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5439884 |
Method of controlling fertilization using bombesin or its agonist
A method of promoting or blocking fertilization, which method includes the step of contacting sperm either at the time of sperm capacitation or at the time of egg fertilization with an effective...
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5436221 |
Tumor metastasis inhibiting compounds and methods
A peptide derivative containing 1 to 20 units of peptide unit represented by the following general formula [I] or a pharmaceutically acceptable salt thereof; [Z]--Arg--X--Asp--[Y] ...
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5434133 |
CNP analog peptides and their use
Novel peptides represented by the general formula: ##STR1## and physiologically acceptable acid addition salts thereof; where (A) represents H-, H-Gly, H-Lys-Gly, H-Ser-Lys-Gly, H-Leu-Ser-Lys-Gly,...
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5433940 |
Inhibitors of thrombin
This invention relates to novel biologically active molecules which bind to and inhibit thrombin. Specifically, these molecules are characterized by a thrombin anion-binding exosite association...
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5430021 |
Hydrophobic drug delivery systems
A pharmaceutical preparation including a drug incorporated into hydrophobic particles comprised of long chain carboxylic acid or ester thereof or long chain alcohol, wherein the particles are...
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5428116 |
Synthesis of complex polyamines for ampholyte production
New synthesis and analysis procedures for novel crosslinked polyamines and ampholytes. Polyamines are crosslinked with tartaric acid ester, malonic acid ester, or polycarboxylic acid esters of the...
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5426100 |
Piptide fragments and analogs of thrombospondin
Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
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5426099 |
Process for inducing analgesia, peptides and therapeutic compositions
Peptides having two or more amino acid residues in the sequence of the amino acid residues of vasoactive intestinal peptide (VIP) segment 11-28, analogs and derivatives thereof and pharmaceutically...
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5422341 |
Motilin-like polypeptides with gastrointestinal motor stimulating activity
This invention pertains to polypeptides, other than motilin, having gastrointestinal motor stimulating activity and represented by the formula: ##STR1## wherein A and D are lipophilic aliphatic or...
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5411943 |
Hepatoma treatment with somatostatin analogs
A method for treating liver cancer in a mammalian subject. The method includes administering to the subject a composition which contains a therapeutically effective amount of an octapeptide of the...
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5409898 |
Compositions and methods for treating infections caused by organisms sensitive to β-lactam antibiotics
The invention is directed to compositions and methods for treating an infection caused by an organism susceptible to a β-lactam antibiotic comprising two or more active agents. In one embodiment,...
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5407914 |
Pulmonary surfactant protein and related polypeptides
The present invention discloses useful peptides and synthetic pulmonary surfactants, as well as methods of making and using same. In a preferred embodiment, a synthetic pulmonary surfactant...
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5403824 |
Methods for the treatment of osteoporosis
Methods of treatment for osteoporosis in a human or other animal subject, comprising administering to said subject a safe and effective amount of an active selected from the group consisting of...
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5401628 |
Polypeptides derived from the human immunodeficiency virus endonuclease protein
A polypeptide linked to a solid matrix useful as a solid support of a diagnostic kit is disclosed. The polypeptide has the formula:...
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5380668 |
Compounds having the antigenicity of hCG
Disclosed are compounds having antigenic binding affinity with antibodies directed against human chorionic gonadotropin. The compounds typically include or consist of an oligopeptide with the...
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5376637 |
Pharmaceutical preparation containing vasoactive intestinal polypeptide or its analogue
There is disclosed a pharmaceutical preparation which contains vasoactive intestinal polypeptide (VIP), its analogue or a salt thereof, and a surfactant. The preparation shall contains further a...
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5374431 |
Synthetic bioadhesive
This invention pertains to a synthetic adhesive composition for use in aqueous environments. The composition comprises polypeptide chains having an α-helical structure in aqueous environments and...
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5374621 |
Neurotensin method for inhibiting vascular leakage
A method of retarding vascular leakage caused by tissue injury comprises administering a neurotensin or a neurotensin analog (SEQ ID NO: 1) at dosages sufficient to prevent or retard injury induced...
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5372933 |
Polypeptides that mimic receptor-induced binding sites, and methods of using same
Receptor-induced binding sites (RIBS) expressed in a ligand when that ligand is bound in a complex with a receptor are disclosed, as are polypeptides that correspond in amino acid residue sequence...
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5371071 |
Peptide and pseudopeptide compounds which are therapeutically active in the blood coagulation cascade
The invention relates to the compounds of formula (I): X - A 1 - A 2 - A 3 - A 4 - A 5 - A 6 - A 7 - A 8 - A 9 - A 10 - Y (I) in which X, A 1 , A 2 , A 3 , A 4...
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5369094 |
Polypeptide bombesin antagonists
Pseudopeptides comprising a peptide of formula I: X-A 1 -A 2 -Trp-Ala-Val-Gly-His-Leu- psi -A 9 -Q wherein X is hydrogen, a single bond linking the alpha amino group of A 1 to the gamma...
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5366734 |
Continuous release pharmaceutical compositions
Pharmaceutical compositions, comprising a polylactide and a pharmacologically active, acid stable polypeptide, which when placed in an aqueous physiological environment release the polypeptide at...
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5364841 |
Treatment of obesity and essential hypertension and related disorders
The administration of antagonists and blockers of amylin or CGRP or both for the treatment of obesity and essential hypertension and associated lipid disorders and atherosclerosis.
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5338725 |
Anti-aggregatory agents for platelets
The present invention provides synthetic antiaggregatory agents for preventing inhibition of fibrinogen-platelet binding. These anti-aggregatory agents have the general formulas (1)-(5). ...
