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9040078 Use of lipid conjugates in the treatment of diseases of the nervous system  
The invention provides a method for treating a subject suffering from a disease of the central nervous system which is associated with an inflammatory response, including, inter alia, multiple...
9029325 Amylin analogues and pharmaceutical compositions thereof  
The invention relates to polypeptides comprising an amino acid sequence which is an analogue of pramlintide, pharmaceutical compositions comprising these polypeptides, and these polypeptides for...
9023794 Use of natriuretic peptide for treating heart failure  
The present invention relates to the use of a natriurectic peptide, such as urodilatin, for treating a patient suffering from heart failure, such as acute decompensated heart failure. Preferably,...
8999340 Methods for treating multiorgan, systemic degos' disease with a complement inhibitor  
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and/or an inhibitor of interferon alpha, and the use of the compositions in methods for...
8992905 Oral composition containing interferon-α  
The present invention provides oral compositions which contain interferon α (IFNα) as an active ingredient for preventing and/or treating periodontal disease. The number of causative...
8992589 Using light to regulate uterine contractions  
Methods of regulating uterine contractions using light are described. An exemplary method of regulating uterine contractions comprises suppressing a nocturnal endogenous melatonin level of a...
8975228 Use of boswellic acids for the prophylaxis and/or treatment of damage to and/or inflammation of the islets of Langerhans  
Disclosed are methods and compositions related to the use of boswellic acids (such as acetyl-11-keto-β-boswellic acid, 11-keto-β-boswellic acid, β-boswellic acid, acetyl-β-boswellic acid,...
8962560 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases  
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use...
8946157 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases  
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use...
8940703 Inhibitors of TLR signaling by targeting TIR domain interfaces  
TIR-domain decoy peptides and TIR domain peptides are disclosed, as well as methods of using the peptides in the regulation of toll-like receptor (TLR) activation and signaling.
8936809 Method for treating prostate diseases based on local delivery of active substances  
A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs,...
8937045 Liquid formulations of tumor necrosis factor-binding proteins  
The invention relates to a stable, pharmaceutically acceptable, aqueous formulation of TNF-binding protein, comprising a TNF-binding protein, a buffer and an isotonicity agent.
8932592 Compositions and methods for treating inflammatory disorders  
The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.
8933011 Treatment of preterm labor with toll-like receptor 9 antagonists  
The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a...
8933029 Antimicrobial and anti-inflammatory peptides  
Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or...
8916161 Method of treating or preventing benign prostatic hyperplasia using modified pore-forming proteins  
The present invention provides a method of treating BPH using modified pore-forming proteins (MPPs). These MPPs are derived from naturally occurring cytotoxic proteins (nPPs) that kill cells by...
8912137 Method for increasing natriuresis or diuresis by isoforms of brain natriuretic peptide  
Methods and materials for diagnosing and treating heart conditions (e.g., heart failure) and kidney conditions (e.g., kidney failure) are described.
8883153 Methods for preventing and treating angioedema  
One aspect of the present invention provides a method of treating or preventing angioedema in a patient in need thereof comprising administering to the patient a therapeutically effective amount...
8883720 Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity  
Template-fixed peptidomimetics formula (Ia) formula (Ib) wherein Z is a template-fixed chain of 14 α-amino and/or α-hydroxy acid residues which, depending on their positions in the chain (counted...
8877706 Maytansinoid derivatives  
Disclosed herein are maytansinoid drug linker derivatives which can be linked to a antigen binding unit (Abu), and maytansinoid drugs linked with an antigen binding unit (Drug-Linker-Antigen...
8877225 Controlled release copolymer formulation with improved release kinetics  
The present invention provides a constant release copolymer composition adapted for use in a controlled release formulation for a bioactive agent, such as a formulation adapted for implantation...
8841254 Method for treatment of anxiety  
Human H3 preprorelaxin, human H3 prorelaxin, human H3 relaxin, human relaxin analogues having a modified A chain and/or a modified B chain are described. Also described are nucleic acid sequences...
8835387 Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases  
The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and...
8822410 Tympanic membrane permeating ear drops and uses thereof  
The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration...
8815803 Method for increasing body height comprising systemic administration of CNP-53  
This invention provides a composition for increasing a body height of a patient with short stature or an individual other than patients with short stature. More specifically, the invention...
