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5900235 |
Interleukin-8 as an antiviral and antitumor agent
Interleukin-8 (IL-8) and analogs thereof is useful in the treatment of viral infections, caused by human and animal viruses, and cancers caused by oncoviruses.
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5897863 |
LHRH hormones
An analogue of lutenising hormone-releasing hormone (LHRH) having the amino acid sequence: pGlg-His-Trp-Ser-Tyr-X-Len-Arg-Pro-Gly-Y-Z wherein X represents Gly or a D-amino acid, Y represents one...
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5891851 |
Antibiotic, feglymycin, processes for its preparation and its use
This invention relates to the antibiotic feglymycin, as well as processes for its preparation and use. Feglymycin is represented by the structural formula (SEQ ID NO:1): ##STR1##
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5891847 |
Treatment of degenerative eye disorders
Retinal dystrophies are treated by melanotropin peptides or analogs.
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5891848 |
Peptide fragments
Peptide fragments and their pharmaceutically acceptable salts, and therapeutic agents containing one or more of them as an effective component possess excellent therapeutic activity for improving...
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5885965 |
Anti-fungal D-amino acid histatin-based peptides
D-amino acid histatins and histatin-based peptides and methods for treatment of fungal or bacterial infection are described. These D-amino acid histatins and histatin-based peptides are...
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5879656 |
Methods of treating metastatic colorectal cancer with ST receptor binding compounds
Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or...
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5880094 |
Polypeptides that stimulate bone growth
Polypeptides which stimulate bone growth are described based on the sequences: (a) Gly Ile Gly Lys Arg Thr Asn Glu His Thr Ala Asp Cys Lys Ile Lys Pro Asn Thr Leu His Lys Lys Ala Ala Glu Thr Leu...
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5880095 |
Cholesteryl ester transfer protein inhibitor peptides and prophylactic and therapeutic anti-arteriosclerosis agents
A peptide consisting of the following amino acid sequence, or an analogue or a fragment thereof, has an inhibitory activity on cholesteryl ester transfer protein: Glu Asp Thr Ser Pro Glu Asp Lys...
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5877154 |
Pharmaceutical compositions for the treatment or prevention of disorders in the eye
Eye diseases or disorders are treated by an active agent being a melanotropin peptide or an analogue thereof, the analogue being an agent having a biological effect resembling that of the...
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5874405 |
Heat shock protein peptides that share sequences with cyclic nucleotide phosphodiesterase and methods for modulating autoimmune central nervous system disease
The invention provides for peptides and methods of using peptides to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are antigens derived from...
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5863900 |
Lhrh antagonists
The present invention provides novel LHRH antagonists and complexes between these antagonists and VB12. The present invention is particularly useful for the oral administration of LHRH antagonists....
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5856087 |
Method for detecting immune response to hepatitis B
The invention comprises an anti-idiotypic antibody designated 2F10 and permitted variants thereof, which have antigenic properties similar to the group specific "a" determinant of human hepatitis B...
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5855884 |
Treatment of stress-induced migraine headache with a corticotropin releasing hormone blocker
Non-traumatic immobilization (restrain) stress causes rapid degranulation of rat dura mast cells, as shown both by light and electron microscopy. These morphologic findings were accompanied by...
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5854204 |
Aβ peptides that modulate β-amyloid aggregation
Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural...
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5851994 |
Compositions that inhibit wound contraction and methods of using same
The present invention provides methods for reducing or inhibiting wound contraction in a subject having a wound comprising administering to the subject a pharmaceutical composition comprising a...
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5846548 |
Combined administration of mitogenic immumo stimulator and a thymomimetic
A method of tumor therapy involves controlling the immune system by co-administration of a mitogenic immuno-stimulating substance and a thymomimetic substance.
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5843882 |
Antiviral proteins and peptides
The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention...
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5840692 |
Peptide fragments and analogs of thrombospondin
Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
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5840682 |
Peptide antagonists of neurotensin
The invention is directed to a compound of formula ##STR1## in which R represents a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH 2 --COOH radical, R 1 represents a hydrogen atom, an...
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5840688 |
Eating suppressant peptides
Peptides corresponding to specific portions of the apolipoprotein A-IV (apo A-IV) are provided. Most of the peptides correspond to the amino terminal region of apo A-IV. In addition, those peptides...
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5840306 |
DNA encoding human papillomavirus type 18
The present invention is directed to DNA molecules encoding purified human papillomavirus type 18 and derivatives thereof.
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5840690 |
Regulation of cell proliferation and differentation using peptides
Disclosed are methods of inhibiting proliferation and enhancing differentiation of a mammalian cell, inducing proliferation of a mammalian cell, enhancing wound healing, and stimulating hair growth...
