|
Match
|
Document |
Document Title |
|
|
5753625 |
Treatment for inhibiting the progression of autoimmune disease
The progression of autoimmune disease is inhibited by the administration of peptides having the sequence of MHC Class I antigen α1-domains. These fragments include the amino acids between...
|
|
|
5753615 |
Neuropeptides and their use as insecticides
This invention relates to novel neuropeptides isolated from Calliphora vomitoria, which are suitable for use in insecticidal formulations for controlling insects.
|
|
|
5750499 |
Receptor-selective somatostatin analogs
Analogs of SRIF which are selective for SSTR1 in contrast to the other cloned SRIF receptors. These analogs are useful in determining the tissue and cellular expression of the receptor SSTR1 and...
|
|
|
5750358 |
Quantitative clotting assay for activated factor VII
An assay for activated factor VII (factor VIIa) has been developed using truncated tissue factor (tTF), a soluble mutant form of tissue factor (TF) that retains the cofactor function of TF toward...
|
|
|
5747447 |
Stable polypeptide composition
A (injectable biologically active) polypeptide is stabilized by dissolving said polypeptide forming a liquid solution in citrate buffer of about pH 5.0-5.5.
|
|
|
5747451 |
Peptide derivatives having binding activity to modified low density lipoprotein
Peptide derivatives represented by the formula (I): ##STR1## which can specifically bind to modified LDL in competition with scavenger receptors on macrophages and are useful in diagnosing,...
|
|
|
5747457 |
Linear adhesion inhibitors
Linear peptides of the formula I X-A-Cys(R 1 )-B-Z I, in which A, B, R 1 , X and Z are as defined, are highly active inhibitors of the binding of the...
|
|
|
5744449 |
Lethal toxin neutralizing factors
Opossum whole serum exhibits a life saving property by neutralizing the lethality of venoms from all major families of poisonous snakes, and therefore an injection of Opossum serum can used as a...
|
|
|
5744135 |
Method of raising an immune response with an anti-idiotypic antibody having correspondence with human hepatitis B surface antigen
The invention comprises an anti-idiotypic antibody designated 2F10 and permitted variants thereof, which have antigenic properties similar to the group specific "a" determinant of human hepatitis B...
|
|
|
5744445 |
Method of treating pulmonary disease states with non-naturally occuring amphipathic peptides
A method of treating pulmonary disease states, e.g., a disease state selected from the group consisting of: cystic fibrosis, neoplasias, bronchogenic cancers, pneumonia, bronchitis,...
|
|
|
5736507 |
Peptides derived from autoantigen for use in immunotherapy of autoimmue diseases
The present invention relates to novel peptides derived from the autoantigen HC gp-39, said peptides comprising at least one of the amino acid sequences FGRSFTLAS (SEQ ID No. 1), FTLASSETG (SEQ ID...
|
|
|
5736517 |
Treatment of cancer with peptides
A method of treating cancer in a human patient, the method involving administering to the patient a cancer cell inhibiting amount of an analog of a naturally occurring biologically active peptide...
|
|
|
5733880 |
Anthracene derivatives for use as anticancer agents
A compound having the structural formula, ##STR1## where R 1 and R 2 are independently hydrogen or hydroxyl. R 2 and R 3 are independently oxo or hydrogen, one of R 5 and R 6 is A--B and the...
|
|
|
5731289 |
Double-chain hemoregulatory peptides
The present invention relates to peptide compounds comprising two single-chain hemoregulatory, for example haemopoiesis-inhibiting, peptides linked by a bridging group terminally attached to the...
|
|
|
5723436 |
Calcineurin interacting protein compositions and methods
An identification and characterization of a calcineurin interacting protein effective to enhance immunosuppressive effects of calcineurin-targeted immunosuppressants by potentiating an interaction...
|
|
|
5714464 |
Anti-viral mushroom extracts
A substantially pure compound extracted from the mushroom Rozites caperata is disclosed. The compound disclosed is SEQ ID NO:1, a twelve amino acid peptide, covalently linked by the epsilon amino...
