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8183231 |
Substituted propane phosphinic acid derivatives
The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention...
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8168617 |
Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating...
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8119617 |
aSMase inhibitors
The present invention relates to compounds of formula wherein the residues have various meanings and their use as pharmaceuticals.
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8003627 |
Urokinase inhibitors
The present invention relates to novel compounds with inhibitory activity towards urokinase plasminogen activator (uPA); to methods for preparation of said uPA inhibitor compounds; to...
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7981874 |
Phosphorus derivatives as histone deacetylase inhibitors
The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are...
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7947665 |
LPA receptor agonists and antagonists and methods of use
Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as...
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7915238 |
Immunomodulatory compounds and methods of use thereof
The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is...
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7915240 |
Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
Method of using immunomodulatory compounds for treating diseases related to an overproduction of inflammatory cytokines, including diseases selected from asthma, atopic dermatitis, allergic...
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7906488 |
Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae
The present invention relates to the use of sphingolipids for the preparation of a food item, a food supplement and/or a medicament for the prevention and/or treatment of elevated blood levels of...
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7855189 |
N-phenylphosphoric acid triamides, method for the production thereof and their use as agents for regulating or inhibiting enzymatic urea hydrolysis
The invention relates to N-phenylphosphoric acid triamides of general formula (I) to a method for the production thereof and to their use as agents for regulating or inhibiting enzymatic urea...
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7838020 |
Cosmetic or dermatological composition comprising an association between a compound of the N-acylaminoamide family and at least one matrix metalloproteinase inhibitor
A cosmetic or dermatological composition characterized in that it comprises an association between an elastase inhibitor compound of the N-acylaminoamide family and at least one metalloproteinase...
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7829530 |
Method of regulating glucose metabolism, and reagents related thereto
One aspect of the present invention relates to a method for treating Type II diabetes in an animal, comprising conjointly administering to the animal metformin and an inhibitor of...
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7803776 |
Combined use of enzyme inhibitors and of pharmaceutical compositions thereof
Provided are combinations of inhibitors of dipeptidyl peptidase IV (DP IV) and of enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl...
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7799824 |
Quaternary salt CCR2 antagonists
Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory...
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7713950 |
Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof
Novel florfenicol compounds having the chemical structure: or a pharmaceutically-acceptable salt thereof or a solvate thereof, or prodrug thereof, wherein R1 is CHCl2, CHClF, CHF2, CHBrCl, CH3,...
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7704978 |
Methods for treating neuropsychiatric disorders
The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, closed...
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7683034 |
Use of enzyme inhibitors of aminopeptidase N and/or dipeptidylpeptidase IV
The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of...
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7459428 |
Method of regulating glucose metabolism, and reagents related thereto
One aspect of the present invention relates to a method for treating Type II diabetes in an animal, comprising conjointly administering to the animal metformin and an inhibitor of...
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7445791 |
Synergistic insecticidal composition containing Chloronicotynyle and Organosphosphorus compounds
A synergistic insecticidal composition is prepared by combining a Chloronicotynyle compound and an Organophosphorus (OP) compound. The preferred synergistically effective amount of the...
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7291599 |
Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases
The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis...
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7282492 |
Insecticidal composition having improved storage stability
An insecticidal composition having improved storage stability is disclosed. Said insecticidal composition comprises Dimethoate stabilized with maleic anhydride. Also a process for the control of...
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7229969 |
Combinations of enzyme inhibitors and the use thereof
Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase...
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7217704 |
LPA receptor agonists and antagonists and methods of use
The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using...
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7176163 |
Pharmacological effect potentiators for pesticides
By applying a compound selected from jasmonic acid represented by the following general formula (I) or 2-substituted form of jasmonic acid or derivatives thereof or salts thereof, the...
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7173020 |
Phosphoramidates and methods therefor
Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable...
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7157092 |
Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same
Compounds of the formula wherein the substitutents are defined as in the specification useful for modulating immune responses in warm-blooded animals.
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7153842 |
Florfenicol prodrug having improved water solubility
The present invention discloses phosphate esters of florfenicol (prodrugs) and florfenicol analogs having superior water solubility that are hydrolyzed to florfenicol or the respective florfenicol...
