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7403883 Three-dimensional in-vitro spinal models and methods of analyzing substance distribution therein  
An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining...
7402657 C-C chemokine receptor 3 proteins  
The present invention relates to isolated and/or recombinant C-C Chemokine Receptor 3 (CKR-3, CCR3) proteins or polypeptides.
7402655 Molecules designated LDCAM  
The invention is directed to LDCAM as a purified and isolated protein, the DNA encoding the LDCAM, host cells transfected with cDNAs encoding LDCAM, processes for preparing LDCAM polypeptides and...
7402566 Peptide inhibitor of TGF-β growth factors  
A potent peptide inhibitor (SuperSog) of TGF-β family growth factor signaling, peptide variants thereof and nucleotide coding sequences therefore are provided by the invention. The Super-Sog...
7402558 Method for aiding implantation or decreasing miscarriage rate  
The invention provides a protocol leading to improved embryo implantation rates and/or decreased miscarriage rates in which hCG or LH, or a bio-analogue thereof, is administered during the...
7402557 Combined treatment with keratinocyte growth factor and epidermal growth factor inhibitor  
The present invention relates to compositions and methods for treating the epithelial toxicity caused by administering to a human cancer patient an epidermal growth factor receptor (EGFR)...
7399849 Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof  
The present invention provides a monoclonal anti-Idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG)...
7399839 Monopegylated growth hormone proteins  
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the...
7399829 Variants of RANKL protein  
The present invention relates to novel, soluble, recombinant variants RANKL (Receptor Activator of Nuclear Factor—κB Ligand) proteins, which may be expressed solubly in E. coli, variants that...
7399746 Agents for wound healing  
The present invention relates to pharmaceutical compositions containing fragments of alpha-1 proteinase inhibitor (API) or chimeric proteins of API and insulin-like growth factor for use in...
7399745 Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use  
The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2...
7399744 Methods for affecting body composition  
Methods for affecting body composition include the use of amylin or amylin agonist(s). Total body weight may be reduced, maintained or even increased; however, the body fat is reduced or body fat...
7399743 Targeted thrombosis  
The invention provided compositions and methods to initiate site-specific thrombosis in tumor vasculature. The present invention also provides methods for using the disclosed compositions and...
7399740 Poly-Glu,Tyr for neuroprotective therapy  
Methods and compositions are provided for preventing or inhibiting neuronal degeneration, or for promoting nerve regeneration, in the central nervous system (CNS) or peripheral nervous system...
7399612 VEGF-binding fusion proteins and nucleic acids encoding the same  
Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating...
7399489 Exendin analog formulations  
Novel formulations containing exendins, exendin agonists and/or exendin analogs are provided.
7396910 Transient receptor potential channel TRPV3 and its use  
This invention provides novel genes and polypeptides of the transient receptor potential channel family, and use of these genes and polypeptides for the treatment of pain and identification of...
7396905 Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto  
This invention discloses endogenous calcineurin inhibitors, Calcipressin, Csp1, Csp2, and Csp3, as shown in SEQ ID Nos: 4-5, or 24. This invention also discloses nucleic acid sequences that can...
7396809 Methods and reagents for treating glucose metabolic disorders  
The invention relates to methods for potentiating, enhancing or restoring glucose responsivity in pancreatic islets or cells. The methods can be used as therapies for diseases caused by, or...
7396664 VEGF-binding fusion proteins and nucleic acids encoding the same  
Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF traps are disclosed which are therapeutically useful for treating VEGF-associated...
7396536 Parasitic helminth cuticlin proteins and uses thereof  
The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised...
7393833 Chimeric proteins with phosphatidylserine binding domains  
Chimeric proteins comprising soluble Tissue Factor (sTF) and another subunit (e.g., annexin V) are described. The proteins promote blood clotting and/or inhibit cancer by targeting sTF to specific...
7393832 Extracellular/epidermal growth factor like protein  
The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by...
7393831 Peptide compositions and their use against HCV  
The invention relates to novel peptide compositions. In particular, the invention relates to a peptide composition comprising at least two peptides which are selected from among the following...
