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7618954 |
Inositol pyrophosphates, and methods of use thereof
The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm...
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7612052 |
Combinations comprising epothilones and pharmaceutical uses thereof
The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I
wherein A represents O...
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7605148 |
Aqueous oral solution of bisphosphonic acid
The present invention relates to stable aqueous oral formulation of bisphosphonic acid or its pharmaceutically acceptable salts. More particularly, the present invention relates to stable aqueous...
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7579333 |
Therapy using a combination of raloxifene and alendronate
Provided are methods of treating bone disease including, but not limited to, osteoporosis, metastatic bone disease, or Paget's disease, by administering a combination of raloxifene and alendronate...
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7576053 |
Methods and compositions for treating degenerative bone disorders
The present disclosure provides methods and compositions using Syk inhibitory compounds for treating degenerative bone disorders and as prophylactic treatment to prevent bone loss. These treatments...
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7517868 |
Phytic citrate compounds and process for preparing the same
The present invention provides a chemical compound or a salt thereof having the chemical formula of:
wherein said R is H or citrate and wherein at least one R is citrate. The salt of the...
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7511028 |
Use of bisphosphonates for otosclerosis
A method of treating otosclerosis in a human in need thereof by administering a bisphosphonate in a defined dosing schedule. The invention demonstrates an effective response and sustained benefit...
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7507715 |
Methods useful in the treatment of bone resorption diseases
The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, said preparation being adapted for (a) the administration of...
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7488786 |
Oxathiazaphospholidine free radical control agent
This invention discloses a process for producing a polymer by controlled polymerization which comprises polymerizing at least one monomer in the presence of a free radical control agent of the...
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7473684 |
Bisphosphonate formulation
A bisphosphonate for treatment of osteoporosis is formulated with an amount of an antifoaming agent effective for reducing foaming in the stomach, leading to reduced reflux and oesophageal...
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7399756 |
Organo-phosphorous compounds for activating gamma/delta T cells
The present invention describes organophosphorus compounds of general formula (I)
their preparation and their uses in the activation of gamma/delta T-cells, in the screening of GcpE and LytB...
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7309698 |
Compositions for delivering bisphosphonates
Compounds and compositions for the delivery of bisphosphonates are provided. Methods of preparation, administration and treatment are provided as well.
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7288535 |
Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates
The invention relates to compositions and methods for use in treating skeletal system disorders in a vertebrate at risk for bone loss, and in treating conditions that are characterized by the need...
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7268124 |
Geranylgeranyl pyrophosphate synthase inhibitors
The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use.
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7262182 |
Sulfonylethyl phosphorodiamidates
Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for...
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7217703 |
8-(2-hydroxyphenoxy)octyldiethanolamine and salts thereof for delivery of active agents
The present invention provides 8-(2-hydroxyphenoxy)octyldiethanolamine) and salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents...
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7199113 |
Pharmaceutically active compounds and methods of use thereof
The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are...
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7176191 |
Antimicrobial compounds and methods for their use
The present invention provides protonated compounds having antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The...
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7112577 |
Pharmaceutically acceptable alendronate salts in amorphous form
A pharmaceutically acceptable alendronate salt in an amorphous form.
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7109184 |
Phosphate transport inhibitors
Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I):
R1 and R2 are independently —H, an electron withdrawing group or a C 1 –C 10 alkyl group....
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7109181 |
Joint lubrication with P2Y purinergic receptor agonists
The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises...
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7101711 |
Phosphoepoxides, method for making same and uses
The invention provides compounds comprising at least one phosphoepoxide group of the formula:
where R1 is selected from among —CH 3 and —CH 2 —CH 3 ,
Cat+ is an organic or...
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7090865 |
Composition and method for treating autoimmune hemolytic anemia
Disclosed are a composition and method to treat or prevent antibody-induced anemia and particularly, autoimmune hemolytic anemia. The composition comprises a bisphosphonate and a pharmaceutically...
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7084126 |
Methods and compositions for enhancing cellular function through protection of tissue components
Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors,...
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7084115 |
Inositol pyrophosphates, and methods of use thereof
The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm...
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7078059 |
Treatment of bone diseases
The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis...
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7008645 |
Method of inhibiting restenosis using bisphosphonates
A method of inhibiting the activity or production of cytokines or growth factors associated with vascular restenosis, by administering to an individual an effective amount of an active ingredient...
