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5707979 |
Phosphinic acid derivatives, their preparation and their use
Compounds of the formula I, ##STR1## in which the symbols or substituents A, B, D, D*, E and E* have the meanings given in the specification, inhibit aspartyl proteases and are suitable for...
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5639732 |
Phosphorous-containing cysteine and serine protease inhibitors
The present invention is directed to novel phosphorous-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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5565439 |
Methods of using lysophosphatidic acid for treating hyperproliferative conditions
The subject invention involves a method for treating hyperproliferative conditions in mammalian epithelial cells comprising administering to the mammal a composition containing a safe and effective...
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5527787 |
Pharmaceutical composition having antiviral and antibacterial activity and method of administration
A novel pharmaceutical composition having anti-bacterial and antiviral activity and method of treating diseases caused by bacterial and viral pathogens through stimulation of the immunologic...
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5521223 |
Methods of using lysophosphatidic acids for regulating skin wrinkles
The subject invention relates to methods for regulating wrinkles in mammalian skin comprising topical application of a lysophosphatidic acid compound having the structure: ##STR1## or a cyclic...
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5519006 |
Phosphonated arylethanolamine compounds with anti-hyperglycemic and/or anti-obesity activity
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5447712 |
Method of reducing cyclophosphamide induced hemorrhagic cystitis
A method is provided for reducing side effects caused by chemotherapeutic agents by administering to a patient in need thereof a therapeutically effective amount of a composition including...
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5418223 |
Method for lyophilization of cyclophosphamide and product
A process for preparing a pharmaceutical preparation consisting essentially of a lyophilized cake of cyclophosphamide monohydrate and a bulking agent which comprises freezing cyclophosphamide, a...
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5413995 |
Lyophilized cyclophosphamide
A lyophilized pharmaceutical solid composition containing cyclophosphamide for reconstitution with water to provide a solution for oral or parenteral administration. This lyophilized...
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5407925 |
Regional chemotherapy within the central nervous system with 4-hydroperoxycyclophosphamide
A method of treating human tumors is provided in which tumors are regionally treated with a cytolytic, pre-activated, bifunctional alkylating agent, namely 4-hydroperoxycyclophosphamide. The...
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5360797 |
Bisphosphonic acid derivatives useful as anti-arthritic agents
Novel acids, esters, and salts of phenyl, naphthyl, quinoxalinyl, and biphenyl bisphosphonic acids and 1,2-oxaphosphepins are described. These compounds are useful as antiinflammatory and...
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5358942 |
Inhibition of protein kinase C with Cyclic phosphonate compounds
Compounds of the present invention are those having the formula: ##STR1## where R 1 and R 3 are the same or different and are a linear or branched chain of 1 to 22 carbon atoms selected from the...
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5336669 |
Cyclophosphamide monohydrate and lactose
A parmaceutical preparation consisting essentially of a lyophilized cake of cyclophosphamide monohydrate and lactose prepared by the process of freezing cyclophosphamide, lactose and water,...
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5321016 |
Use of certain substituted α-amino acids in treating stress-related psychiatric disorders
The invention discloses certain substituted α-aminoacids having the formula ##STR1## where m and n are 1 or 2, and R, R 1 , R 2 , R 3 and Y have various significances, which compounds are useful...
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5268368 |
Cyclophosphamide--amino acid lyophilizates
A stable rapidly dissolving lyophilized composition of cyclophosphamide and an amino acid selected from the group consisting of glycine, valine and serine is provided which contains an amount of...
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5262419 |
Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
Ulcerative conditions of the gastro-intestinal tract, e.g., antiinflammatory-drug-induced ulcers, are treated or prevented by the administration of a potassium channel activator. Methods and...
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5242908 |
Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses
The use of a compound of the formula I ##STR1## in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group,...
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5242909 |
Method of using 4-(2-(P-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) propenyl)phenoxy)ethyl)morpholine with cytostatics
The use of 4-[2-[p-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-nap
hthyl)-propeny l]phenoxy]ethyl]-morpholine, simultaneously, separately or sequentially in combination with a synergistically...
