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7521529 |
Differentially protected orthogonal lanthionine technology
The present invention provides a method of synthesizing an intramolecularly bridged polypeptide comprising at least one intramolecular bridge. The present invention further provides a method of...
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7521415 |
Methods of intracellular peptide delivery
Methods and kits for transporting heterologous compounds into cells, particularly mammalian cells, are disclosed. The method involves the pretreatment of the cell with a polycation, cationic...
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7517654 |
Peptide and a derivative thereof promoting cell adhesion and spreading
The present invention relates to a peptide promoting cell adhesion and spreading, fragments, and derivatives thereof, more particularly, integrin-α3β1-dependent peptide in human laminin-5 α3...
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7517855 |
Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
The present invention relates generally to peptides, which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, methods of making peptides, which inhibit angiogenesis, cell...
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7514407 |
Spheron component peptides and pharmaceutical compositions
The present invention relates to racemized proteins and racemized protein components of spherons that are useful for identifying compounds capable of preventing and/or ameliorating symptoms of...
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7511012 |
Myostatin binding agents
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one...
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7507717 |
Type II chi-conotoxin peptides (noradrenaline transporter inhibitors)
An isolated, synthetic or recombinant X-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5...
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7507718 |
Polymyxin B analogs for LPS detoxification
The invention relates to SAEP II peptide dimers that mimic polymyxin B i.a. in its ability to bind non-covalently the lipopolysaccharide (LPS) of Gram-negative bacteria with high affinity, and...
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7504381 |
Antimicrobial agents
A novel class of antimicrobial polymeric agents, which include a plurality of amino acid residues, such as positively charged amino acid residues, and at least one hydrophobic residue linking there...
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7501397 |
Helical peptidomimetics with enhanced activity
Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors have sequences with lengths from 11 to 16 amino acids, inclusive. These inhibitors potently...
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7501398 |
Inhibitor of the folding of the HIV-1-protease as antiviral agent
The invention relates to the design of inhibitors of the HIV-1-PR homodimer which do not create resistance, by blocking the folding of single monomers with the help of peptides which attach to...
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7498306 |
Peptides binding to the phosphatase 2A protein
The invention relates to novel synthetic or natural E4orf4 or Bcl-2 peptides particularly useful in antitumoral, antiviral and antiparasitic treatments, said peptides being less than 30 amino acids...
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7498404 |
Compositions, methods and uses for a novel family of peptides
The present invention includes compositions and methods for the characterization and use of novel peptide from Brevibacillus sp., and peptides related thereto, including an isolated and purified,...
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7494979 |
Method for treating congestive heart failure and other disorders
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders,...
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7491701 |
Peptides that bind to HSP90 proteins
YSLPGYMVKKLLGA (SEQ ID NO:1) and its active analogs, compositions, and methods of use.
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7491699 |
Peptide nanostructures and methods of generating and using the same
A tubular or spherical nanostructure composed of a plurality of peptides, wherein each of the plurality of peptides includes no more than 4 amino acids and whereas at least one of the 4 amino acids...
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7491690 |
Self-assembly and mineralization of peptide-amphiphile nanofibers
Peptide-amphiphilic compositions capable of self-assembly into useful nanostructures.
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7491691 |
Connective tissue stimulating peptides
Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or...
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7488793 |
Isolated peptide which binds to HLA-Cw*07 and uses thereof
Peptides which consist of amino acid sequences found in MAGEA3 bind to HLA-Cw*07 molecules to form T cell epitopes. The therapeutic and diagnostic ramifications of this are the subject of this...
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7488717 |
Methods of inhibiting chemokine binding to chemokine receptors
Novel peptides or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed...
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7485321 |
Peyer's patch and/or M-cell targeting ligands
Purified synthetic polypeptide ligands for targeting pharmaceutical agents and carriers comprising such agents to intestinal epithelial tissue, especially Peyer's patch and/or M-Cell tissue. Also...
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7482433 |
Peptides and compounds that bind to the IL-5 receptor
Interleukin-5 receptor (IL-5R) ligands comprising amino sequences of formula TGGGDGYVX 3 VEX 4 ARCPTCK, EGYVX 3 VEX 4 ARCPTCK, EGYVX 3 VEX 4 ARCPTCR, GYVX 3 VEX 4 ARCPTCG, EGYVX 3 VEX 4 ARCPTCG,...
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7482429 |
Kahalalide F and related compounds
A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity.
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7479483 |
Tumor-targeted drug delivery systems and uses thereof
The present invention relates to targeted delivery systems for delivering therapeutic agents to tumor. The invention further relates to methods of delivering a therapeutic agent to a tumor for the...
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7476656 |
Fluorescent affinity tag to enhance phosphoprotein detection and characterization
The invention relates to target-associative tags incorporating cysteamine as the target-associative moiety. The invention further relates to a method for producing a target-associative tag by...
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7473682 |
Angiogenic peptides and uses thereof
A peptide comprising an amino acid sequence as set forth in SEQ ID NO: 2, 4, 6, 8, 10 or 12 is provided. The peptide being at least 6 and no more than 50 amino acid residues in length. Also...
