|
Match
|
Document |
Document Title |
|
|
7053041 |
Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin α v β 5 antagonists. The α v β 5 -mediated angiogenesis is correlated with exposure to...
|
|
|
7053058 |
Pharmaceutical preparations and methods for inhibiting tumors
The invention provides pharmaceutical compositions and method for inhibiting growth of prostatic adenocarcinoma, stomach cancer, breast cancer, endometrial, ovarian or other cancers of epithelial...
|
|
|
7052673 |
Pharmaceuticals for the imaging of angiogenic disorders
The present invention describes novel compounds of the formula:
(Q) d —L n —C h ,
|
|
|
7049282 |
Inhibition of complement action
The present invention relates to a method of blocking biochemical function of the classical complement pathway and thereby preventing immunologic damage in a variety of diseases and conditions...
|
|
|
7049292 |
Therapeutically effective peptides related to preproinsulin
A peptide having a sequence comprising or consisting of QPLALEGSLQK.
|
|
|
7049295 |
Compounds and use thereof to modify transport across cell membranes
The invention provides the use of a compound capable of preferential interaction with plasma membrane lipid microdomains (PMLMs) as enhancers of transport processes across endothelial, epithelial...
|
|
|
7049294 |
Use of thrombin-derived peptides for the therapy of chronic dermal ulcers
Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an...
|
|
|
7041649 |
Method for treating neurological conditions and inducing immunosuppression with cephaibols
Embodiments of the present invention relate to administering cephaibols to treat conditions of the nervous system and to treat those conditions in which suppressing the immune system would have...
|
|
|
7037889 |
Pharmaceutical compositions for sustained drug delivery
Sustained delivery formulations comprising a water-insoluble complex of a peptide and a plurality of ligands are disclosed. The formulations of the invention allow for loading of high...
|
|
|
7026129 |
IG lambda biopolymer markers predictive of Alzheimers disease
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
|
|
|
7015192 |
Neuronal exocytosis inhibiting peptides and cosmetic and pharmaceutical compositions containing said peptides
The peptide has a sequence of 3 to 30 adjacent amino acids from the amino end of protein SNAP-25 and is useful as neuronal exocytosis inhibitor. The cosmetic and pharmaceutical compositions contain...
|
|
|
7005418 |
Method for the therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction
The present inventions provides a method for therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction by short term induction...
|
|
|
6991776 |
Intracorporeal medicaments for high energy phototherapeutic treatment of disease
New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described,...
|
|
|
6989371 |
Bombesin analogs for treatment of cancer
The present invention encompasses novel peptides that are antagonists to bombesin and bombesin like peptides and are useful in the treatment of cancer. The invention particularly relates to the...
|
|
|
6982247 |
Compounds exhibiting an antibiotic activity
The present invention relates to compounds having antibiotic activity which are obtained from body fluids of mollusks, namely of certain West-African snails, to therapeutic drugs comprising these...
|
|
|
6977242 |
Two gonadotropin releasing hormones and a method to isolate the same
The present invention relates to two novel Gonadotropin releasing hormones muGnRH I and muGnRH II of amino acid SEQ ID 1 as QHWSAWRLPG, and SEQ ID 2 QHWSWGILPG respectively, useful for induced...
|
|
|
6964766 |
Peptides for use in immunotherapy of autoimmune diseases
The invention relates to the use of novel peptides in a peptide induced tolerance therapy to prevent autoimmune disorders and in particular their use in treatment of chronic destruction of...
|
|
|
6964948 |
Therapeutic peptide-based constructs derived from Domain II of bactericidal/permeability-increasing protein
The present invention relates generally to small peptide-based constructs, including derivatized constructs, and their therapeutic uses. The constructs and derivatized constructs can have at least...
|
|
|
6960566 |
Compositions and methods for treatment of cancer
Compositions containing one or more peptido-mimetics or modified peptido-mimetics of a carbohydrate ligand of an adhesion molecule in a physiologically acceptable carrier are useful for methods of...
|
|
|
6951652 |
Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases
A vaccine is disclosed which is useful for protecting a host from Gram negative infections and the effects of endotoxin, therefore preventing sepsis and septic shock. The vaccine is prepared by...
|
|
|
6949512 |
Therapeutic agent for the treatment of septicaemia its preparation and use
A therapeutic agent for the treatment of septicemia, its preparation and use, with application in the pharmaceutical industry and medicine. This therapeutic agent contains essential element, the...
|
|
|
6949507 |
Use of agents which bind G proteins for treating septic shock
The present invention provides for the use of G protein binding agents for prophylactic and/or therapeutic treatments of septic shock. The present invention provides methods of using agents which...
|
|
|
6943150 |
Survivin, a protein that inhibits cellular apoptosis and its modulation
The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this...
|
|
|
6939546 |
Model for testing immunogenicity of peptides
Assay methods for determining whether a peptide is likely to be immunogenic are based on a computer modeling of binding to a Class II MHC DR1 receptor. This is confirmed by competitive inhibition...
|
|
|
6939847 |
Use of colostrinin, constituent peptides thereof, and analogs thereof, as oxidative stress regulators
The present invention provides methods that utilize compositions containing colostrinin, an constituent peptide thereof, an active analog thereof, and combinations thereof, as an oxidative stress...
|
|
|
6936423 |
Anti-LTNF for in vitro assay of biological toxins
Lethal Toxin Neutralizing Factor has been isolated in purity from opossum serum by high pressure liquid chromatography (HPLC) fractionation. The amino acid sequence from the N-terminal for the...
