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7351693 |
Peptides and nucleic acids of the cathelicidin family, derived from fish, and uses thereof
The invention relates to anti-microbial and immunostimulatory molecules of the cathelicidin family derived from fish. The invention provides a novel cathelicidin molecule, fragments, derivatives...
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7348312 |
Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
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7345019 |
Modulation of excitable tissue function by peripherally administered erythropoietin
Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as...
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7344858 |
Glycosylated human granulocyte colony-stimulating factor (G-CSF) isoform
Disclosed are human G-CSF isoforms having a modified amino acid sequence containing a glycosylation sequence Asn-X-Ser/Thr (N-X-S/T) at one or more specific amino acid positions according to the...
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7345021 |
Method for PR-39 peptide regulated stimulation of angiogenesis
The present invention provides both a method and means for regulating angiogenesis within living cells, tissues, and organs in-situ. The regulation is performed using native PR-39 peptide or one of...
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7344719 |
Homologous 28-kilodalton immunodominant protein genes of Ehrlichia canis and uses thereof
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family...
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7341994 |
GD3-mimetic peptides
GD3-Mimetic peptides which contain an amino acid sequence represented by any of SEQ ID NOS: 1 to 4 or an amino acid sequence derived therefrom by substitution, deletion, addition, or insertion of...
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7341999 |
Povidone-containing carriers for polypeptide growth factors
A liquid carrier medium is provided which is suitable for solubilizing growth factors, such as mixtures of bone morphogenetic proteins, that are found to induce an angiogenic response in ischemic...
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7341730 |
Inhibitors of angiogenesis and tumor growth
This invention provides for polypeptides that have surprising anti-angiogenic activity. These peptides are derived from Saposin B, a previously known protein involved in the hydrolysis of...
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7341996 |
Processed vascular endothelial growth factor-B polypeptides
VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides,...
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7341732 |
Methods for treating mastitis in a milk producing animal
The present invention provides methods for treating mastitis in a milk producing animal. The methods include administering compositions including siderophore receptor polypeptides and porins from...
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7341995 |
Use of SARP-1 for the treatment and/or prevention of scleroderma
The invention relates to the use of SARP-1 for the preparation of a medicament for the treatment and/or prevention of scleroderma, in particular of systemic sclerosis.
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7342048 |
Bioabsorbable pharmaceutical formulation
A bioabsorbable release-sustaining pharmaceutical formulation using a biodegradable release-sustaining base material which can prevent an effective component drug from being released too rapidly...
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7341997 |
Method of treatment
The present invention relates generally to a method of treatment and in particular a method of treating disorders of the nervous system such as arising from or during disease or injury. The method...
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7341998 |
Conus californicus neurotoxins
Novel conotoxin polypeptide and polynucleotide sequences are provided.
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7338935 |
Chromatographic separation of therapeutic polypeptides
The present invention is directed to the purification and commercialization of therapeutic polypeptides that have. In one aspect of the invention, a method of purifying Interferon β-1b using size...
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7338937 |
Calcium-activated chloride channel proteins and their use in anti-metastatic therapy
Nucleotide sequences which encode a mammalian lung endothelial cell adhesion molecule are disclosed. Also disclosed are nucleotide sequences which encode a lung endothelial cell adhesion...
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7338766 |
Compositions and methods for treating malaria with cupredoxin and cytochrome
The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the...
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7339037 |
Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins
The invention provides a method of inhibiting prophylactically or therapeutically an influenza viral infection in a host. The method comprises instilling into or onto a host a cell producing an...
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7338939 |
Abuse-resistant hydrocodone compounds
The present invention decreases the potential for abuse of opioids, particularly hydrocodone, by covalent modification. The invention provides methods of delivering hydrocodone as conjugates that...
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7338670 |
Use of an agent that restores tissue perfusion and oxygenation
The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders...
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7338934 |
Fibroblast growth factor-14
Disclosed is a human Fibroblast growth factor-14 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also...
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7335641 |
Method for stimulating hair follicle cell proliferation
The present invention relates to novel hair follicle growth factor (HFGF) proteins, genes encoding HFGFs, methods for preparing HFGF proteins and therapeutic uses of HFGF proteins. The HFGF...
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7335636 |
SPRR1A and axonal regeneration
The present invention provides polynucleotides, polypeptides, pharmaceutical compositions, and methods for modulation of nerve growth and regeneration.
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7335639 |
IGF-1 composition and its use
A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I...
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7335634 |
Use of plasma proteins concentrates containing VWF with a high proportion of high molecular weight multimers
Use of plasma proteins concentrates containing VWF with a high proportion of high molecular weight multimers prevents a bleeding diathesis and reduces pre-, peri- and postoperative blood loss in...
