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5866128 Method for the treatment and prevention of gastric and duodenal ulcer  
Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a...
5866544 Peptide-chelator conjugates  
Peptide-chelator conjugates are provided that when labelled with a traceable metal are useful for diagnostic imaging of sites of inflammation. The peptide component is an antagonist of the...
5863901 Use of bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders and acute liver disorders  
This invention relates to a method of treating a chronic fibrogenetic liver disorder and/or an acute liver disorder and/or complications associated therewith, comprising administering to a patient...
5863899 Bradykinin antagonists  
A bradykinin antagonist of the formula: (BKAn) (X) (Y)where BKAn is a bradykinin antagonist peptide; Y is a Pharmacophore; and X is a bridging link chemically joining the BKAn and Y components.
5863540 Adhesion molecule  
The present invention relates, in general, to a method of treating inflammation or inhibiting cancer cell metastasis. In particular, the present invention relates to a method of suppressing T cell...
5858969 Therapeutic methods employing sialylated glycoforms of soluble complement receptor 1 (SCR 1)  
Provided are therapeutic methods employing preparations of recombinant soluble Complement Receptor type 1 (sCR1) defined with respect to the distribution of sCR1 glycoforms. The methods are...
5858971 Cyclic peptide and method of making same by culturing a strain of actinomyces S. nobilis  
The present invention relates to a peptide represented by formula I!. The peptide of the present invention exhibits allergic and anallergic inflammation inhibitory, antibacterial, antitumor and...
5856309 Amidinopyrroline derivatives, processes for their production and pharmaceutical agents containing these compounds  
Compound of formula (I) are disclosed ##STR1## as well as optically active isomers or pharmacologically acceptable salts thereof. The compounds are useful active ingredients in pharmaceutical...
5856307 Peptide derivatives as kininogenase inhibitors  
The invention relates to compounds of the formula A1 --A2 --NH--(CH2)n --B Formula Iand A1 --A2 --NH--(CH2)n --B--D Formula Vas well as stereoisomers and physiologically acceptable salts thereof...
5853623 Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases  
The present invention concerns novel mercaptoalkylpeptidyl compounds of formula (I) which are useful inhibitors of matrix metalloproteinase and/or TNF-mediated diseases including degenerative...
5854202 Peptide fragments of calreticulin, peptide mimetics thereof, and pharmaceutical compostions comprising same  
This invention relates to isolated and purified proteins, such as calreticulin and mimetics of calreticulin, for a novel use of modulating hormone responsiveness. These proteins are useful in gene...
5851983 Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology  
The present invention provides an elastase inhibitory polypeptide comprising a C-terminal half of a human secretory leukocyte protease inhibitor (SLPI) and having an elastase inhibitory activity...
5851528 Methods of inhibiting complement activation  
The present invention relates to novel chimeric proteins comprising a first polypeptide which inhibits complement activation, linked to a second polypeptide which inhibits complement activation,...
5849696 Composition and method of treating hepatitis C  
Compositions and methods of use for treating hepatitis C virus-infected mammals are disclosed. The compositions include one or more thymosins alone or in combination with one or more interferons....
5849859 Polyesters  
A biodegradable and biocompatible polyester comprising (C3-10) alkylene carbonic acid ester units, each alkylene group being a C3 -alkylene group having 1 oxy substituent or a (C4-10) alkylene...
5849297 Modified human C3 proteins  
Narrative complement pathway proteins modified such that the protein is capable of forming a stable C3 convertase. Preferably the modified protein is a modified human C3 protein. DNA sequences...
5846532 Method and composition for the treatment of disorders involving immunological dysfunction  
A method and composition are provided for treatment of disorders involving immunological dysfunction. The invention comprises the administration of a low level of ribonucleotide polymerase protein...
5846942 Cholecystokinin antagonists, their preparation and therapeutic use  
Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further,...
5846548 Combined administration of mitogenic immumo stimulator and a thymomimetic  
A method of tumor therapy involves controlling the immune system by co-administration of a mitogenic immuno-stimulating substance and a thymomimetic substance.
5837230 Methods of treating allergies with M-CSF  
This invention provides medical uses of a M-CSF, particularly a method and composition for treating inflammatory disease and allergy using natural M-CSF or recombinant M-CSF or the derivatives...
5834431 Des-Arg9 -BK antagonists  
The present invention provides des-Arg9 bradykinin analogs which are selective B1 receptor antagonists.
5834433 Compounds and pharmaceutical uses of peptides of bombesin and GRP  
A method for controlling the growth of tumor tissues, especially small cell lung. Treatment comprises administering to a patient in need thereof, an effective amount of a bombesin/GRP type...
5830869 Thiadiazole amide MMP inhibitors  
The present invention provides novel thiadiazole amide derivatives represented by formula I ##STR1## The compounds of the present invention inhibit various enzymes from the matrix...
5830453 Use of IL-13 to induce 15-lipoxygenase  
Methods are disclosed for inducing the production of 15-lipoxygenase (15-LO) in animal or human cells comprising monocytes via the administration of Interleukin 13 (IL-13). These methods are...
