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7612051 |
Powder composition, dispersion of this powder composition in oil and cosmetic material containing same
This invention relates to a powder composition comprising a silicone represented by the following formula (1) comprising an alcoholic hydroxyl group, and a powder, to an oil-based powder...
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7569558 |
Topical delivery of trace metals for skin care
The present invention relates to a method for topical delivery of trace metals for the modulation of certain metalloenzymes. The method of topical delivery of the present invention comprises; (i)...
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7514244 |
Lipid and food compositions containing docosahexaenoic acid and docosapentaenoic acid
A process for preparing lipids which contain docosahexaenoic acid (DHA) and/or docosapentaenoic acid (DPA) is disclosed. The process includes the steps of cultivating in a medium a microorganism...
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7456214 |
Chromene-containing compounds with anti-tubulin and vascular targeting activity
Chrome compounds have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are...
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7419657 |
Treatment of atherosclerotic disorders
The present invention relates to the identification of lipid oxidizing abzymes as a key pathogenic factor in atherosclerotic disorders. Methods and means for the reduction of abzyme mediated lipid...
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7417156 |
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers
In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily...
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7232809 |
Mitochondrially targeted antioxidants
The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred...
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7229979 |
Hypoestoxides, derivatives and agonists thereof for use as stent-coating agents
Methods of treating a host suffering from restenosis are provided. The methods include delivery of a stent coated with a hypoestoxide, hypoestoxide derivative or hypoestoxide agonist compound to a...
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7192939 |
Pestalotiopsis microsporia isolates and compounds derived therefrom
The present invention relates to the novel isolated 12–30 strain of Pestalotiopsis microspora capable of producing novel antioxidant and antimycotic agents. The present invention also relates...
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7192905 |
Organophosphate insecticide synergists for fly and tick control
Combination of a cytochrome P450 monooxygenase inducer with an organophosphate pesticide (insecticide or acaracide) provides effective control of ticks and flies, particularly against...
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7144867 |
Anticancer glycoside compounds
The present invention relates to new classes of anti-cancer compounds. In particular, the present invention provides glycoside compounds as anti-cancer agent, alone, or in combination with other...
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7122525 |
Targeted therapeutics and uses thereof
The invention features a method of delivering a drug to a diseased cell by linking the drug to a rifamycin derivative, compositions that include drug-rifamycin conjugates of the invention, and...
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7084134 |
Thrombin inhibitors
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:
or a pharmaceutically acceptable salt thereof.
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7060290 |
Phosphocholine linked prodrug derivatives
Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or...
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7056499 |
Treating method for suppressing hair growth
The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present...
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7019024 |
Pharmaceutical for treatment of neurological and neuropsychiatric disorders
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof.
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6974806 |
Lipid-rich plaque inhibitors
The present invention provides a lipid-rich plaque regressing agent comprising a compound represented by Formula:
in which ring A is a cyclic hydrocarbon or the like; ring B is a heterocyclic...
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6858593 |
Anti-inflammatory androstane derivative compositions
There is provided a crystalline chemical composition comprising a compound of formula (I)
in which the crystal lattice is stabilized by the presence of a guest molecule, characterized in the...
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6858209 |
Means for detecting bacteria of the taylorella equigenitalis species and their biological applications
Means for detection of bacteria of the genus Taylorella and biological applications thereof are described. In particular, the detection of T. equigenitalis and the treatment or prevention of...
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6780430 |
Stabilzation method of nano-sized emulsion using tocopheryl derivatives and external application for skin containing the same
Disclosed herein is a stabilization method of nano-sized emulsion by using lecithin and tocopheryl derivatives represented by the following formula (I) and (Wherein, R 1 , R 2 and R 3 are H or...
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6774142 |
Inhibition by 3-deoxyflavonoids of T-lymphocyte activation and therapies related thereto
3-Deoxyflavonoid compounds and methods for inhibiting T-cell activity and treating diseases and disorders (e.g., autoimmune disorders, inflammatory disorders, diabetes, ALS, MS, rheumatoid...
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6656927 |
Ip3 receptor ligands
A compound represented by the general formula (I) or a salt thereof, wherein R represents a group represented by the following formula (A), (B) or (C) wherein R 1 and R 2 independently represent...
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6645951 |
Benzopyran or thiobenzopyran derivatives
The present invention provides novel benzopyran compounds, pharmaceutically acceptable salts thereof and stereoisomers thereof where the benzopyran compounds of the invention are compounds...
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6642216 |
Isoprenoid pathway inhibitors for stimulating bone growth
Compounds of the formula wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6C; Y is of the formula or a...
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6552007 |
Use of somatostatin analogs for the delivery of anti-tumor drugs to tumor cells
A conjugate of somatostatin-spacer-drug and a method of making the same. The conjugate can be used to enhance an anti-cancer drug's specificity on the targeted tumor cells, thus increasing its...
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6537759 |
Folylpolyglutamate synthetase gene sequence variances having utility in determining the treatment of disease
The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods...
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6498151 |
Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors
The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and...
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6429202 |
Phospholipid complexes of proanthocyanidin A2 as antiatherosclerotic agents
The present invention relates to complexes of proanthocyanidin A2 and one or more phospholipids, pharmaceutical compositions containing the complex of proanthocyanidin A2 and one or more...