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5304496 |
Biological regulation of mineralization
An aspartic acid rich protein isolated from human urine, as well as proteins having substantial homology thereto and active portions of the foregoing are effective modulators of mineralization in...
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5281581 |
Treatment of insulin resistance
Compounds and methods for blocking the effects of diabetes-associated peptide, or "amylin", a hormone found in the amyloid masses of Type 2 diabetics. This putative hormone has been discovered to...
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5266562 |
Anti-inflammatory agents
Synthetic oligopeptides having potent anti-inflammatory and phospholipase A 2 inhibiting properties are described. A method of controlling inflammation of body tissue is also described.
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5260272 |
Polyanionic polyamino acid inhibitors of mineral deposition and their synthesis
Polypeptides of the formula poly (X) m (Y) n , wherein X is selected from the group consisting of aspartate, glutamate, glutamine, asparagine, mixtures and block polymers thereof, Y is...
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5260273 |
Pulmonary surfactant protein and related polypeptide
A synthetic pulmonary surfactant comprising a pharmaceutically acceptable phospholipid admixed with a polypeptide comprising at least 10 amino acid residues and no more than about 60 amino acid...
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5260276 |
Linear and monocyclic endothelin antagonists
Novel linear and monocyclic antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling...
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5256559 |
Methods and compositions for inhibiting platelet aggregation
This invention relates to anticoagulant and platelet inhibitory compositions, combinations and methods characterized by biologically active peptides which display the anticoagulant and platelet...
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5254535 |
Composition and treatment with biologically active peptides and antibiotic
A composition comprising at least one biologically active amphiphilic peptide, said peptide being an ion channel-forming peptide, and an antibiotic selected from the class consiting of bacitracins,...
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5254537 |
Composition and treatment with peptide combinations
A composition comprising a magainin peptide or an analogue or derivative thereof, and at least one member selected from the group consisting of a PGLa peptide or analogue or derivative thereof, and...
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5252467 |
Method of making antibodies to antigenic epitopes of IGE present on B cells but not basophil cell surface or secreted, soluble IGE
A method for producing antibodies specific for antigenic associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane is disclosed. The epitopes...
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5244883 |
Nonapeptide bombesin antagonists
The novel pseudo polypeptides of this invention are potent bombesin antagonists. There are provided processes for their production, pharmaceutical compositions comprising said polypeptides and...
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5242904 |
Peptide boronic acid inhibitors of trypsin-like proteases
Peptides comprising C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, are reversible inhibitors of trypsin-like...
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5242902 |
Defensin peptide compositions and methods for their use
A method for treating cutaneous and corneal wounds as well as certain microbial-related diseases comprises topically applying a defensin peptide to the affected tissue. The compositions comprise a...
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5240912 |
Transforming growth factor (TGF) peptides
Novel biologically active polypeptides, including a new class of transforming growth factor (TGF) polypeptides, which exhibit cell growth promoting properties are disclosed, as well as a process...
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5238919 |
Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor
This invention provides a peptide fragment of human von Willebrand Factor (vWF) and sub-fragment thereof isolated as enzymtic digestion products from naturally occurring human vWF, or isolated from...
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5236898 |
Cyclic anticoagulant peptides
This invention relates to cyclic peptide derivatives which are useful anticoagulant agents.
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5236903 |
Polypeptide comprising repeated cell-adhesive core sequences
A polypeptide comprising repeated amino acid sequences of a cell-adhesive protein represented by the formula: (Arg-Gly-Asp)n or (Tyr-Ile-Gly-Ser-Arg)n wherein n is a number ranging from 2 to 20;...
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5225205 |
Pharmaceutical composition in the form of microparticles
A method for preparing a pharmaceutical composition in the form of microparticles, the composition thus obtained and its use for preparing injectable suspensions.
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5223484 |
Peptide which regulates weight gain in mammals
A dodecapeptide for regulating weight gain in mammals, as defined in the sequence: CHHRKKGYADLY wherein C is cysteine, H is histidine, R is arginine, K is lysine, G is glycine, Y is tyrosine, A...
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5217955 |
Treatment of cancer with peptide analog of bombesin, GRP, litorin or neuromedin
A method of treating cancer in a human patient, the method involving administering to the patient a cancer cell inhibiting amount of an analog of a naturally occurring biologically active peptide...
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5212156 |
SRIF-related peptides and uses thereof
Compositions and methods for modulating SRIF activity as well as enhancing the reproductive performance and immunological function in vertebrates are disclosed. Compositions containing SRIF-related...
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5211657 |
Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
The present invention relates to peptides and derivatives thereof having laminin-like activity. The invention further relates to pharmaceutical compositions containing these peptides, to antibodies...
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5210075 |
Interleukin 6 antagonist peptides
Peptides and derivatives useful as antagonists to interleukin 6, and uses for the same, are disclosed.
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5204097 |
Shiga toxin B chain polypeptides and vaccine thereto
The invention relates to a number of synthetic polypeptides which correspond to a part of the sequences of the Shiga B peptide chain. More specifically, the invention relates to polypeptides...
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5200397 |
Use of peptide analogs of thrombospondin for the inhibition of angiogenic activity
Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
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5198425 |
Inhibitors of bacterial ribonucleotide reductase
Disclosed herein are peptides of the formula Y--R 1 --R 2 --R 3 --R 4 --R 5 --R 6 --R 7 --R 8 --R 9 --Z wherein R 1 to R 9 are designated amino acid residues; Y is hydrogen or lower...
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