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6984400 |
Method of treating restenosis using bisphosphonate nanoparticles
A method of treating or preventing restenosis by administering to an individual an effective amount of an active ingredient comprising a bisphosphonate particle or a bisphosphonate particulate. The...
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6905701 |
Formulations for transmucosal vaginal delivery of bisphosphonates
Devices, methods, and improved formulation for transmucosal vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the systemic circulation using a vaginal device...
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6864228 |
Use of bisphosphonates for the treatment of osteogenesis imperfecta
This procedure consists in the first stage, of the administration of enough quantity of bisphosphonate preparation during the necessary period of time to acquire a degree of volumetric mineral...
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6803057 |
Hydrogen peroxide disinfectant with increased activity
An acidic aqueous hydrogen peroxide solution is provided with improved disinfectant activity. Concentrated solutions preferably contain up to about 8 wt./wt. % H2O2 and as-used concentrations...
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6719998 |
Treatment of restenosis
Bisphosphonate (BP), pyrophosphate (PP) a complex of BP or PP, a polymer of BP or PP or pharmaceutically acceptable salt or ester thereof, are used for the prevention or treatment of vascular...
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6682718 |
Remedies for periodontosis
The invention relates to an alveolar bone resorption inhibitor for use in topical injection by an alveolar mucosa injection method, which comprises a bisphosphonic acid derivative or a salt thereof...
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6680307 |
Use of ibandronate for promoting osseointegration of endoprostheses
The invention relates to use of ibandronic acid (1-hydroxy-3-(N-methyl-N-pentyl)aminopropyl-1,1-diphosphonic
acid) or physiologically compatible salts or esters thereof for improving the...
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6677320 |
Parenteral bisphosphonate composition with improved local tolerance
The present invention relates to a parenteral composition comprising a bisphosphonic acid or a pharmaceutically acceptable salt thereof (bisphosphonate) as active component and a pharmaceutically...
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6605603 |
Uses of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid
The present invention relates to novel uses of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid or any of its soluble salts or any of its hydrates, in particular its use for the...
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6589564 |
Use of magnesium based products for the treatment of neoplastic diseases
A method of treating solid neoplastic diseases is disclosed, which involves administering to a host in need of such treatment an effective amount of a pharmaceutically acceptable magnesium salt or...
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6583182 |
Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy and diagnosis
This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or...
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6583126 |
Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B)
The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods...
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6566304 |
Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture
The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a)...
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6555138 |
Polyethylene glycol matrix pellets for greasy, oily or sticky drug substances
A drug delivery system for oral administration in solid dry form of greasy/oily/sticky substance(s) and pharmaceutically active substance(s) or pharmaceutically active substance(s) which...
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6548042 |
Bis-phosphonate compounds
The present invention provides a pharmaceutical compound, or pharmaceutically acceptable salt thereof, for use in medicine, wherein said compound is of formula I wherein R is a pharmaceutically...
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6541454 |
Phosphonates, biphosphonates and pharmaceutical compositions containing them
A method for treating patients having calcium related disorders includes using di- or tripeptide derivatives of bisphosphonates to enhance oral bioavailability of such compounds.
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6534488 |
Radiolabelled bisphosphonates and method
The present invention relates to 32 P or 33 P-labelled bisphosphonates as radiotherapeutic radiopharmaceuticals. The 32 P- or 33 P-labelled bisphosphonates, which are chemically identical to...
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6525035 |
Therapeutic composition and methods
The invention provides composition comprising, 1) polyprenol monophosphates of the formula H—[—CH2-C(CH3)═CH—CH2]n-O—P(═O)(OH)2 wherein n is an integer from 6-19 inclusive or a salt...
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6509324 |
Chelating compounds, their complexes with paramagnetic metals
Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging.
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6506733 |
Compounds and compositions as protease inhibitors
Compounds of the formula: are provided, and are useful as cysteine protease inhibitors, particularly in the treatment of diseases such as osteoporosis or autoimmune disorders in which cathepsins...
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6476006 |
Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
The present invention provides compacted pharmaceutical composition for oral administration to a patient which expands upon contact with gastric fluid to retain a dosage form in the patient's...
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6468559 |
Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods
Oral dosage forms are provided for the administration of a bisphosphonic acid compound in the prevention and treatment of conditions involving calcium or phosphate metabolism, i.e., conditions...
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6436913 |
Use of estramustine phosphate in the treatment of bone metastasis
Estramustine phosphate is shown to act as an inhibitor of bone resorption and can thus be used to treat, prevent or alleviate the symptoms of bone metastasis which arise due to said bone resorption.
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