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7514442 |
Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7498320 |
Cyclic phosphate diesters of 1,3-propane-1-aryl diols and their use in preparing prodrugs
Compounds of Formula I, their preparation and synthetic intermediates, and their use in the synthesis of prodrugs:
wherein: V and L are trans relative to one another; V is selected from...
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7470695 |
N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7468420 |
Process for purifying glycopeptide phosphonate derivatives
Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods...
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7326695 |
Anti-bacterial agents based upon oxoanion binding
Compounds of the structure I:
are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T 1 and T 2 are each independently selected from...
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7297330 |
Low dose haptenized tumor cell and tumor cell extract immunotherapy
This invention relates to compositions comprising haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such haptenized tumor cells, and methods...
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7199162 |
Use of treosulfan for patient conditioning before bone marrow or blood stem cell transplantation
The invention relates to the use of treosulfan as a conditioning agent before allogenic transplantation of bone marrow or haematopoietic stem cells, whereby treosulfan is administered, either as...
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7199111 |
Aqueous ifosfamide compositions for parenteral administration and a process for their preparations
The present invention provides aqueous Ifosfamide compositions and a process for their preparation, in which the compositions have a reduced toxicity over and above the concomitant use of the...
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7182942 |
Vaccine immunotherapy for immune suppressed patients
A method of immunotherapy to treat cancer or a synergistic anti-cancer treatment by administering an effective amount of a natural cytokine mixture (NCM), an effective amount of cyclophosphamide...
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7160865 |
Cancer treatment including glycolytic inhibitors
Glycolytic inhibitors are useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as...
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7153499 |
Vaccine immunotherapy for immune suppressed patients
The present invention provides a formulation for inhibiting metastasis which includes 150–600 units of IL-2, a nonsteroidal anti-inflammatory drug (NSAID), and cyclophosphamide. The present...
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7151092 |
Cytarabine monophosphate prodrugs
Compounds of Formula I, their preparation and uses are described:
wherein:
M and V are cis to one another and MH is cytarabine; the 5′ oxygen of said cytarabine is attached to the...
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7098197 |
Phosphonate compounds
The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and...
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7094772 |
Phosphonate compounds
The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and...
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6964952 |
Therapeutic composition for broad spectrum dermal disease
The invention relates to a therapeutic composition for broad spectrum dermal disease and in particular, to a composition comprising principal lipid components of skin, preferably having about 30 to...
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6949529 |
Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof.
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6919322 |
Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors
Novel FBPase inhibitors of the formula I
are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
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6914056 |
Pharmaceutical compositions comprising cyclic glycerophosphates and analogs thereof for promoting neural cell differentiation
Cyclic glycerophosphates and analogs thereof (CGs) are shown to exert neutral promoting activities in target cells. Such activities include promotion of neuronal outgrowth, promotion of nerve...
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6809120 |
Composition containing propargylamine for enhancing cancer therapy
Antineoplastic drug modulators are described. The specific modulators referred to are propargylamines which can enhance the cytotoxic effects of antineoplastic drugs on cancer cells while...
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6784169 |
MMP inhibitors
Novel compounds according to formula I n is 0, 1, 2 or 3; X represents hydroxamic acid (CONHOH), carboxylic acid, phosphonic acid, acetylthiomethyl group or a mercaptomethyl group; R2, R10 and...
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6762174 |
Low molecular weight compounds administered together with anti-cancer agents to prevent or treat cancer and pharmaceutical compositions thereof
The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
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6635627 |
Anti-cancer products for treating cystic fibrosis
The invention concerns a novel approach for treating cystic fibrosis using, in particular, anti-cancer chemotherapy. For the treatment of cystic fibrosis it proposes the use of at least one product...
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6630442 |
Reparatives for chemosurgery and laser (thermal) therapy
A composition of glutathione and selenium, as a selenoamino acid or selenium yeast extract and an epidermal growth factor in a topical carrier and method of using the composition to reduce and...
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6566304 |
Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture
The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a)...
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6559139 |
Combination chemotherapy
This invention relates to combination chemotherapy, particularly involving vitamin D or a derivative thereof. In one aspect, the invention provides a method of killing a cell by first administering...
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6440951 |
Method for treatment of diabetes
Fosfomycin or a pharmaceutically acceptable salt thereof has been found to have an action of lowering the serum glucose level and is recognized to be useful as an orally administrable remedy for...
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6413947 |
Anilide derivative, production and use thereof
This invention is to provide a compound of the formula: wherein R 1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: wherein the ring A is an...
