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7312198 |
Protein compositions for promoting wound healing and skin regeneration
Methods for stimulating proliferation and inhibiting death of cells in the epidermis and dermis of wounded and non-wounded as well as transplanted mammalian skin and transplanted skin cell...
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7312197 |
Method of modifying glucose activity using polypeptides selectively expressed in fat tissue
Isolated omentin polypeptides that selectively express in omental fat tissue and methods for the use of the polypeptides. The polypeptides can be used in a method for modifying insulin action...
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7311912 |
Epithelial tissue targeting agent
Targeting molecules for use in delivering biological agents to epithelial tissue are disclosed. Upon delivery, the biological agent(s) may remain within an epithelial cell or may undergo...
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7309484 |
Compositions and methods for screening antibacterial compounds
The present invention pertains to compositions and methods used to ascertain if putative antibiotics trigger a cell envelope stress response in bacterial organisms. In one aspect of the invention,...
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7309483 |
Method of treatment using Tie2 ligand2
The invention provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or...
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7309687 |
Methods for treatment and prevention of neuromuscular and muscular conditions by peripherally administered erythropoietin
Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as...
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7307064 |
Methods for treating cardiovascular disease using a soluble CTLA4 molecule
The present invention relates to compositions and methods for treating cardiovascular system diseases by administering to a subject soluble CTLA4 molecules that block endogenous B7 molecules from...
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7306799 |
Use of VEGF inhibitors for treatment of eye disorders
Modified chimeric polypeptides with improved pharmacokinetics and improved tissue penetration are disclosed useful for treating eye disorders, including age-related macular degeneration and...
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7306801 |
Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein
Methods for treating a subject with a cancer that is characterized by overexpression of HER2 receptor protein using a combination of interleukin-2 (IL-2) or variant thereof and at least one...
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7303746 |
Methods of treating eye disorders with modified chimeric polypeptides
Modified chimeric polypeptides with improved pharmacokinetics are disclosed useful for treating eye disorders, including age-related macular degeneration and diabetic retinopathy.
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7303814 |
Immobilized bioactive hydrogel matrices as surface coatings
The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having...
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7304033 |
Methods for protecting allogeneic islet transplant using soluble CTLA4 mutant molecules
The present invention is a method of inhibiting islet cell transplant rejection, particularly to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective...
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7304029 |
Neuroprotective effect of growth hormone
The invention relates to neuroprotection and to medicaments for use therein. Neuroprotection is induced by activation of neural growth hormone receptors, primarily using medicaments comprising...
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7303748 |
Method of treating eye injury with local administration of a VEGF inhibitor
Methods of reducing or treating angiogenesis and/or inflammation associated with eye injury in a subject in need thereof, comprising administering an agent capable of blocking or inhibiting...
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7304034 |
Use of HMGB fragments as anti-inflammatory agents
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The...
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7303885 |
Screening method for candidate drugs
The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to...
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7300920 |
Antiangiogenic peptide agents
The current invention provides novel antiangiogenic peptides which correspond to about 133 consecutive amino acids of the N-terminal sequence of growth hormone.
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7300654 |
Method of treating corneal transplant rejection in high risk keratoplasty patients
Methods of preventing, reducing, or treating corneal transplant rejection to improve transplant survival in a high risk subject comprising administering an agent capable of blocking or inhibiting...
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7297680 |
Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
Disclosed are immortalized human embryonic retina cells, having a nucleic acid sequence encoding an adenoviral E1A protein integrated into the genome of the cells, and further comprising a nucleic...
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7294613 |
Beta-defensins
The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the β-defensin family. The polypeptides, and polynucleotides encoding them, exhibit...
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7294617 |
Method for nonsurgical treatment of the intervertebral disc and kit therefor
This invention relates to a method and compositions for treating pathological intervertebral discs comprising the step of delivering an agent that causes chemical crosslinking of the native...
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7294615 |
Compounds that associate on the intermolecular level and aggregate bodies that contain them
Compound of the general formula (I)
X(B) m (I)
wherein
X is an m-valent...
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7294339 |
Method for treating allodynia by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7291598 |
Nanoparticles for protein drug delivery
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for...
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7291588 |
Immunogenic detoxified mutant E. coli LT-A toxin
An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of an E. coli heat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72...
