|
Match
|
Document |
Document Title |
|
|
6214812 |
Bisphosphonate conjugates and methods of making and using the same
Bisphosphonate conjugates capable of releasing antibacterial and/or cytotoxic components upon binding with bone tissue. Such conjugates are useful in the treatment and prevention of bone cancer,...
|
|
|
6200961 |
Concentrates of organophosphorous insecticides
A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is...
|
|
|
6190695 |
Pharmaceutical composition containing osteogenesis-promoting substance
This invention provides a pharmaceutical composition comprising a non-peptide osteogenesis-promoting substance and a polyethylene glycol or a derivative thereof, which can be advantageously used as...
|
|
|
6177411 |
Method for treating heavy metal poisoning
This invention relates to a method of treating patients afflicted with heavy metal poisoning. The method includes administering to a patient in need of treatment an antidotal amount of a thiol or...
|
|
|
6174857 |
Composition and method for the treatment of osteoporosis in mammals
Pharmaceutical compositions and methods for the treatment of osteoporosis in mammals are disclosed. The compositions are suitable for parenteral administration and comprise Insulin-Like Growth...
|
|
|
6172119 |
Method of treating acute renal failure
This invention relates to a method of treating patients afflicted with acute renal failure. The method includes administering to a patient in need of treatment an effective amount of a thiol or...
|
|
|
6133261 |
Amino acid derivatives useful to treat stroke
The invention provides a therapeutic method for treating or preventing stroke and other ischemic disorders, as well as novel compounds and pharmaceutical compositions useful for carrying out such...
|
|
|
6117856 |
Topical bisphosphonates for prevention of bone resorption
Bisphosphonates inhibit bone resorption associated with periodonatal or orthopedic surgery when applied topically to the bone. A novel formulation for topical application contains a gelatin matrix...
|
|
|
6114340 |
Fungicidal compositions
An improved fungicidal composition is a mixture of (a) fungicide used to combat phytopathogenic fungi and (b) at least one phosphonate or phosphinate of formula R 1 R 2 P(O)OR 3 where R 1 is C...
|
|
|
6114316 |
Combination of bisphosphonate and tetracycline
Tissue-destructive conditions related to excess protemase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a...
|
|
|
6100247 |
Method of treating diabetic neuropathy
This invention relates to a method of treating patients afflicted with diabetic neuropathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or...
|
|
|
6087349 |
Method for blocking neoplastic transformation of cells induced by ras oncogenes
A method is provided by blocking or preventing the prenylation of CAAX box containing proteins including ras oncogene products thereby preventing and/or treating ras-related tumors which includes...
|
|
|
6057306 |
Method of treating the navicular disease in horses
The invention relates to a method of treating the navicular disease in horses, which comprises treating the navicular disease in horses with an effective amount of at least one compound of formula...
|
|
|
6043274 |
Method of treating diabetic cardiomyopathy
This invention relates to a method of treating patients afflicted with diabetic cardiomyopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or...
|
|
|
6034126 |
Method for treating glycol poisoning
This invention relates to a method of treating patients afflicted with glycol poisoning. The method includes administering to a patient in need of treatment an antidotal amount of a thiol or...
|
|
|
6008205 |
Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses
The present invention is directed to presqualene diphosphate (PSDP) analogs having an active region of natural PSDP and a metabolic transformation region resistant to rapid intracellular...
|
|
|
6008207 |
Anhydrous alendronate monosodium salt formulations
Disclosed is a method for treating and preventing bone loss in patients by administering a formulation of anhydrous alendronate sodium. Also described is a pharmaceutical doage form of said...
|
|
|
6008206 |
Sodium alendronate preparation for local administration
The object of the present invention is to provide a preparation for local administration to permit selective delivery of an effective amount of sodium alendronate to the bone site where bone...
