Matches 101 - 150 out of 186 < 1 2 3 4 >
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5366965 Regimen for treatment or prophylaxis of osteoporosis  
Methods for treating or preventing osteoporosis, including regimens for intermittent dosing of bone resorption inhibiting polyphosphonate compound or a pharmaceutically acceptable salt or ester of...
5356887 Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids  
Crystalline and amorphous insoluble calcium salts of bisphosphonic acids may be formulated to provide compositions suitable for I.M. (intramuscular) and S.C. (subcutaneous) administration. As...
5344825 Methanediphosphonic acid formulations with ion exchangers  
The invention relates to a novel advantageous oral dosage form for methanediphosphonates, especially the active ingredient disodium pamidronate. A preferred dosage form comprises: a)...
5338731 Bisphosphonates, processes for preparation and pharmaceutical compositions containing the same  
Bisphosphonate compounds are of the Formula (I): ##STR1## wherein Y is O or N--OH and n is from 3 to 24, and further wherein when Y is O, (i) R 1 is hydrogen and R 2 is sodium, or (ii) R...
H001345 Method for preventing or treating hepatitis D  
A method is provided for blocking or preventing the prenylation of CXXX box containing proteins thereby preventing and/or treating hepatitis D which includes the step of administering a...
5332728 Method for treating a fungal infection  
A method is provided for treating a fungal infection which includes the step of administering a therapeutically effective amount of a phosphorus-containing squalene synthetase inhibitor.
5296475 Pharmaceutical compositions comprising methanediphosphonic acid derivatives and macrocyclic polyethers  
The invention relates to pharmaceutical compositions for peroral administration comprising (a) pharmaceutically useful methanediphosphonic acid derivatives, e.g. those of formula I ##STR1## wherein...
5294608 Guanidinoalkyl-1,1-bisphosphonic acid derivatives, process for their preparation and their use  
The invention describes tautomeric compounds of the formula Ia, Ib or Ic ##STR1## and/or their physiologically tolerable salts, in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are a hydrogen...
5273969 Phosphorus-containing squalene synthetase inhibitors and method  
Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are...
5270365 Prevention and treatment of periodontal disease with alendronate  
This invention claims a method for treating periodontal disease in mammals, including humans, by administering an effective amount of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or a...
5260287 Polyphosphorylated organic compounds: compositions useful in protecting biological tissues  
Compositions and methods for protecting the luminal lining against gastric acid challenge are disclosed. The compositions provide effective anti-ulcer preparations which include phosphorylated...
5254544 Hydroxyphosphinyl phosphonate squalene synthetase inhibitors and method  
Hydroxyphosphinyl phosphonate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula ##STR1## wherein R 2...
5227506 Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors  
The invention relates to acyloxymethyl esters of bisphosphonic acids, halo-bisphosphonic acids and hydroxy-bisphosphonic acids which exhibit oral bioavailability and are useful in the treatment of...
5212164 Phosphorus-containing squalene synthetase inhibitors  
Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are...
5196409 Bisphosphonates, pharmaceutical compositions, and process for the treatment of irregularities in calcium metabolism  
Novel bisphosphonates comprise compounds of the formula (I) ##STR1## wherein m and l are independently 1 or 2; R 1 represents hydrogen, a lower alkyl group, or an alkali metal cation; R 2 ...
5157027 Bisphosphonate squalene synthetase inhibitors and method  
Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are...
5120721 Acaricidal composition  
An acaricidal composition comprising as active ingredients (A) either α-cyano-3-phenoxybenzyl 2,2,3,3-tetramethylcyclopropanecarboxylate or α-cyano-3-phenoxybenzyl...
5096717 Double-coated granules of disodium pamidronate  
The invention relates to an advantageous oral administration from the disodium pamidronate in capsules. These capsules are filled with double-coated granules. The inner coating is hydrophilic and...
5037812 Tumor cell growth-inhibiting pharmaceutical compositions containing phosphino-hydrocarbon-gold, silver or copper complexes  
Pharmaceutical compositions and a method for inhibiting the growth of tumor cells by administering a tumor cell growth-inhibiting amount of a bis[bis (diphenylphosphino)hydrocarbon]-,...
5002937 Diphosphonic acid compounds and use for calcium metabolism disorders  
The present invention provides compounds of the formula: ##STR1## The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing...
4975423 Inhibition of tumor development  
Non-toxic water-soluble pharmaceutically acceptable compound derivative of peroxydiphosphoric acid when administered orally or systemically supplements inhibition of malignant myeloma carcinoma...
4957939 Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging  
Pharmaceutical compositions comprising gadolinium chelates are useful for enhancing NMR images.
4942157 1-hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid, pharmaceutical compositions and methods of use  
The present invention provides 1-Hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid of formula ##STR1## wherein R is hydrogen or C 1 -C 4 alkyl and the pharmacologically acceptable...
4927814 Diphosphonate derivatives, pharmaceutical compositions and methods of use  
The present invention provides disphosphonates of the general formula: ##STR1## wherein R 1 is a straight-chain or branched, saturated or unsaturated aliphatic hydrocarbon radical of 1-9 carbon...
4892679 Oxa-alkane polyphosphonic acids, their use as thresholders, and complexing compositions containing these compounds  
Oxa-alkane polyphosphonic acids corresponding to general formula (I) ##STR1## in which R 1 is a C 1 -C 10 alkyl group, an optionally substituted C 6 -C 10 aryl group, a phenyl- or...
4876248 Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation  
The present invention relates to products of the formula ##STR1## where R 1 is H or alkyl, n is an integer from 0 to 10, and R 2 is chosen from amongst H, unsubstituted or substituted alkyl...
