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7482430 |
Compositions and methods relating to multimeric and oligomeric soluble fragments of the TWEAK receptor
The present invention provides methods and compositions relating to fusion proteins comprising multimeric soluble TWEAK receptor fragments and an oligomerization domain. Such fusion proteins are...
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7482001 |
Method of administering and using VEGF inhibitors for the treatment of non small cell lung cancer
A method of treating a human patient suffering from cancer, comprising administering an effective amount of a vascular endothelial growth factor (VEGF) trap antagonist to the human patient, the...
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7479281 |
Botulinum toxin for treating postherpetic neuralgia
Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The...
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7479483 |
Tumor-targeted drug delivery systems and uses thereof
The present invention relates to targeted delivery systems for delivering therapeutic agents to tumor. The invention further relates to methods of delivering a therapeutic agent to a tumor for the...
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7479478 |
Human parathyroid hormone modifications, preparation and use
The present invention is related to synthetic and/or recombinant biologically active peptide derivatives of PTH(1-28). Some of the peptides of the invention are at least 90% identical to a peptide...
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7479482 |
Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid β, prion protein, amylin, α-synuclein, or polyglutamine repeats for induction of an immune response thereto
The present invention relates to immunogenic but non-depositing-forming polypeptides or peptides homologous to amyloid β, prion, amylin or α-synuclein which can be used alone or conjugated to an...
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7479539 |
Hedgehog fusion proteins
A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a hedgehog (X); Y is an optional linker moiety; and Z is a...
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7479537 |
Reagents and methods useful for detecting diseases of the breast
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the...
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7476654 |
Method for modulating, regulating and/or stabilizing angiogenesis
A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in need thereof, in which the PDGF-D level or activity or both in the mammal are modulated or increased. In preferred...
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7476648 |
Vessel embolic material comprising hydrogel and therapy with the use thereof
According to the present invention, a vessel embolic material comprising a hydrogel containing a cell growth factor, which is applicable to embolic operations for various vascular disorders,...
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7476655 |
Materials and methods for regulating blood flow
The subject invention provides materials and methods useful in regulating blood flow. In a preferred embodiment, the subject invention provides peptides that are able to enhance nitric oxide (NO)...
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7476388 |
Composition comprising a gastrin/CCK receptor ligand and an EGF receptor ligand
Compositions and methods are provided for achieving in vivo islet cell regeneration in subjects with preexisting diabetes. The methods comprise short term treatment with a composition having a...
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7476381 |
Methods of reducing serum alanine transferase levels in a subject with hepatitis
CC-Chemokine mutants having reduced Glycosaminoglycans (GAG)-binding properties are effective against liver fibrotic inflammatory and/or autoimmune diseases. Particularly preferred are the mutants...
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7473760 |
Cyclic peptide compositions for treatment of sexual dysfunction
A cyclic peptide of the structural formula:
or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 5 , R 6 , m, n and p are as defined. Further provided are compositions for...
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7470666 |
Use of Ulinastatin and its pharmaceutical composition for treating severe acute respiratory syndrome
The present invention relates to use of Ulinastatin and its pharmaceutical composition for treating and/or preventing Severe Acute Respiratory Syndrome (SARS). Ulinastatin is effective for treating...
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7470660 |
Treatment for dark adaptation
The present invention addresses the treatment of age-related macular degeneration, and treatment of individuals with impaired visual function such as impaired dark adaptation, using regulation of...
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7470665 |
Methods for targeting cells that express fibroblast growth receptor-3 or -2
Fibroblast growth factor-18 (FGF-18) binds with FGF receptors-2 and -3. Compositions comprising an FGF-18 component can be used to target cells that express these receptors. Suitable targets...
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7470667 |
Methods of treating cancer using a modified endostatin protein
The present invention provides methods of treating an angiogenesis-related disease of a subject using a therapeutically effective amount of a modified endostatin protein. In particular, the methods...
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7470659 |
Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
The present invention addresses the treatment of age-related macular degeneration using regulation of pathogenic mechanisms similar to atherosclerosis. In further specific embodiments, compositions...
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7470670 |
Peptide inhibitors of cyclin-dependent kinase activity and uses thereof
Novel polypeptides or derivatives comprising cdk2 binding site are disclosed. The novel polypeptides or derivatives have growth suppressive activity. Nucleic acids encoding those polypeptides are...
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7470669 |
Isolated polypeptide comprising a leptin fragment
The present invention is drawn to methods of screening for new compounds for the treatment of obesity and obesity-related diseases and disorders, as well as methods of treating obesity-related...