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6410592 |
Aminomethylcarboxylic acid derivatives
The present invention relates to aminomethylcarboxylic acid derivatives general formula (I), wherein Z is (CH 2 ) n , O, S, SO, SO 2 or N—R 5 ; n is 0, 1 or 2; X represents 1-3 substituents...
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6410521 |
Nutritional supplements for stimulating bone growth
A food or food supplement which comprises a compound that enhances bone growth in vertebrates is described wherein the food or foodstuff is formulated so as to provide the desired bone growth...
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6380175 |
Method for enhancement of delivery of THC by the administration of its prodrugs via the nasal route
The present invention is directed to a method for enhancing the delivery of delta-9-tetrahydrocannabinol (“THC”) to the brain of a mammal in need of treatment with this drug, by administering...
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6379684 |
Cosmetic compositions containing cromolyn compounds for revitalizing the skin
Cosmetic compositions and methods are provided for revitalizing the skin especially where it is placed in an environment that can cause injury to the skin. The compositions contain an effective...
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6277834 |
Agents for relieving side effects of adrenal cortex hormone
A medicament for reducing side effects of adrenocortical hormones comprising a phosphodiester compound of the following formula or a pharmacologically acceptable salt thereof ##STR1## wherein R 1 ...
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6258539 |
Restriction enzyme mediated adapter
The present invention relate to methods and compositions for simultaneously analyzing multiple different polynucleotides of a polynucleotide composition comprising multiple diverse polynucleotide...
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6096740 |
Dexanabinol derivatives and their use as neuroprotective pharmaceutical compositions
The present invention relates to pharmaceutical compositions for preventing or alleviating neurotoxicity. Said pharmaceutical compositions comprise as their active ingredient the stereospecific (+)...
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6087347 |
3-substituted-D-homo-1,3,5(10)-estratriene derivatives
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6083874 |
Composition and method for plant desiccation
This invention relates to an improved composition of matter for and method of desiccating plants such as, for example, cotton. More particularly, this invention relates to an improved desiccating...
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6069139 |
Method and composition for prophulaxis and treatment of retinal diseases
A pharmaceutical composition is provided for prophylaxis and treatment of a retinal disease in a human comprising (a) a compound of the formula I: ##STR1## wherein R 1 and R 2 independently from...
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6054448 |
2-amino-2-(3-substituted cyclobutyl) acetic acid derivatives
Compounds of the formula ##STR1## in which R 1 is Y or Y--C 1 -6 alkyl, where Y is carboxy, tetrazolyl, --SO 2 H, --SO 3 H, --OSO 3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or...
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6046181 |
Highly purified tocopheryl phosphate, process for producing the same, analytical method therefor and cosmetic
Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl...
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6022867 |
Method of administering vitamin E to animals and compositions containing tocopheryl phosphates and salts thereof for animals
A vitamin E source composition for administration to animals, which comprises a tocopheryl phosphate, a salt thereof or a composition containing a tocopheryl phosphate or a salt thereof. Also,...
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6017935 |
7-sulfur substituted paclitaxels
The present invention relates to novel taxane derivatives wherein, the taxol ring is substituted by sulfur groups on the C-7, their use as antitumor agents and pharmaceutical formulations.
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5994328 |
Hypoestoxides, derivatives and agonists thereof for use as anticancer agents
A method for inhibiting the growth of cancer cells ous tumors. The method comprises administering to a subject in need of anticancer or antitumor therapy a pharmaceutical composition comprising a...
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5985856 |
Water soluble prodrugs of secondary and tertiary amine containing drugs and methods of making thereof
The present invention is drawn to water soluble derivatives aliphatic acid aromatic secondary and tertiary amine containing drugs. The present invention is further drawn to methods of making water...
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5981514 |
(N-alkyl-N-hydroxymethylamino)alkoxybenzoylbenzofurans and the phosphate esters thereof
Disclosed herein are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein R 1 is alkyl of 1-6 carbon atoms; A is alkylene having from 2-5 carbon atoms,...
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5962438 |
Estrogen derivative having carriers to bone
A novel estrogen derivative represented by the formula: ##STR1## is useful for treating or preventing diseases caused by estrogen deficiency.
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5955453 |
Membrane-permeant phosphoinositides
Membrane-permeant phosphoinositides, including phosphatidylinositol phosphate esters, are described. A membrane-permeant phosphoinositide includes groups that neutralize the charges of the...
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5952001 |
Use of an α-tocopherol phosphate or a derivative thereof for preparing cosmetic, dermatological or pharmaceutical compositions, and compositions thereby obtained
The present invention relates to the use of an α-tocopherol phosphate, especially in its dl or d form, or an ester thereof, of the general formula ##STR1## in which: R 1 is a hydrogen atom, an...
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5880111 |
Therapeutic derivations of diphosphonates
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, and infectious urinary tract stones, are obtained by...
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5861384 |
Immunosuppressive-activity potentiating compositions
According to the present invention, there are provided immunosuppressive-activity potentiating compositions which comprise a phosphoric acid diester compound represented by the following formula ...
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