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7128912 |
Fibronectin binding protein compositions and methods of use
Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB...
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7128905 |
Method of treating graft versus host disease by administration of a Fas antagonist
The present invention is drawn to methods of preventing and treating diseases wherein the involvement of apoptosis has been indicated.
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7125851 |
Endoprosthesis with long-term stability
The invention relates to the use of an active substance complex for creating biological parts, in particular organs for living organisms, with the following components which differ from one another...
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7125850 |
Methods of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA...
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7125848 |
Methods of treating non-inflammatory gastrointestinal tract disorders using Cav2.2 subunit calcium channel modulators
A method is provided for using Cav2.2 subunit calcium channel modulators to treat non-inflammatory gastrointestinal tract disorders.
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7125847 |
Mechanically activated channel blocker
The present invention discloses a peptide of SEQ ID NO:2 and its variants that blocks stretch-activated ion channels. The peptide, designated as GsMTx-4, is present in the venom of the spider ...
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7125846 |
Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides
The present invention relates to a composition comprising factor VII or a factor VII-related polypeptide, and factor V or a factor V-related polypeptide, and the use thereof for treating bleeding...
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7122521 |
Collagen mimics
A novel collagen mimic comprising a tripeptide unit having the formula (flpYaaGly) n , where flp is 4(S)-fluoro-L-proline, is disclosed. The collagen mimic has increased stability relative to the...
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7122520 |
Methods of modulating appetite using agouti-related transcript polypeptides
Disclosed is a novel gene termed ART which is expressed primarily in selected regions of the brain, as well as adrenal and lung tissues. Polypeptides encoded by ART are also disclosed, as are...
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7119070 |
Antimicrobial theta defensins, analogs thereof, and methods of use
The invention provides theta defensin analogs having antimicrobial activity. The invention also provides a method of reducing or inhibiting growth or survival of a microorganism in an environment...
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7119069 |
Human kininogen D3 domain polypeptide as an anti-angiogenic and anti-tumor agent
Human kininogen domain 3 (HK-D3) polypeptides and biologically active variants and derivatives of HK-D3 are anti-angiogenic. These molecules are used to inhibit angiogenesis or treat a disease or...
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7119068 |
Methods of screening for compounds that modulate TAFIa activity, compounds, and methods of using the compounds
Provided are methods of screening compounds for any aspirin-related activity other than TAFI inhibition, and also for non-inhibition of TAFI. Compounds identified by the screening methods can be...
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7119067 |
Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
Nucleic acid molecules encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the nucleic acid molecules, and methods for...
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7119066 |
Modified ciliary neurotrophic factor (CNTF)
Modified ciliary neurotrophic factor, methods for production and methods of use, especially in the treatment of Huntington's disease, obesity, and gestational or adult onset diabetes.
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7119064 |
Use of colostrinin, constituent peptides thereof, and analogs thereof as modulators of intracellular signaling molecules
The present invention provides methods that utilize compositions containing colostrinin, a constituent peptide thereof, an active analog thereof, and combinations thereof, as modulators of...
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7118872 |
Binding polypeptides for B lymphocyte stimulator protein (BLyS)
Binding polypeptides comprising specific amino acid sequences are disclosed that bind B Lymphocyte Stimulator (BLyS) protein or BLyS-like polypeptides. The binding polypeptides can be used in...
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7118752 |
Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
A method is described for using an a-type or b-type E domain of the human or trout IGF peptide for the inhibition of proliferation and invasiveness of a broad spectrum of malignant cells and for...
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7115571 |
Retro-inverso peptides derived from interleukin-3
Retro-inverso peptides derived from interleukin-3 (IL-3) having between 12 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native...
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7115570 |
Cloning and characterization of a human adenylyl cyclase
A DNA sequence encoding a human adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described.
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7115569 |
Exendins, exendin agonists, and methods for their use
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist,...
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7115568 |
Methods using TCF II
The present invention provides an agent for preventing and/or treating cachexia comprising TCF-II as an effective ingredient. An agent for preventing and treating cachexia caused by cancer,...
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7115567 |
Purified STAT proteins and methods of purifying thereof
The present invention describes methods of producing milligram quantities of three forms of purified Stat1 protein from recombinant DNA constructs. In addition, the Stat proteins may be isolated in...
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7115557 |
Use of certain drugs for treating nerve root injury
The present invention relates to a method and a pharmaceutical composition for treatment of nerve disorders comprising administration of a therapeutically effective dosage of at least two...
