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8178712 |
Process for the synthesis of Ibandronate sodium
The present invention relates to an improved process for the synthesis of Ibandronate sodium of formula (I). The present invention also provides novel processes for the synthesis of...
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8153588 |
Methods useful in the treatment of bone resorption diseases
The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, said preparation being adapted for (a) the administration of...
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8143236 |
Chemoprotective methods
Compositions and methods for reducing, preventing, mitigating, and/or delaying the onset of, attenuating the severity of, and/or hastening the resolution of, for example, one or more...
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8026227 |
Chemoprotective methods and compositions
Compositions and methods for reducing, preventing, mitigating, and/or delaying the onset of, attenuating the severity of, and/or hastening the resolution of, for example, one or more...
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8008329 |
Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmacuetical composition comprising benzamidine derivative or it's salt, and bisphosphonate
The present invention provides a method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising...
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7932241 |
Pharmaceutical products comprising bisphosphonates
A pharmaceutical product comprises a container containing a bisphosphonate solution, in which at least the internal surface of the container comprises a plastic material and in which the container...
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7928091 |
Cathepsin cysteine protease inhibitors
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for...
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7915239 |
Process for treating lameness administration of a bisphosphonic acid derivative
The invention relates to a process for treating lameness with an osseous, articular or osteoarticular component, comprising the administration, to a human or to an animal not suffering from...
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7875597 |
Treatment of spinal mechanical pain
The invention is directed to a method of treating chronic spinal mechanical pain by intravenous administration to a subject in need of chronic spinal mechanical pain relief of an effective amount...
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7871992 |
Organophosphorous compounds for the activation of gamma/delta T cells
The present invention describes organophosphorus compounds of general formula (I) their preparation and their uses in the activation of gamma/delta T-cells, in the screening of GcpE and LytB enzyme...
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7846474 |
Use of bisphosphonates for the treatment of osteogenesis imperfecta
This procedure consists in the first stage, of the administration of enough quantity of bisphosphonate preparation during the necessary period of time to acquire a degree of volumetric mineral...
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7820197 |
Percutaneous preparations
A bisphosphonic acid derivative-containing percutaneous preparation of an excellent percutaneous permeability, comprising a bisphosphonic acid derivative such as incadronic acid, minodronic acid,...
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7781420 |
Use of clodronic acid for treatment podotrochlosis
The invention describes the use of clodronic acid, its addition salts or esters as active ingredient for the preparation of a pharmaceutical for treating podotrochlosis with associated osteoporosis...
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7749543 |
Methods useful in the treatment of bone resorption diseases
The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, said preparation being adapted for (a) the administration of...
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7718634 |
Method of treatment using bisphosphonic acid
The present invention refers to a pharmaceutical composition of a bisphosphonic acid or salt thereof, and an excipient thereof, and a method of treating disorder characterized by pathologically...
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7612052 |
Combinations comprising epothilones and pharmaceutical uses thereof
The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I wherein A represents O or...
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7579333 |
Therapy using a combination of raloxifene and alendronate
Provided are methods of treating bone disease including, but not limited to, osteoporosis, metastatic bone disease, or Paget's disease, by administering a combination of raloxifene and alendronate...
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7507715 |
Methods useful in the treatment of bone resorption diseases
The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, said preparation being adapted for (a) the administration of...
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7410957 |
Method of treatment using bisphosphonic acid
The present invention refers to a pharmaceutical composition of a bisphosphonic acid or salt thereof, and an excipient thereof, and a method of treating disorder characterized by pathologically...
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7399756 |
Organo-phosphorous compounds for activating gamma/delta T cells
The present invention describes organophosphorus compounds of general formula (I) their preparation and their uses in the activation of gamma/delta T-cells, in the screening of GcpE and LytB enzyme...
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7309698 |
Compositions for delivering bisphosphonates
Compounds and compositions for the delivery of bisphosphonates are provided. Methods of preparation, administration and treatment are provided as well.
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7288535 |
Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates
The invention relates to compositions and methods for use in treating skeletal system disorders in a vertebrate at risk for bone loss, and in treating conditions that are characterized by the need...
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7176192 |
Method for treating patients for radiation exposure
This invention relates to a method of treating a patient suffering from ionizing radiation exposure, or of treating a patient about to undergo ionizing radiation therapy. The method includes...
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7157092 |
Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same
Compounds of the formula wherein the substitutents are defined as in the specification useful for modulating immune responses in warm-blooded animals.
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7138388 |
Methods to treat autoimmune and inflammatory conditions
This invention provides methods for treating inflammatory or autoimmune diseases by contacting the affected cell or tissue with a therapeutic compound as described herein. Such pathologies include,...
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7084126 |
Methods and compositions for enhancing cellular function through protection of tissue components
Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors,...
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7078059 |
Treatment of bone diseases
The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis...
