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8183206 |
Drugs comprising combination of antithrombotic agent with pyrazolone derivative
It is intended to provide drugs for treating ischemic diseases which are safe and have little side effects. Namely, drugs having a combination of an antithrombotic agent and a pyrazolone derivative...
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8178489 |
Formulation for aviptadil
The present invention relates to pharmaceutical formulations of Aviptadil and its derivatives. The stability of the Aviptadil formulation was shown to be improved by a formulation having a defined...
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8148355 |
Phophylactic and therapeutic use of hydroxysteroids
3-Hydroxy-7-hydroxy steroids and 3-oxo-7-hydroxy steroids, especially the 7β-isomers thereof, and pharmaceutically acceptable esters thereof are useful for protection against ischaemia-induced ...
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8119597 |
Non-neurotoxic plasminogen activating factors for treating of stroke
The invention concerns the use and the production of non-neurotoxic plasminogen activating factors, derived, for example, from the common vampire Desmodus rotundus (DSPA), for therapeutic treatment...
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8119137 |
Prevention of thrombus formation and/or stabilization with inhibitors of factor XII or activated factor XII
The present invention relates to the use of at least one antibody and/or one inhibitor for inhibiting factor XII and preventing the formation and/or the stabilization of three-dimensional thrombi....
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8062638 |
Prevention and treatment of diseases associated with blood coagulation
Provided herein is an animal having a persistent hypercoagulable state by implanting a cell, for example a tumor cell, in which the gene of human tissue factor is implanted to an experimental...
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8034769 |
Oxidized proteins and oxidized protein inhibitor compositions and methods of use thereof
The invention relates to substances which inhibit the binding of oxidized proteins to CD36 or inhibit the functions of CD36 that are induced by the interaction of CD36 with oxidized proteins. The...
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7968515 |
Protein S protects the nervous system from injury
Protein S is a significant neuroprotectant when administered after focal ischemic stroke and prevents hypoxic/re-oxygenation injury. Purified human plasma-derived or recombinant protein S improves...
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7951356 |
Tissue factor compositions and kits for coagulation and tumor treatment
The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic...
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7935498 |
Methods for identifying patients with increased risk of an adverse cardiovascular event
Methods, compositions and kits are disclosed for identifying patients with an increased risk of experiencing an adverse cardiovascular event where the patient is undergoing aspirin antiplatelet...
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7879803 |
Methods of treatment involving the protease for activating clotting factor VII
This application describes methods of treatment involving a protease for activating the blood clotting factor VII, which (a) activates blood clotting factor VII, (b) is inhibited by the presence of...
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7833978 |
Thrombomodulin derivatives and conjugates
The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured...
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7736636 |
Method for treating occlusive vascular diseases & wound healing
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of Nicotine, nicotinic acid analogs thereof,...
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7732400 |
Method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury
This invention provides for a method for inhibiting new tissue growth in blood vessels in a subject, wherein the subject experienced blood vessel injury, which comprises administering to the...
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7666842 |
Elastin peptide analogs and uses thereof
Compositions used to enhance the elasticity and/or appearance of tissue are described. The compositions include peptides and/or peptide-like compounds and combinations thereof having low molecular...
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7655624 |
Peptide and peptide mimetic conjugates with integrin-inhibitor properties
The invention relates to compounds of formula (1) B-Q-X1, wherein B is bioactive cell adhesive mediating molecule. Q is absent or is an inorganic spacer molecule and X1 is an anchor molecule,...
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7635676 |
Modified annexin proteins and methods for their use in organ transplantation
Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrhage and to attenuate...
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7629319 |
Heteroaryl peptidomimetics as thrombin receptor antagonists
The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis,...
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7585844 |
Myosin light chain kinase inhibitors and methods of use
Disclosed are inhibitors of myosin light chain kinase, pharmaceutical compositions and kits comprising the inhibitors and methods of use.
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7576060 |
Inhibition of adhesion and migration of an endothelial cell to fibronectin by neutrophil alpha-defensins
The present invention relates to the inhibition of angiogenesis by neutrophil alpha-defensins. Further, the present invention relates to methods involving the inhibition of endothelial cell...
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7553811 |
Methods and compositions for modulating immunity
Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The...
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7531516 |
Peptidic compounds selectively binding to P-selectin
The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence...