5817625 Methods of prevention of oral mucositis with transforming growth factor beta  
The present invention provides methods of preventing oral mucositis in a subject susceptible to mucositis which comprises administering to the subject a prophylactically effective amount of...
5811395 Relaxin analogs and derivatives methods and uses thereof  
The present invention relates to a relaxin analogs and derivatives, and uses thereof. The present invention further relates to compositions comprising a relaxin analogs and derivatives, and...
5811388 Delivery of drugs to the lower GI tract  
Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration...
5807830 Method for treatment of purulent inflammatory diseases  
This invention provides methods of treating purulent inflammatory diseases by administering L-Glu-L-Trp or a salt thereof.
5795574 Use of an extract from a non-photosynthetic filamentous bacterium and composition containing it  
The present invention relates to the use of at least one extract from at least one non-photosynthetic filamentous bacterium as substance P antagonist in a cosmetic composition or for the...
5795857 Mimetic insect pyrokinin analogs for insect control  
Novel pseudopeptide analogs of the insect pyrokinin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a...
5792451 Oral drug delivery compositions and methods  
The present invention relates to an oral drug delivery system, and in particular to modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The...
5786213 Inhibition of endogenous gastrin expression for treatment of colorectal cancer  
The present invention discloses is for the treatment of colon cancer. The expression of gastrin by colon cancers is inhibited by the use of antisense gastrin expression. Methods are disclosed for...
5785970 Method of the treatment of gastrointestinal disorders with immunogenic compositions against gastrin  
Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies...
5786322 Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1  
Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking...
5776885 Sustained and controlled release of water insoluble polypeptides  
A pharmaceutical composition for the sustained release of a peptide wherein the composition includes a polylactide polymer, a polymer of lactic acid and glycolic acid, or a mixture of such...
5766593 Anti-inflammatory CD14 peptides  
The invention relates to anti-inflammatory peptides that are based on peptide regions 7-10, 11-14, and 57-64 of CD14.
5760002 Diflouro pentapeptide derivative anti-inflammatory agents  
The subject invention involves anti-inflammatory compounds having the following structure: ##STR1## wherein: a) --X is cyclic alkyl, having from 4 to 15 carbon atoms; branched alkyl, having from 6...
5756463 Use of insulin and IGF-1  
A method is disclosed for counteracting a decrease in nitrogen balance and counteracting a decrease in protein synthesis in an individual, comprising administering to the individual a combination...
5750506 Bradykinin antagonists with extended hydrophobic side chains  
Bradykinin antagonists, particularly Cys6 analogs, which have an extended hydrophobic side chain.
5741776 Method of administration of IGF-I  
A method is disclosed that comprises administering insulin-like growth factor-I (IGF-I) to a mammal so as to sustain its biological activity in the mammal comprising administering a...
5739106 Appetite regulating compositions  
Compositions and methods for reducing food intake, suppressing appetite and controlling body weight are provided. Such compositions may include an amylin agonist and a CCK agonist or a hybrid peptide.
5736518 Peptide compounds of (L) amino acids and ring molecules, and therapeutical applications thereof  
Compounds of general formula A--B--C in which: A is a monovalent radical of a L-ring molecule; B is a bivalent radical of a L-α-aminoacid; and C is a monovalent radical of a L-aromatic molecule....
5731166 Recombinant production of chemotactic CP-10 polypeptides and therapeutic methods using them  
The chemotactic protein CP-10, in essentially pure form, having an apparent molecular weight of approximately 10 kD and having chemotactic activity for neutrophils, monocytes/macrophages and/or...
5728548 Retinoid receptor-1 (RR1) and DNA encoding RR1  
Polynucleotides encoding retenoid receptor-1 (RR1) are disclosed. RR1 proteins and methods for their production, ligands for the RR1 and methods for their identification, and inhibitors of binding...
5726040 Cosmetic compositions including tropoelastin isomorphs  
A cosmetic composition including a non naturally-occurring extracellular matrix protein in combination with a cosmetic carrier is described. The protein is preferably of human origin and has not...
5723116 Decreased mortality of severe acute pancreatitis following proximal cytokine blockade  
A method for treating acute pancreatitis is disclosed. The method comprises administering to a patient with acute pancreatitis an effective amount of a suitable tumor necrosis factor (TNF)...
5721210 Cyclic cell adhesion modulation compounds  
Cyclized integrin receptor antagonist compounds useful in modulating cell adhesion, including adhesion related to fibronectin, as well as leukocyte adhesion to endothelial cells, are disclosed....
5719120 Use of endoglin polypeptides for modifying the regulatory activity of TGF-β  
This invention provides a novel purified TGF-β-binding glycoprotein, endoglin, an isolated nucleic acid molecule that encodes an amino acid sequence corresponding to the TGF-β-binding...
5714140 Method for inhibiting the production of bioactive IL-1 by administering M-CSF  
This invention provides medical uses of a M-CSF, particularly a method and composition for treating inflammatory disease and allergy using natural M-CSF or recombinant M-CSF or the derivatives...
5710123 Peptide inhibitors of selectin binding  
The present invention provides novel peptides having as their core region portions of the 109-118 amino acid sequence of P-selectin, E-selectin or L-selectin. The invention also provides...