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5958882 |
Compounds that inhibit T cell proliferation and methods using the same
Compounds which display a surface similar to the surface presented by one of five distinct lateral domains of CD4 are disclosed. Methods of treating individuals suspected of suffering from or...
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5958875 |
Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity
This invention provides compounds displaying NGF agonist activity, wherein the compounds comprise a multimer of a sequence of amino acid residues or biologically functional equivalents thereof, the...
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5952294 |
Peptidyl prodrugs and methods of making and using the same
Peptidyl prodrugs of therapeutic agents having an activating function are sclosed. These therapeutic agents having activating functions include those having an amino, thiol, or hydroxyl function....
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5952228 |
Isolated cytolytic T cells which are specific for complexes OF HLA- B35 molecules and the peptide PHE Pro Ser Asp Ser Trp Cys Tyr PHE, and uses thereof
The invention relates to isolated cytolytic T cells which recognize complexes of HLA-B35 molecules and the peptide defined by SEQ ID NO: 2, as well as methods for identifying HLA-B35 positive...
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5952293 |
Receptor derived peptides involved in inhibition of receptor internalization in response to ligand binding
Oligopeptides having an amino acid sequence corresponding to a receptor's extracellular domain, and having sequence similarity to regulatory peptides from MHC class I antigens, enhance the...
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5948764 |
Methods for treatment of multiple sclerosis utilizing peptide analogues of human myelin basic protein
The present invention is directed toward peptide analogues of human myelin basic protein for use in the treatment of multiple sclerosis. Within one aspect, peptide analogues suitable for treating...
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5942493 |
LH-RH antagonists having improved action
New LH-RH antagonists are disclosed, in particular peptidomimetics and peptides modified in a side chain, their salts with pharmaceutically acceptable acids and a process for preparing these LH-RH...
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5942401 |
Method of determining favorable prognosis against progressing from an asymptomatic condition to AIDS in an human immunodeficiency virus (HIV) positive subject
The presence of cytotoxic T-cells to the Rev and/or Tat protein in samples from a subject infected with immunodeficiency virus, particularly HIV in humans, is an indication of a stable disease...
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5942491 |
Method and compositions for treating arthritis
The present invention provides a process for the treatment of arthritis including the step of administering to an animal or human patient in need of such treatment a plurality of peptides each of...
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5942492 |
Cyclic peptides that bind to urokinase-type plasminogen activator receptor
Cyclic peptide compounds having 11 amino acids joined by a linking unit L, such that the linear dimension between the C α carbon of the first amino acid and the C α carbon of eleventh amino...
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5942539 |
Methods of treating or preventing endometriosis with phytoestrogens
Methods of using phytoestrogens, in particular, isoflavones in the prevention and treatment of endometriosis and related disease conditions in females. One method comprises administering a...
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5939385 |
Transglutaminase cross-linkable polypeptides and methods relating thereto
Polypeptides of from about 9-120 amino acid residues comprising a truncated segment of fibrinogen which may be flanked by elastomeric peptides, wherein the polypeptides are cross-linkable by a...
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5935932 |
Bradykinin antagonists containing pentafluorophenylalanine
The present invention provides bradykin antagonists containing pentafluorophenylalanine which are therapeutically useful. Moreover, the present invention provides methods to antagonize bradykinin...
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5932546 |
Peptides and compounds that bind to the thrombopoietin receptor
Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and...
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5932545 |
Antiangiogenic drug to treat cancer, arthritis and retinopathy
Peptides having the formula: T-Gly-Val-D-Ile-Thr-Arg-Ile-U, V-Gly-D-Val-Ile-D-Thr-D-Arg-D-Ile-W, X-D-Arg-D-Ile-D-Arg-D-Thr-lle-D-Val-Y, and Z-Gly-Val-Ile-Thr-Arg-Ile-U wherein T is absent...
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5932548 |
Lysine containing peptides for treatment of heart disease
The present invention relates a number of different lysine containing peptides which can be administered to a mammal to normalize cardiac pressure for treatment of heart disease conditions such as...
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5929027 |
Physiologically active polypeptide-containing pharmaceutical composition
A pharmaceutical composition comprising a physiologically active polypeptide, an absorption promoting agent consisting of a combination of an organic acid and a fatty acid sucrose ester in...
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5928644 |
T-cell epitopes
T-cell epitopes of or derived from the TraT protein of E. coli have been identified and used in the preparation of complexes with immunogens to enhance or provide immune responses to the...
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5925619 |
Formulation for peptide release
A pharmaceutical or veterinary formulation comprising deslorelin and an excipient is provided which releases in vitro deslorelin into phosphate buffered saline at 370° C. at a rate of about 2-80...
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5922680 |
Stabilized composition for oral administration of peptides
A solid pharmaceutical composition for oral administration of small and medium size peptides, particularly vasopressin, oxytocin, and their analogues, comprises said peptide, an enteric coat and a...
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5916869 |
Method of treating birds in ovo
Methods are disclosed for administering Peptide YY (PYY) receptor agonists to birds in ovo to promote altricial development of the intestinal tract of neonatal birds. Enhanced altricial development...
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5916876 |
Peptide inhibitors of leukocyte adhesion
The present invention provides novel peptides derived from portions of the sequence of amino acids 42-48 of P-selectin. The invention also provides pharmaceutical compositions comprising the...
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5914340 |
Leukotriene antagonists useful for treating dermatoses
This invention provides methods for the treatment or inhibiting of dermatitis which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a...
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5912230 |
Anti-fungal and anti-bacterial histatin-based peptides
Histatin-based peptides representing defined portions of the amino acid sequences of naturally occurring human histatins and methods for treatment of fungal or bacterial infection are described....
