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7612238 |
Amino-propanol derivatives
Compounds of formula I
wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
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7598232 |
Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted-benzylsulfones for treating proliferative disorders
Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X 1 , X 2 , R a , R 1 , R 2 ,R 3 , R 4 , R 5 , R 6 , R 7...
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7579333 |
Therapy using a combination of raloxifene and alendronate
Provided are methods of treating bone disease including, but not limited to, osteoporosis, metastatic bone disease, or Paget's disease, by administering a combination of raloxifene and alendronate...
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7524981 |
Phospholipid derivatives and process for the production there
A phospholipid derivative represented by the following formula (1):
wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R 1 CO and R 2...
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7504389 |
Protein tyrosine phosphatase inhibitors and methods of use thereof
The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of...
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7504388 |
Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders,...
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7488496 |
Effervescent compositions comprising bisphosphonates and methods related thereto
The invention provides effervescent composition comprising a bisphosphonate, an acidic compound, an alkaline effervescing component, and optionally an anti-ulcer agent and methods of treating...
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7485320 |
Liposome for incorporating large amounts of hydrophobic substances
A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as...
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7465716 |
Targeted drug delivery with a hyaluronan ligand
The invention is a drug delivery system of a delivery vehicle having a low molecular weight hyaluronan ligand with an affinity for CD44 receptors. Preferably, the delivery vehicle is a liposome but...
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7456157 |
Aminophosphonic acid derivatives, addition salts thereof and S1P receptor modulators
Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methy
lpentylphosphonate monoester) are represented by the following general formula (1):
and act...
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7429575 |
N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use
The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a...
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7427608 |
Protection against and treatment of hearing loss
The present invention provides a method for protecting against or treating hearing loss in a subject. This method involves administering an effective amount of a protein tyrosine kinase inhibitor...
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7419970 |
Cosmetic compositions comprising N-acylamino amides
The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing,...
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7410956 |
Caspase inhibitor prodrugs
The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of...
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7407779 |
Modification of solid 3-sn-phosphoglycerides
Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A 2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine,...
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7402576 |
Phosphinic acid analogs of glutamate
Inhibitors of axillary malodour having the formula
wherein R has the same meaning as given in the specification.
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7384925 |
Functionalized stilbene derivatives as improved vascular targeting agents
Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with...
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7375097 |
Increasing ATP availability by inhibition of creatine kinase (CK) leakage resulting from high-intensity exercise
The present invention relates to a method of increasing Adenosine Triphosphate levels in a mammal wherein 2-(carbamimidoyl-methyl-amino)ethoxyphosphonic acid inhibits the leakage of the Adenosine...
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7368441 |
Method of increasing intracellular concentrations of phosphate and increasing the force of muscular contractions
The present invention relates to a method of increasing the intracellular concentration of phosphate by employing 2-(carbamimidoyl-methyl-amino)ethoxyphosphonic acid as vehicle and method to...
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7368440 |
Methods for the administration of amifostine and related compounds
The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy or chemotherapy in a manner that significantly reduces...
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7345033 |
Carbamoyl-and thiocarbamoyl-phosphonates and pharmaceutical compositions comprising them
The present invention provides a compound of the following formula I:
R 3 —NH—C(═X)—P(═O)OR 1 OR 2
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7319095 |
Use of GABAB receptor agonists
The present invention relates to the use of GABA B receptor agonists for the treatment as well as the prevention of cough.
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7291599 |
Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases
The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis...
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7262182 |
Sulfonylethyl phosphorodiamidates
Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for...
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7244305 |
Antibacterial gypsum composition for dental surgery
Disclosed is an antibacterial gypsum composition for dental surgery, which eliminates pathogens transferred from the mouth of a patient, so that a dentist or others participating in dental surgery...
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7229969 |
Combinations of enzyme inhibitors and the use thereof
Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase...
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RE39593 |
1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects
1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I
a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical...
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7199214 |
Process for the preparation of polyalkoxyamines which can be used as initiators for the radical polymerization of polyfunctional living (CO)polymers
The present invention is directed to a process for the preparation of polyalkoxyaminies from monoalkoxyamine(s) of formula (I)
and of at least one polyunsaturated compound of formula (II):
...
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7199112 |
Use of phospholipid arachidonic acids for increasing muscle mass in humans
This invention discloses a method of increasing muscle mass comprising administering phospholipid arachidonic acid to a human in need thereof.
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7195775 |
Protection of the female reproductive system from natural and artificial insults
Described are methods for protecting the female reproductive system against natural and artificial insults by administering to women a composition comprising an agent that antagonizes one or more...
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7192931 |
Treatment of demyelinating diseases
This invention relates to methods for the treatment or prevention of central nervous system (CNS) cell damage and functional damage in mammals due to demyelinating disease including multiple...
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7186705 |
Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives
The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I,
which are valuable pharmaceutical active ingredients and...
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7186703 |
Derivatives of branched-chain lipophilic molecules and uses thereof
The present invention discloses novel phospho-derivatives of branched-chain lipophilic molecules useful for permeabilizing biological barriers and for inhibiting tumor growth. The invention further...
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7173019 |
Linked cyclitols and their polysulfated derivatives
The invention relates to compounds of the following formula (I). In these compounds, R 1 , R 2 , R 3 and R 4 are each independently a substituted or unsubstituted cyclitol with a ring comprising...
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7151094 |
Topical administration of amifostine and related compounds
The present invention is directed to methods of treating or protecting mucosal tissue from damage associated with radiation and/or chemotherapeutic treatment of cancers, by the topical application...
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7151093 |
Use of sphingosine 1-phosphate as active ingredient for the treatment of pulmonary fibrosis
An anti fibrotic agent, comprising a sphingosine 1-phosphate (S1P) receptor agonist or sphingosine 1-phosphate (S1P) as an active ingredient. Since an S1P receptor agonist, particularly S1P, has...
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7148208 |
Pharmaceutical compositions for headache, migraine, nausea and emesis
S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of...
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7129229 |
Hydrazide building blocks and hydrazide modified biomolecules
This invention relates to attachment chemistries for binding macromolecules to a substrate surface or to other conjugation targets. More particularly, this invention relates to attachment...
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7105575 |
Methods for the treatment of neuro- disorders using aminothiol compounds
The present invention relates to new uses of S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by...
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7101864 |
Compositions comprising oxophosphonate-based metalloproteinase inhibitors
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active...
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7084126 |
Methods and compositions for enhancing cellular function through protection of tissue components
Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors,...
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7078059 |
Treatment of bone diseases
The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis...
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7041658 |
Method of inhibiting hair growth
Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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6962907 |
Neurologically-active compounds
The invention provides compounds of the formula II:
wherein R represents propyl, butyl, pentyl, neo-pentyl or cyclohexyl, and salts thereof. These compounds are selective GABA C receptor...
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6939894 |
Methods for reducing excessive barking of a dog
Methods for reducing excessive barking of a dog are disclosed wherein GABA or SKF97541 is administered.
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6927212 |
Design and synthesis of renal dipeptidase inhibitors
Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent...
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6919322 |
Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors
Novel FBPase inhibitors of the formula I
are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
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6903080 |
Disease treatment with novel phospholipid derivatives
A method of treating protozoal and fungal diseases is described, in which an effective amount of a compound of formula I is administered to a host having a protozoal or fungal disease. Also...
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6881706 |
Use of a quaternary ammonium glycoside surfactant as an adjuvant for fertilizers or pesticides
The present invention relates to the use of a quaternary ammonium glycoside surfactant as an adjuvant for fertilizers or pesticides, such as herbicides. The surfactant contains at least one...
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