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7517858 |
Prodrugs of pharmaceuticals with improved bioavailability
Lipid prodrugs of pharmaceutical agents and their analogs that have increased anticancer, anti-viral, anti-inflammatory, anti-proliferative activity over the parent drug, and methods for making...
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7511095 |
Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs...
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7109181 |
Joint lubrication with P2Y purinergic receptor agonists
The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises...
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7084126 |
Methods and compositions for enhancing cellular function through protection of tissue components
Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors,...
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7053150 |
Segmented polymers and their conjugates
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene...
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6774180 |
Synthesis of high molecular weight non-peptidic polymer derivatives
High molecular weight derivatives of activated poly(ethylene glycol) and the like polymers are prepared in high purity by conjugating a large PEG molecule to a small PEG molecule. Most of the...
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6680307 |
Use of ibandronate for promoting osseointegration of endoprostheses
The invention relates to use of ibandronic acid (1-hydroxy-3-(N-methyl-N-pentyl)aminopropyl-1,1-diphosphonic
acid) or physiologically compatible salts or esters thereof for improving the...
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6677320 |
Parenteral bisphosphonate composition with improved local tolerance
The present invention relates to a parenteral composition comprising a bisphosphonic acid or a pharmaceutically acceptable salt thereof (bisphosphonate) as active component and a pharmaceutically...
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6627660 |
Stabilized thyroxine compounds
Throxinyldimethylphosphinate was invented as a prodrug to stabilize thyroxine, a drug widely used to treat hypothyroidism. The presence of the dimethylphosphinate group at the phenolic hydroxyl of...
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6605603 |
Uses of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid
The present invention relates to novel uses of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid or any of its soluble salts or any of its hydrates, in particular its use for the...
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6436913 |
Use of estramustine phosphate in the treatment of bone metastasis
Estramustine phosphate is shown to act as an inhibitor of bone resorption and can thus be used to treat, prevent or alleviate the symptoms of bone metastasis which arise due to said bone resorption.
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6326363 |
Methylenebisphosphonic acid derivatives
The object of the invention are novel halogen substituted methylenebisphosphonic acid anhydrides, ester anhydrides, amide anhydrides, and ester amide anhydrides, processes for the preparation of...
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6303588 |
Therapeutic methods utilizing naturally derived bio-active complexes and delivery systems therefor
Methods are disclosed for correcting biological information transfer in a patient in need of such therapy which comprise administration to a patient of a composition comprising a therapeutically...
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6221856 |
Inositol derivatives for inhibiting superoxide anion production
Inositol derivatives, compositions comprising inositol derivatives, and methods for using compositions comprising inositol derivatives as agents for inhibiting superoxide anion production are...
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6200961 |
Concentrates of organophosphorous insecticides
A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is...
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6114316 |
Combination of bisphosphonate and tetracycline
Tissue-destructive conditions related to excess protemase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a...
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5998485 |
Method for modulating immune response with inositol
A composition for modulating immune response in mammals, comprises a therapeutic agent such as a stereoisomer of inositol, derivatives, salts, and mixtures thereof, and optionally a carrier. The...
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5955453 |
Membrane-permeant phosphoinositides
Membrane-permeant phosphoinositides, including phosphatidylinositol phosphate esters, are described. A membrane-permeant phosphoinositide includes groups that neutralize the charges of the...
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5846957 |
Use of an ester of inositoltrisphosphate for the preparing of medicaments
The present invention relates to the use of an ester of inositoltrispbosphate for the preparing of a medicament effective against retroviral diseases.
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5827838 |
Method for the treatment of diseases related with protein isoprenylation
The invention provides a method for inhibiting protein isoprenylation by administration of a polyisoprenyl pyrophosphate analogue. The polyisoprenyl pyrophosphate analogue may have formula 1,...
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5827837 |
Polyanion anti-inflammatory agents
Selectin binding and inflammation is modulated by a method which utilizes inositol polyaninon.
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5760022 |
Pharmaceutical composition with improved bioavailability of inositol phosphate
The invention relates to an inositol phosphate containing pharmaceutical composition which comprises an aliphatic ester or ether for improvement of the bioavailability of the inositol phosphate in...
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5726164 |
Nanosuspensions for intravenous administration
The present invention relates to a pharmaceutical composition for the intravenous administration of the sparingly soluble staurosporin derivative N-benzoyl-staurosporin. The composition comprises...
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5726163 |
Dermatologic composition
A dermatologic composition is disclosed which comprises a hydrogenated phospholipid having an iodine value of 10 or less and a phosphatidylcholine content of 90% or more, a cholesterol and an oily...
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5668120 |
Iontophoretic delivery of bisphosphonates to the alveolar bone
The present invention relates to methods of inhibiting alveolar bone resorption or the undesirable movement of teeth of a human or other animal comprising: a) administering a reservoir to the...
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5663179 |
Certain isoquinoline derivatives having anti-tumor properties
Compounds are described of general formula (I) ##STR1## and salts and solvates thereof, including physiologically acceptable salts and solvates thereof, in which: Z represents either Het,...
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5628986 |
Oral compositions
Disclosed are oral compositions such as toothpastes, mouthrinses, liquid dentifrices, lozenges and gums containing at least one phosphate derivative and a copper source.
