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7279155 |
Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine
The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof,...
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7279459 |
Methods employing and compositions containing plaque associated molecules for prevention and treatment of atherosclerosis
Methods and compositions employing plaque associated molecules effective in inducing mucosal tolerance and inhibiting inflammatory processes contributing to atheromatous vascular disease and...
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7279172 |
Treatment of autoimmune conditions with copolymer 1 and related copolymers
The present invention provides heteropolymer compositions and peptide compositions, and methods of making and using therapeutic compositions comprising amino acid heteropolymers for treatment of a...
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7279460 |
Chemokine TECK polypeptides
Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods...
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7276241 |
Methods of treating a tumor that expresses APRIL by administering BCMA
A novel receptor in the TNF family is provided: APRIL-R. Chimeric molecules and antibodies to APRIL-R and methods of use thereof are also provided.
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7276477 |
Crystals of etanercept and methods of making thereof
The present invention relates to crystalline etanercept and to methods of making crystalline etanercept; to pharmaceutical compositions comprising crystalline etanercept; and to therapeutic uses of...
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7276245 |
Method for treating hyperalgesia by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7276251 |
Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid
A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in...
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7276479 |
Methods of treating intestinal ischemia using heparin-binding epidermal growth factor
The present invention provides methods of treating pathologic conditions associated with intestinal ischemia. In the methods, patients at risk for or suffering from intestinal ischemia are treated...
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7276371 |
Stimulation of hematopoietic cells in vitro
Methods, compositions, and devices for stimulating the number and/or differentiation of hematopoietic cells in vitro are provided. The methods involve contacting the hematopoietic cells with an...
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7276480 |
Prevention and reduction of blood loss
Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient...
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7276491 |
Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors
Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
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7276478 |
Methods of treating autoimmune diseases using IL-21
Administration of IL-21 results in decreasing autoimmune responses and thereby provides a beneficial treatment for autoimmune diseases. Specific autoimmune diseases that may be treated include...
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7276342 |
Xobesin agonists and antagonists for the treatment of metabolic disorders
The present invention relates to the field of metabolic research, in particular the discovery of compounds effective for reducing body mass and useful for treating obesity-related diseases and...
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7276244 |
Methods of treating abnormalities of the first metatarsophalangeal joint of the foot
Disclosed is a method for treating abnormalities of the first metatarsophalangeal joint of the foot of a mammal comprising administering a therapeutically effective amount of neuromuscular toxin to...
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7273847 |
Peptides with antioxidant and antimicrobial properties
Methods of treating conditions associated with lipid oxidation or microbial proliferation include the step of administering a composition comprising a pharmacologically effective amount of an...
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7273724 |
Polypeptide-human actin-binding protein 54 and a polynucleotide encoding the same
The present invention discloses a novel polypeptide—human actin-binding protein 54 and a polynucleotide encoding the same, as well as a method of producing the polypeptide by DNA recombinant...
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7273849 |
ProapolipoproteinA-I mutant and pharmaceutical composition comprising the same for prevention and treatment of atherosclerosis and hyperlipidemia
The proapoA-I mutants of the present invention exhibit superior LDL-antioxidant activities over the wild-type proapoA-I and higher efficiencies for delivering cholesterol to hepatocytes than the...
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7271149 |
GLP-1 fusion proteins
The present invention relates to glucagon-like-1 compounds fused to proteins that have the effect of extending the in vivo half-life of the peptides. These fusion proteins can be used to treat...
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7270826 |
Methods of using Botulinum toxin for the treatment of hypervolemic lip deformity (lip ectropion)
The present invention uses pharmaceutical preparations of Botulinum toxin to induce neurogenic atrophy to alter muscle volume and subsequently, facial contour. Reduction in lip volume is...
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7271148 |
Inhibition of cellular proteases
The invention provides a method of decreasing viral replication in cells, the method comprising decreasing levels of functional cellular protease in the cells. The invention further provides a...
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7271145 |
Methods and compositions for oxygen transport comprising modified hemoglobin in plasma
The present invention relates to blood products, and more particularly to compositions comprising a modified hemoglobin in plasma.
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7270822 |
Active complex of alpha-lactalbumin (hamlet) and cofactor
The use of a biologically active complex of α-lactalbumin, selected from HAMLET (human α-lactalbumin made lethal to tumour cells) or a biologically active modification thereof, or a biologically...
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7271146 |
Methods for treatment of Helicobacter pylori-associated disorders
The present invention relates to methods for treating pathological conditions associated with Helicobacter sp infections, specifically H. pylori infection. The present invention further relates...