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5840691 |
Method for treating ischemia using polypeptides with fibronectin activity
Methods for treating ischemia using polypeptides with fibronectin related activity are provided. The methods involve administering an effective amount of one or more polypeptides which include an...
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5834430 |
Potentiation of antibiotics
The present invention is concerned with methods of potentiating an antibiotic. The invention also includes compositions of an antibiotic and a peptide having units of the formula: (a) (A) n ...
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5830851 |
Methods of administering peptides that bind to the erythropoietin receptor
Peptides of 10 to 40 or more amino acid residues in length and having the sequence X 3 X 4 X 5 GPX 6 TWX 7 X 8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter...
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5830854 |
Method of treating cystic fibrosis using a tachykinin receptor antagonist
Tachykinin receptor antagonists are useful for the treatment of cystic fibrosis.
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5830860 |
Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are preferably about 10 to 100...
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5821225 |
Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which...
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5821226 |
BAL C-tail drug delivery molecules
Drug delivery conjugates of including a BAL C-tail peptide including all or a portion of the carboxy terminal region of human bile salt-activated lipase (BAL) conjugated to a biologically active...
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5811394 |
Technetium-99m labeled polypeptides for imaging
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides...
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5807819 |
Peptides useful for altering bone resorption
The present invention provides Arg--Gly--Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also...
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5807827 |
Des-Tyr dynorphin analogues
Novel peptides of the invention are dynorphin analogues and have similar activity to endogenous dynorphin, but are des-Tyr or des-Tyr-Gly with respect to endogenous dynorphin and have at least...
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5807693 |
Calcineurin inhibitory compounds and anchoring protein
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are...
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5801149 |
Inhibition of signal transduction molecules
A peptide capable of inhibiting the interaction of an SH2 domain containing protein with a second protein.
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5795866 |
ETS1 gene: a human tumor suppressor gene
The present invention relates, in general, to methods for reducing cell tumorigenicity. More particularly, the present invention provides a method for reducing cell tumorigenicity comprising...
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5789382 |
Retro-peptide fibroblast growth factor which blocks FGF receptor
A fibroblast growth factor receptor-blocking peptide is provided. In one embodiment, the peptide is a retro-peptide of the fibroblast growth factor receptor. The receptor-blocking peptide may be...
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5786324 |
Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are about 10 to 100 amino acids...
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5786322 |
Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1
Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking...
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5783179 |
C-reactive protein fragment with immunomodulatory activity
Compounds having immunomodulatory activity comprising the optionally modified dodecapeptide fragment A-(SEQ ID No: 1)-B corresponding to residues 174 to 185 of C-reactive protein (CRP),...
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5776899 |
Polypeptide and anti-HIV agent prepared therefrom
A polypeptide represented by formula (I), and one example of such polypeptide be represented as formula 1 is presented. The above presented polypeptide may be useful in a pharmaceutical composition...
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5773412 |
Use of peptides for altering α.sub.V β.sub.3 -mediated binding
The present invention provides Arg--Gly--Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also...
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5773413 |
Method of combating mammalian neoplasias, and lytic peptides therefor
A method of treating neoplasias, including female mammalian neoplasias such as breast, cervical, uterine, and ovarian neoplasias, as well as other neoplasias including prostatic, dermal, and...
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5770565 |
Peptides for reducing or inhibiting bone resorption
The present invention provides Arg-Gly-Asp peptides that can reduce or inhibit the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention...
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5767078 |
Agonist peptide dimers
The present invention is directed to the dimerization of agonists and antagonists of cell surface receptors and particularly to peptide dimers which behave as cell surface receptor agonists in...
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5767234 |
Peptides and compounds that bind to the IL-1 receptor
Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids...
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5763402 |
Promotion or inhibition of spermatogenesis
A method of promoting or inhibiting spermatogenesis, said method comprising administering to a male an effective amount of PACAP, a PACAP agonist, a PACAP antagonist, PC4, a PC4 agonist, or a PC4...
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5753226 |
Methods of enhancing epithelial cell proliferation
Methods of enhancing epithelial cell proliferation are disclosed. The methods comprise the step of contacting epithelial cells with a compound that binds to reovirus type 3 receptor. Methods of...
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5753628 |
Peptide inhibitors of TNF containing predominantly D-amino acids
Peptides which consist of six to eight, predominately D-amino acids and which bind to tumor necrosis factor-alpha, prevent tumor necrosis factor-alpha from binding to its receptors and inhibit...
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5753621 |
Pulmonary surfactant protein fragments
This invention discloses that certain fragments of a pulmonary surfactant protein exhibit unexpected surface activity. These protein fragments are useful in preparing formulations for the treatment...
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