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7265157 Sustained release compositions, process for producing the same and use thereof  
Sustained release compositions containing a physiologically active substance or its salt, hydroxynaphthoic acid or its salt and a lactic acid-glycolic polymer or its salt, wherein the product of...
7256172 Method of treatment and agents useful for same  
The present invention relates generally to a method of inducing, stimulating or otherwise facilitating bronchoprotection in humans and animals by modulating bronchial constriction and/or...
7256171 Use of core 2 G1cNAc transferase inhibitors in treating inflammation  
This invention provides compounds and methods for treating inflammation. The compounds modulate the core 2 oligosaccharide-mediated binding of inflammatory cells, such as neutrophils, to...
7256266 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Human DRG11-Responsive Axonal Guidance and Outgrowth of Neurite (DRAGON) proteins and variants thereof
 
This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein....
7253143 Peptides based on the sequence of human lactoferrin and their use  
The invention relates to new peptides formed of at least seven subsequent amino acids of the amino acids in position 12-40, counted from the N-terminal end, in the sequence constituting human...
RE39705 Method of treating glutathione deficient mammals  
Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intra-cellularly either by forming a direct complex with an electrophilic agent...
7235248 Pharmaceutical compositions comprising cyclosporins  
Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or [Nva]2-Ciclosporin, in “microemulsion pre-concentrate” and microemulsion form. The compositions typically comprise (1.1) a...
7232567 Anti-CCR1 antibodies and methods of use thereof  
The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 1 (CCR1) or a portion of the receptor and blocks binding...
7232804 Use of KPV tripeptide for dermatological disorders  
The present invention is directed to a prevention and treatment for dermatological disorders. One aspect of this invention involves a dermatological treatment comprising one or more polypeptides...
7229961 Compositions and methods for enhancing drug delivery across and into ocular tissues  
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions...
7211566 Selective bradykinin (BK) B1 peptidic receptor antagonists and uses thereof  
The present invention provides for a novel peptidic antagonist for the bradykinin B1 (BKB1) receptor having very good to excellent affinities and selectivity for the BKB1 receptor, in vitro and in...
7208167 Treatment of hepatitis C with thymosin and peptide combination therapy  
A method and pharmaceutical combination for treating hepatitis C by administering to a hepatitis C patient an effective amount of at least one alpha thymosin peptide, in combination with...
7208466 Use of a lectin or conjugates for modulation of c-fibre activity  
The present invention relates to the treatment of pain and to compounds that modulate C-fibre activity. In particular, the present invention relates to the use of a lectin in the manufacture of a...
7208166 Use of botuline toxin to obtain a product to be used in articular pathologies, particularly coxarthrosis, epicondylitis and rotator muscle cap pathology  
Use of botulin toxin to obtain a product intended to be administered intramuscular with lissive effect in treating articular pathologies, particularly coxarthrosis, or arthrosis of the hip,...
7192930 Method and peptide for regulating cellular activity  
Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be...
7179787 Methods of using human Zven proteins  
The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal...
7175679 Oligopeptide treatment of NF-κB mediated inflammation  
The invention relates to the modulation of gene expression in a cell, also called gene control, in particular in relation to the treatment of anthrax. The invention provides a method for...
7166568 Compositions and methods to inhibit formation of the C5b-9 complex of complement  
Compounds modulating CD59 mediated complement activity, compositions including these compounds, and methods of making and using the compounds are disclosed, which are based on the identification...
7157433 Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules  
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of...
7151084 Compound and method of treating neurogenic conditions using non-steroidal anti-inflammatory drug complexes  
A complex is provided for the treatment of neurogenic conditions having the formula: where R1 is M is a metal ion Ca(II), Mg(II), Cu(II) or Ni(II); n is an integer 1 or 2; R is BBB peptide,...
7147838 Gastrin receptor-avid peptide conjugates  
A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin...
7138375 Use of exendins and agonists thereof for lowering plasma lipid  
Provided are methods for lowering plasma lipid in an individual in need of or desirous of lowering plasma lipid by administering an amount of an exendin or an exendin agonist analog effective to...
7125848 Methods of treating non-inflammatory gastrointestinal tract disorders using Cav2.2 subunit calcium channel modulators  
A method is provided for using Cav2.2 subunit calcium channel modulators to treat non-inflammatory gastrointestinal tract disorders.
7109172 Inhibitors of serine proteases, particularly HCV NS3-NS4A protease  
The present invention relates to compounds of formula I or formula Ia or pharmaceutically acceptable salts thereof, that inhibit serine protease activity, particularly the activity of hepatitis C...
7109176 Nonsteroidal anti-inflammatory substances, compositions and methods for their use  
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of...
7101855 Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4  
Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by...
7094760 Peptides for treatment of inflammation and shock  
Submandibular peptides have been isolated and characterised and provide pharmaceutical compositions for the treatment or prevention of anaphylactic reactions, endotoxic reactions and SIRS-induced...