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7271150 |
Modified growth hormone
The invention provides a growth hormone (GH) in which amino acids within the regulated secretory pathway (RSP) sorting signal have been mutated as well as a GH in which the three-dimensional...
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7268114 |
Protein and process for preparing the same
A protein having amino acid sequence in SEQ ID NO: 1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by...
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7268113 |
Long lasting growth hormone releasing factor derivatives
This invention relates to growth hormone releasing factor (GRF) derivatives. In particular, this invention relates to GRF peptide derivatives having an extended in vivo half-life, for promoting the...
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7268155 |
Photosensitizer conjugates for pathogen targeting
Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.
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7268118 |
Thymosin β4 compositions
A composition with a polypeptide including amino acid sequence LKKTET [SEQ ID NO:1] or a conservative variant thereof, the composition further including a carrier for application to a surface of a...
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7268117 |
Compositions, kits, and methods for identification, assessment, prevention, and therapy of endometriosis
The invention relates to newly discovered marker polypeptides associated with endometriosis. Compositions, kits, and methods for detecting, characterizing, preventing, and treating endometriosis...
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7268116 |
Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins
Methods and compositions for producing secreted soluble receptors and biologically active polypeptides in trimeric forms are disclosed. The process involves fusing the DNA template encoding a...
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7268109 |
Method for reducing pain
The present invention is direct to a method of producing analgesia in a mammalian subject. The method includes administering to the subject an omega conopeptide, preferably ziconotide, in...
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7268110 |
Agents for preventing and treating thrombocytopenia
Method of increasing blood platelet formation by administering a parathyroid hormone (PTH) or at least one PTH derivative as an active ingredient.
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7265089 |
KGF polypeptide compositions
Compositions comprising keratinocyte growth factor (KGF) polypeptides and methods of using the same are described. The KGF polypeptides of the present invention display enhanced bioactivity...
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7265088 |
Method and compositions for altering mucus secretion
Methods and compounds for increasing or decreasing mucus secretion in subjects, and particularly mucus secretion in the airways, are described. Methods of screening compounds for the ability to...
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7265090 |
Nanoparticles for paracellular drug delivery
The invention discloses the nanoparticles composed of chitosan/poly-γ-glutamic acid characterized with a positive surface charge and their enhanced permeability through Caco-2 cells for...
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7265091 |
Methods and compositions for treating male erectile dysfunction
The invention provides a method for preventing or treating male erectile dysfunction or female sexual arousal disorder by administering an effective amount of one or more factors from a group of...
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7265087 |
Exendin improves β-cell response in subjects with impaired glucose tolerance
A composition for the treatment of impaired glucose tolerance (IGT) including a compound which binds to a receptor for glucagon-like peptide-1, and a pharmaceutical carrier. The amount of the...
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7262168 |
Compositions providing for increased IGF-I solubility
Novel IGF-I compositions are described. The compositions include a solubilizing compound comprising a guanidinium group that provides for IGF-I compositions in which IGF-I is highly soluble at pHs...
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7261894 |
Methods of treating inflammatory and/or autoimmune disease
The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such...
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7261882 |
Methods for treating neuropathic pain by administering IL-10 polypeptides
Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous...
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7262166 |
Chemically modified novel erythropoietin stimulating protein compositions and methods
The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).
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7262167 |
Drug, in particular for modulating the immunological response for the control of viruses, tumors, bacteria and parasites
A method of treating tumors and other conditions in a patient is provided. The method involves administering to the patient a treatment medicament. The medicament contains a first component and a...
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7261881 |
Modulation of angiogenesis and wound healing
Methods of regulating angiogenesis, ischemic injury and/or wound healing by modulating the activity of leptin, particularly as mediated by the leptin receptor, and/or the interaction between leptin...
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7259144 |
Methods for diagnosing and treatment of hyperphosphatemic conditions using FGF20 polypeptides
The present invention describes novel methods for diagnosis and treatment of conditions that alter phosphate transport in mammals. The fibroblast growth factor proteins and nucleotides that may be...
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7259147 |
Methods of treating multiple sclerosis with a JTT-1 polypeptide
Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have...
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7258853 |
Antagonists of interleukin-15
Disclosed herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient.
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7259137 |
Peptides and related molecules that bind to TALL-1
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz 2 Lz 4 ...
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7259143 |
Method of extending the dose range of vitamin D compounds
Inhibitors of bone calcium resorption are administered to allow high doses of vitamin D compounds or mimetics to be given with the intent of treating non-calcium related diseases such as cancer,...
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7258856 |
Proteases from Carica having mitogenic activity and their methods of use
Proteases having mitogenic activity isolated from the genus Carica are provided. In particular the proteases are cysteine proteases isolated from Carica candamarcensis. In addition, the...
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