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8106034 |
Angiotensin II receptor antagonists
A compound having the structure wherein R is an angiotensin receptor blocking groupY is —(CR1R20)1-7R5, or —C(O)(CR1R20)1-7R5;R1 and R20 are independently selected from the group consisting of hyd...
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8101589 |
Nitric oxide-releasing molecules
This invention relates to compositions comprising carbon-based diazeniumdiolates that release nitric oxide (NO). The carbon-based diazeniumdiolated molecules release NO spontaneously under...
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7863262 |
Nitroxyl progenitors in the treatment of heart failure
Administration of an HNO/NO− donating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart f...
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7829553 |
Nitric oxide-releasing polymers
This invention relates to compositions comprising carbon-based diazeniumdiolates attached to hydrophobic polymers that releases nitric oxide (NO). The carbon-based diazeniumdiolated polymers...
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7569559 |
Nitric oxide-releasing molecules
This invention relates to compositions comprising carbon-based diazeniumdiolates that release nitric oxide (NO). The carbon-based diazeniumdiolated molecules release NO spontaneously under...
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7511029 |
Pesticidal diazene oxide carboxylates
Pesticidal compounds having the structural formula wherein: R2 is C1-C6 branched or straight chain alkyl; C1-C4 branched or straight-chain haloalkyl; or C3-C6 cycloalkyl;m is 0, 1, or 2;X is...
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7452872 |
Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
A method of increasing the bioavailability of balsalazide by administration of an oral dosage form with food is provided, as well as an article of manufacture comprising an oral dosage form of...
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7435408 |
Porous particles comprising excipients for deep lung delivery
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
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7348319 |
Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same
The present invention relates to nitric oxide-releasing amidine diazeniundiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate...
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7285533 |
Apo-2 ligand
A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2...
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7122529 |
Compounds that release nitric oxide at controlled rates upon photolysis
Chemical compounds which release nitric oxide in a controlled manner upon photolysis with light are provided. These compounds are O2-benzyl, O2-naphthylmethyl and O2-naphthylallyl substituted...
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7105502 |
Nitric oxide-releasing imidate and thioimidate diazeniumdiolates
The invention provides NO- or NO−-releasing imidate; and thioimidate, diazeniumdiolates, in which the N2O2− functional group is bonded to a carbon atom. The imidate and thioimidate dia...
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6825181 |
Aminoisoquinoline derivatives
Aminoisoquinoline derivatives of the following formulae or analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an excellent effect of inhibiting...
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6780854 |
Orally active androgens
Novel, orally active androgens are 7α-substituted Δ14-nandrolone derivatives. The compounds satisfy the general formula: whereinR1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, o...
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6407081 |
Method for inhibiting cytokine production by cells
The invention concerns a method for inhibiting cytokine production by cells, in particular animal or human cells, and their secretion, which consists in applying on said cells at least an azo...
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6306841 |
Treatment of female sexual dysfunction
Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina,...
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5952334 |
Carbocyclic compounds
A compound of formula ##STR1## wherein Z is a tetrahydro-pyrano group selected from ##STR2## having antifungal activity in combination with other antifungal agents.
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5840759 |
Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5837736 |
Nitric oxide-releasing compounds to sensitive cancerous cells to chemotherapeutic agents
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5814656 |
Selective prevention of organ injury is sepsis and shock using selective release of nitric oxide vulnerable organs
A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically...
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5814667 |
Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5795878 |
Biocidal compounds their preparation and use
A phenylazoxycyanide compound of formula I ##STR1## is useful as an antimicrobial and fungicidal composition. A method for using the antimicrobial and fungicidal compositions, and for manufacturing...
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5700830 |
Use of nitric oxide-releasing agents for reducing metastasis risk
A method for inhibiting the adherence between cancerous cells and noncancerous structures in a mammal, comprising the administration to the mammal of a nitric oxide-releasing compound containing a...