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5912231 |
Substitution analogues of magainin peptides
A compound comprising a Magainin I or Magainin II peptide wherein at least one substitution may be made for certain amino acid residues with other amino acid residues, said peptides known as...
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5912232 |
Anti-inflammatory polypeptide antagonists of human I1-8
Polypeptides derived from human interleukin-8 (IL-8) or other alpha chemokines which act as anti-inflammatory agents for the therapy of autoimmune disease, inflammatory conditions, and various...
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5910505 |
Leukotriene antagonists for use in the treatment or inhibition of oral squamous cell carcinoma
This invention provides methods for the treatment or inhibitor of oral squamous cell carcinoma which comprises administering to a mammal in need thereof an effective amount of a compound having...
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5910478 |
Peptidomimetics inhibiting the oncogenic action of p21 ras
The present invention provides peptides, cyclized peptides and peptidomimetics which inhibit the oncogenic and/or transforming activity of the p21 ras protein, pharmaceutical compositions...
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5908825 |
Dosage composition for nasal delivery and method of use of the same
A nasal dosage composition for nasal delivery comprising (A) a therapeutic agent; and (B) zonula occludens toxin, as well as a method for the use of the same.
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5908824 |
Nasally administrable compositions containing physiologically active peptides
A nasally administrable composition having a physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto a unique carrier. The composition contains an effective amount...
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5900405 |
Polymers responsive to electrical energy
A composition that expands or contracts upon a change in exposure to electrical energy is provided that comprises a protein or protein-based polymeric material having an inverse temperature...
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5888512 |
Lymphocyte activity regulation by HLA peptides
Fragments from the polymorphic domains of Class I HLA antigen domains are used to modulate T-cell activity. The peptides are from the α1- or α2 domains, particularly of the HLA-A, and B antigens....
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5885965 |
Anti-fungal D-amino acid histatin-based peptides
D-amino acid histatins and histatin-based peptides and methods for treatment of fungal or bacterial infection are described. These D-amino acid histatins and histatin-based peptides are...
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5880095 |
Cholesteryl ester transfer protein inhibitor peptides and prophylactic and therapeutic anti-arteriosclerosis agents
A peptide consisting of the following amino acid sequence, or an analogue or a fragment thereof, has an inhibitory activity on cholesteryl ester transfer protein: Glu Asp Thr Ser Pro Glu Asp Lys...
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5880096 |
Peptides and compounds that bind to the IL-1 receptor
Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids...
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5874405 |
Heat shock protein peptides that share sequences with cyclic nucleotide phosphodiesterase and methods for modulating autoimmune central nervous system disease
The invention provides for peptides and methods of using peptides to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are antigens derived from...
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5863901 |
Use of bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders and acute liver disorders
This invention relates to a method of treating a chronic fibrogenetic liver disorder and/or an acute liver disorder and/or complications associated therewith, comprising administering to a patient...
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5863899 |
Bradykinin antagonists
A bradykinin antagonist of the formula: (BKAn) (X) (Y) where BKAn is a bradykinin antagonist peptide; Y is a Pharmacophore; and X is a bridging link chemically joining the BKAn and Y components.
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5863718 |
Small peptides which inhibit to T-4 receptors and act as immunogens
Short peptide of the formula: R a -Ser-Thr-Thr-Thr-Asn-Tyr-R b (I) where R a represents an amino terminal residue Ala- or D-Ala and R b represents a carboxy terminal residue...
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5863763 |
Insect neuropeptides
The present invention relates to novel peptides isolated from the blowfly Calliphora vomitoria. The invention also relates to nucleic acid molecules encoding these peptides, vectors and host cells...
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5863900 |
Lhrh antagonists
The present invention provides novel LHRH antagonists and complexes between these antagonists and VB12. The present invention is particularly useful for the oral administration of LHRH antagonists....
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5855884 |
Treatment of stress-induced migraine headache with a corticotropin releasing hormone blocker
Non-traumatic immobilization (restrain) stress causes rapid degranulation of rat dura mast cells, as shown both by light and electron microscopy. These morphologic findings were accompanied by...
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5851994 |
Compositions that inhibit wound contraction and methods of using same
The present invention provides methods for reducing or inhibiting wound contraction in a subject having a wound comprising administering to the subject a pharmaceutical composition comprising a...
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5849323 |
Collagen mimetic and method of treating rheumatoid arthritis using same
A collagen mimetic peptide having the nine amino acid sequence glycine-proline-hydroxyproline-glycine -proline-glutamine-glycine-methionine-glycine, and analogs thereof is described. The collagen...
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5849701 |
Peptide inhibitors of fibronectin and related collagen-binding proteins
Peptides derived from the second type 1 repeat of human endothelial cell thrombospondin which bind to the gelatin-binding domain of fibronectin have been isolated and synthetically produced. The...
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5846548 |
Combined administration of mitogenic immumo stimulator and a thymomimetic
A method of tumor therapy involves controlling the immune system by co-administration of a mitogenic immuno-stimulating substance and a thymomimetic substance.
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5846826 |
Isolated cytolytic T cell line specific to complexes of HLA-B44 molecules and specific nonapeptides
The invention involves cytolytic T cell lines which are specific for complexes of HLA-B44 molecules and nonamers which bind to these.
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5846939 |
Use of a decapeptide with benzodiazepine-type activity for preparing medicines and food supplements
The present invention relates to the use of the decapeptide having the amino acid sequence of SEQ ID NO.:1 ##STR1## in the preparation of medicines having benzodiazepine-type activity, particularly...
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5846743 |
Polyphoshoinositide binding peptides for intracellular drug delivery
Methods and compositions for facilitating the transport of a membrane-impermeable extracellular agent having an intracellular activity across the membrane of a cell are provided. The methods...
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5843882 |
Antiviral proteins and peptides
The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention...
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