Patents in Class 514/14

Matches 1 - 50 out of 867

Match	Document	Document Title
1	7615533	TPO peptide compounds for treatment of anemia Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
2	7612171	DB, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
3	7612164	Cardiac muscle function and manipulation This invention relates to polypeptides which affect myocardial cell differentiation and organisation of cardiac muscle contractile units, assay for identifying such polypeptides, and methods for...
4	7612162	Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for...
5	7612044	Melanoma antigens and their use in diagnostic and therapeutic methods The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid...
6	7608589	Peptidyl diacylglycerides Peptide and peptides that may be covalently linked to a lipid and methods of using such peptides and lipopeptides to prevent or treat disease are disclosed herein.
7	7601694	CLK-peptide and SLK-peptide The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially...
8	7601361	Process for providing antimicrobial surfaces Processes for providing durable antimicrobial surfaces are disclosed that comprise treating a polymer substrate surface with formaldehyde followed by treatment with an antimicrobial peptide....
9	7597904	Metalloproteinase inhibitory agent The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The...
10	7595298	Polypeptides having anti-HIV activity and compositions comprising same The present invention relates to a polypeptide represented by the formula: A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit-Cys-A7 ...
11	7589170	Synthesis of cyclic peptides This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in...
12	7589063	Molecules which promote hematopoiesis Peptides, methods for the preparation thereof, medicaments containing the peptides, and their use in selected indications, such as the treatment of various forms of anemia and stroke.
13	7589058	Ghrelin analogs The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof.
14	7588757	Methods of treating Parkinson's disease using recombinant adeno-associated virus virions Methods for treating Parkinson's disease (PD) are provided. Recombinant adeno-associated virus (rAAV) virions are used to deliver genes encoding dopamine-synthesizing enzymes to the central nervous...
15	7585938	Gamma-secretase inhibitors Disclosed, as a γ-secretase inhibitor, is a compound consisting of an amino acid sequence which consists of at least three consecutive amino acids of the amino acid sequence...
16	7585843	Treatment of demyelinating autoimmune disease with modified ordered peptides Compositions and methods are provided for the treatment or prevention of autoimmune disease. Therapeutic doses of one or more modified therapeutic ordered peptide(s) comprising amino acids...
17	7582610	Melanocortin receptor templates, peptides and use thereof The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to...
18	7582609	Method for the treatment of skin fibrosis and suitable compositions for such treatment A Method for the treatment of skin fibrosis with a peptide that inhibits TGF-β, and suitable compositions for its administration. The method includes in particular, the use of peptide P144, a...
19	7579315	Casein peptides for alleviating or preventing aging of skin Provided is use of a peptide, or a derivative of a peptide, in the manufacture of a medicament effective in alleviating or preventing periodontal disease, wherein the peptide comprises an amino...
20	7576175	Alpha-4 beta-1 integrin ligands for imaging and therapy The present invention provides α 4 β 1 integrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino...
21	7576056	Peptides and compounds that bind to a receptor Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
22	7572599	Metalloprotease activation of myostatin, and methods of modulating myostatin activity It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents...
23	7569547	Inhibiting furin with polybasic peptides Small, polybasic peptides are disclosed that are effective as furin inhibitors, e.g. hexa- to nona-peptides having L-Arg or L-Lys in most positions. Removing the peptide terminating groups can...
24	7569542	Anti-microbial targeting chimeric pharmaceutical The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target...
25	7569540	Method for enhanced parenteral nutrition A method for improved administration of nutrient is provide. The method includes co- or separate administration of a source of nutrients, especially carbohydrates, and insulinotropic peptides and...
26	7566695	Multimeric apoprotein agonists The present invention provides multimeric apoprotein agonists. Pharmaceutical compositions which include a multimeric apoprotein agonist and a pharmaceutically acceptable carrier, excipient or...
27	7563771	Synthetic single domain polypeptides mimicking apolipoprotein E The present invention is directed to a synthetic apolipoprotein-E mimicking polypeptide consisting of a single domain. The invention is also directed to nucleic acid encoding the polypeptide,...