7091176 Methods for treating arthritis pain  
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
7067480 Compositions and methods of use for anti-inflammatory agents  
This invention relates to the use of a phosphorylcholine-containing glycoprotein in the treatment or prophylaxis of diseases associated with inflammation. In particular, the present invention...
7056533 Medicament incorporation matrix  
A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating...
7033997 Use of natriuretic peptides as antibiotically active substances for the treatment of bacterial infections  
The present invention relates to antibiotically active natriuretic peptides for use as antibiotically active preparations prepared using biotechnological and recombinant methods and chemical...
7026283 Calcium-independent negative regulation by CD81 of receptor signalling  
Calcium independent CD81 inhibition of IgE-mediated degranulation in mast cells, particularly through the FcγRIII and FcεRI receptors, is described, as well as methods of inhibiting allergic...
7026284 Formative agent of protein complex  
The present invention proposes formative agent of protein complex, in which a polyphenol is useful component, and the agent is useful as gene complex, cell adhesion inhibitor or immune tolerogen....
7026295 Lactoferrin in the reduction of circulating cholesterol, vascular inflammation, atherosclerosis and cardiovascular disease  
The present invention relates to methods of using lactoferrin (LF) to reduce circulating levels of cholesterol and vascular inflammation, in order to treat, prevent or reduce the incidence of...
7012060 TNF receptor and steroid hormone in a combined therapy  
The present invention relates to the use of a TNF Receptor together with a steroid hormone to produce a pharmaceutical composition for the treatment of lethal bacterial and viral infections as...
6998137 Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix  
The present invention relates to compositions and methods for the modulated release of one or more proteins or peptides. The composition is comprised of a biocompatible polymeric matrix, a protein...
6995141 Interleukin 1β protease and interleukin 1β protease inhibitors  
There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1β and for a substrate comprising: R1—Asp—R2—R3 wherein R1 and R3 are...
6991810 Product from starfish  
The invention relates to a product capable of having one or more properties sected from: anti-fouling properties, anti-adhesive properties, anti-inflammatory properties, and wherein said product...
6992060 Prolonged efficacy of islet neogenesis therapy methods with a gastrin/CCK receptor ligand and an EGF receptor ligand composition in subjects with preexisting diabetes  
Compositions and methods are provided for achieving in vivo islet cell regeneration in subjects with preexisting diabetes. The methods comprise short term treatment with a composition having a...
6987089 Mouse CIA protein and CIA gene having anti-apoptotic activity as a selective inhibitor of CAD interacting ASK1 use thereof  
The present invention relates to novel mouse CIA protein and CIA gene having anti-apoptotic activity isolated by yeast 2-hybrid screening which inhibit apoptosis mediated by caspase...
6982248 Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue  
Individuals in need of treatment of ischemia-related reperfusion are treated, preferably intravenously, with a composition which includes a compound which binds to a receptor for the glucagon-like...
6974796 Therapeutic compositions for treatment of a damaged tissue  
The present invention relates to a therapeutic composition and uses thereof for treatment of damaged tissue, wherein the composition comprises at least one extracellular matrix compound, at least...
6964948 Therapeutic peptide-based constructs derived from Domain II of bactericidal/permeability-increasing protein  
The present invention relates generally to small peptide-based constructs, including derivatized constructs, and their therapeutic uses. The constructs and derivatized constructs can have at least...
6955908 Organism associated with nongonococcal urethritis  
The invention features a biologically pure culture of a newly identified single-celled organism Spiky Rotating Cells (SPR), methods to diagnose an SPR infection in a human patient, an instrument...
6939855 Anti-inflammatory compositions and method  
The disclosed invention includes pharmaceutical compositions and methods for treating inflammatory conditions, particularly those that are characterized by increased binding of alpha-9 integrin to...
6936586 Synthetic IL-10 analogues  
The nonapeptide NH2-Ala-Tyr-Met-Thr-Met-Lys-Ile-Arg-Asn-COOH (SEQ ID NO: 1) and related molecules are useful as IL-10 agonists.
6930090 Methods of activating a receptor using amphiphilic drug-oligomer conjugates  
The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic...
6903074 Neuromedin b and somatostatin receptor agonists  
A novel class of analogs which exhibit both high affinity and selectivity for Neuromedin B and Somatostann receptors are claimed. One example is Nal-Tyr-cyclo(D-Cys-D-Trp-Lys-D-Cys)-Abu-Nal-NH2.
6884781 Treatment of shock using adrenomedullin binding protein-1  
Methods of treating a mammal in shock or at risk for shock are provided. The methods involve administration of an adrenomedullin binding protein-1 to the mammal. Also provided are methods of...
6872704 Acidic mammalian proteins and polynucleotides encoding the same  
Genes are disclosed that are differentially-regulated during feeding and fasting cycles. These genes, and their encoded polypeptides are useful to combat obesity and other metabolic disorders.