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5484707 Assay for free secretory component and methods for monitoring organ rejection  
Methods of monitoring and detecting the early onset of organ injury incident rejection of a organ rejection in an animal are disclosed. The described methods are capable of distinguishing organ...
5480869 Anti-inflammatory peptide analogs and treatment to inhibit vascular leakage in injured tissues  
Small, anti-inflammatory compounds that are peptide analogs are described useful to inhibit inflammation of a mammal's skin, mucous membranes, or lacerations of the musculature or injury to the...
5478821 Method of accelerating the proliferation of emdothelial cells with inhibition of no synthases  
A method of accelerating the proliferation of endothelial cells with inhibition of NO synthases in warm-blooded animals comprising administering to warm-blooded animals an amount of at least one...
5476663 Prolonged release microcapsule  
A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer...
5472939 Method of treating complement mediated disorders  
The present invention relates to the C3b/C4b receptor (CR1) gene and its encoded protein. The invention also relates to CR1 nucleic acid sequences and fragments thereof comprising 70 nucleotides...
5470832 Inhibitors of geranylgeranyl-protein transferase  
The compounds disclosed am analogs of the CAAX motif of proteins that can be modified by geranylgeranylation in vivo that selectively inhibit the geranylgeranylation of several proteins. The...
5468729 Method for treatment of autoimmune hepatitis  
A method and composition for treating autoimmune hepatitis in a patient utilizes an immunomodulatory amount of Tα1 and an anti-inflammatory amount of a corticosteroid.
5468727 Methods of normalizing metabolic parameters in diabetics  
The invention relates to a method of diagnosing and treating individuals with diabetes or at risk to develop diabetes mellitus. In particular, gastric emptying determinations are used to assess...
5457090 Protease nexin-I variants  
One or more amino acid residues within the reactive site region of protease nexin-I are altered in order to create analogs or variants of protease nexin-I. These analogs have substantially...
5451399 [ALA IL-8]77 and [SER IL-8]72 as Leukocyte adhesion inhibitors  
A novel polypeptide [Ala IL-8]77 is provided which is a potent modulator of neutrophil functions. The polypeptide factor and related compositions find use as anti-inflammatory agents and as...
5449662 Atrial natriuretic peptide clearance inhibitors which resist degradation  
Compounds with natriuretic, diuretic and/or vasodilation activity which enhance the function of an endogenous ANP are provided. These compounds are capable of both binding to the clearance...
5445832 Process for the preparation of microspheres made of a biodegradable polymeric material  
The process is aimed at providing a composition designed for the sustained and controlled release of medicamentous peptide substances, obtained in the form of microspheres of a biodegradable...
5441932 Sugar compounds for inhibition of the biosynthesis of sugar chains containing sialic acid  
An inhibitor of the biosynthesis of sugar chains containing sialic acid that is excellent in the suppression of inflammation or allergy, which comprises as an active ingredient a sugar compound of...
5439884 Method of controlling fertilization using bombesin or its agonist  
A method of promoting or blocking fertilization, which method includes the step of contacting sperm either at the time of sperm capacitation or at the time of egg fertilization with an effective...
5430021 Hydrophobic drug delivery systems  
A pharmaceutical preparation including a drug incorporated into hydrophobic particles comprised of long chain carboxylic acid or ester thereof or long chain alcohol, wherein the particles are...
5424292 5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases  
5-Aminosalicylic acid derivatives acylated at the amino group with glutamic or aspartic acid and/or having the carboxy group involved in a peptide bond with the leucyl-prolyl residue are useful as...
5414014 Methods for efficacious removal of attached, sucking antropods from human dermis  
The present invention provides methods of using compositions containing local anesthetic compounds for facilitating the removal of sucking arthropods from the skin of a mammal; for reducing...
5409899 Pseudopeptide compounds having anti-inflammatory activity  
Compound of formula: G-Arg-Pro-Hyp-Gly-Thia-Ser-Tic-Oic-Arg-OHwhere G, Arg, Pro, Hyp, Gly, Thia, Ser, Tic and Oic are defined in the description.Medicinal products.
5409816 Process for producing immunosuppressives and a novel microbial species to be employed therein  
The invention relates to a process for producing a cyclosporin, especially cyclosporin A, by cultivating the strain (LEA3) of the novel Tolypocladium species aerobically at a temperature of 20°-30...
5401649 2-methyl-4-hexene-and 3-methyl-5-heptene-1,2-diol derivatives  
2-methyl-4-hexene- and 3-methyl-5-heptene-l,2-diol derivatives are disclosed together with methods for preparing such derivatives. Where the derivative is a 2-methyl-4-nexene- or...
5393740 Neurotensin Hexapeptides  
A hexapeptide represented by formula (II): A-B-Pro-C-D-E (I)where A represents an L- or D- form of arginine or lysine whose N-terminal amino group is alkylated or acylated, B represents an L- or...
5389382 Hydrosols of pharmacologically active agents and their pharmaceutical compositions comprising them  
The invention provides a hydrosol of a pharmacological active agent in an intravenous applicable, stabilised, pharmaceutically acceptable form, which form is suspended or is dry and re-suspendable...
5376636 Method for promoting tissue repair and regeneration using PDGF and glucocorticoids  
Disclosed is a method for the regeneration of tissue, the treatment of external wounds and the treatment of periodontal disease comprising applying to the affected tissue an effective amount of a...
5364842 Method of producing analgesia  
A method of producing analgesia and enhancing opiate analgesia is disclosed. The method includes administering TVIA (SNX-185) or MVIIA (SNX-111) omega-conopeptide, or derivative thereof which is...
5362629 Detection of immunosuppressants  
A method of evaluating the immunosuppressive activity of a compound including contacting the compound with calcineurin and determining the ability of the compound to bind to the calcineurin. The...