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7151093 |
Use of sphingosine 1-phosphate as active ingredient for the treatment of pulmonary fibrosis
An anti fibrotic agent, comprising a sphingosine 1-phosphate (S1P) receptor agonist or sphingosine 1-phosphate (S1P) as an active ingredient. Since an S1P receptor agonist, particularly S1P, has...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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7001896 |
Compositions for treating diabetes
The present invention provides a pharmaceutical composition for treating diabetes containing 4-diethoxyphosphinoylmethyl-N-(4-bromo-2-cyanophenyl)benzami
de, particularly a pharmaceutical...
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6939866 |
Quinazoline derivatives
The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; process for the preparation, pharmaceutical...
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6906048 |
N-acetylcolchinol-O-phosphate combination therapies with vascular damaging activity
The invention relates to a method for the production of a vascular damaging effect in a warm-blooded animal such as a human, which comprises administering to said animal an effective amount of...
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6806261 |
Methods for treating certain diseases using naaladase inhibitors
The present invention relates to methods for regulating the release of TGF-β from living cells in vitro or in vivo, comprising bringing the cells into contact with an effective amount of a ...
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6737416 |
Phosphonic acid derivative having inhibitory activity against carboxypeptidase B
A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the...
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6699851 |
Cytotoxic compounds and their use
Novel amides of polyunsaturated fatty acids with cysteamine-S-phosphate have been synthesized. Combinations of the all-trans-retinoic acid and/or amides of the 13-cis-retinoic acid with...
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6649646 |
Insecticidal and miticidal compositions
The invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr in combination with one or more organophosphoric acid ester-type compounds and...
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6620800 |
Methods and compositions to assess oxidative brain injury
A method to assess oxidative stress in vivo includes the steps of measuring an amount of neuroprostanes in a biological sample before the ex vivo development of neuroprostanes in a sample,...
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6576627 |
Phosphonic acid derivatives having carboxypeptidase b inhibitory activity
A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the...
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6498152 |
Use of a farnesyl transferase inhibitor in the manufacture of a medicament for local administration to the vascular wall in the prevention of restenosis
The present invention relates to the prevention of restenosis of vascular passages following surgical removal of obstructions, by means of local administration of farnesyl transferase inhibitors to...
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6468992 |
Phosphonic acid diester derivatives
The present invention provides novel phosphonic acid diester derivatives useful as medicines. The phosphonic acid diester derivatives are represented by the general formula:wherein R1 represents...
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6432933 |
Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases
Compounds of Formula I are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as...
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6429202 |
Phospholipid complexes of proanthocyanidin A2 as antiatherosclerotic agents
The present invention relates to complexes of proanthocyanidin A2 and one or more phospholipids, pharmaceutical compositions containing the complex of proanthocyanidin A2 and one or more...
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6413947 |
Anilide derivative, production and use thereof
This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: wherein the ring A is an optionally...
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6391866 |
(α-aminophosphino) peptides derivative and compositions containing same
The invention concerns (α-aminophosphino) peptide derivative compounds of general formula (I) wherein: R1 and R2 represent each a hydrogen atom or together form an imine with the adjacent nitrogen ...
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6274570 |
Pesticidal compositions
A liquid pesticidal composition, which is substantially free of water, comprising a hydrophobic pesticide or mixture of pesticides dissolved in an organic solvent and comprising as surfactants (a)...
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6268354 |
Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative
This invention is to provide a pharmaceutical composition for antagonizing CCR5 which comprises a compound of the formula: ##STR1##wherein R1 is an optionally substituted 5- to 6-membered ring; W...
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6242433 |
Geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions
The present invention relates to novel geranylgeranyl derivatives and the pharmaceutically acceptable salts thereof having antiproliferative activity in eukaryotic cells with respect to the...
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6150344 |
Hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases
Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases...
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6136797 |
Phospholipid derivatives of phosphono-carboxylic acids, the production of said derivatives and the use of said derivatives as antiviral medicaments
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6133261 |
Amino acid derivatives useful to treat stroke
The invention provides a therapeutic method for treating or preventing stroke and other ischemic disorders, as well as novel compounds and pharmaceutical compositions useful for carrying out such...
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