|
|
|
5714468 |
Method for reduction of migraine headache pain
The invention is a method for reducing headache pain and symptoms associated with the onset or occurrence of headache in mammals. The method is performed by delivering an invertebrate presynaptic...
|
|
|
5712160 |
Method of stimulating growth using neurotrophic peptides
The present invention involves peptides derived from nerve growth factor receptor protein. Such peptides are characterized by competing for NGF binding to NGF receptor at high concentrations while...
|
|
|
5710128 |
Pharmaceutical compositions of lipopolysaccharide-binding polypeptides
A novel polypeptide sequence having the formula ##STR1## in which A 1 is a hydrogen or at least one and no more than two amino acids selected from the group consisting of lysine and arginine, A...
|
|
|
5710126 |
T cell epitopes of ryegrass pollen allergen
The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne. Therapeutic peptides within the scope of the invention comprise at least one T...
|
|
|
5700779 |
Bradykinin antagonist peptides incorporating N-substituted glycines
The present invention provides bradykinin type peptides containing N-substituted glycines, particularly bradykinin antagonist peptides useful for the treatment of conditions mediated by bradykinin...
|
|
|
5696087 |
Method and compositions for reducing cholesterol absorption
Compositions including all or a portion and chemically or recombinantly synthesized analogues of the carboxy terminal region of bile salt-activated lipase (BAL) are described, which, when orally...
|
|
|
5696093 |
Method of treating nasal congestion using neuropeptide Y Y2 agonist peptides
The invention relates to neuropeptide Y-Y 2 receptor specific peptides. Preferred peptides areas follows: ##STR1## The peptides are preferably used in relieving nasal congestion.
|
|
|
5691311 |
Methods for coating invasive devices with inhibitors of thrombin
This invention relates to novel biologically active molecules which bind to and inhibit thrombin. Specifically, these molecules are characterized by a thrombin anion-binding exosite association...
|
|
|
5691307 |
O.sup.6 -substituted guanine compositions and methods for depleting O.sup.6
Novel O 6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O 6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful...
|
|
|
5688770 |
Antiglaucoma compositions and methods
The present invention relates to ophthalmo-logical pharmaceutical compositions comprising a renin inhibitor and to methods for using said composition in the treatment of glaucoma.
|
|
|
5688760 |
Polypeptides having bone resorption inhibitory activity comprising PTHrP-derived sequences
Polypeptides comprising an N-terminal amino acid sequence corresponding to amino acids 107-111 of parathyroid hormone related protein (PTHrP) having bone resorption inhibitory activity are...
|
|
|
5683982 |
Synthetic lung surfactant having antioxidant properties
Synthetic pulmonary surfactants having antioxidant properties consisting of a complex of a polypeptide, with an antioxidant moiety, having an alpha-helical structure and a lipid consisting of one...
|
|
|
5681568 |
Device for delivery of substances and methods of use thereof
This invention comprises devices and methods for producing a composite microporous membrane specifically tailored to be useful for optimizing the delivery of macromolecules to a therapeutic target.
|
|
|
5679640 |
Immunosuppressant peptides
Peptide compositions are provided which bind MHC molecules of interest and inhibit T cell activation. The peptide compositions of the present invention comprise various isosteres of naturally...
|
|
|
5679639 |
Serine protease derived-polypeptides and anti-peptide antibodies, systems and therapeutic methods for inhibiting coagulation
The present invention describes polypeptides and anti-peptide antibodies capable of inhibiting serine protease enzymatic activity. In particular, polypeptides and anti-peptide antibodies derived...
|
|
|
5677276 |
Immobilization of peptides to hyaluronate
The present invention provides novel conjugates of a synthetic polypeptide containing RGD or (dR)GD and a biodegradable polymer, hyaluronate. The conjugates are prepared by any one of three...