5346907 Amino acid analog CCK antagonists  
Analogs of CCK-tetrapeptides, which analogs have the formula ##STR1## wherein A, B, D, R1, R2, R3, and R4 are specifically defined, having activity as CCK antagonists, useful in the treatment or...
5340802 Peptide analog type-B CCK receptor ligands  
Peptide analog type-B CCK receptor ligands or pharmaceutically-acceptable salts thereof, which are useful for treating central nervous system disorders, substance abuse, gastrointestinal...
5340801 Compounds having cholecystokinin and gastrin antagonistic properties  
This invention relates to N-arylcarbamoyl proline analogues which are useful as cholecystokinin and gastrin antagonists, to pharmaceutical compositions including such proline analogues, and to...
5308833 Method for treating hepatitis B carriers with minimal disease  
Methods for treating minimal disease hepatitis B infection are disclosed. Minimal disease carriers are given thymosin α-1, or biologically active fragments or analogs thereof In this way, the...
5304377 Prolonged release preparation and polymers thereof  
A polymer for a prolonged release preparation which comprises (A) a polylactic acid and (B) a copolymer of glycolic acid and a hydroxycarboxylic acid of general formula ##STR1## wherein R stands...
5290762 Treatment of inflammation  
A method for the prophylaxis or direct treatment of inflammatory diseases or injuries in a patient which comprises administering to the site of the disease or injury an effective amount of at...
5283236 Systemic delivery of polypeptides through the eye  
Compositions and methods for systemic delivery of polypeptides through the eyes are disclosed. The compositions include a systemically active polypeptide at a concentration such that the...
5278146 CRF analogs  
Analogs of CRF, which are based upon hCRF, oCRF, sauvagine and alpha-helical CRF, are disclosed that can be administered to achieve a substantial elevation of ACTH, β-endorphin, β-lipotropin,...
5270302 Derivatives of tetrapeptides as CCK agonists  
Selective and potent Type-A CCK receptor agonists of formula (I): X--Y--Z--Q (I)or a pharmaceutically acceptable salt thereof, wherein, X is selected from ##STR1## Y is selected from ##STR2## Z is...
5242904 Peptide boronic acid inhibitors of trypsin-like proteases  
Peptides comprising C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, are reversible inhibitors of trypsin-like...
5234910 Acid inhibitor of bacterial origin  
An acid inhibitor of bacterial origin which is effective in inhibiting acid secretion from gastric parietal cells; a method of producing this acid inhibitor; a method of administering the acid...
5234907 Synthetic vasoactive intestinal peptide analogs  
Vasoactive intestinal compound analogs containing substitutions of appropriately selected amino acids at specific positions of the VIP molecule.
5217714 Method for stimulating the secretion of ACTH by administration of IL-1B analogues  
A method for testing the inducibility of the hypothalamus to effect the secretion of andrenocorticotropic hormone comprising the steps of: (a) administering to a test subject a pharmaceutically...
5217955 Treatment of cancer with peptide analog of bombesin, GRP, litorin or neuromedin  
A method of treating cancer in a human patient, the method involving administering to the patient a cancer cell inhibiting amount of an analog of a naturally occurring biologically active peptide...
5206017 Use of protease nexin-I as an antiinflammatory  
Methods and pharmaceutical compositions for treatment of inflammation and arthritis using protease nexin-I as an active ingredient are disclosed.
5204328 Peptides having atrial natriuretic factor activity  
Atrial natriuretic factor analogs containing N-alkylated amino acids and showing enhanced potency and increased metabolic stability. These analogs have natriuretic, diuretic and vasorelaxant...
5190916 Use of ovomacroglobulin as an agent for treating wound and inflammation  
A treating agent such as a wound therapeutic agent, inflammation therapeutic agent, hair growth agent and hair tonic, and a cosmetic, comprising as an effective component ovomacroglobulin are...
5190750 Methods for the treatment of demyelinating disease, uveitis, or graft-versus-host disease using TNF  
A pharmaceutical composition and a method for its use in the treatment of severe chronic inflammatory diseases, such as demyelinating disease, uveitis and graft-versus-host disease are provided....
5187154 Diagnosis and treatment of humans with diabetes or at risk to develop diabetes  
The invention relates to a method of diagnosing and treating individuals with diabetes or at risk to develop diabetes mellitus. In particular, gastric emptying determinations are used to assess...
5166133 Method for inhibing adhesion of white blood cells to endothelial cells  
Proteins are described that affect adhesion of white blood cells (WBCs) to endothelial cells (ECs). The proteins include inter-α-trypsin inhibitor, α1 -M, and HI-30. When administered in...
5158936 Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors  
Thiol protease inhibitors are disclosed having the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein: n is 0 or 1; m is 0, 1 or 2; X is H or an...
5145676 Method and agents for promoting wound healing  
The present invention relates to the treatment of wound healing dysfunction by the administration of one or more would healing modulators. The wound healing modulator may be selected from...
5137874 Partially coated C10 -C20 fatty acid salts of peptides having molecular weights up to about 5,000  
The invention relates to compositions for the parenteral administration of an essentially uniform and continuous amount of a peptide, which has a molecular weight of up to about 5,000, over an...
5135915 Method for the treatment of grafts prior to transplantation using TGF-.beta .  
A method is provided for the treatment of grafts such as tissue or organs prior to transplantation into a suitable host. The grafts are incubated, coated, or perfused with TGF-β for an effective...
5132402 Adsorbent, method for production thereof, and method for use thereof  
There is disclosed an adsorbent, comprising a carrier on which is immobilized a peptide possessing an ability to bind to the human antibody to the nicotinic acetylcholine receptor and represented...