8815811 Peptides and methods for their preparation and use  
The present invention is in the field of treatment of diabetes and relates to peptides that exhibit activity for both glucose-dependent insulinotropic peptide receptor (GIP-R) and glucagon-like...
8815795 Methods for preventing or treating eye diseases using adiponectin  
A composition for preventing or treating an eye disease includes adiponectin as an active ingredient. Adiponectin as an active ingredient is eventually revealed to show prevention or therapeutic...
8815233 Method for treating pervasive development disorders  
A method of utilizing the chymotrypsin level of an individual as a measure of the success of secretin, other neuropeptides, and peptides or digestive enzyme administration to such individuals, and...
8809281 Small peptides and methods for blocking IGE mediated activation of an immune cell  
Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of an...
8802622 Composition for nasal administration and method for preparing same  
The invention provides a powdered composition for nasal administration, comprising a physiologically active peptide and cellulose acetate as the base, and having excellent nasal absorption for...
8791069 Pharmaceutical composition of nanoparticles  
The invention discloses use of a pharmaceutical composition for slow-release delivery of a bioactive agent, comprising mixing the bioactive agent with a partially hydrophobic chitosan solution at...
8785384 Peptide synthesis  
A process for producing an insulin type peptide, for example a relaxin, involving oxidizing a methionine residue on a B-chain having cysteine residues and combining the B chain with an A chain...
8785401 Methods for treating diseases having an inflammatory component related to phospholipase A2  
The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods...
8778404 Nutritional compositions  
The present inventors discovered that the onset of galactosamine hepatopathy is suppressed by nutritional compositions comprising as essential ingredients: whey protein hydrolysates; lecithin and...
8758822 Method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs  
The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size...
8759317 Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP)  
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as...
8747852 Methods of treating pterygium  
Methods for treating pterygium recurrence following pterygiectomy, and for treating keloid recurrence, following surgical removal of the keloid, are disclosed. The methods include administering an...
8741842 Chimeric natriuretic polypeptides with unique pharmacologic profiles  
This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic...
8735353 Polypeptides and uses thereof  
The present invention provides polypeptides comprising or consisting of an amino acid sequence from thrombin, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment,...
8716012 Alpha thymosin peptides as vaccine enhancers  
The present invention provides methods of vaccination as well as pharmaceutical combinations and kits for enhancing vaccine effectiveness, including for immunodeficient or immunecompromised...
8715654 Methods of modulating the negative chemotaxis of immune cells  
The current invention is directed to methods of inducing migration of an immune cell toward a cancer cell comprising inhibiting the activity of a chemorepellant released from the cancer cell.
8710006 Use of natriuretic peptide for treating heart failure  
The present invention relates to the use of a natriurectic peptide, such as urodilatin, for treating a patient suffering from heart failure, such as acute decompensated heart failure. Preferably,...
8710009 HSP20 inhibits amyloidogenesis and neurotoxicity  
The present invention compositions and methods of using at least a portions of an isolated and purified α-crystallin polypeptide that includes one or more β-pleated sheets and that prevents...
8703703 MCPIP as wound therapy  
Disclosed herein are methods and compositions of treating a subject suffering from a wound. In exemplary examples, the method involves elevating MCPIP levels in a subject in need. Elevating MCPIP...
8703704 Method for growing, restoring and regenerating hair  
A treatment method effective for promoting hair growth utilizes atrial natriuretic peptide.
8691940 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Relaxin polypeptides comprising non-naturally encoded amino acids
 
Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide...
8691772 HSP60, HSP60 peptides and T cell vaccines for immunomodulation  
The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention...
8691765 Metallothionein based neuronal therapeutic and therapeutic methods  
A method of stimulating neuronal growth or repair comprising exposing a target neuron or neuronal area to a solution of the metallothionein isoform MT-IIA.
8691764 Inhibitors of NF-κB activity  
The present invention provides a method for inhibiting NF-κB activity in a subject, the method comprising providing an agent capable of inducing expression of annexin 1, whereby said agent induces...
8658196 Graft materials and methods for staged delivery of bioactive components  
Described, in certain aspects of the invention, are multilaminate medical graft products, as well as methods for preparing and using the same. An illustrative multilaminate medical graft product...