28	7563766	Methods and compositions for the promotion of a hair growth utilizing actin binding peptides Disclosed herein are methods and compositions suitable for the promotion of hair growth on humans and other animals. Disclosed embodiments include compositions comprising actin-binding peptides. In...
29	7557087	Compositions and methods for treating diseases This invention relates to compositions and methods for treatment of vascular conditions. The invention provides arginine polymers and arginine homopolymers for the treatment and/or prevention of...
30	7557083	Gastrokines and derived peptides including inhibitors A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for...
31	7553876	Polycationic compounds and uses thereof Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a...
32	7550558	Antimicrobial peptides and methods for identifying and using such peptides This invention relates to a method for identifying peptides having antimicrobial activity and to the antimicrobial peptides identified thereby and methods for their use.
33	7550438	Methods for production of growth-promoting proteins and peptides for kidney epithelial cells Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not fibroblastic cells, in particular, kidney...
34	7550436	Compositions containing peptide and electrolyte excretion promoter and foods containing the same A composition containing a peptide and an electrolyte excretion promoter, which comprises a peptide or a peptide mixture which is obtained by lysing a food-origin protein with a protease and has an...
35	7547677	Plant virus transmission inhibitor and methods Provided is a peptide, peptide multimer or fusion protein containing such peptide which binds to the gut of sap-sucking insects, e.g., aphids. When bound, this peptide inhibits the binding of...
36	7547676	Antagonist peptides to the C5A chemotactic function of vitamin D binding protein It has been demonstrated that one of Vitamin D Binding Protein (DBP) biological functions is to enhance the chemotactic activity of C5 a and C5 a des Arg. The present invention has found that...
37	7544653	Additive cytoprotective effects of two bioactive regions of pro-opiomelanocortin hormone Repetitive and bioreactive regions of pro-opiliomelanocortin were identified using computational analysis. These regions KOMET, KOMET-1, KOMET-2, and KOMET-3 exhibit cytoprotective effects and may...
38	7541430	Peptides for use in treating obesity Novel cyclic and linear peptides of the formula R 1 —X—X 1 —X 2 —X 3 —X 4 —X 5 —X 6 —X 7 —X 8 —X 9 —X 10 —X 11 —R 2 are useful in the treatment of obesity are provided.
39	7531516	Peptidic compounds selectively binding to P-selectin The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence XA x...
40	7531515	Peptides selectively lethal to malignant and transformed mammalian cells The present invention provides peptides corresponding to all or a portion of amino acid residues 12-26 of human p53 protein, which peptides are lethal to malignant or transformed cells when fused...
41	7531512	Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes A method for preventing or delaying the onset of autoimmune diseases is disclosed.
42	7528227	Histone H2A peptide derivatives and uses thereof Peptides derived from a segment of human histone H2A, the segment corresponding to amino acid residues 36-44 of human histone H2A, are capable of reducing or ameliorating the extent of injury...
43	7528104	Peptides that bind to the erythropoietin receptor The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat...
44	7524926	Mucin hypersecretion inhibitors and methods of use Peptides are provided that comprise less than 24 amino acids. The peptides have an amino acid sequence selected from the group consisting of: (a) an amino acid sequence having from 4 to 23...
45	7524819	Compositions and methods for counteracting effects of reactive oxygen species and free radicals Peptide compounds and methods for upregulating expression of a gene encoding an antioxidative enzyme, such as superoxide dismutase or catalase, to counteract harmful oxidative effects of reactive...
46	7521529	Differentially protected orthogonal lanthionine technology The present invention provides a method of synthesizing an intramolecularly bridged polypeptide comprising at least one intramolecular bridge. The present invention further provides a method of...
47	7521415	Methods of intracellular peptide delivery Methods and kits for transporting heterologous compounds into cells, particularly mammalian cells, are disclosed. The method involves the pretreatment of the cell with a polycation, cationic...
48	7517855	Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell...
49	7517654	Peptide and a derivative thereof promoting cell adhesion and spreading The present invention relates to a peptide promoting cell adhesion and spreading, fragments, and derivatives thereof, more particularly, integrin-α3β1-dependent peptide in human laminin-5 α3...
50	7514407	Spheron component peptides and pharmaceutical compositions The present invention relates to racemized proteins and racemized protein components of spherons that are useful for identifying compounds capable of preventing and/or ameliorating symptoms of...

Matches 1 - 50 out of 867

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