7393830 Prolactin induced increase in neural stem cell numbers  
The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ,...
7393829 Pharmaceutical compositions comprising fragments and homologs of troponin subunits  
The present invention relates to pharmaceutical compositions comprising therapeutically effective amounts of fragments or homologs of troponin C, I or T subunits for the treatment of diseases or...
7393828 Modified MscL protein channel  
The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles...
7393660 CC-chemokine binding tick proteins  
A novel CC-chemokine binding protein is isolated from the saliva of Rhipicephalus sanguineus . Compounds prepared in accordance with the present invention can be used as anti-inflammatory...
7390877 PRO4381 polypeptides  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
7390786 Protein formulations with reduced viscosity and uses thereof  
Protein formulations and methods for reducing the viscosity of a protein formulation are provided. The method for reducing the viscosity of a protein formulation comprises adding a viscosity...
7390785 τ-conotoxin peptides  
The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or...
7390781 Methods of using truncated glial cell line-derived neurotrophic factor  
Disclosed are novel proteins, referred to as truncated glial cell line-derived neurotrophic factor (truncated GDNF) proteins, that promote dopamine uptake by dopaminergic cells and promote the...
7390481 Mammalian cytokine complexes  
Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using...
7388089 Anti-arthropod vector vaccines method of selecting and uses thereof  
The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent...
7387994 Compositions and methods for producing vascular occlusion using a solid-phase platelet binding agent  
The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or...
7385024 Heterocarpine, a human GHRH-binding protein  
The invention relates to a human GHRH-binding protein (human Growth Hormone-releasing hormone). Said protein, which is obtained from the Pilocarpus Heterophyllus plant, can be used to prepare...
7384918 Botulinum toxin for treating muscle contracture  
The invention provides for the use of a botulinum toxin to treat contracture, such as muscle contracture, in patients by transdermal administration of the botulinum toxin.
7384917 Chimeric natriuretic peptides  
Peptides of Dendroaspis , including chimeric peptides thereof, are provided, as well as methods of using the peptides as natriuretics, diuretics, and/or vasodilators.
7384912 Treatment of bone disorders with skeletal anabolic drugs  
Disclosed herein are methods for the prevention and treatment of a variety of mammalian conditions manifested by loss of bone mass, including osteoporosis. The present invention provides methods of...
7381705 Inhibitors of hepatitis C virus  
The present invention relates to methods that employ peptides or peptide derivatives to inhibit hepatitis C virus infection. The present invention is based in part on the discovery that E2 envelope...
7381704 Methods for use of short bioactive peptides  
Short bioactive peptides containing phenylalanine, leucine, alanine, and lysine residues are disclosed. The peptides can be used in antibacterial, antifungal, anticancer, and other biological...
7381699 Reagents and methods for smooth muscle therapies  
The present invention provides novel polypeptides comprising heat shock protein 20(HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth...
7381698 Methods for treatment of acute pancreatitis  
The invention relates generally to methods for treating acute pancreatitis in patients. The methods comprise administering a therapeutically effective amount of a pharmaceutical composition...
7378507 PRO217 polypeptides  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
7378491 Secreted and transmembrane polypeptides and nucleic acids encoding the same  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
7378395 Mutants of bone morphogenetic proteins  
The present invention relates to novel mutants of bone morphogenetic proteins (BMPs) useful as inhibitors of heterotopic ossification. Specifically, the present invention related to novel mutants...
7378394 Sustained-release microparticle preparation of human growth hormone and process for producing thereof  
Provided is a sustained-release microparticle preparation of a human growth hormone which combines biodegradability with sustained-release performance while avoiding the use of an organic solvent...
7378393 Recombinant anticoagulant proteins  
Novel recombinant anticoagulation proteins, methods of their use and methods of their production are described. In particular, recombinant fusions of annexin V (ANV) and Kunitz protease inhibitors...
7378392 Bone and cartilage inductive proteins  
Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and...
7378388 Method of utilizing neurotrophins to manipulate reproductive capacity  
Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins,...
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