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6413946 |
Composition for treatment of diabetes and treatment of diabetes
Fosfomycin or a pharmaceutically acceptable salt thereof has been found to have an action of lowering the serum glucose level and is recognized to be useful as an orally administrable remedy for...
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6372719 |
α&ngr β3 integrin antagonists in combination with chemotherapeutic agents
The present invention is directed to compounds of the formula and pharmaceutically acceptable salts and isomers thereof administered in combination with chemotherapeutic agents.
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6329355 |
Method for inhibiting the growth of cancers
A method for inhibiting the growth of tumors and cancers in mammals comprising administering a chemotherapeutic agent to significantly reduce the tumor in mass and then administering a...
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6277835 |
Method of tumor treatment
The present invention provides methods for treating mammalian cancer tumors, preferably solid tumors, comprising administering to a mammal in need of such treatment an effective amount of a...
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6271217 |
Method of treating cancer with a benzimidazole and a chemotherapeutic agent
A method for inhibiting the growth of tumors and cancers in mammals comprising administering a chemotherapeutic agent to significantly reduce the tumor in mass and then administering a...
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6268354 |
Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative
This invention is to provide a pharmaceutical composition for antagonizing CCR5 which comprises a compound of the formula: ##STR1## wherein R 1 is an optionally substituted 5- to 6-membered ring;...
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6261573 |
Immunoadjuvants
The present invention provides immunogenic compositions and methods for inducing enhanced immune responses using an antigen and a combination of water soluble polymer and an amphiphilic compound.
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6232263 |
Hydroformylation process using novel phosphite-metal catalyst system
Disclosed are catalyst compositions comprising one or more transition metals selected from the Group VIII metals and rhenium and one or more chlorophosphite compounds having the general Formula...
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6221856 |
Inositol derivatives for inhibiting superoxide anion production
Inositol derivatives, compositions comprising inositol derivatives, and methods for using compositions comprising inositol derivatives as agents for inhibiting superoxide anion production are...
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6207171 |
Polyphosphazene microspheres
A soluble polyphosphazene polyelectrolyte immunoadjuvant is disclosed. In one embodiment, the polymeric adjuvant is poly[di(carboxylatrophenoxy)phosphazene] which is in the form of a microsphere...
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6171599 |
Process for producing efonidipine hydrochloride preparations
An amorphous solid dispersion of efonidipine hydrochloride having a high intestinal absorbability can be formed by subjecting a mixture containing efonidipine hydrochloride of the formula (I),...
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6162427 |
Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization
The invention relates to the use of G-CSF in combination with a chemotherapeutic agent (in particular, cyclophosphamide) to produce a pharmaceutical preparation for boosting the mobilization of...
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6087350 |
Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
The present invention provides a method of killing a cell by first administering to the cell a vitamin D derivative and subsequently administering to the cell a cytotoxic agent. Where the cell is...
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6037337 |
Use of the enantiomers of ifosfamide in antitumor therapy for reducing side effects
(R)-Ifosfamide is administered as a cytotoxic drug, in order to minimize side effects. (S)-Ifosfamide may be administered subsequently.
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6015563 |
Polyphosphazene polyelectrolyte immunoadjuvants
A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or...
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5908868 |
Retinol derivatives useful for enhancing immune response
The present invention provides a purified retinoid compound characterized by a molecular mass of about 320 daltons and an atomic composition of C 20 H 32 O 3 . The present invention also provides...
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5863912 |
Method of treatment of hormone-unresponsive metastiatic prostate cancer
Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity...
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5854240 |
Methylene blue for the treatment or prophylaxis of encephalopathy caused by ifosfamide
The encephalopathy caused by ifosfamide and similarly acting compounds can be prevented or treated by the administration of methylene blue or another compound which is able to oxidize a reduced...
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5840647 |
Hydroformylation process using novel phosphite-metal catalyst system
Disclosed are catalyst systems comprising one or more transition metals selected from the Group VIII metals and rhenium and one or more fluorophosphite compounds having the general formula ##STR1##...
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5750131 |
Ifosfamide lyophilizate preparations
The invention relates to improved ifosfamide preparations which are distinguished in that as primary auxiliary a polysaccharide, in general a glycan, preferably dextran, starches or cellulose, in...
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5726165 |
Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor
A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, or solvate thereof, wherein, R o represents an aryl group, optionally substituted; X represents O or S; R 1 and...
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5709890 |
Polyaspartic acid and its analogues in combination with insecticides
An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small...
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