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7414023 Peptide ligands for prostate specific antigen  
The present invention relates to novel peptide ligands for prostate specific antigen (PSA) binding specifically with it and enhancing its enzyme activity, to a process for preparation of these...
7351790 Peptide-based compounds  
The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise a targeting vector which binds to receptors associated...
RE39887 Dehydrodidemnin B  
Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives.
7265118 Regulation of substrate activity  
A method for regulating substrate activity in vivo is useful for the treatment of medical disorders such as inflammation, arteriolosclerosis and angiogenesis. The method involves the administration...
7217690 Compositions of sunflower trypsin inhibitors  
The present invention provides methods of using small cyclic peptides that can inhibit or prevent skin irritation caused by proteolytic activity.
7199101 Gelling agent for oil  
A gelling agent for an oil, which contains at least one compound (A) and at least one compound (B), and a gel composition containing the gelling agent and an oil: wherein R 1 is a straight...
7173004 Macrocyclic isoquinoline peptide inhibitors of hepatitis C virus  
Macrocyclic isoquinoline peptides are disclosed having the general formula: A compound of formula I: wherein R 1 to R 9 , Q and W are described in the description. Compositions comprising the...
7138103 Use of bi-specific antibodies for pre-targeting diagnosis and therapy  
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable...
7125845 Aza-peptide macrocyclic hepatitis C serine protease inhibitors  
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of...
7122519 Didemnin analogs and fragments and methods of making and using them  
The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes...
7101848 Bicyclic oligopeptides  
The invention relates to a bicyclic oligopeptide or ester thereof having the capability to inhibit the glucagon receptor, comprised of: (a) a first cyclic group, which comprises at least one...
7098024 Depsipeptide compound  
This invention relates to a novel compound which has a cytotoxic activity and TGF-β like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition...
7094431 Method of healing skin wounds in mammals and a composition therefor  
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
7064105 Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them  
The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents...
7056884 Reduced FK228 and use thereof  
The present invention relates to reduced FK228 of the formula (I) wherein R 1 and R 2 are the same or different and each is a hydrogen atom or a thiol-protecting group, or a salt thereof, and...
7041639 Depsipeptide and congeners thereof for use as immunosuppressants  
Depsipeptides and congeners thereof are disclosed having the following structure: wherein m, n, p, q, X, R 1 , R 2 and R 3 are as defined herein. These compounds, including FR901228, have...
7030147 Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative  
Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
7015208 C2-substituted indan-1-ols and their derivatives, processes for their preparation and their use as pharmaceuticals  
Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention...
6979697 Regulation of substrate activity  
A method for regulating substrate activity in vivo is useful for the treatment of medical disorders such as inflammation, arteriolosclerosis and angiogenesis. The method involves the administration...
6955908 Organism associated with nongonococcal urethritis  
The invention features a biologically pure culture of a newly identified single-celled organism Spiky Rotating Cells (SPR), methods to diagnose an SPR infection in a human patient, an instrument...
6946441 Inhibition of histone deacetylase as a treatment for cardiac hypertrophy  
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression,...
6841530 Semi-synthetic studies toward didemnin analogues  
Disclosed are semi-synthetic methods for the preparation of Didemnin Analogs. The compounds of this type are illustrated in Formula (I).
6838441 Albumin for treating meconium aspiration syndrome  
The present invention provides a method of treating meconium aspiration syndrome, said method comprising administering to a subject in need of treatment a therapeutically effective amount of...
6831061 Apicidin-derivatives, their synthetic methods and anti-tumor compositions containing them  
A substituted apicidin derivative, a method of synthesis therefore, and an anti-tumor composition comprising the same are disclosed. The substituent of the derivative is preferably semicarbazone,...
6828302 Therapeutic uses of depsipeptides and congeners thereof  
Depsipeptides and congeners thereof are disclosed having the following structure: wherein m, n, p, q, X, R 1 , R 2 and R 3 are as defined herein. These compounds including FR901228, have...
6828301 Pharmaceutical compositions for hepatitis C viral protease inhibitors  
Disclosed are pharmaceutical compositions of hepatitis C viral protease inhibitors having improved bioavailability, and methods of using these compositions for inhibiting the replication of the...
6706686 Inhibition of histone deacetylase as a treatment for cardiac hypertrophy  
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression,...