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7473679 |
Treatments employing neuronal exocytosis-inhibiting peptides
The peptide has a sequence of 3 to 30 adjacent amino acids from the amino end of protein SNAP-25 and is useful as neuronal exocytosis inhibitor. The cosmetic and pharmaceutical compositions contain...
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7465708 |
Branched cationic copolymers and methods for antimicrobial use
The invention provides a branched copolymer for the treatment of bacterial, fungal, and viral infections. The branched copolymer is characterized as having (i) at least 10 amino acids, (ii) at...
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7462462 |
Peptide capable of binding to nanographite structures
It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as...
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7462360 |
Alloferons—immunomodulatory peptides
The invention belongs to the field of biologically active peptides specifically stimulating antiviral, antimicrobial and antitumor activity of the human and animal immune system.
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7456252 |
Therapeutic peptides for demyelinating conditions
The invention provides peptide compositions and methods of making and using therapeutic compositions comprising peptides for the treatment of a subject having a demyelinating condition.
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7452867 |
Use of ADNF polypeptides for treating peripheral neurotoxicity
This invention relates to the use of ADNF polypeptides in the treatment of neurotoxicity induced by chemical agents or by disease processes. The ADNF polypeptides include ADNF I and ADNF III (also...
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7439228 |
Bioactive peptides
The present invention provides a cytotoxic 7 to 25-mer peptide with three or more catonic residues which has one or more non-genetic bulky and lipophilic amino acids, as well as esters, amides,...
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7438890 |
Binding peptides for carcinoembryonic antigen (CEA)
The present invention provides binding moieties for CEA, which have a variety of uses wherever detecting, isolating or localizing CEA, and particularly CEA as opposed to cross-reactive antigens...
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7435716 |
Compounds pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia
Novel conjugates of bacterial outer membrane binding peptides, preferably having bacterial sensitization activity, and immune cells chemotactic peptides, and pharmaceutical compositions containing...
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7435721 |
Transport peptides such as C-terminal Erns peptide and analogues thereof
The invention relates to peptides derived from or similar to the E rns protein of pestiviruses for type-specific diagnosis of infection, for eliciting antibiotic activity, and for transport of...
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7435718 |
CXCR4 antagonist treatment of hematopoietic cells
In accordance with various aspects of the invention, CXCR4 antagonists may be used to treat hematopoietic cells, such as progenitor or stem cells, to promote the rate of cellular multiplication,...
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7435790 |
Dihydroxypropyl cysteine peptide and agent containing this peptide
The invention relates to a S-(2,3-dihydroxypropyl)-cysteine peptide which has two long-chain fatty acids bonded in the form of esters at the dihydroxypropyl group, and which has the following...
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7432246 |
Sir2 products and activities
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from...
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7425541 |
Enzyme-cleavable prodrug compounds
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is...
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7423114 |
GD2 ligands
The invention provides ligands of ganglioside GD2, including peptide ligands such as GGITNYNSALM; YCGGITNYNSACY; YCITNYNSCY; YCGGITNYNCY; YCTNYGVHCY; YCTNYGVCY; GGIANYNTS; YCGGIANYNCY;...
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7417025 |
Use of poly-α2,8-sialic acid mimetic peptides to modulate NCAM functions
The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a...
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7417023 |
Targeted delivery of bioaffecting compounds for the treatment of cancer
A homogeneous conjugate for targeting and treating diseased cells wherein the conjugate comprises an anti-cancer drug and a targeting protein, wherein said anti-cancer drug is selected from the...
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7414023 |
Peptide ligands for prostate specific antigen
The present invention relates to novel peptide ligands for prostate specific antigen (PSA) binding specifically with it and enhancing its enzyme activity, to a process for preparation of these...
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7410950 |
Peptides of CaV2.2 that inhibit pain
The present invention relates to peptides of CaV2.2 and their use in the treatment of pain. The sequence of the peptides is derived from the C-terminus of CaV2.2. and is believed to inhibit the...
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7410949 |
Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
Provided herein are neuropeptide-2 receptor agonists of the formula (I):
Y—R 1 —R 2 —X—R 3 —R 4 —R 5 —R 6 —R 7 —R 8...
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7408025 |
Lipopeptides as antibacterial agents
The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial...
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7402653 |
Biologically active peptides
Thirty substantially pure and biologically active peptides are disclosed. Nucleic acids that have sequences coding for the biologically active peptides and pharmaceutical formulations produced...
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7399826 |
Peptide for promoting healing of fractures
The peptide for promoting healing of fractures is a 13-amino acid peptide which is sequenced and synthesized in the laboratory. The peptide SHMSP has the sequence represented by the formula...
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7396815 |
Cosmetic or pharmaceutical composition containing peptides
A cosmetic and/or dermatological and/or pharmaceutical composition includes, as the active ingredient, at least one peptide with sequence X 1 -Y-Phe-Thr-X 2 -Ala-Thr-Z-Ile-X 3 -Leu-X 4 -Phe-Leu-X 5...
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