|
|
|
5674848 |
Bioreactor compositions with enhanced cell binding
Compositions of the invention include packing materials having compounds thereon with enhanced cell binding with respect to collagen. These packing materials are useful for in vitro uses such as...
|
|
|
5670484 |
Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders
The invention is a method for treatment of cutaneous cell-proliferative disorders. More specifically, the method of the invention is useful in mitigating and inducing remission of lesions...
|
|
|
5670481 |
Dorsal tissue affecting factor (noggin) and compositions comprising same
A novel and soluble polypeptide that is highly conserved among vertebrates has been discovered, which is designated "noggin." The properties of noggin include dorsal growth inducing activity....
|
|
|
5670483 |
Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are...
|
|
|
5668109 |
Peptides for inhibiting pepsin release
Peptides derived from the C terminal sequence of sorbin, but containing at least one D-amino acid residue, inhibit pepsin release and are therefore likely to be useful in the treatment of ulcers or...
|
|
|
5658885 |
Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
This invention relates to Novel α-aminoacid and α-aminoboronic acid and corresponding peptide analogs of the following formula: ##STR1##
|
|
|
5652211 |
Peptides for neutralizing the toxicity of Lipid A
The present invention is concerned with a peptide composition which includes a peptide having units of the formula: (a) (A) n wherein A is Lysine or Arginine and n is an integer with a minimum...
|
|
|
5650392 |
Method and composition for the treatment of septic shock
The present invention contemplates a composition and method for treating septic shock in a mammal or as a prophylactic treatment prior to a surgical procedure, comprising administering a...
|
|
|
5650393 |
Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems
Amphiphilic derivatives of amino acids or peptides are provided, comprising a polyhydroxylated hydrophilic part derived from a sugar, from a polyol, from an aminopolyol or from an oligosaccharide,...
|
|
|
5650394 |
Use of urinastatin-like compounds to prevent premature delivery
The present invention provides a method of diagnosing and treating a pregnant female at risk for impending preterm delivery. The method comprises the step of diagnosing imminent preterm delivery by...
|
|
|
5646119 |
D-amino acid histatin-based peptides as anti-fungal and anti-bacterial agents
D-amino acid histatins and histatin-based peptides histatins and methods for treatment of fungal or bacterial infection are described. These D-amino acid histatins and histatin-based peptides are...
|
|
|
5643872 |
Cyclic anti-aggregatory peptides
This invention relates to compounds of the formula: ##STR1## wherein: A' is absent, Asn, Gln, Ala or Abu; A is absent or a D- or L-amino acid chosen from Arg, HArg, (Me 2 )Arg, (Et 2 )Arg, Abu,...
|
|
|
5641751 |
Tumor necrosis factor inhibitors
Peptides which consist of 4-25 amino acids and which bind to tumor necrosis factor-alpha, prevent tumor necrosis factor-alpha from binding to its receptors and inhibit tumor necrosis factor-alpha...
|
|
|
5639726 |
Peptide mediated enhancement of thrombolysis methods and compositions
The invention relates generally to peptides which decrease the half-life of active plasminogen activator inhibitor-1. This invention further relates to methods and compositions for using peptides...
|
|
|
5633230 |
Treatment of cytomegalovirus infection
Described herein are anti-cytomegalovirus peptides. In a preferred embodiment, the peptide is acetyl-[D-Arg] 9 -NH 2 . The use of these peptides, either per se or in combination with other...
|
|
|
5632988 |
Polypeptide inhibitors of gamma interferon
Novel synthetic polypeptides comprising the amino acid subsequence Arg-Arg-Lys-Trp-Gln are provided by this invention. Also provided are methods for the use of such polypeptides, other known...
|
|
|
5630842 |
Biocompatible surgical implant
The invention provides a biocompatible surgical implant particularly useful for breast or testicular reconstruction or augmentation comprising a stabilized fibrin semisolid, optionally sealed in a...
|
|
|
5622702 |
Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a...
|