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5670537 |
Method for effecting tumor regression with a low dose, short infusion taxol regimen
Taxol dosages of about 135 mg/m2 or greater are administered via infusions of less than 6 hours duration; the method makes it possible to provide taxol infusions on an out-patient basis to patients...
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5627175 |
Azoxycyanobenzene compounds
The invention is directed to azoxycyanobenzene derivatives of the formula: ##STR1## wherein n is 0-3; each R represents halogen, nitro, cyano, alkyl, haloalkyl, alkoxy, or haloalkoxy; and each R1...
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5541169 |
Azoxy compound
An azoxy compound represented by the following general formula ##STR1## wherein R1 denotes a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a lower alkoxy-lower alkoxy group...
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5439897 |
Azoxycyanobenzene derivatives, compositions containing them and their use as fungicides
This invention relates to certain azoxycyanobenzene derivatives of the general formula. ##STR1## in which R represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl,...
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5376679 |
Bicyclic or tricyclic biocidal compounds
Compounds of the general formula ##STR1## where R2 and R3 together, or R3 and R4 together, represent an optionally substituted hydrocarbyloxy chain; the ring is optionally substituted at any or...
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5366997 |
Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular...
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5350744 |
Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
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5273997 |
Biocidal compounds
The invention provides compounds of general formula ##STR1## wherein m is 0 or 1; each of R1 and R2, and R3 and R4 if present, independently represents a hydrogen or halogen atom or an optionally...
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5089487 |
Circulation-active dibenzo[1,5]dioxocin-5-ones
Cardioactive compounds of the formula ##STR1## in which R1 and R8 and R14 and R15 can be hydrogen or various organic radicals.
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5089486 |
Biocidal azophenyl compounds
Compounds of the general formula R--NNX (I)or N-oxides thereof, where R represents on amidophenyl group, and X represents a cyano group, a group --COOH or a salt, ester or amino derivative t...
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5084448 |
Fungicidal phenyl azoxime compositions
Novel compounds of the general formula ##STR1## where R represents an optionally substituted aryl or heteroaryl group; X represents a hydrogen atom or an amino group or an optionally substituted...
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5057504 |
1-heterocyclic bicyclo-octanes
Pesticidal bicyclo-octanes are of the formula ##STR1## where R is a substituted or unsubstituted aliphatic or aromatic group, R' and R3 are H or a substituted or unsubstituted aliphatic or aromatic...
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4997820 |
Microbicides
Novel macrocyclic compounds of the formual I ##STR1## where the dotted line in the 9,10-position is a saturated bond or a double bond, alternatively, and R is hydrogen, methyl or certain acyl...
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4981954 |
Novel azoxy compounds and process for production thereof
Novel azoxy compounds having antifungal activity and being useful for the treatment of mycoses, represented by the following formula ##STR1## are prepared by culturing a microorganism of...
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4954526 |
Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
A method of treating cardiovascular disorders in a mammal, by administering to said mammal an effective amount of a compound of the formula: [R--N(H)N(NO)O--]y Xwherein R is loweralkyl, aryl,...
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4876274 |
New class of pesticides comprising 1,4-bis-substituted-2,6,7-trioxabicyclo(2.2.2)octanes
A pesticidal composition comprising a compound having the formula R--C(CH2 O)3 C--X wherein R and X are each organic substituents and wherein the compound has an LD50, in micrograms of compound per...
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4814161 |
Drug-containing chlorofluorocarbon aerosol propellent formulations
Complete dissolution of a wide range of drugs in chlorofluorocarbon aerosol propellents is achieved by the presence of glycerol phosphatides, preferably phosphatidylcholine.
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H000303 |
Glycoside-containing agricultural treatment composition
This invention describes a composition of matter and a method of treating agricultural substrates in which an active ingredient selected from the group consisting of fungicides, bactericides,...
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3642990 |
PROCESS OF INHIBITING TRANSPLANTED MAMMARY ADENOCARCINOMA IN MICE USING POLYHALO (AZO OR AZOXY) BENZENE COMPOUNDS
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2987436 |
Para-chloroazoxybenzene pesticide
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