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7291341 |
Stresscopins and their uses
The invention provides novel nucleic acids and polypeptides, referred to herein as stresscopin 1 and stresscopin 2, which preferentially activate the CRH-R2 receptor over the R1 receptor....
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7291344 |
Method for treating phantom pain by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7291597 |
Growth factor therapy mobilization of stem cells into the peripheral blood
Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the...
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7291596 |
Pharmaceutical composition for thrombin peptide derivatives
Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical...
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7291589 |
Uses of human Zven proteins and polynucleotides
The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders...
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7291593 |
Use of fish for treating infertility
The present invention relates to the use of FSH and/or a biologically-active analogue thereof in the production of a medicament for the treatment of infertility in women. The medicament is for...
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7291594 |
GLP-1 derivative and preparation thereof absorbable via mucous membrane
A GLP-1 derivative is provided including an amino acid sequence of GLP-1 (7-35) having deletion, substitution and/or addition of one or more amino acids and having Waa-(Xaa)n-Yaa (in which Waa is...
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7291595 |
Use of Alpha-1 antitrypsin for the preparation of medicaments for the treatment of fibromyalgia
The invention is based on the use of alpha-1 antitrypsin for the preparation of medicaments for the treatment of fibromyalgia, comprising the preparation of therapeutic concentrates of alpha-1...
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7288259 |
Treatment of holocrine gland dysfunction with clostridia neurotoxins
Methods of using clostridial toxins and other biological agents to control holocrine gland dysfunction in humans is provided. In preferred embodiments the methods provide beneficial effects in...
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7288406 |
Active variants of FGF with improved specificity
The present invention provides active fibroblast growth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3...
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7288260 |
Method for treating pain by peripheral administration of a neuroptoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7285277 |
Anticancer agent
The present application discloses a method of reducing tumor growth that includes contacting the tumor with a tumor growth reducing effective amount of a composition comprising LK8 or LK68 protein...
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7285534 |
Corticotropin-releasing hormone analogs and their uses
This invention provides members of the corticiotropin-releasing hormone superfamily and peptide analogs thereof wherein the 38 th amino acid from the N-terminus is D-Nle, i.e. [D-Nle 38 ]-CRH...
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7285531 |
Method for prophylaxis or treatment of a nervous system, pathophysiological condition involving a glial growth factor sensitive cell by administration of a glial growth factor
The invention involves prophylaxis or treatment of nervous system pathological conditions. This is accomplished by administering secretable glial growth factors, such as the molecule referred to as...
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7285535 |
Toll/interleukin-1 receptor adapter protein (TIRAP)
TIRAP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TIRAP polypeptides and...
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7285532 |
Therapeutic method for treating bone formation diseases
Methods of treating and/or inhibiting a bone morphogenetic protein (BMP)-related disorder or condition by administering a BMP antagonist to a subject suffering from a BMP-related disorder or...
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7285533 |
Apo-2 ligand
A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2...
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7282209 |
Tango 240 polypeptides and uses thereof
The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid...
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7282206 |
Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
Methods are provided for treating or inhibiting the formation of tissue fibrosis using IL-13 antagonists, including without limitation soluble forms of the IL-13 receptor.
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7282482 |
NGF for the prevention of demyelination in the nervous system
This invention pertains to the discovery that nerve growth factor (NGF) is capable of preventing further demyelination of nervous tissue in pathologies characterized by the demyelination of nervous...
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7282201 |
Methods of promoting the growth or differentiation of hematopoietic stem or progenitor cells by non-muscle type cofilin
This invention has as its object providing promoters of the growth and/or differentiation of hematopoietic stem cells and/or hematopoietic progenitors which are useful as therapeutics of diseases...
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7282483 |
Method of ameliorating the harmful effects of TNF using a polypeptide having the ability to bind to TNF
The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for...
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7282214 |
Biomedical devices with antimicrobial coatings
Biomedical devices with antimicrobial coatings are provided. One or more surfaces of the device are coated with a cationic peptide, cationic proteins, or mixtures thereof to impart antimicrobial...
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7279159 |
VEGF inhibitor polypeptides
Nucleic acid molecules and multimeric proteins capable of binding vascular endothelial growth factor (VEGF). VEGF traps are disclosed which are therapeutically useful for treating VEGF-associated...
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7279461 |
Rabconnectin-3-binding protein
A protein useful for clarifying the regulation mechanism of Ca 2+ -dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for...
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