|
|
|
5998479 |
Method of treating adult respiratory syndrome
This invention relates to a method of treating patients afflicted with Adult Respiratory Distress Syndrome (ARDS). The method includes administering to a patient in need of treatment an effective...
|
|
|
5990098 |
Therapeutic use of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid and its salts
Use of 1-amino-3-N,N-dimethylamino)-propyliden-1,1-bisphosphonic acid of the structural formula: ##STR1## or of its monosodium or other pharmaceutically acceptable salt, as a biological carrier for...
|
|
|
5972913 |
Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
Disclosed is a therapy for treating and for preventing periprosthetic bone loss by the administration of a bisphosphonate bone resorption inhibitor, e.g., alendronate, in patients who have an...
|
|
|
5968498 |
Freshness retaining gel composition
The freshness of meat, vegetables and fruits in a refrigerator or food storage box can be retained for a long period of time by using (1) a freshness retaining gel composition which comprises a...
|
|
|
5965547 |
Use of certain methanebishosphonic acid derivatives to prevent prosthesis loosening and prosthesis migration
The invention relates to the use of certain methanebisphosphonic acid derivatives (for the manufacture of a pharmaceutical composition) for the prevention and treatment of prosthesis loosening and...
|
|
|
5958906 |
Phospholipid derivatives containing higher elements of the fifth main group
Phospholipid derivatives containing higher elements of the Vth main group (P, As, Sb, Bi), their method of preparation and antineoplastic and antimicrobially active medications that can be prepared...
|
|
|
5958907 |
Pharmaceutical compositions and uses of inorganic pyrophosphates
Pharmaceutical compositions comprising an inorganic pyrophosphate (PPi) in a form that renders the PPi accessible to ABC proteins when administered to a subject in vivo, as well as use of the...
|
|
|
5932563 |
Methods for treating spinal cord injury
New methods for treating patients with a traumatic contusion-type spinal cord injury are provided. The method comprises the steps of providing a patient having a contusion-type injury and...
|
|
|
5914323 |
Intravenous alendronate formulations
Disclosed is a therapy protocol for treating patients having metastatic bone disease, hypercalcemia of malignancy and/or metabolic bone disease by administering an intravenous, citrate-buffered...
|
|
|
5914099 |
Prevention of tooth loss by the administration of alendronate or its salts
Alendronate, a bisphosphonate can prevent tooth loss not necessarily associated with periodontal disease. Preferably, alendronate (or a pharmaceutically acceptable salt thereof) is given daily for...
|
|
|
5858996 |
Compositions and methods for stabilizing polymers
Compositions and methods for reducing the decomposition rate of polymeric bioadhesives and viscosity enhancers, such as poly(acrylic acids). The compositions include at least one strong, stable...
|
|
|
5843993 |
Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same
A complex and method for making same for use as a diagnostic or therapeutic pharmaceutical includes a ligand comprising at least one hydroxyalkyl phosphine donor group bound to a gold atom to form...
|
|
|
5824661 |
Sulfur-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S (b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a...
|
|
|
5804570 |
Method of lessening the risk of non-vertebral bone fractures
Alendronate, a bisphosphonate, when administered daily over a substantial period of time, can reduce the rate of non-vertebral fractures, in post-menopausal women.
|
|
|
5712261 |
Method for preventing or treating hypertriglyceridemia
A method is provided for preventing and/or treating hypertriglyceridemia, and/or atherosclerosis and/or pancreatitis resulting from hypertriglyceridemia, employing a squalene synthetase inhibitor.
|
|
|
5668120 |
Iontophoretic delivery of bisphosphonates to the alveolar bone
The present invention relates to methods of inhibiting alveolar bone resorption or the undesirable movement of teeth of a human or other animal comprising: a) administering a reservoir to the...
|
|
|
5616571 |
Bisphosphonates prevent bone loss associated with immunosuppressive therapy
Bisphosphonate, particularly alendronate, can prevent or treat bone loss associated with immunosuppressive therapy, whether or not the immunosuppressive therapy is associated with an organ transplant.
