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5128320 Method of restoring normal growth, weight gain or lean body mass in patients with glucocorticoid excess by administering IGF-I  
A method is disclosed for at least partially restoring normal growth, weight gain, and lean body mass of a mammal afflicted with glucocorticoid excess. This method comprises the administration to...
5124314 Pharmaceutical compositions containing amylin  
The present invention relates to pharmaceutical compositions for use in treating diabetes Mellitus or hypoglycemia containing Amylin as the effective additive.
5124315 Liquid pharmaceutical composition for nasal administration containing a polypeptide as active ingredient  
A liquid composition for nasal administration of polypeptide/s containing ammonium tartrate and a buffer together with optional adiuvants.
5122368 Anthracycline conjugates having a novel linker and methods for their production  
The invention relates to anthracycline conjugates comprising at least one anthracycline molecule linked to a molecule that is reactive with a cell population to be eliminated such as antibody,...
5120714 Method for the diagnosis and treatment of human granulomatous inflammatory disease  
A method for the diagnosis of human granulomatous inflammatory disease comprising determining the level of Granuloma Enhancing Factor (GEF) activity in a bodily fluid and comparing said level to...
5120711 Synergistically active veterinary compositions and process for preparing same  
The invention relates to synergistically active veterinary compositions useful particularly for the treatment of mastitis and metritis. The invention further relates to a process for preparing...
5118615 Peptide and gene coding for same  
Disclosed is a DNA fragment comprising a base sequence coding for a peptide occurring in human atrium cordis and having diuretic action or a precursor of the peptide, plasmids containing the DNA...
5114917 Treatment of inflammation using alpha 1-antichymotrypsin  
A method for the prophylaxis or direct treatment of inflammation in a mammal which comprises administering an effective amount of alpha 1-antichymotrypsin, its salts or derivatives, and...
5112596 Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability  
The permeability of the blood-brain barrier to endogenous or exogenous neuropharmaceutical or diagnostic agents in an individual's blood stream is increased by administering a bradykinin agonist...
5089475 Treatment of ventilator dependency with growth hormone  
The invention relates to a method of treating pulmonary dysfunction in a mammal comprising administration of growth hormone to said mammal. In one embodiment wherein the pulmonary dysfunction...
5086039 Pharmaceutical compositions and use thereof in treating inflammation  
Inflammation in mammals is treated by administering anti-inflammatory agent complexed with corticosteroid binding globulin (CBG).
5080907 Pharmaceutical preparations containing non-steroidal anti-inflammatory agents  
Pharmaceutical preparations for oral administration are disclosed which comprise (a) an acidic non-steroidal anti-inflammatory agent having the mean particle size of about 100 μm or less and (b) a...
5064810 Use of branched chain amino acids to effect diaphragm contractility and fatigue  
A method for reducing respiratory muscle fatigue comprising the steps of administering a composition that includes branched chain amino acids. The composition can be administered either enterally...
5039660 Partially fused peptide pellet  
A bioerodible pellet capable of administering an even and continuous dose of a peptide over a period of up to a year, when subcutaneously implanted, is provided. The bioerodible implant is a...
5039790 Bioactive fragment of interleukin-1-B that has antagonistic activity  
The present invention discloses a peptide capable of blocking activity of Interleukin-1. The peptide corresponds to the 157-186 amino acid residue of the IL-1β molecules.
5028592 Antipyretic and anti-inflammatory peptides  
An antipyretic tripeptide, having the amino acid sequence lysine-proline-valine, and a method for utilizing the tripeptide to reduce fever and inflammation in mammals are disclosed. The tripeptide...
5013552 Modified pollen grains for delivering biologically active substances to plants and animals  
Loaded pollen grains are disclosed which are suitable for use as delivery systems for introducing biologically active substances into or on plants and animals. Such pollen grains are suitable to...
5013722 Cholecystokinin analogs for controlling appetite  
Cholecystokinin analogs useful for suppressing food intake in mammals and humans.
5008243 Pharmaceutical composition containing a glycoprotein  
Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretics activity, anti-hyperlipemic activity and anti-inflammatory...
5004602 Continuous release pharmaceutical compositions formed by freeze drying acetic acid solutions of polylactide  
Pharmaceutical compositions, comprising a polylactide and a pharmacologically active, acid stable polypeptide, which when placed in an aqueous physiological equipment release the polypeptide at an...
4994439 Transmembrane formulations for drug administration  
Compositions for the administration of protein or peptide drugs across membranes show low toxicity and efficient permeation when the medium is a mixture of a bile salt or fusidate with a nonionic...
4977244 Uromodulin and a process of purifying it  
This invention relates to processes for producing uromodulin, a glycoprotein having a molecular weight of 85 kilo daltons. This glycoprotein, which is isolated from crude urine, as well as its...
4973478 Treating inflammation with hepatocyte stimulating factor interferon β2  
Interferon β2 has been identified as the major factor responsible for stimulating hepatocytes to produce anti-inflammatory agents. A method for its use in so stimulating hepatocytes is described...
4963525 Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments  
Acylcarnitine used as a nasal, buccal, sublingual and vaginal drug absorption enhancing vehicle for poorly absorbed drugs.
4943561 Gastrin releasing peptide antagonist  
Small cell lung carcinoma (SCLC) cells contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of peptide derivatives that act as...
4942035 Continuous release formulations  
Pharmaceutical compositions comprising a pharmacologically active polypeptide and a pharmacologically or veterinarily acceptable amphipathic, non-cross-linked linear, branched or graft block...