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5618804 |
Methanediphosphonic acid derivative, process for production thereof and use for pharmaceuticals
A methane diphosphonic acid derivative represented by the general formula (I): ##STR1## wherein, X and Y are defined in the specification; m represents an integer of 0 to 3; n represents an integer...
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5616571 |
Bisphosphonates prevent bone loss associated with immunosuppressive therapy
Bisphosphonate, particularly alendronate, can prevent or treat bone loss associated with immunosuppressive therapy, whether or not the immunosuppressive therapy is associated with an organ transplant.
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5614511 |
Cosmetic compositions for treating itchy skin
The invention is directed to controlling and alleviating itchiness of human skin. Itchiness is treated with a composition that includes inositol phosphate, particularly phytic acid and its salts,...
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5545632 |
Method of treating retroviral disease
A method of preventing or alleviating retroviral disease by administering to a human or a mammal in need thereof a pharmaceutical composition comprising an amount of at least one specific isomer of...
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5512552 |
Bisphosphonic acid derivatives, and pharmaceutical use
A bisphosphonic acid derivative of the general formula (I): ##STR1## wherein A is an optionally substituted cyclic group; R 1 is hydrogen atom or a lower alkanoyl group; R 2 , R 3 , R 4 and R 5 ...
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5464754 |
Assay and substrate for arachidonoyl-specific phospholipase A2
A non-radioactive, spectrophotometric, microtiter plate assay for human cystolic phospholipase A 2 (cPLA 2 ) is described. The assay utilizes a novel synthetic thiol-phospholipid analog as a...
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5415855 |
Cosmetic composition
Modified ceramides are defined, together with their synthesis and compositions comprising them for topical application to human skin, hair and nails. The modified pseudoceramides have a structure:...
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5407924 |
Method of treating pain using inositol triphosphate
A method of preventing or alleviating pain by administering to a human or other mammal in need thereof of a pain preventing or alleviating effective amount of a pharmaceutical composition...
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5360797 |
Bisphosphonic acid derivatives useful as anti-arthritic agents
Novel acids, esters, and salts of phenyl, naphthyl, quinoxalinyl, and biphenyl bisphosphonic acids and 1,2-oxaphosphepins are described. These compounds are useful as antiinflammatory and...
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5344825 |
Methanediphosphonic acid formulations with ion exchangers
The invention relates to a novel advantageous oral dosage form for methanediphosphonates, especially the active ingredient disodium pamidronate. A preferred dosage form comprises: a)...
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5342832 |
Use of mono and di inositolphosphates for treating inflammation
A method of preventing or alleviating tissue damage, diabetes and complications thereof, bone disorders, disorders related to transplantation, disorders related to abnormal levels of lipoproteins,...
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5330979 |
Method of treating renal disorders with inositoltriphosphate
A method of preventing or alleviating renal disorders by administering to a human or an animal in need thereof a pharmaceutical composition comprising an effective amount amount of at least one...
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5284839 |
Use of inositoltrisphosphate to treat abnornal gastrointestinal motility and secretion
The present invention relates to the use of inositoltrisphosphate (IP 3 ) for the preparing of a medicament effective as a neuropeptide Y- (NPY-) antagonist and to a pharmaceutical composition...
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5280020 |
Drug and method for increasing the microcirculatory flow-rate and volume in the capillaries to the skin
A drug is described which includes a physico-chemical complex between molecules of a phospholipid and an aminoketone derivative of fluoroglucinol which is useful, particularly when administered...
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5268176 |
Method and compositions for the non-invasive treatment of telangiectasia
This invention is directed to a non-invasive, topical treatment for telangiectasia, a dermatological condition commonly known as spider veins. The treatment preferably includes repeated...
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5260287 |
Polyphosphorylated organic compounds: compositions useful in protecting biological tissues
Compositions and methods for protecting the luminal lining against gastric acid challenge are disclosed. The compositions provide effective anti-ulcer preparations which include phosphorylated...
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5135923 |
Method of treating cardiovascular diseases
A method of reducing the negative effect of cadmium or aluminum ion or free-radicals in body tissues and a method of alleviating cardiovascular diseases and conditions by administering to a human...
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5128332 |
Method of treating cardiovascular diseases using inositoltrisphosphate
A method of preventing or alleviating certain conditions by administering to a human or an animal a pharmaceutical composition comprising an amount of at least one specific isomer of inositol...
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5122603 |
Purified insulin mediators and purification process for same
A method for purifying two distinct insulin mediators to substantial homogeneity, and relative purity values above 80%, comprises adsorption on first anion exchange resin and subsequently on a...
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5120721 |
Acaricidal composition
An acaricidal composition comprising as active ingredients (A) either α-cyano-3-phenoxybenzyl 2,2,3,3-tetramethylcyclopropanecarboxylate or α-cyano-3-phenoxybenzyl...
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5089265 |
Stabilized phytic acid compositions
A stabilized phytic acid composition is provided, which comprises phytic acid or its salt and at least one stabilizer selected from the group consisting of a product obtained by the lactic...
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5059594 |
Phytic acid compositions
A novel composition contains phytic acid and ferric ions as main ingredients and carboxylic acid ions as a dissolution accelerator, and may further include at least one or more or two additives...
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5057507 |
Method of alleviating bone damage with inositoltriphosphate
A method of preventing or alleviating tissue or bone damage in mammals is disclosed. The method comprises administering, to a mammal, a tissue damage or a bone damage preventing or alleviating...
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