Patents in Class 514/13.8

Matches 1 - 50 out of 73

1 2 >

Match	Document	Document Title
1	8119135	Antibodies which bind to epitopes of glycoprotein VI The present invention provides anti-thrombotic agents, methods for screening for said anti-thrombotics agents and methods of treating thrombotic and other cardiovascular disorders.
2	8119137	Prevention of thrombus formation and/or stabilization with inhibitors of factor XII or activated factor XII The present invention relates to the use of at least one antibody and/or one inhibitor for inhibiting factor XII and preventing the formation and/or the stabilization of three-dimensional thrombi....
3	8048421	Agonist antibody to human thrombopoietin receptor This invention provides an agonist antibody to a human thrombopoietin receptor (alias: human c-Mpl). More particularly, this invention provides an agonist antibody to a human thrombopoietin...
4	7947282	Methods of treatment using vascular occlusion in combination therapies The present invention relates generally to methods and compositions for treating a disease or condition by administering a first therapeutic protocol comprising targeting and delivering solid-phase...
5	7928066	Recombinant platelet collagen receptor glycoprotein vi and its pharmaceutical use The invention relates to Glycoprotein VI (GPVI), its isolation, purification, and methods for recombinant production. Especially, the invention relates to the use of GPVI, preferably recombinant...
6	7879793	Treatment of medical condition with A2 domain of von willebrand factor The present invention is directed to methods for the prevention, treatment and/or diagnosis of a medical condition, such as sepsis, systemic inflammatory reaction syndrome, and/or thrombosis, for...
7	7645739	Modified annexin compositions and methods of using same Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrhage, enhancing the survivability of...
8	7635676	Modified annexin proteins and methods for their use in organ transplantation Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrhage and to attenuate...
9	7585844	Myosin light chain kinase inhibitors and methods of use Disclosed are inhibitors of myosin light chain kinase, pharmaceutical compositions and kits comprising the inhibitors and methods of use.
10	7579013	Formulations for coated microprojections containing non-volatile counterions The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation.
11	7354897	Method and composition for inhibiting or slowing blood coagulation A method and composition for inhibiting or slowing blood coagulation includes lactadherin, a fragment of lactadherin, a functional equivalent of lactadherin, or a functional equivalent of a...
12	7285530	Use of SERP-1 as an antiplatelet agent Compositions and methods for antiplatelet/anti-thrombotic therapy in a mammalian subject are provided. The method involves administering a therapeutically effective amount of SERP-1 admixed with a...
13	7223730	Antithrombosis enzyme from the snake venom of agkistrodon acutus This invention features an antithrombosis enzyme extracted and purified from the snake venom of Southern-Anhui Agkistrodon acutus and pharmaceutical uses thereof.
14	7166577	Albumin having enhanced antimicrobial activity The present invention provides a nitrosylated albumin variant wherein one or more amino acid residues of constituent amino acid sequences are substituted, or a different amino acid residue is...
15	7101840	Polymeric drug formulations A method of forming a polymeric drug formulation in which a water-soluble drug is blended with a water-insoluble tissue-compatible polymer that is miscible in the solid phase with the drug, and...
16	7087573	Methods of inhibiting platelet anti-HLA alloimmune antibody responses with soluble 18 KDa CD40L The invention relates to a method for inhibiting an in vivo alloimmune response, and to the use of a soluble recombinant human CD40L protein containing the active binding site with CD40. In...
17	7033788	Protein derived from Agkistrodon saxatilis emelianov and process preparing the same The present invention relates to Saxatilin, a protein derived from the venom of a Korean snake, Agkistrodon saxatilis emelianov, a process for preparing Saxatilin, and pharmaceutical application of...
18	6982249	Bradykinin analogs as selective inhibitors of cell activation The present invention provides bradykinin peptide analogs, compositions, and methods of inhibiting thrombin-induced platelet and other cell activation. The bradykinin analogs comprise single or...
19	6911427	No-modified hemoglobins and uses therefore S-nitrosohemoglobin (SNO-Hb) can be formed by reaction of Hb with S-nitrosothiol and by other methods described herein which do not result in oxidation of the heme Fe. Other methods can be used...
20	6881722	Saratin for inhibiting platelet adhesion to collagen Use of the polypeptide Saratin for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation after vascular injuries or...
21	6800612	S-nitrosothiols as agents for the treatment of circulatory dysfunctions The present invention is directed to a S-nitrosothiol derivative of penicillamine or glutathione, of formula I: or its pharmaceutically acceptable salt thereof, in which: A and B are independently...
22	6737405	Stabilized protein preparation and process for its preparation A stabilized protein preparation is described which contains no antithrombin III and is protected against loss of activity during pasteurization by the addition of stabilizers which comprise one or...
23	6544946	Inhibitors for use in hemostasis and immune function The present invention relates to polynucleotide and polypeptide molecules for use as inhibitors in hemostasis and immune function. Such inhibitors are members of the family of proteins bearing a...
24	6544750	Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 The invention relates to inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 with peptide analogs corresponding to those of Formula I and II, wherein Formula I...