4857513 Diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same  
A compound of the formula: ##STR1## wherein R 1 --A-- is a group of the formula: ##STR2## in which R 1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s)...
4851217 All aqueous formulations of organo-phosphorous pesticides  
A composition of matter and method of making the composition which relates to an all aqueous, phase stable emulsion of organophosphorous pesticides which is free of organic solvents. The...
4820698 Antimicrobial agents and process for their manufacture  
Disclosed are tetraalkyl enthenylidenebisphosphonates and a method for their manufacture. These compounds are suitable for use as antimicrobial agents in combating a number of pathogenic...
4814326 Pharmaceutical compositions based on diphosphonates for the treatment of arthrosis and osteoarthritis  
This invention relates to pharmaceutical compositions for the treatment of arthrosis by intraarticular administration of the compositions diluted in a suitable aqueous or lyophilized carrier,...
4719050 Diphosponylated oxonitriles, processes and uses therefor, and compositions containing them  
3-Alkyl-3-oxo-1-aminopropane-1,1-diphosphonic acids and water-soluble salts thereof corresponding to the formula ##STR1## in which R 1 represents an unbranched or branched C 1 -C 8 alkyl group,...
4719203 Diphosphonic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them  
Diphosphonate compounds, processes for their preparation and pharmaceutical compositions containing them and being useful for treating calcium metabolism disorders. The diphosphonates are of the...
4666895 Diphosphonic acid derivatives  
The present invention provides diphosphonic acid derivatives of the general formula: ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 , independently of one another or also together, signify...
4645762 Diphosphonic acid derivatives and pharmaceutical preparations containing same  
Diphosphonic acid derivatives of the formula ##STR1## wherein X is cyano, 2-cyanoethyl, or 3- aminopropyl and Y is H, or X and Y together represent dimethylaminomethylene ((CH 3 ) 2 NCH), and ...
4634691 Method for inhibiting tumor metastasis  
A method for inhibiting the formation of tumor cell metastases without treating the underlying cancer itself in humans and animals having metastatic cancer involving the skeleton is disclosed. In...
4624695 O-diaminophosphinyl derivatives of oximes as urease inhibitors  
The invention relates to novel urease inhibited fertilizer compositions containing urea and a urease inhibiting amount of one or more o-diaminophosphinyl derivatives of oximes, and methods and...
4624947 4-dimethylamino-1-hydroxybutane-1,1-diphosphonic acid, salts thereof, and processes therefor  
4-Dimethylamino-1-hydroxybutane-1,1-diphosphonic acid and water-soluble salts thereof, methods for their preparation, and uses thereof as complexing agents.
4621077 Pharmacologically active biphosphonates, process for the preparation thereof and pharmaceutical compositions therefrom  
Biphosphonic acids of general formula I: ##STR1## in which R is a fluorine atom of a linear or branched alkyl radical containing between 1 and 5 carbon atoms, which may also be substituted by one...
4578376 Pharmaceutical compositions for the treatment of osteopathias  
A pharmaceutical composition for the treatment of osteopathias is described which contains an effective amount of the active ingredient 6-amino-1-hydroxyhexane-1,1-diphosphonic acid or a...
4446052 Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate  
Calcium 1-hydroxy-3-aminopropane-1,1-diphosphonate forms a gel when mixed with water. As compared to soluble salts of APD, the gel provides slow systemic release and reduced tissue damage when used...
4357329 Combating pests with N-phosphonylcarbonyl-carbamates  
N-Phosphonylcarbonyl-N-methylcarbamic acid esters of the formula ##STR1## in which R 1 and R 2 can be identical or different and each represents alkyl, alkenyl or alkynyl, it being possible for...
4330530 Anti-arthritic compositions and method using gold salts and organophosphonates  
Compositions comprising pharmaceutically-acceptable gold salts and organophosphonates, especially the geminal diphosphonates, useful in the treatment of arthritic conditions, are disclosed. The...
4330537 Compositions for inhibiting mobilization of calcium phosphate in animal tissue  
Compositions for inhibiting the anomalous mobilization of calcium phosphates in animal tissue comprising an effective amount of certain phosphonate compounds as herein defined in combination with...
4282214 Phenylacetate anti-inflammatory composition  
The anti-inflammatory activity of fenoprofen, ketoprofen, MK-830 and other phenylacetic acid-based anti-inflammatory drugs is enhanced by administration thereof in conjunction with a phosphonate...
4275059 Salicylate anti-inflammatory composition  
The anti-inflammatory activity of aspirin and other salicylate-based, anti-inflammatory drugs is enhanced by administration thereof in conjunction with a phosphonate compound such as EHDP or Cl 2 ...
4269828 Indole anti-inflammatory composition  
The anti-inflammatory activity of indomethacin, indoxole, and other indole-based drugs is enhanced by administration thereof in conjunction with a phosphonate compound such as EHDP or Cl 2 MDP.
4264582 Isobutylphenylacetate anti-inflammatory composition  
The anti-inflammatory activity of ibuprofen, ibufenac and other p-(isobutylphenyl)acetic acid-based anti-inflammatory drugs is enhanced by adminstration thereof in conjuction with a phosphonate...
4254114 Control of pyrophosphate microorganisms with organophosphonates  
A method of selectively controlling pyrophosphate-utilizing microorganisms comprises contacting said microorganisms with an organism controlling amount of certain organophosphonate compounds....
4234645 Pharmaceutical composition  
Dichloromethane diphosphonates affect the biosynthesis of collagen.
4230700 Methods for inhibiting mobilization of calcium phosphate in animal tissue  
Compositions for inhibiting the anomalous mobilization of calcium phosphates in animal tissue comprising an effective amount of certain phosphonate compounds as herein defined in combination with...
Matches 101 - 150 out of 186 < 1 2 3 4 >