|
|
|
5616576 |
Controlling bone resorption with pyrroloquinoline quinone (PQQ) and related compounds
PQQ and PQQ-generating compounds inhibit osteoclast cell formation and bone resorption, and those compounds can be used to treat medical conditions characterized by undesired bone resorption....
|
|
|
5591730 |
Inhibition of urinary calculi growth
The present invention provides metal ion/bisphosphonate complexes that are useful for the treatment and diagnosis of urinary calculi. Preferred bisphosphonates include etidronate, pamidronate...
|
|
|
5488041 |
Method of promoting bone repair using tiludronic disodium salt
The present invention relates to a method of promoting bone repair in human or veterinary medicine; which method comprises the administration of therapeutically effective amounts of bisphosphonic...
|
|
|
5466682 |
Acylamino-alkyliden-hydroxy-bisphosphonic acids esters and salts thereof, wherein the acyl group is derived from an acid having antiinflammatory activity
Compounds of formula (I) ##STR1## in which A is (CH 2 ) n in which n is 1-10, preferably 3 or 5, and R is the acyl group from a known anti-inflammatory agent, exhibit high anti-inflammatory...
|
|
|
5462932 |
Oral liquid alendronate formulations
Disclosed is a therapy protocol for treating and for preventing bone loss in patients who have difficulty in swallowing by administering a liquid formulation of alendronate which can be easily...
|
|
|
5461039 |
Method for treating hypertension employing a cholesterol lowering drug
A method is provided for treating hypertension in normotensive patients having insulin resistance by administering a cholesterol lowering drug, such as pravastatin, alone or in combination with an...
|
|
|
5457083 |
Synergistic antimicrobial combination of polyether phosphonates and non-oxidizing biocides
Synergistic antimicrobial combinations of polyether polyamino methylene phosphonates and one or more members selected from the group consisting essentially of the following non-oxidizing biocides: ...
|
|
|
5451401 |
Diphosphonic acid esters as tartar control agents
Polyphosphonic acid ester compounds with flavorant, coolant and/or sweetener components, and tartar, plaque and/or calculus control compositions with improved taste comprising one or more...
|
|
|
5438048 |
Methylenebisphosphonic acid derivatives
Novel pharmacologically active methylenebisphosphonates having formula (I) wherein R 1 , R 2 , R 3 and R 4 independently are straight or branched, optionally unsaturated C 1 -C 10 -alkyl,...
|
|
|
5434145 |
N-alkythio polyamine derivatives as radioprotective agents
The present invention relates to certain polyamine thiols which are useful as radioprotective agents.
|
|
|
5431920 |
Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents
The present invention relates to a novel oral dosage form of a bisphosphonic active ingredient for use in treatment of diseases involving bone resorption and formulated in an enteric-coated form...
|
|
|
5428028 |
Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor
A method is provided for inhibiting cholesterol biosynthesis by inhibiting de novo squalene production employing methylene phosphonoalkylphosphinate compounds.
|
|
|
5403829 |
Use of bisphosphonates in endo-osteal bone surgery
A method of enhancing the formation of bone tissue and/or eliminating late complications subsequent to bone surgery comprising administering an amount, which is safe and sufficient to promote the...
|
|
|
5376649 |
Partial esters of (Di) chloromethanediphosphonic acid useful for treating disorders relating to the metabolism of calcium
Novel pharmaceutically active bisphosphonic acid derivatives of formula (I), in which R 1 , R 2 , R 3 and R 4 independently are C 1 -C 22 -alkyl, C 2 -C 22 -alkenyl, C 2 -C 22 -alkynyl, C 3...
|
|
|
5369099 |
Method and composition for inhibiting the formation of hardwater deposits on fruit
The present invention provides an improved method and mixture for cooling fruit on the tree or vine while inhibiting the formation of scales or deposits on the fruit. The method and mixture provide...
|