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7335362 |
Methods of treating pre-eclampsia or eclampsia
Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels...
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7335638 |
Prevention and treatment of mycoplasma-associated diseases
The invention relates to the prevention and treatment of diseases associated with undesirable cell proliferation comprising preventing and treating mycoplasma and other microorganism co-infection....
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7335635 |
14-3-3 binding molecules as sensitizers for anticancer therapies
Methods are provided for enhancing the death of a neaplastic cell comprising the administration of a therapeutically effective concentration of a 14-3-3 antagonist and at least one antineoplastic...
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7335640 |
Administration of hypocretin-1 for treatment of narcolepsy
The invention provides compositions and methods for treatment of sleep disorders. Such methods entail administering to the patient a therapeutically effective dosage regime of an agonist of a...
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7335637 |
Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with...
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7332156 |
Methods of treating wounds using IL-23
Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods...
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7332473 |
Peptides and medicinal compositions containing the same
This invention provides a pharmaceutical composition comprising, as an active ingredient, a peptide derived from a PACAP or VIP peptide or a pharmaceutically acceptable salt thereof. This invention...
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7332158 |
Compositions and treatments for myelosuppression by ex vivo activated immune cells
The disclosure includes protocols of activating and administering human blood cells to myelosuppressed patients, including patients treated for cancer, e.g., by chemotherapy or radiation. The...
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7329645 |
TGF-α polypeptides, functional fragments and methods of use therefor
Disclosed are TGF-α polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods...
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7329410 |
Compositions and method for WT1 specific immunotherapy
A method for enhancing or inducing an immune response to WT1 is disclosed. In particular, the method comprises administering to a patient an immunogenic composition comprising an isolated...
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7329646 |
Derivatives of the insulinotropic peptide exendin-4 and methods of production thereof
The present invention is directed to the development of novel exendin-4 derivatives exhibiting advantageous glucose-regulatory properties, and to methods of producing these derivatives, including...
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7326688 |
Analogs of gastric inhibitory polypeptide and their use of treatment for diabetes
The present invention provides peptides which stimulate the release of insulin. The peptides, based on GIP 1-42 include substitutions and/or modifications which enhance and influence secretion...
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7326411 |
Use of amino-terminally truncated RANTES to inhibit HIV viral replication
The present invention relates to amino-terminally truncated RANTES, lacking NH 2 -terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3 or 1-4 of the naturally-occurring RANTES (SEQ...
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7326685 |
Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
Disclosed are peptide agents and uses thereof that are analogs of biologically active peptides such as somatostatin and bombesin. The compounds of the invention have the general formula X-Y-Z-Q,...
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7326686 |
Compounds and methods for regulating cell adhesion
Methods for using modulating agents to enhance or inhibit cadherin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. In particular, the modulating agents may be...
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7326678 |
GMG-3 GMG-4 and GMG-6 polynucleotides and polypeptides and uses thereof
The present invention relates to the field of metabolic research. Metabolic disorders, such as obesity, are a public health problem that is serious and widespread. GMG-3, GMG-4, Cluster 1, GMG-6A,...
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7323440 |
De-immunized MOG (poly)peptide constructs
The present invention relates to a (poly)peptide construct consisting of at least two domains of at least two pluralities of domains wherein one of said domains or pluralities of domains comprises...
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7323164 |
Use of interleukin-24 to treat ovarian cancer
The present invention relates to the anti-cancer activity of IL-24 polypeptide molecules. IL-24 is a cytokine involved in inflammatory processes and human disease. The present invention includes...
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7323445 |
Methods and compositions for healing and repair of articular cartilage
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The...
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7320959 |
Use of calmodulin kinase II inhibitors to treat myocardial dysfunction in structural heart disease
The present invention provides a method for treating structural heart disease in a subject, comprising administering an effective amount of an inhibitor of CaMKII to the subject, whereby the...
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7319089 |
Maurocalcine, analogues thereof and their therapeutical uses
Maurocalcine, a novel toxin isolated from the venom of the Tunisian chactidae scorpion Scorpio maurus palmatus , has the amino acid sequence GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR (SEQ. ID. No. 1). It...
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7319090 |
Methods of treating cerebral ischemia
The present invention provides methods of treating cerebral ischemia in mammals comprising inducing hypothermia in a mammal before, during, or following cerebral ischemia in the mammal. The...
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7319091 |
Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body, and the cloning of full length cDNA thereof
Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons,...
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7317002 |
Site-specific preparation of polyethylene glycol-GRF conjugates
A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys 12 and/or Lys 21 and/or N α ,...
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