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5227373 |
Lyophilized ifosfamide compositions
Improved lyophilizate compositions of ifosfamide comprising urea as the primary excipient and, optionally, mesna, are produced in a modified freeze-drying process to give products with increased...
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5208224 |
Phosphorus containing compounds as antihypercholesterolemic and antiatherosclerotic agents
Novel phosphorus containing compounds are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of...
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5206018 |
Use of rapamycin in treatment of tumors
This invention provides a method of treating, inhibiting the proliferation of, reducing the size of, or eradicating malignant neoplasms in a mammal in need thereof which comprises administering an...
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5190929 |
Cyclophosphamide analogs useful as anti-tumor agents
Cyclophosphamides possessing anti-tumor activity and having the formula ##STR1## and salts thereof; wherein R is lower alkyl, aryl, aryl-lower alkyl or a nitrogen, sulfur or oxygen containing...
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5162311 |
α-amino-α(3-alkyl-phenyl)alkyl ethanoic acids wherein the 3-alkyl moiety bears a phosphorus oxo acid group or an ester thereof, their preparation and pharmaceutical compositions containing them
The invention discloses certain substituted α-aminoacids having the formula ##STR1## where m and n are 1 or 2, and R, R 1 , R 2 , R 3 and Y have various significances, which compounds are useful...
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5130305 |
Cyclophosphamide - sodium bicarbonate lyophilizates
A stable rapidly dissoloving lyophilized and hydrated composition of cyclophosphamide and sodium bicarbonate is provided which contains an amount of water which is at least equimolar to the...
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5082832 |
Novel cyclopropane carboxylates
Novel 2,2-dimethyl-cyclopropane carboxylic acid derivatives of the formula ##STR1## wherein X 1 and X 2 are individually halogen, R 1 is selected from the group consisting of halogen, alkyl of 1...
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5066647 |
Cyclophosphamide - alanine lyophilizates
A stable rapidly dissolving lyophilized composition of cyclophosphamide and alanine is provided.
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5057304 |
Active compounds for use in the treatment of tumors
Antitumor compositions and methods in which a cancerostatic agent and an effective amount of (+)-verapamil, (+)-gallopamil, (+)-devapamil and/or (+)-emopamil which reinforce the antitumor action of...
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5057541 |
Composition for external application
An emulsion-like or creamy composition for external application is disclosed. The composition is prepared by applying a shear force to an aqueous suspension comprising 0.1 to 20% by weight of one...
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5051425 |
Therapeutic composition for combatting AIDS
A therapeutic composition for combatting acquired immune deficiency syndrome (AIDS) comprising: (A) a pharmaceutically effective amount of at least one carcinostatic agent selected from alkylating...
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5004593 |
Hexamethylmelamine formulation exhibiting reduced neurotoxicity
A method is provided for reducing the side effects of chemotherapy with hexamethylmelamine (HMM) comprising intravelously administering a stabilized solution of HMM in an aqueous lipid dispersion,...
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4983593 |
Pharmaceutical composition of dihydropyridine compound
A pharmaceutical composition comprising: a 1:1 solvate of 5-(5,5-dimethyl-1,3,2-dioxaphosphorinane-2-yl)-1,4-dihydro-2
,6-dimethyl-4- (3- itrophenyl)-3-pyridine carboxylic acid...
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4952575 |
Solutions of oxaphosphorins having improved stability and process for the preparation thereof
Solutions comprising oxazaphosphorins having the general formula ##STR1## wherein R 1 , R 2 and R 3 are radicals and at least two of said radicals are 2-chloroethyl and/or...
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4929607 |
oxazaphosphorin-4-thio alkanesulphonic acids, neutral salts thereof and method to treat cancer diseases and to produce immunosuppression
This invention relates to new oxzaphosphorin-4-thio-alkanesulphonic acids and to the neutral salts thereof corresponding to the general formula I ##STR1## and to methods to use such compounds to...