4904763 Physiologically-active novel peptides  
Disclosed herein is a physiologically-active peptide represented by the following general formula (I): ##STR1## wherein X means H or H-Asp-Ser-Gly- and Y denotes -Asn-Val-Leu-Arg-Arg-Tyr-OH,...
4902708 CCK antagonists  
In general, the invention features compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein each R1 is, independently, an alkyl group having 1-5, inclusive,...
4891356 Proteinase inhibitors for treatment of gastrointestinal ulcer disease  
A method of treating gastrointgestinal ulcer disease is provided which involves administration of a proteinase inhibitor or analogue to patients suffering from same. Of particular interest is the...
4882359 Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparations containing the absorption promoters  
An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient...
4840785 Mammal intestinal hormone precursor and its use  
A mammal intestinal hormone precursor having the following peptide structure: His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-L-M- Ala-Arg-Leu-Gl n -Arg-Leu-Leu-Gln-Gly-Leu-Val-Gly-N-O,...
4822773 Enhancement of absorption of drugs from gastrointestinal tract using choline ester salts  
Choline ester salts are used as drug absorption enhancing agents for orally and rectally administered drugs.
4816449 Immunotherapeutic anti-inflammatory peptide agents  
Anti-inflammatory peptides of the formula A-B-C-D-E, useful in treating allergies, autoimmune diseases, and other disorders, and methods for using them are described.
4816443 Piptides having ANF activity  
Novel peptides having potent natriuretic activity are disclosed with the following amino acid sequence: ##STR1## wherein Z is H, acetyl, Boc or Ser-Leu, E is Phe, NMP, OMT, ChA, F is Gly or DAl, G...
4794103 Pharmaceutical compositions containing peptides of the cholecystokinin-cerulein group for the therapy of shock conditions and of respiratory and cardiocirculatory insufficiencies  
Pharmaceutical compositions containing a polypeptide of the cholecystokinin-cerulein group are effective in the treatment of shock conditions and of respiratory and cardiocirculatory...
4782044 Composition containing cordiodilatin or fragments thereof and methods of obtaining cardiodilatin  
This invention teaches therapeutic compositions containing the hormone cardiodilatin of active fragments thereof, as well as methods for obtaining the cardiodilatin. The compositions are useful in...
4772588 Treatment of parasitic diseases with calf thymus extract  
A course of a parasitic, e.g. protozoal, infection is combated by administering to the host an immunomodulating effective amount of a calf thymus hormone extract.
4767753 Methods and compositions for preventing ulcers  
A variety of compositions suitable for use within methods for (a) reducing the formation of stomach ulcers in warm-blooded animals, (b) reducing the secretion of stomach acid in warm-blooded...
4745100 Stimulation of tear secretion  
A method and preparation for the stimulation of tear secretion. The method involves topically applying to the ocular surface gastrointestinal hormones and/or biologically active peptides and their...
4728638 Somatostatine derivatives  
Somatostatine derivatives of the general formula ##STR1## wherein either (a) A is ##STR2## W is -CO-N(A4) or -N(A5)-CO- and Y1 and Y2 are H or together a bond or (b) A is H, alkyl, phenylalkyl or...
4716148 Prothymosin alpha  
A new biological polypeptide hormone has been isolated from mammalian thymus and has been given the designation prothymosin alpha. This peptide contains approximately 107 to 113 amino acid...
4713367 Retro-inverso analogs of the bradykinin potentiating peptide BPP5a  
New partially retro-inverso peptides of the following general formula ##STR1## wherein R1 and R2 are the same or different and represent, each independently, the side chain of the aminoacid...
4696915 Parathymosin alpha  
Parathymyosin alpha is a novel peptide isolated from mammalian thymus and contains approximately 105 amino acid residues. It bears a high degree of homology to prothymosin alpha both in sequence...
4687760 Reduced peptides which inhibit gastric secretion, process for their preparation and pharmaceutical compositions in which they are present  
The invention relates to the peptides of the formula: ##STR1## in which: R1 represents hydrogen or a protecting group for the amine group, such as t-butoxycarbonyl, benzyloxycarbonyl or lower...
4687759 Tripeptide and tetrapeptide esters which inhibit gastric secretion, process for their preparation and pharmaceutical compositions in which they are present  
The invention relates to the peptides of the formula: ##STR1## in which: R represents hydrogen or a protecting group for the terminal amine group, such as t-butoxycarbonyl (Boc), benzyloxycarbonyl...
4670419 Pharmaceutical composition and its rectal use  
A pharmaceutical composition containing a hydrophilic drug which is poorly absorbable through the gastrointestinal tract, and cyclodextrin, increases the absorbability of the drug into the...
4659696 Pharmaceutical composition and its nasal or vaginal use  
A pharmaceutical composition containing a hydrophilic drug which is poorly absorbable through the gastrointestinal tract, and cyclodextrin, increases the absorbability of the drug into the...
4657893 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors  
Novel 2-amino-4H-3,1-benzoxazin-4-ones represented by the formula ##STR1## wherein R1, R2, R3 and X are defined herein are useful as enzyme inhibitors in animals.
4650787 Biologically active octapeptides  
Novel compositions of the formula ##STR1## wherein A represents an L, D or DL amino-acid selected from the group consisting of Ala, Val, Phe, p-Cl-Phe, Trp, Pro, Ser, Thr, Glu, Gly, Beta Ala, Abu,...
4647455 Process for extracting atrial natriuretic factor  
Diuretic and natriuretic extracts, at least partially characterized as peptides, have been obtained by homogenization of mammalian heart atria with an aqueous solution of a lower carboxylic acid....