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7470668 |
Method of use of specific natriuretic peptide receptor c ligands, transgenic non-human mammals expressing specific natriuretic peptide receptor c antagonists and cells thereof
A method of using an osteocrin (Ostn) or a NPR-C specific Ostn peptide derivative for increasing osteogenesis in a mammal comprising administering a therapeutically effective amount of said Ostn or...
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7468352 |
Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of cell-surface metalloproteinases or plasminogen activator receptors
The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by...
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7468350 |
Glue composition for lung volume reduction
The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an...
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7468188 |
Multi-step therapy for injured muscles
Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle.
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7468189 |
Neuropathic pain treatment method
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7465707 |
Methods of treatment with TR10 polypeptides
The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic...
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7465704 |
Methods for enhancing healing of diabetic foot ulcers by injecting epidermal growth factor (EGF)
The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-injectable pharmaceutical composition which is administered by means of infiltration into and around chronic...
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7465453 |
Polypeptide fragments of CKLF1
Polypeptides having an amino acid sequence of SEQ ID NO: 2, and having amino acid residues 9 to 27 of SEQ ID NO: 2 are disclosed, which are together named C-terminal polypeptides of CKLF1. Also...
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7465706 |
GDF3 propeptides and related methods
In certain aspects, the present invention provides compositions and methods for regulating body weight, in particular, for treating obesity and obesity-associate disorders. The present invention...
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7465783 |
Plant peptide with antimicrobial activity
The invention concerns novel peptides, in particular plant peptides, having an antimicrobial activity and a cytotoxic activity, in particular for plant cells. The invention also concerns...
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7465441 |
Use of gp130 activators in diabetic neuropathy
The invention relates to the use a substance signaling through gp130 for the manufacture of a medicament for the treatment and/or prevention of diabetic neuropathy. The use of IL-6 is preferred.
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7465705 |
Nogo receptor antagonists
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding...
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7465785 |
Polypeptide encoded by a nucleic acid over-expressed in melanoma
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7462350 |
Cancer treatments including administering IL-2 fusion proteins with modulated selectivity
The invention provides cytokine fusion proteins with an increased therapeutic index, and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are...
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7462360 |
Alloferons—immunomodulatory peptides
The invention belongs to the field of biologically active peptides specifically stimulating antiviral, antimicrobial and antitumor activity of the human and animal immune system.
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7462598 |
Antimicrobial theta defensins, analogs thereof, and methods of use
The invention provides theta defensin analogs having antimicrobial activity. The invention also provides a method of reducing or inhibiting growth or survival of a microorganism in an environment...
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7459438 |
Specific mechanism for inhibiting platelet adhesion to collagen
The present invention relates to the polypeptide Saratin and its use for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation...
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7459528 |
Glycoproteins which bind to TNF
Tumor necrosis factor receptor DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed.
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7459437 |
Molecular determinants of myeloma bone disease and uses thereof
To identify molecular determinants of lytic bone disease in multiple myeloma, the expression profiles of ˜12,000 genes in CD138-enriched plasma cells from newly diagnosed multiple myeloma patients...
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7459532 |
Variants of the TRP channel family member, LTRPC3G
The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host...
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7459525 |
Factor VIII glycoforms
The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked...
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7459523 |
Equine P-selectin glycoprotein ligand-1 and uses thereof
A novel equine P-selectin glycoprotein ligand-1 (ePSGL-1) is disclosed having the amino acid sequence set forth in SEQ ID NO:2. DNA sequences encoding the ePSGL-1 are also disclosed, along with...
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7459531 |
50 Human secreted proteins
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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7459534 |
Inactivation resistant factor VIII
The present invention provides novel purified and isolated nucleic acid sequences encoding procoagulant-active FVIII proteins. The nucleic acid sequences of the present invention encode amino acid...
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7459522 |
Peptide dimers as agonists of the erythropoietin (EPO) receptor, and associated methods of synthesis and use
Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R 1 and a second...
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7459164 |
Composition for therapeutic and cosmetic botulinum toxin
This invention relates to a composition of botulinum based pharmaceuticals used for therapeutic and cosmetic treatment. This invention offers an improvement on the prior art by eliminating the...
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7459434 |
Peptide interacting with anti-apoptotic proteins of the Bcl-2 family
The invention relates to the identification of a new peptide interacting with the anti-apoptotic proteins Bcl-2, Bcl-W and/or Bcl-XL, and also to screening methods allowing identification of...
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7459436 |
Treatment of disturbances of iron distribution
The present invention relates to the use of erythropoietin for the treatment of disturbances of iron distribution in heart diseases.
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7459433 |
Homotrimeric extended OBG3 globular head and uses thereof
The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, homotrimer of OBG3 polypeptide fragment comprising...
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