6689749 Neuropeptides originating in scorpion  
The invention provides a peptide capable of blocking voltage-gated K + channels and inhibiting IL-2 production, which is represented by an amino acid sequence of: ...
6670326 Depsipeptide compound  
This invention relates to a novel compound which has a cytotoxic activity and TGF-β like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition...
6620782 Substituted 2-aminobenzamide caspase inhibitors and the use thereof  
The present invention is directed to novel 2-aminobenzamide thereof, represented by the general Formula I: where R 1 -R 3 , X, and A—D are defined herein. The present invention also relates to...
6613734 Peptides-containing liposomal surfactants  
The present invention discloses useful surfactant molecules including polypeptides, proteins, and a variety of other organic molecules, as well as methods of making and using same. Surfactant...
6608027 Macrocyclic peptides active against the hepatitis C virus  
The present invention covers macrocyclic compounds of formula I active in-vitro and in cellular assays against the NS3 protease of the hepatitis C virus. wherein W, R 21 , R 22 , R 3 , R 4 , D...
6589536 Soft gelatin capsule manufacture  
Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a...
6586393 Antibiotics GE 23077, pharmaceutically acceptable salts and compositions, and use thereof  
The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated GE23077 complex and the individual factors which constitute it, a mixture of said factors in any...
6548479 Therapeutic uses of depsipeptides and congeners thereof  
Depsipeptides and congeners thereof are disclosed having the following structure: wherein m, n, p, q, X, R 1 , R 2 and R 3 are as defined herein. These compounds, including FR901228, have...
6509315 Didemnin analogs and fragments and methods of making and using them  
The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes...
6407059 Conformationally constrained backbone cyclized peptide analogs  
Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building...
6403555 Depsipeptide and congeners thereof for use as immunosuppressants  
Depsipeptides and congeners thereof are disclosed having the following structure: wherein m, n, p, q, X, R 1 , R 2 and R 3 are as defined herein. These compounds, including FR901228, have...
6380156 Total synthesis of the amino hip analogue of didemnin A  
Disclosed is a synthetic method for the preparation of analogs of Didemnin A (1), particularly the Amino-Hip analog of Didemnin A, also known as “AipDidemnin A” (8). These compounds have the...
6365571 FGF inhibitor, angiogenesis inhibitor and antitumor agent containing complestatin or its derivative as effective ingredient  
There are an FGF inhibitor, a angiogenesis inhibitor and an antitumor agent which are useful as a pharmaceutical and so forth, and comprise complestatin or its derivative as an effective ingredient.
6355614 Cyclic boroproline compounds  
Substantially pure preparations of cyclic boroProline compounds that bind, in cyclic or linear form, to CD26 are provided. Methods for using the cyclic compounds to stimulate the activation and/or...
6331522 Antibacterial and antifungal peptide  
The present invention provides a peptide with antibacterial and antifungal properties, and compositions containing the peptide. Methods of making and using the antibacterial and antifungal peptide...
6319890 Inhibition of binding of complement Factor H  
Pathogen-specific peptide chains are provided which prevent pathogens from escaping complement-mediated lysis. The peptide chains bind to known binding sites on pathogens to which complement...
6284733 Peptide, immunogenic composition and vaccine or medical preparation, a method to immunize animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine  
The invention relates to a modified tandem LHRH-peptide vaccine preparation in which the amino acid glycine at position (6) of one or both LHRH decapeptides that constitute the tandem unit is...
6265375 Conformationally constrained backbone cyclized peptide analogs  
Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building...
6211145 Bicyclic depsipeptides  
The present invention provides a bicyclic depsipeptide having the formula (1) ##STR1## wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched...
6204243 Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis  
The invention relates to a pharmaceutical preparation, which contains an immunosuppressive active agent in dissolved form in a starch capsule, or hard or soft gelatin capsule which has been coated...
6171856 Methods and compositions relating to no-mediated cytotoxicity  
The present invention relates to methods and compositions for the treatment of diabetes involving free radicals. In particular, the present invention is directed to the treatment or prophylactic...
6156724 Uses of didemnins as immunomodulating agents  
The present invention is based upon the immunomodulatory activity of synthetic and semi-synthetic didemnin compounds. It has surprisingly been discovered that certain didemnin compounds possess...
6127336 Antibacterial and antifungal peptide  
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