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7511009 |
Retinal pigmented epithelium derived neurotrophic factor
The present invention relates to a purified retinal pigmented epithelium derived neurotrophic factor composition and a method for purifying such a retinal pigmented epithelium neurotrophic factor....
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7494973 |
Therapeutic fibrin-derived peptides and uses thereof
The invention relates to peptides having the general formula (I), or a salt or amide thereof, wherein R1 and R2 are either the same or different, wherein R1 and R2 are each selected from the group...
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7429564 |
Oral insulin therapy
Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically...
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7417030 |
Indazole peptidomimetics as thrombin receptor antagonists
The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis,...
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7407475 |
Modified annexin proteins, and methods and compositions for using them
A modified annexin protein, preferably annexin V, is used to prevent thrombosis without increasing hemorrhage. Annexin binds to phosphatidylserine on the outer surface of cell membranes, thereby...
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7399743 |
Targeted thrombosis
The invention provided compositions and methods to initiate site-specific thrombosis in tumor vasculature. The present invention also provides methods for using the disclosed compositions and...
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7393833 |
Chimeric proteins with phosphatidylserine binding domains
Chimeric proteins comprising soluble Tissue Factor (sTF) and another subunit (e.g., annexin V) are described. The proteins promote blood clotting and/or inhibit cancer by targeting sTF to specific...
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7390497 |
Poly(ester amide) filler blends for modulation of coating properties
Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the...
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7297343 |
Bioactive medical films
A wound dressing, method of making, and method of use, utilizing a polymeric film having complexed thereto by hydrophobic interaction a construct including a polyanion covalently bonded to a...
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7279155 |
Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine
The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof,...
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7276491 |
Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors
Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
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7276482 |
Peptide and peptide mimetic derivatives with integrin-inhibitors properties II
The invention relates to compounds of formula (I) B-Q-X1, wherein B is a bioactive, cell adhesive mediating molecule, selected from the group (i) and Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys...
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7276474 |
Methods of making and using surfactant polymers
Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional...
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7271152 |
Compounds and methods for the modulation of CD154
The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved...
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7247300 |
Therapeutic use of soluble CD39L3
The present invention provides soluble forms of CD39L3 polypeptides and compositions, and methods useful inhibiting platelet activation and recruitment for the treatment and prevention of...
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7247451 |
Antithrombin protein and DNA sequences from black fly
The invention is drawn to anti-thrombin proteins from the salivary glands of the species, Simulium. Methods for recombinant production of the protein as well as biomedical uses are provided.
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7247611 |
Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
The invention includes compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator.
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7235530 |
Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing...
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7223730 |
Antithrombosis enzyme from the snake venom of agkistrodon acutus
This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.
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7208288 |
Methods for enhancing the lysis of coagulated blood with apolipoprotein E2 phenotype
Methods for enhancing the lysis of coagulated blood comprise administering to coagulated blood a combination of clot clysis agent and a lysis enhancing amount of apolipoprotein E2 (Apo E2) or a...
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7196063 |
Peptides and pharmaceutical compositions comprising same
The present invention relates to an NST500 compound of general formula (I): comprising the following components: X1—X2—{(X3)a/X4/X5}—X6, wherein: X1 stands for a saturated or unsaturated fatty...
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7153829 |
Kallikrein-inhibitor therapies
Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient.
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7135305 |
Methods for controlling the lysis of coagulated blood with apolipoprotein e4 phenotype
Methods for inhibiting lysis of coagulated blood and reducing risk of excessive lysis comprising administration of lysis-inhibiting amounts of apolipoprotein E4, and methods for inhibiting lysis of...
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7109170 |
Region of factor IXa protease domain that interacts with factor VIIIa and methods therefor
Novel polypeptides or derivatives comprising the factor VIIIa binding site on factor IXa are disclosed. The novel polypeptides or derivatives have anti-coagulation activity. Nucleic acids encoding...
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7101846 |
Methods and compositions for optimization of oxygen transport by cell-free systems
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof....
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7087215 |
Methods of administering and enhancing absorption of pharmaceutical agents
Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least...
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7087578 |
Formulations and methods for treating hypercoagulable states
A method of treating a human patient with a hypercoagulable state or protein C deficiency, which comprises administering activated Protein C and protein C Zymogen.
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7084109 |
FVIIa antagonists
This invention provides novel compounds which prevent or block a FVIIa mediated or associated process or event such as the catalytic conversion of FX to FXa, FVII to FVIIa or FIX to FIXa. In...
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