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7115394 |
Hedgehog interacting proteins and uses related thereto
The present invention concerns the discovery of a new family of hedgehog binding proteins, refered to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to...
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7115388 |
Production of functional polypeptides originating from silk protein and use thereof
It is an object to provide polypeptide compositions originating from silk protein which have not only excellent cell growth-promoting activity associated with undegraded silk fibroin and sericin,...
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7115272 |
Compositions and methods for WT1 specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise a WT1 polypeptide comprising an immunogenic portion of WT1,...
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7112569 |
Protein inhibiting aggregation of beta amyloid peptide
The present invention relates to a novel protein inhibiting β amyloid aggregation and a strain producing the protein, more precisely, to a novel protein inhibiting β amyloid aggregation, a gene...
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7112568 |
Anti-allergic complex molecules
The present invention discloses novel anti-allergic complex molecules, and in particular, peptidic or peptidomimetic molecules, comprising a first part which is competent for cell penetration and a...
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7112567 |
Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders
This invention relates to glucagon-like peptide 2 (GLP-2) derivatives. In particular this invention relates to GLP-2 peptide derivatives having an extended in vivo half-life, for the treatment or...
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7112566 |
Systemic administration of Hypocretin-1
The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a...
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7112560 |
Angiogenically effective unit dose of FGF-2 and method of use
The present invention has multiple aspects. In particular, in one aspect, the present invention is directed to a unit dose composition comprising 0.2 μg/kg to 48 μg/kg of an FGF-2 of SEQ ID NO:...
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7112341 |
Pulmonary administration of dry powder formulations for treating infertility
Provided are stabilized follicle stimulating protein (FSP) dry powder compositions for aerosolized delivery to the deep lung, methods of preparing and administering such compositions, and methods...
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7112333 |
T cell epitopes of ryegrass pollen allergen
The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne . Therapeutic peptides within the scope of the invention comprise at least one T...
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RE39299 |
INGAP protein involved in pancreatic islet neogenesis
Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display...
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7109168 |
Retro-inverso peptides derived from leukemia inhibitory factor
Retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same...
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7109167 |
Compounds for targeting endothelial cells, compositions containing the same and methods for their use
The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use....
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7109030 |
Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other...
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7108999 |
Modulators of the function of FAS/AP01 receptors
Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein...
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7108857 |
Therapy for injured muscles
Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle.
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7105490 |
Methods and compositions for treating polycystic ovary syndrome
The present invention relates to methods of treating polycystic ovary syndrome (PCOS) comprising administering glucagon-like peptide-1 (GLP-1), exendin, and analogs and agonists thereof, to...
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7105489 |
Methods and compositions for treating polycystic ovary syndrome
The present invention relates to methods of treating polycystic ovary syndrome (PCOS) comprising administering glucagon-like peptide-1 (GLP-1) to subjects suffering therefrom.
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7105486 |
Abuse-resistant amphetamine compounds
The invention describes compounds, compositions and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for...
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7105485 |
HO-1 suppressor as a diagnostic and prognostic test for dementing diseases
The invention relates to an improved method for predicting the onset of, diagnosing, prognosticating and/or treating dementing diseases. The method comprises determining the level of heme...
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7105484 |
GDNF receptorα
GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are...
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7105481 |
Method for stimulating connective tissue growth or wound healing
PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and...
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7105480 |
Method of treatment and agents useful for same
The present invention relates generally to a method of modulating bone resorption and to agents useful for same. More particularly, the present invention provides for the use of leptin and its...
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7105168 |
Method of improving ischemic muscle function by administering placental growth factor
The present invention relates to prevention and treatment of strokes and ischemic diseases and to post-ischemic therapeutic treatment. The invention furthermore relates to the use of a growth...
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7105167 |
Methods for treating clinical manifestations of GH/GF axis dysregulation by administration of an IGF-I variant
IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder...
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7101853 |
Method for treating or preventing gastritis using amylin or amylin agonists
Methods for treating or preventing gastritis or gastric injury are disclosed, comprising administering a therapeutically effective amount of an amylin or an amylin agonist. Methods are also...
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7101852 |
Composition and method for treatment and prevention of restenosis
Compositions and methods are disclosed which employ PARIS proteins that are useful for suppressing proliferation of smooth muscle cells. Preferred PARISs are soluble proteins that are secreted by...
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