sup.9 -BK antagonists
The present invention provides des-Arg 9 bradykinin analogs which are selective B1 receptor antagonists.
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5830851 |
Methods of administering peptides that bind to the erythropoietin receptor
Peptides of 10 to 40 or more amino acid residues in length and having the sequence X 3 X 4 X 5 GPX 6 TWX 7 X 8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter...
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5830863 |
Neurokinin A antagonists
Antagonists of neurokinin A which are derivatives of naturally occurring neurokinin A in which the amide bond connecting the two amino acids on the carboxy terminal end is modified are described....
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5830854 |
Method of treating cystic fibrosis using a tachykinin receptor antagonist
Tachykinin receptor antagonists are useful for the treatment of cystic fibrosis.
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5830860 |
Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are preferably about 10 to 100...
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5824650 |
Topical composition containing a substance P antagoinst
The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating...
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5821225 |
Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which...
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5821230 |
GnRH antagonist decapeptides
Peptides are provided which have improved duration of GnRH antagonistic properties and/or which can be synthesized more economically. These antagonists may be used in the same manner as the...
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5821226 |
BAL C-tail drug delivery molecules
Drug delivery conjugates of including a BAL C-tail peptide including all or a portion of the carboxy terminal region of human bile salt-activated lipase (BAL) conjugated to a biologically active...
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5817628 |
Dynorphin a suppression of natural killer cell activity
This invention provides a method of suppressing the cytotoxic activity of mammalian Natural Killer (NK) cells. The method of this invention comprises administering to an individual in need of...
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5811394 |
Technetium-99m labeled polypeptides for imaging
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides...
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5807819 |
Peptides useful for altering bone resorption
The present invention provides Arg--Gly--Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also...
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5807830 |
Method for treatment of purulent inflammatory diseases
This invention provides methods of treating purulent inflammatory diseases by administering L-Glu-L-Trp or a salt thereof.
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5807832 |
Oral delivery of biologically active substances bound to vitamin B.sub.12
Complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule vitamin B12 and a method for delivering the complex to the intestine of a host vertebrate in order to deliver...
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5804553 |
Prophenins - antibiotic peptides
Peptide-based compounds containing multiple proline residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection, especially Gram-negative bacterial...
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5801149 |
Inhibition of signal transduction molecules
A peptide capable of inhibiting the interaction of an SH2 domain containing protein with a second protein.
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5798335 |
Method for the treatment or prevention of eczema/dermatitis
The present invention provides a method for the treatment or prevention of eczema/dermatitis. This method involves the administration of Peptide T or its derivatives or analogues. Preferred...
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5795866 |
ETS1 gene: a human tumor suppressor gene
The present invention relates, in general, to methods for reducing cell tumorigenicity. More particularly, the present invention provides a method for reducing cell tumorigenicity comprising...
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5795574 |
Use of an extract from a non-photosynthetic filamentous bacterium and composition containing it
The present invention relates to the use of at least one extract from at least one non-photosynthetic filamentous bacterium as substance P antagonist in a cosmetic composition or for the...
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5795858 |
Treatment or prevention of Crohn's disease and/or ulcerative colitis
The present invention provides a method for the treatment or prevention of Crohn's disease and/or ulcerative colitis. The method involves the administration of Peptide T or its derivatives or...
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5789383 |
Bradykinin antagonists for the prophylaxis or treatment of virus diseases
Bradykinin antagonists and their physiologically tolerated salts are suitable for the treatment or prophylaxis of virus diseases.
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5786324 |
Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are about 10 to 100 amino acids...
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5786322 |
Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1
Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking...
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5783562 |
Luteinizing hormone releasing hormone analogs
A method is provided for the design and synthesis of Leuteinizing Hormone Releasing Hormone (LHRH) antagonists having exact amino acid sequences and containing 5-100 amino acids. This method can be...
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5780434 |
Composition for oral administration of peptides
A solid pharmaceutical composition for oral administration of small and medium size peptides, particularly vasopressin, oxytocin, and their analogues, comprises the peptide, a protease inhibitor,...
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5776892 |
Anti-inflammatory peptides
The present invention relates to peptides, peptide analogs and peptide derivatives related to platelet factor 4 which exhibit anti-inflammatory activity, to pharmaceutical compositions comprising...
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5776885 |
Sustained and controlled release of water insoluble polypeptides
A pharmaceutical composition for the sustained release of a peptide wherein the composition includes a polylactide polymer, a polymer of lactic acid and glycolic acid, or a mixture of such polymers...
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5776900 |
Hemoregulatory peptides
The invention provides compounds of the general formula: ##STR1## The compounds have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and...
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5773412 |
Use of peptides for altering α.sub.V β.sub.3 -mediated binding
The present invention provides Arg--Gly--Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also...
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5773415 |
Use of des-aspartate-angiotensin I as an anti-cardiac hypertrophic agent
The use of des-Aspartate-angiotensin I (Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) as an anti-cardiac hypertrophic agent is described. The compound, given either intravenously or orally, prevented the...
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5770565 |
Peptides for reducing or inhibiting bone resorption
The present invention provides Arg-Gly-Asp peptides that can reduce or inhibit the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention...
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5767068 |
Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
An anti-Pseudomonas aeruginosa agent which is substantially pure biologically active colistin, its component, a mixture thereof or a pharmaceutically acceptable salt thereof delivered as an aerosol...
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5767082 |
Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
Synthetic nona- and decapeptide LHRH antagonist analogs are disclosed, having a sterically hindered guanidino-substituted arginyl or homoarginyl residue at position 8, with no arginyl substituent...
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5767071 |
Sevenmer cyclic peptide inhibitors of diseases involving α.sub.v β.sub.3
The present invention includes non-RGD, nine amino acid cyclic peptides that inhibit the function of the integrin receptor, α v β 3 . These peptides display surprisingly potent antagonist...
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5767078 |
Agonist peptide dimers
The present invention is directed to the dimerization of agonists and antagonists of cell surface receptors and particularly to peptide dimers which behave as cell surface receptor agonists in...
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5767234 |
Peptides and compounds that bind to the IL-1 receptor
Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids...
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5767235 |
Anticoagulant hirudin variants and methods for their production
The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients....
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5763407 |
High-purity desmopressin produced in large single batches
A process for the manufacture of high purity desmopressin produced in single batches of substantial size and a method of treating diabetes insipidus with the high purity desmopressin produced...
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5763398 |
Nasal administration of desmopressin
A pharmaceutical composition for single, effective and consistent plasma level, nasal administration of an aqueous solution of from about 5 to about 75 μl and from about 0.2 to about 2.0 mg/ml of...
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5763404 |
Methods for using LHRH antagonists with low histamine release
Antide is the decapeptide, N-Ac-D-2-Nal,D-pClPhe, D-3-Pal, Ser,NicLys, D-NicLys, Leu, ILys, Pro, D-Ala,NH 2 which is an antagonist of luteinizing hormone releasing hormone (LHRH). This...
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5763402 |
Promotion or inhibition of spermatogenesis
A method of promoting or inhibiting spermatogenesis, said method comprising administering to a male an effective amount of PACAP, a PACAP agonist, a PACAP antagonist, PC4, a PC4 agonist, or a PC4...
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