25	6521594	Method and composition for treating thrombosis The invention provides cyclic peptides which inhibit platelet aggregation without causing prolonged bleeding time. The invention provides RGD or KGD containing peptides which are cyclized and...
26	6403578	Bicyclic fibrinogen antagonists This invention relates to compounds of the formulae: whereinA1 is O, S, N—R1 or CHR1;A4 is N—R4 or CHR4;R2 is a sidechain containing an acid or ester group;R1, R4 and R5 are substituents such as ...
27	6239110	Synthetic analogs of thrombospondin and therapeutic use thereof Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.
28	6087332	Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy Streptokinase derivatives having platelet glycoprotein binding domains adjacent to the termini of the streptokinase sequence. These derivatives produce higher local concentrations of plasmin in...
29	6048854	2,3-diaminopropionic acid derivative The present invention relates to a 2,3-diaminopropionic acid derivative of the formula (1): ##STR1## or a pharmaceutically acceptable salt thereof. The compounds of the present invention are useful...
30	6046289	Propenamide derivatives containing Arg-Gly-Asp polymers obtained therefrom A propenamide derivative of the formula (I) having, as an essential structural unit, an adhesive peptide represented by the formula (II) in the side chain or salts thereof:Formula (I): R1 R2...
31	6036958	Tsetse thrombin inhibitor A potent and specific inhibitor of thrombin is purified from salivary gland extracts of the tsetse fly, Glossina morsitans morsitans. The inhibitor has a molecular weight of 3530 Daltons as...
32	6022854	Platelet specific therapeutic compound and method of treating A therapeutic compound comprises a KGD-containing peptide, tandem repeats thereof, combinations thereof, or combinations thereof with an RGD-containing peptide or tandem repeats thereof, or peptide...
33	6022857	Radiolabeled compounds for thrombus imaging This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including...
34	5968902	Platelet aggregation inhibitors The isolated and purified PAI from several active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K* -(G/Sar)-D wherein...
35	5952296	Method of using relaxin as therapeutic or preventing agent Methods of using relaxin (RLX), a peptide hormone of the insulin family, which has been found to produce effects on the walls of blood vessels, on blood clotting and on blood lipids and...
36	5932606	Pyrazinone, pyridinone, piperidine and pyrrolidine thrombin inhibitors A compound which inhibits human thrombin and where has the structure and pharmaceutically acceptable salts thereof, wherein such as ##STR1## which are useful for inhibiting formation of blood...
37	5882887	Process for manufacture of a modified collagen-induced platelet aggregation inhibitor pallidipin The invention provides a process of manufacture of a recombinant protein called Asp-Pallidipin. Asp-Pallidipin inhibits the collagen-induced platelet aggregation of mammalian platelets. The...
38	5872122	Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation This invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions of such compounds and a method of...
39	5866592	Fibrinogen receptor antagonist and pharmaceutical compositions comprising the same Compounds of the following general formula (I) and pharmaceutically acceptable salts thereof.
40	5834420	Fibrinogen concentrate obtained from blood plasma, process and plant for its preparation A fibrinogen concentrate has a purity of 98% or higher and is free of viral contaminants and proteases. The fibrinogen concentrate is obtained by subjecting a solubilized plasma fraction containing...
41	5763408	Amino acid derivatives and application thereof There are disclosed amino acid derivatives represented by the following general formula (I): ##STR1## wherein L1 and L2 represent an amino acid residue etc., A1 and A3 represent CO, A2 r...
42	5756454	Collagen-induced platelet aggregation inhibitor The invention provides a protein which inhibits collagen-induced platelet aggregation, derived from Triatoma pallidipennis, and derivatives thereof. The protein is useful for inhibition of...
43	5747457	Linear adhesion inhibitors Linear peptides of the formula I X-A-Cys(R1)-B-Z I,in which A, B, R1, X and Z are as defined, are highly active inhibitors of the binding of the blood platelet integrin GP IIbIIIa (aIIb β3) to ...
44	5747447	Stable polypeptide composition A (injectable biologically active) polypeptide is stabilized by dissolving said polypeptide forming a liquid solution in citrate buffer of about pH 5.0-5.5.
45	5700468	Extracts of ginkgo biloba and their methods of preparation A process is provided for producing a purified extract from Ginkgo biloba leaves by solvent extraction with selected solvents. In the process, a crude or partially purified extract is subjected to...
46	5679345	Method for preventing complement-dependent rejection of organ or tissue transplants Interference with formation of the complement-based membrane attack complex (MAC) will mitigate or even prevent tissue injury associated with the effects of complement in inflammation and graft...
47	5672582	Thrombin inhibitors 4-substituted cyclohexylamine derivatives which are thrombin catalytic site inhibitors and which are useful as anticoagulants. These compounds show selectivity for thrombin over other trypsin-like...
48	5643872	Cyclic anti-aggregatory peptides This invention relates to compounds of the formula: ##STR1## wherein: A' is absent, Asn, Gln, Ala or Abu; A is absent or a D- or L-amino acid chosen from Arg, HArg, (Me2)Arg, (Et2)Arg, Abu, Ala,...
49	5614535	Adhesion receptor antagonists Compounds of the formula I ##STR1## in which R1 and X have the meanings herein defined, their physiologically unobjectionable salts and/or solvates inhibit the binding of fibrinogen to the...
50	5589462	Method of preparing a biological adhesive enriched with platelet factors, and application A method for the preparation of a platelet factor-enriched biological adhesive comprising freezing a platelet-enriched plasma and isolating a cryoprecipinate from the frozen platelet-enriched...

Matches 1 - 50 out of 73

1 2 >