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4879286 |
Cyclophosphamide
A storage-stable liquid oncolytic formulation of cyclophosphamide for parenteral administration is presented. Currently utilized lyophilized formulations have inherent diseconomies and increased...
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4879274 |
External medication for skin
Novel external medications comprise, as essential components, the following three components (A) to (C): (A) an α-monoglyceryl ether represented by the following formula (I): ##STR1## wherein R...
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4853221 |
Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]-methyl]-2,4-quin
azolinediamine (trimetrexate) has been shown to possess clinical activity against non-small cell lung cancer, head and neck squamous...
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4797388 |
Pharmaceutical compositions with galactitol as carrier
An improved pharmaceutical composition contains galactitol as carrier for the therapeutic agent. One example is a lyophilized composition of about 20 parts by weight of cyclophosphamide, taken as...
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4753789 |
Method for treating nausea and vomiting
The invention relates to the use of compounds of the general formula (I) ##STR1## wherein R 1 represents a hydrogen atom or a C 1 -10 alkyl, C 3 -7 cycloalkyl, C 3 -7 cycoalkyl-(C 1 -4) alkyl, C 3...
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4710493 |
Therapeutic agent for the use in cancer treatment
Good results are obtained in the selective destruction of tumor cells when a glycosaminoglycan polysulfate, except heparin, is combined with a cytostatic drug. The known serious secondary effects...
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4695449 |
Composition and method for treatment of melanomas
A composition and method for the treatment of melanomas in human beings wherein the composition comprises at least one O-phosphorylated derivative of 3-(3,4-dihydroxy)phenylalanine.
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4678777 |
Pest-combating agents containing phosphorus-heterocyclic compounds
An arthropodicidal composition comprising an arthropodicidally effective amount of an arthropodicidally active compound and a synergistically effective amount of at least one compound of the...
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4636387 |
Anesthetic polyorganophosphazenes
A long-acting, local anesthetic, comprising a polymeric phosphazene backbone, and certain radicals having local anesthetic activity and an amino functional group on the ring of said radical through...
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4620973 |
Use of nootropics
The invention relates to the use of nootropics, particularly Piracetam®, in connection with the treatment of cancer with cytostatically effective preparations, for the prevention or mitigation of...
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4609646 |
2-(thi)oxo-1,3,2-oxazaphospholanes as synergizing agents for pesticides
In a synergistic pesticidal composition comprising (1) a pesticidally active compound and (2) a synergizing agent in amount sufficient to synergize the pesticidal activity of the pesticidally...
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4605647 |
Oxaazaphosphorine compounds and pharmaceutical compositions
New oxaazaphosphorine compounds corresponding to the formula: ##STR1## in which R is alkyl, cycloalkyl or alkoxy, phenyl, phenylalkyl, phenoxy or thiophenoxy in which the phenyl ring may be...
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4565806 |
Composition and method for rational treatment of cancer
The invention concerns a composition, i.e., a multifunctional medically active agent for rational therapy of malignant (cancerous) diseases based on cause-and-effect relationship. The new...
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4562185 |
Five-membered nitrogen-containing hetero-cyclic compounds and their use as pest-combating agents
The present invention relates to combating pests with five-membered nitrogen-containing heterocyclic compounds of the formula (I) ##STR1## in which R 1 , R 2 , R 3 , X and Y have the meaning given...
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4546110 |
Pheromones
Compounds which are β-farnesene derivatives obtainable as a Diels-Adler adduct of β-farnesene and a dienophile or by a modification of such an adduct in a manner as defined herein are of value in...
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4541858 |
Chlorinated phosphorylmethylcarbonyl derivative plant protection agents
Novel chlorinated phosphorylmethylcarbonyl derivatives of the formula ##STR1## in which R 1 represents an optionally substituted radical from the series comprising alkyl, aryl, aralkyl, alkoxy and...
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4508706 |
Composition for increasing melanin in mammalian skin and hair
A composition and method useful for increasing the accumulation of melanin in the skin of humans and other mammals wherein the composition comprises at least one O-phosphorylated derivative of...
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