|
|
|
6936586 |
Synthetic IL-10 analogues
The nonapeptide NH2-Ala-Tyr-Met-Thr-Met-Lys-Ile-Arg-Asn-COOH (SEQ ID NO: 1) and related molecules are useful as IL-10 agonists.
|
|
|
6933272 |
Use of non-peptidyl compounds for the treatment of insulin related ailments
The present invention relates to the use of at least a non-peptidyl compound as a biological modulator of insulin activity or insulin-related activity, which compound possesses ionic and...
|
|
|
6933274 |
Methods for treatment of diabetes using a peptide analogues of insulin
The present invention is directed toward peptide analogues of insulin B chain that are generally derived from peptides comprising residues 9 to 23 of the native B chain sequence. The analogues are...
|
|
|
6930091 |
Peptides and remedy for bone diseases containing the same as active ingredient
A new substance useful as a drug for the treatment of osteopathy is disclosed. The present invention provides a peptide and derivative thereof having an amino acid sequence SEQ ID NO: 1 designated...
|
|
|
6930085 |
G-type peptides to ameliorate atherosclerosis
This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, the...
|
|
|
6924268 |
Method for inactivating gonadotrophs
Certain toxic compounds (T) such as, for example, compounds based upon diphtheria toxin, ricin toxin, pseudomonas exotoxin, α-amanitin, pokeweed antiviral protein (PAP), ribosome inhibiting...
|
|
|
6923965 |
Modulators of polysaccharides and uses thereof
The present invention provides peptides with a specific affinity for glycosaminoglycan molecules. These peptides may have any number of functions, including but not limited to use as inhibitors of...
|
|
|
6921538 |
Therapeutic treatments for neuropsychiatric disorders
Methods for treating psychiatric disorders include intracranial administration of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A, to a human patient.
|
|
|
6913761 |
Bioimplant formulation
A pharmaceutical and/or veterinary formulation comprising about 2-30% (w/w) (on an active basis) of at least one active agent, about 0.5-20.0% (w/w) of a pore-foaming agent and the balance stearin....
|
|
|
6914048 |
Method for delivery of molecules to intracellular targets
Disclosed are β-peptides and β-peptide conjugates that are capable of diffusing or otherwise being transported across the cell membranes of living cells. The β-peptides contain at least six...
|
|
|
6911316 |
Medical uses of scuPA/suPAR complex
Methods of using a complex (scuPA/suPAR) which has thrombolytic activity under physiological conditions and in the presence of IgG, or of at least one IgG-derived peptide, which complex comprises a...
|
|
|
6906037 |
Therapeutic peptide-based constructs
The present invention relates generally to small peptide-based constructs and their therapeutic uses. The sequences of these peptide-based constructs are based on a reverse subsequence derived from...
|
|
|
6890902 |
Cytotoxic modified lactoferrin peptides
The present invention provides a modified lactoferrin peptide which is cytotoxic, 7 to 25 amino acids in length, with three or more cationic residues and which has one or more extra bulky and...
|
|
|
6887847 |
Virus derived antimicrobial peptides
The invention is directed to peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides of the present invention are analogs of the Lentivirus Lytic Peptide 1...
|
|
|
6881718 |
Disulfide conjugated cell toxins and methods of making and using them
The invention pertains to the discovery of novel disulfide linked cell toxins which can ablate NK-1 receptor expressing cells. These toxins are used as pharmaceutical compositions for the ablation...
|
|
|
6875609 |
Methods for the early diagnosis of ovarian cancer
The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically,...
|
|
|
6872705 |
Use of antimicrobial peptides as preservatives in ophthalmic preparations, including solutions, emulsions, and suspensions
Methods for preserving ophthalmic compositions are disclosed. In one embodiment, such compositions include a liquid medium and an antimicrobial component which is preferably substantially...
|
|
|
6863891 |
Oligopeptide lyophilisate, their preparation and use
A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the...
|
|
|
6858210 |
Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
The present invention provides domain 1 β 2 GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 β 2 GPI polypeptides and...
|
|
|
6858396 |
Positively charged non-natural amino acids, methods of making and using thereof in peptides
This invention relates to positively charged non-natural amino acids, methods of making thereof, and utilization thereof in peptides.
|
|
|
6855695 |
Water-soluble SHPs as novel alkylating agents
The present invention relates to compounds according to the structure (I):
Where R is —CH 3 or —CH 2 CH 2 Cl; R′ is C 1 -C 7 alkyl or —CH 2 CH 2 Cl; R 2 or R 4 is OPO 3 H 2 , NO 2...
|
|
|
6852696 |
Inhibitors of glycosaminoglycans
The present invention provides peptide derivatives with a specific affinity for glycosaminoglycan molecules. These peptide derivatives include multimers as well as chemically modified peptides and...
|
|
|
6852688 |
Compositions for treating diabetic retinopathy and methods of using same
The subject invention provides novel methods and materials for treating diabetic retinopathy. One embodiment of the subject invention involves the co-administration of a somatostatin, or analogue...
|
|
|
6852685 |
Use of colostrinin, constituent peptides thereof, and analogs thereof to promote neuronal cell differentiation
The present invention discloses a use of colostrinin, a constituent peptide thereof, and/or an analog thereof as a neural cell regulator in animals including humans.
|