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6896871 |
Biphosphonate conjugates and methods of making and using the same
The present invention is directed to particular bisphosphonate compounds, and in particular, to bisphosphonate conjugates that are useful in the treatment of soft tissues surrounding bone and...
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6864228 |
Use of bisphosphonates for the treatment of osteogenesis imperfecta
This procedure consists in the first stage, of the administration of enough quantity of bisphosphonate preparation during the necessary period of time to acquire a degree of volumetric mineral...
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6844320 |
Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
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6835722 |
Pharmaceutical compositions and preparations for treatment of metabolic bone disease
The present invention relates to a pharmaceutical composition for the treatment of metabolic bone disease and the method of preparation thereof, and more particularly, to an improved pharmaceutical...
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6824794 |
Method and apparatus for preventing bacteria and algae growth in water
A water treatment agent and method of treating water to inhibit, reduce, or prevent the formation of algae and bacteria in a water body. The water treatment agent may include copper sulfate...
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6812214 |
Use of harpagid-related compounds for prevention and treatment of osteoporosis, arthritis and ruptured disc and pharmaceutical composition containing the same
In the present invention, it is discovered that a compound of formula (I) has a potent effect for treatment of osteoporosis, arthritis and ruptured disc: in which R1 represents hydrogen atom or...
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6803057 |
Hydrogen peroxide disinfectant with increased activity
An acidic aqueous hydrogen peroxide solution is provided with improved disinfectant activity. Concentrated solutions preferably contain up to about 8 wt./wt. % H2O2 and as-used concentrations...
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6794371 |
Aminoalkylenephosphonates for treatment of bone disorders
A method for preventing loss of bone mineral in mammals which method comprises administering to a mammal an amount of an aminoalkylenephosphonate which is effective to prevent or minimize loss of...
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6784168 |
Biocidal compositions and treatments
A synergistic biocide comprises a tris(hydroxymethyl)phosphine or a tetrakis (hydroxymethyl)phosphonium salt and at least one non-surfactant biopenetrant, such as a polymer or copolymer having a...
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6699850 |
Compositions and methods for inhibiting bone resorption
The present invention relates to oral compositions and methods for inhibiting bone resoprtion in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The...
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6696429 |
Process for treating lameness by administration of a bisphosphonic acid derivative
The invention relates to a process for treating lameness with an osseous, articular or osteoarticular component, comprising the administration, to a human or to an animal not suffering from...
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6692764 |
Wet granulation formulation for bisphosphonic acids
Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by wet granulation tablet formulation. These pharmaceutical compositions are useful in the treatment of...
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6682718 |
Remedies for periodontosis
The invention relates to an alveolar bone resorption inhibitor for use in topical injection by an alveolar mucosa injection method, which comprises a bisphosphonic acid derivative or a salt thereof...
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6680307 |
Use of ibandronate for promoting osseointegration of endoprostheses
The invention relates to use of ibandronic acid (1-hydroxy-3-(N-methyl-N-pentyl)aminopropyl-1,1-diphosphonic
acid) or physiologically compatible salts or esters thereof for improving the...
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6677320 |
Parenteral bisphosphonate composition with improved local tolerance
The present invention relates to a parenteral composition comprising a bisphosphonic acid or a pharmaceutically acceptable salt thereof (bisphosphonate) as active component and a pharmaceutically...
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6670343 |
Drugs for periodontal disease
An agent for periodontal disease includes, as an active component, a methanebisphosphonic acid derivative or a hydrate thereof represented by the general formula (I): [wherein X, Y, m, n,The...
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6649601 |
Process for increasing the egg production and strengthening the eggshells of poultry
The present invention relates to a process for increasing the egg production and strengthening the eggshells of poultry, which comprises the administration to the animal of at least one...
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6638920 |
Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses
The present invention relates to compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses. The present invention further relates to compositions and...
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6627221 |
Pharmaceutical composition containing diphosphonic acid or salt thereof
The invention relates to a solid pharmaceutical form of administration containing a diphosphonic acid or a physiologically compatible salt thereof as the active substance, wherein the active...
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6624151 |
Compounds selectively inhibiting gamma 9 delta 2 T lymphocytes
The invention concerns compounds CH3—R1—(CH1)2—R2 wherein: R1 is selected among a tertiary alcohol; a 1,2-diol; a halohydrine; an apoxide; an alkene; an aldehyde or an α-hydroxyaldehyde; and R2 is ...
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6610682 |
Pharmaceutical compositions and methods for the treatment of arteriosclerosis
A pharmaceutical composition comprising as its active ingredients one or more drugs selected from the group consisting of angiotensin II receptor antagonists and angiotensin converting enzyme...
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6593313 |
Co-administration of a prostaglandin and an androgenic agent in the treatment of female sexual dysfunction
Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina,...
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6573252 |
Medicine nitrate salts
The present invention relates to nitrate salts of compounds having therapeutic activity in bony disorders, such compounds being characterized in that they contain at least a reactive group capable...
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